GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1976 - 2000** of **2090** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	14-3-3 protein sigma Apoptosis regulator BAX Aurora kinase A Cellular tumor antigen p53 Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Growth arrest and DNA damage-inducible protein GADD45 alpha Histone acetyltransferase p300 Histone-arginine methyltransferase CARM1 M-phase inducer phosphatase 3 Proliferating cell nuclear antigen Protein arginine N-methyltransferase 1 Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F4 Zinc finger protein 385A	O14965 P04637 P06493 P12004 P14635 P24522 P28749 P30307 P31947 Q07812 Q08999 Q09472 Q14186 Q14188 Q16254 Q86X55 Q96PM9 Q99873	AIK AIRK1 ARK1 AURA AURKA AYK1 BAX BCL2L4 BTAK CARM1 CCNB CCNB1 CDC2 CDC25C CDC28A CDK1 CDKN1 DDIT1 DP1 DP2 E2F4 EP300 GADD45 GADD45A HME1 HMT2 HRMT1L2 HZF IAK1 IR1B4 P300 P34CDC2 P53 PCNA PRMT1 PRMT4 RB2 RBL1 RBL2 RZF SFN STK15 STK6 TFDP1 TFDP2 TP53 ZNF385 ZNF385A
HSF1 activation	14-3-3 protein epsilon Elongation factor 1-alpha 1 Heat shock factor protein 1 Heat shock factor-binding protein 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Histone deacetylase 6 Prostaglandin E synthase 3 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Transitional endoplasmic reticulum ATPase	O75506 P07900 P08238 P15927 P27694 P35244 P55072 P62258 P68104 Q00613 Q15185 Q9UBN7	EEF1A EEF1A1 EF1A HDAC6 HEL-220 HEL-S-70 HSBP1 HSF1 HSF1BP HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB HSTF1 KIAA0901 LENG7 P23 PTGES3 REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 TEBP VCP YWHAE
NADE modulates death signalling	14-3-3 protein epsilon Beta-nerve growth factor Caspase-2 Caspase-3 Protein BEX3 Tumor necrosis factor receptor superfamily member 16	P01138 P08138 P42574 P42575 P62258 Q00994	BEX3 CASP2 CASP3 CPP32 DXS6984E ICH1 NADE NEDD2 NGF NGFB NGFR NGFRAP1 TNFRSF16 YWHAE
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	14-3-3 protein epsilon Amyloid-beta precursor protein Bcl-2-like protein 11 Calpain small subunit 1 Calpain small subunit 2 Calpain-1 catalytic subunit Calpain-2 catalytic subunit Calpastatin Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 Forkhead box protein O3 Golgin subfamily A member 2 Lamin-B1 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 M-phase inducer phosphatase 3 Peroxiredoxin-1 Peroxiredoxin-2 Superoxide dismutase [Mn], mitochondrial Transcription factor Jun Tumor necrosis factor ligand superfamily member 6	O43521 O43524 P04179 P04632 P05067 P05412 P07384 P17655 P20700 P20810 P30304 P30305 P30307 P32119 P48023 P62258 Q00535 Q06830 Q08379 Q15078 Q96L46	A4 AD1 APP APT1LG1 BCL2L11 BIM CANPL1 CANPL2 CAPN1 CAPN2 CAPN4 CAPNS CAPNS1 CAPNS2 CAST CD95L CDC25A CDC25B CDC25C CDC25HU2 CDK5 CDK5R CDK5R1 CDKN5 FASL FASLG FKHRL1 FOXO3 FOXO3A GOLGA2 JUN LMN2 LMNB LMNB1 NCK5A NKEFB PAGA PAGB PRDX1 PRDX2 PSSALRE SOD2 TDPX1 TDPX2 TNFSF6 YWHAE
Regulation of HSF1-mediated heat shock response	14-3-3 protein epsilon Active regulator of SIRT1 Aladin BAG family molecular chaperone regulator 1 BAG family molecular chaperone regulator 2 BAG family molecular chaperone regulator 3 BAG family molecular chaperone regulator 4 BAG family molecular chaperone regulator 5 Cell cycle and apoptosis regulator protein 2 DnaJ homolog subfamily B member 1 DnaJ homolog subfamily B member 6 DnaJ homolog subfamily C member 2 DnaJ homolog subfamily C member 7 E3 SUMO-protein ligase RanBP2 Endoplasmic reticulum chaperone BiP Glycogen synthase kinase-3 beta Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 12A Heat shock 70 kDa protein 12B Heat shock 70 kDa protein 13 Heat shock 70 kDa protein 14 Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock 70 kDa protein 4 Heat shock 70 kDa protein 4L Heat