GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **251 - 275** of **499** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism
Pre-NOTCH Processing in Golgi	CUB domain-containing protein EGF-like domain-containing protein Protein lin-12 Suppressor/enhancer of lin-12 protein 9	O17528 P14585 P90891 Q21850	CELE_F55H12.3 CELE_R08E3.1 lin-12 sel-9	Caenorhabditis elegans
TRP channels	CUP-5L GTL-1 Ion transport domain-containing protein Ion transport domain-containing protein Ion transport domain-containing protein Ion transport domain-containing protein Ion transport domain-containing protein Ion_trans domain-containing protein LSDAT_euk domain-containing protein Protein ced-11 Transient receptor ion channel domain-containing protein Transient receptor potential channel Transient-receptor-potential-like protein	G5ECM4 G5EDR9 O61220 P34586 P34641 Q19377 Q20766 Q22374 Q23141 Q8I6Y9 Q8T666 Q93971 Q9N3Y9	CELE_F13B12.3 ced-11 cup-5 gon-2 gtl-1 gtl-2 ocr-1 ocr-2 ocr-3 ocr-4 strpc1 trp-1 trp-2 trpl-2	Caenorhabditis elegans
Transferrin endocytosis and recycling	CUP-5L Probable V-type proton ATPase subunit F Probable V-type proton ATPase subunit G Probable V-type proton ATPase subunit H 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c 2 V-type proton ATPase 16 kDa proteolipid subunit c 3 V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B 1 V-type proton ATPase subunit B 2 V-type proton ATPase subunit C V-type proton ATPase subunit D V-type proton ATPase subunit E V-type proton ATPase subunit S1 V-type proton ATPase subunit e V-type proton ATPase subunit	B2MZD0 C0HLB3 C0HLB4 G5EDB8 G5EEK9 G5EGP4 P30628 P34462 P91303 Q19626 Q20591 Q22494 Q23680 Q8T666 Q95X44 Q