shock 70 kDa protein 6 Heat shock cognate 71 kDa protein Heat shock factor protein 1 Heat shock protein 105 kDa Heat shock-related 70 kDa protein 2 Hsc70-interacting protein MAP kinase-activated protein kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NAD-dependent protein deacetylase sirtuin-1 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Protein Hikeshi Protein SEC13 homolog Putative heat shock 70 kDa protein 7 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Stress-70 protein, mitochondrial mRNA export factor RAE1	A8CG34 O15504 O43301 O75190 O75694 O95429 O95757 O95816 O95817 P0DMV8 P0DMV9 P11021 P11142 P12270 P15927 P17066 P25685 P27361 P27694 P28482 P34931 P34932 P35244 P35658 P37198 P38646 P48723 P48741 P49137 P49790 P49792 P49841 P50502 P54652 P55735 P57740 P62258 P78406 Q00613 Q0VDF9 Q12769 Q13315 Q13535 Q53FT3 Q5SRE5 Q7Z3B4 Q86WX3 Q8N163 Q8N1F7 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92598 Q92621 Q96EB6 Q96HA1 Q96MM6 Q99543 Q99567 Q99615 Q99933 Q9BTX1 Q9BW27 Q9NRG9 Q9UKX7 Q9UL15	AAAS AAG2 ADRACALA APG1 APG2 AROS ATM ATR BAG1 BAG2 BAG3 BAG4 BAG5 BIS C11orf73 C20orf60 C7orf14 CAIN CAN CCAR2 CG1 D3S1231E DBC1 DNAJ1 DNAJB1 DNAJB6 DNAJC2 DNAJC7 ERK1 ERK2 FAM10A1 FRP1 GRP75 GRP78 GSK3B HAP HDJ1 HIKESHI HIP HSC70 HSF1 HSJ2 HSP105 HSP110 HSP60 HSP70B HSP70B' HSP70L1 HSP72 HSP73 HSPA1 HSPA10 HSPA12A HSPA12B HSPA13 HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA4L HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 HSPA9B HSPF1 HSPH1 HSPH2 HSPH3 HSTF1 HSX70 KIAA0023 KIAA0095 KIAA0169 KIAA0197 KIAA0201 KIAA0225 KIAA0417 KIAA0618 KIAA0791 KIAA0873 KIAA0906 KIAA1967 MAPK1 MAPK3 MAPKAPK2 MP44 MPHOSPH11 MPP11 MRJ MRNP41 MSJ1 NDC1 NPAP60L NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 OSP94 PCNT1 POM121 POM121A POM121C PRKM1 PRKM2 PRKM3 RAE1 RANBP2 REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS19BP1 SEC13 SEC13A SEC13L1 SEC13R SIR2L1 SIRT1 SNC6 SODD ST13 STCH TMEM48 TPR TPR2 TTC2 YWHAE ZRF1 mt-HSP70
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal-like protein Alsin Ankyrin repeat domain-containing protein 27 BLOC-3 complex member HPS1 BLOC-3 complex member HPS4 C-myc promoter-binding protein DENN domain-containing protein 1A DENN domain-containing protein 1B DENN domain-containing protein 1C DENN domain-containing protein 2A DENN domain-containing protein 2B DENN domain-containing protein 2C DENN domain-containing protein 2D DENN domain-containing protein 3 DENN domain-containing protein 4B DENN domain-containing protein 4C DENN domain-containing protein 5A DENN domain-containing protein 5B GTPase-activating protein and VPS9 domain-containing protein 1 Guanine nucleotide exchange factor for Rab-3A Guanine nucleotide exchange factor subunit RIC1 Myotubularin-related protein 13 Myotubularin-related protein 5 Protein DENND6A Protein DENND6B RAB6A-GEF complex partner protein 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein non-catalytic subunit Rab5 GDP/GTP exchange factor Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like protein Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-35 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B Serine/threonine-protein kinase ULK1 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Vacuolar fusion protein CCZ1 homolog B Vacuolar fusion protein CCZ1 homolog Vacuolar fusion protein MON1 homolog A Vacuolar fusion protein MON1 homolog B	A2RUS2 A5PLN9 O00194 O43617 O75064 O75385 O75865 O95248 P0DI81 P20336 P20339 P20340 P24386 P26374 P31150 P31749 P31751 P48553 P50395 P51148 P51149 P51151 P51153 P51159 P57729 P61006 P61020 P61026 P61106 P62258 P62820 P78524 P86790 P86791 Q13636 Q13637 Q13671 Q14964 Q14C86 Q15042 Q15286 Q4ADV7 Q5VZ89 Q60I27 Q68D51 Q6IQ22 Q6IQ26 Q6P3S1 Q6ZS11 Q6ZUT9 Q7L1V2 Q7Z392 Q7Z401 Q86SZ2 Q86VX9 Q86WG5 Q8IUR0 Q8IV53 Q8IWF6 Q8NEG7 Q8TB24 Q8TBN0 Q8TEH3 Q8WVT3 Q8WYP3 Q92546 Q92902 Q92930 Q96AH8 Q96DA2 Q96NW4 Q96Q05 Q96Q42 Q96QF0 Q9H0U4 Q9H2M9 Q9H6A0 Q9NP72 Q9NP90 Q9NQG7 Q9NRW1 Q9UJ41 Q9UL25 Q9UL33 Q9ULE3 Q9Y243 Q9Y296 Q9Y2L5 Q9Y5R8	AKT1 AKT2 AKT3 ALS2 ALS2CL ALS2CR6 ANKRD27 BET3 BET5 C1orf218 C4orf41 C5orf44 C7orf28A C7orf28B C9orf55 C9orf55B CCZ1 CCZ1B CHM CHML CIP150 CMT4B2 DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B EHOC1 FAM116A FAM116B FAM31A FAM31B FAM31C GAPEX5 GAPVD1 GDI1 GDI2 GDIL HPS HPS1 HPS4 HSRG1 HTS1 IRLB KIAA0066 KIAA0118 KIAA0258 KIAA0476 KIAA0722 KIAA0839 KIAA0870 KIAA0872 KIAA1012 KIAA1091 KIAA1277 KIAA1432 KIAA1521 KIAA1563 KIAA1608 KIAA1667 KIAA1766 KIAA1882 MEL MON1A MON1B MTMR13 MTMR5 MUM2 MYCPBP NIBP OPHN2 PKB PKBG RAB1 RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB1C RAB21 RAB22B RAB27 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3GAP RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB6IP1 RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABEX5 RABGDIA RABGDIB RABGEF1 RABIN8 RABL RAC RAP6 RASSF4 RAY REP1 REP2 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SAND1 SAND2 SBDN SBF1 SBF2 SEDL ST5 TCD TMEM1 TRAMM TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TTC15 ULK1 XAP4 YWHAE
Recruitment of mitotic centrosome proteins and complexes	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cyclin-dependent kinase 11A Cyclin-dependent kinase 11B Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic Gamma-tubulin complex component 2 Gamma-tubulin complex component 3 Gamma-tubulin complex component 4 Gamma-tubulin complex component 5 Gamma-tubulin complex component 6 HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Mitotic-spindle organizing protein 1 Mitotic-spindle organizing protein 2A Mitotic-spindle organizing protein 2B Ninein-like protein Nuclear distribution protein nudE homolog 1 Nucleoside diphosphate kinase homolog 7 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain Tubulin gamma-2 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P21127 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61163 P61981 P62258 P63167 P68366 P68371 Q08AG7 Q13409 Q13561 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q6NZ67 Q6P582 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96CW5 Q96MT8 Q96RT7 Q96RT8 Q96SN8 Q99871 Q99996 Q9BSJ2 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NRH3 Q9NVX0 Q9NXR1 Q9P209 Q9UGJ1 Q9UPN4 Q9UPV0 Q9UQ88 Q9Y2I6 Q9Y5B8	76P ACTR1A AKAP350 AKAP450 AKAP9 ALMS1 AZI1 BBS14 BITE C13orf37 C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCP110 CDC2 CDC28A CDC2L1 CDC2L2 CDC2L3 CDK1 CDK11 CDK11A CDK11B CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM128A FAM128B FAM29A FGFR1OP FOP GCP2 GCP3 GCP4 GCP5 GCP6 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 KIAA1669 KIAA1899 LAP LIP1 LIS1 MAPRE1 MAST1 MDCR MDS MOZART1 MOZART2A MOZART2B MZT1 MZT2A MZT2B NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NME7 NPHP10 NPHP15 NPHP6 NUDE ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PITSLREA PITSLREB PK58 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SAK SDCCAG8 SFI1 SSNA1 STK18 TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UCHL5IP UIP1 YWHAE YWHAG
Loss of proteins required for interphase microtubule organization from the centrosome	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Ninein-like protein Nuclear distribution protein nudE homolog 1 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61163 P61981 P62258 P63167 P68366 P68371 Q13409 Q13561 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96MT8 Q96SN8 Q99871 Q99996 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXR1 Q9P209 Q9UPN4 Q9UPV0 Q9Y2I6	ACTR1A AKAP350 AKAP450 AKAP9 ALMS1 AZI1 BBS14 BITE C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM29A FGFR1OP FOP HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 LAP LIP1 LIS1 MAPRE1 MAST1 MDCR MDS NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NPHP10 NPHP15 NPHP6 NUDE ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SAK SDCCAG8 SFI1 SSNA1 STK18 TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UCHL5IP UIP1 YWHAE YWHAG
Loss of Nlp from mitotic centrosomes	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Ninein-like protein Nuclear distribution protein nudE homolog 1 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61163 P61981 P62258 P63167 P68366 P68371 Q13409 Q13561 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96MT8 Q96SN8 Q99871 Q99996 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXR1 Q9P209 Q9UPN4 Q9UPV0 Q9Y2I6	ACTR1A AKAP350 AKAP450 AKAP9 ALMS1 AZI1 BBS14 BITE C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM29A FGFR1OP FOP HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 LAP LIP1 LIS1 MAPRE1 MAST1 MDCR MDS NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NPHP10 NPHP15 NPHP6 NUDE ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SAK SDCCAG8 SFI1 SSNA1 STK18 TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UCHL5IP UIP1 YWHAE YWHAG
Recruitment of NuMA to mitotic centrosomes	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic Gamma-tubulin complex component 2 Gamma-tubulin complex component 3 Gamma-tubulin complex component 4 Gamma-tubulin complex component 5 Gamma-tubulin complex component 6 HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Mitotic-spindle organizing protein 1 Mitotic-spindle organizing protein 2A Mitotic-spindle organizing protein 2B Ninein-like protein Nuclear distribution protein nudE homolog 1 Nuclear mitotic apparatus protein 1 Nucleoside diphosphate kinase homolog 7 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain Tubulin gamma-2 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61163 P61981 P62258 P63167 P68366 P68371 Q08AG7 Q13409 Q13561 Q14008 Q14204 Q14980 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q6NZ67 Q6P582 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96CW5 Q96MT8 Q96RT7 Q96RT8 Q96SN8 Q99871 Q99996 Q9BSJ2 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NRH3 Q9NVX0 Q9NXR1 Q9P209 Q9UGJ1 Q9UPN4 Q9UPV0 Q9Y2I6 Q9Y5B8	76P ACTR1A AKAP350 AKAP450 AKAP9 ALMS1 AZI1 BBS14 BITE C13orf37 C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM128A FAM128B FAM29A FGFR1OP FOP GCP2 GCP3 GCP4 GCP5 GCP6 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 KIAA1669 KIAA1899 LAP LIP1 LIS1 MAPRE1 MAST1 MDCR MDS MOZART1 MOZART2A MOZART2B MZT1 MZT2A MZT2B NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NME7 NMP22 NPHP10 NPHP15 NPHP6 NUDE NUMA NUMA1 ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SAK SDCCAG8 SFI1 SSNA1 STK18 TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UCHL5IP UIP1 YWHAE YWHAG
Anchoring of the basal body to the plasma membrane	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin B9 domain-containing protein 1 B9 domain-containing protein 2 C2 domain-containing protein 3 CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 162 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosomal protein of 83 kDa Centrosomal protein of 89 kDa Centrosomal protein of 97 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Coiled-coil and C2 domain-containing protein 2A Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic Fas-binding factor 1 HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha IQ calmodulin-binding motif-containing protein 1 Jouberin Kinesin-like protein KIF24 MAP/microtubule affinity-regulating kinase 4 Meckelin Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Nephrocystin-1 Nephrocystin-4 Ninein-like protein Nuclear distribution protein nudE homolog 1 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Protein fantom Rab-3A-interacting protein Ras-related protein Rab-11A Ras-related protein Rab-8A Septin-2 Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Sodium channel and clathrin linker 1 Tau-tubulin kinase 2 Tectonic-1 Tectonic-2 Tectonic-3 Tectonic-like complex member MKS1 Transmembrane protein 216 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O15078 O15259 O43303 O43805 O75161 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61006 P61163 P61981 P62258 P62491 P63167 P68366 P68371 Q13409 Q13561 Q14008 Q14204 Q15019 Q15051 Q15154 Q15691 Q2MV58 Q4AC94 Q5BJF6 Q5HYA8 Q5JTW2 Q5T7B8 Q5TB80 Q66GS9 Q68CZ1 Q68CZ6 Q6IQ55 Q6NUS6 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8IW35 Q8N157 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q8TES7 Q96CS2 Q96GX1 Q96L34 Q96MT8 Q96NL6 Q96QF0 Q96SN8 Q96ST8 Q99871 Q99996 Q9BPU9 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXB0 Q9NXR1 Q9P0N5 Q9P209 Q9P2K1 Q9UPM9 Q9UPN4 Q9UPV0 Q9Y2I6 Q9Y592	ACTR1A AHI1 AKAP350 AKAP450 AKAP9 ALB ALMS1 AZI1 B9D1 B9D2 BBS14 BITE C10orf61 C12orf38 C14orf94 C15orf25 C18orf9 C2CD3 C4orf15 C6orf84 C9orf48 C9orf81 CALT CC2D2A CCCAP CCDC123 CCDC41 CCDC5 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP162 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CEP83 CEP89 CEP97 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DIFF6 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM29A FBF1 FGFR1OP FOP FTM HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HSP90A HSP90AA1 HSPC1 HSPCA IQCB1 KIAA0036 KIAA0092 KIAA0097 KIAA0158 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0673 KIAA0803 KIAA0841 KIAA0847 KIAA0912 KIAA0980 KIAA1005 KIAA1009 KIAA1052 KIAA1118 KIAA1345 KIAA1519 KIAA1569 KIAA1574 KIAA1633 KIAA1860 KIAA1863 KIF24 LAP LIP1 LIS1 LRRIQ2 MAPRE1 MARK4 MARKL1 MAST1 MDCR MDS MEL MKS1 MKS3 MKSR1 MKSR2 NA14 NDE1 NEDD1 NEDD5 NEK2 NEK2A NINL NLK1 NLP NPH1 NPHP1 NPHP10 NPHP15 NPHP4 NPHP5 NPHP6 NPHP8 NUDE ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B QN1 RAB11 RAB11A RAB3IP RAB8 RAB8A RABIN8 RPGRIP1L SAK SAP1 SCLT1 SDCCAG8 SEPT2 SEPTIN2 SFI1 SSNA1 STK18 TCTN1 TCTN2 TCTN3 TECT1 TECT2 TECT3 TMEM216 TMEM67 TSGA14 TSP57 TTBK2 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UCHL5IP UIP1 YWHAE YWHAG
AURKA Activation by TPX2	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin Aurora kinase A CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha Hyaluronan mediated motility receptor Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Ninein-like protein Nuclear distribution protein nudE homolog 1 Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Protein NEDD1 Protein SFI1 homolog Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serologically defined colon cancer antigen 8 Targeting protein for Xklp2 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O14965 O15078 O43303 O43805 O75330 O75665 O75935 O94927 O94986 O95613 O95684 P04350 P06493 P07437 P07900 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61163 P61981 P62258 P63167 P68366 P68371 Q13409 Q13561 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96MT8 Q96SN8 Q99871 Q99996 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXR1 Q9P209 Q9ULW0 Q9UPN4 Q9UPV0 Q9Y2I6	ACTR1A AIK AIRK1 AKAP350 AKAP450 AKAP9 ALMS1 ARK1 AURA AURKA AYK1 AZI1 BBS14 BITE BTAK C14orf94 C15orf25 C18orf9 C20orf1 C20orf2 C4orf15 C9orf81 CALT CCCAP CCDC5 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DIL2 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 FAM29A FGFR1OP FOP HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCA519 HCKID HDLC1 HEIC HICE1 HMMR HSP90A HSP90AA1 HSPC1 HSPCA IAK1 IHABP KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 LAP LIP1 LIS1 MAPRE1 MAST1 MDCR MDS NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NPHP10 NPHP15 NPHP6 NUDE ODF2 OFD1 P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP2R1A PRKACA PRKAR2B RHAMM SAK SDCCAG8 SFI1 SSNA1 STK15 STK18 STK6 TPX2 TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UCHL5IP UIP1 YWHAE YWHAG
Regulation of PLK1 Activity at G2/M Transition	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin Aurora kinase A CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cullin-1 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha LIM domain-containing protein ajuba Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Ninein-like protein Nuclear distribution protein nudE homolog 1 Optineurin Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Polyubiquitin-B Polyubiquitin-C Protein NEDD1 Protein SFI1 homolog Protein aurora borealis Protein phosphatase 1 regulatory subunit 12A Ras-related protein Rab-8A S-phase kinase-associated protein 1 Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O14965 O14974 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95067 O95613 O95684 P04350 P06493 P07437 P07900 P0CG47 P0CG48 P14635 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61006 P61163 P61981 P62140 P62258 P62979 P62987 P63167 P63208 P68366 P68371 Q13409 Q13561 Q13616 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q6PGQ7 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96CV9 Q96IF1 Q96MT8 Q96SN8 Q99871 Q99996 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXR1 Q9P209 Q9UKB1 Q9UPN4 Q9UPV0 Q9Y297 Q9Y2I6	ACTR1A AIK AIRK1 AJUBA AKAP350 AKAP450 AKAP9 ALMS1 ARK1 AURA AURKA AYK1 AZI1 BBS14 BITE BORA BTAK BTRC BTRCP BTRCP2 C13orf34 C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCNB CCNB1 CCNB2 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CUL1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 EMC19 FAM29A FBW1A FBW1B FBXW11 FBXW1A FBXW1B FGFR1OP FIP2 FOP GLC1E HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HIP7 HSP90A HSP90AA1 HSPC1 HSPCA HYPL IAK1 JUB KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0696 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 LAP LIP1 LIS1 MAPRE1 MAST1 MBS MDCR MDS MEL MYPT1 NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NPHP10 NPHP15 NPHP6 NRP NUDE OCP2 ODF2 OFD1 OPTN P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP1CB PPP1R12A PPP2R1A PRKACA PRKAR2B RAB8 RAB8A RPS27A SAK SDCCAG8 SFI1 SKP1 SKP1A SSNA1 STK15 STK18 STK6 TCEB1L TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCHL5IP UIP1 YWHAE YWHAG
SHOC2 M1731 mutant abolishes MRAS complex function	14-3-3 protein beta/alpha Leucine-rich repeat protein SHOC-2 RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	O14807 P04049 P10398 P15056 P31946 P36873 P62140 Q9UQ13	ARAF ARAF1 BRAF BRAF1 KIAA0862 MRAS PKS PKS2 PPP1CB PPP1CC RAF RAF1 RAFB1 RRAS3 SHOC2 YWHAB
Gain-of-function MRAS complexes activate RAF signaling	14-3-3 protein beta/alpha Leucine-rich repeat protein SHOC-2 RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	O14807 P04049 P10398 P15056 P31946 P36873 P62140 Q9UQ13	ARAF ARAF1 BRAF BRAF1 KIAA0862 MRAS PKS PKS2 PPP1CB PPP1CC RAF RAF1 RAFB1 RRAS3 SHOC2 YWHAB
MTOR signalling	14-3-3 protein beta/alpha GTP-binding protein Rheb Neutral amino acid transporter 9 Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O43504 P31749 P31946 P42345 Q0VGL1 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1 AKT1S1 C11orf59 C7orf59 FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PKB PRAS40 RAC RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 URLC11 XIP YWHAB
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O00418 O43504 P06730 P23443 P23588 P31946 P42345 P62753 P62942 Q04637 Q0VGL1 Q13541 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1S1 C11orf59 C7orf59 EEF2K EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FKBP1 FKBP12 FKBP1A FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PRAS40 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK14A URLC11 XIP YWHAB
Frs2-mediated activation	14-3-3 protein beta/alpha Beta-nerve growth factor Crk-like protein Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Rap guanine nucleotide exchange factor 1 Ras-related protein Rap-1A Serine/threonine-protein kinase B-raf	P01138 P15056 P27361 P28482 P31946 P36507 P46109 P62834 Q02750 Q13905 Q8WU20	BRAF BRAF1 CRKL ERK1 ERK2 FRS2 GRF2 KREV1 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 NGF NGFB PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAFB1 RAP1A RAPGEF1 YWHAB
Negative regulation of MAPK pathway	14-3-3 protein beta/alpha BRCA1-associated protein Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Polyubiquitin-B Polyubiquitin-C Progestin and adipoQ receptor family member 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase non-receptor type 3 Tyrosine-protein phosphatase non-receptor type 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01111 P01112 P04049 P0CG47 P0CG48 P10398 P15056 P26045 P27361 P27448 P28482 P28562 P30086 P30153 P30154 P31946 P35236 P53041 P53778 P62714 P62979 P62987 P67775 Q05923 Q13115 Q13202 Q13362 Q14738 Q15172 Q15173 Q16537 Q16690 Q16828 Q16829 Q6TCH7 Q7Z569 Q8IVT5 Q99956 Q9BY84 Q9Y6W6	ARAF ARAF1 BRAF BRAF1 BRAP C11orf81 CL100 CTAK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 EMK2 ERK1 ERK2 ERK6 HRAS HRAS1 KIAA0044 KIAA1700 KSR KSR1 MAPK1 MAPK12 MAPK3 MARK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 NRAS PAC1 PAQR3 PBP PEBP PEBP1 PKS PKS2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTPH1 PTPN10 PTPN3 PTPN7 PYST1 PYST2 RAF RAF1 RAFB1 RNF52 RPS27A SAPK3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VH1 VH2 VH3 VH5 YWHAB
RAF activation	14-3-3 protein beta/alpha BRCA1-associated protein Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 Leucine-rich repeat protein SHOC-2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase kinase kinase 11 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Tyrosine-protein kinase JAK2	O14807 O60674 P01111 P01112 P04049 P0DP23 P10398 P12931 P15056 P27448 P30153 P30154 P31946 P35232 P36507 P36873 P62140 P62714 P67775 Q02750 Q13362 Q13554 Q13555 Q13557 Q14738 Q15172 Q15173 Q16537 Q16584 Q7Z569 Q8IVT5 Q9UQ13 Q9UQM7	ARAF ARAF1 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CTAK1 EMK2 HRAS HRAS1 JAK2 KIAA0044 KIAA0862 KIAA0968 KSR KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 MEK1 MEK2 MKK2 MLK3 MRAS NRAS PHB PHB1 PKS PKS2 PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RNF52 RRAS3 SHOC2 SPRK SRC SRC1 YWHAB
Signaling by high-kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
MAP2K and MAPK activation	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Interleukin-17 receptor D Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin WD repeat domain-containing protein 83 von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8NFM7 Q8WXI2 Q969H4 Q9BRX9 Q9UHA4 Q9Y2Q5 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IL17RD IL17RLM IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K1IP1 MAP2K2 MAPBPIP MAPK1 MAPK3 MAPKSP1 MARK3 MEK1 MEK2 MKK2 MORG1 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM ROBLD3 SEF SRC SRC1 TLN TLN1 VCL VWF WDR83 YWHAB
Signaling by RAF1 mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
Signaling downstream of RAS mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Signaling by moderate kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB

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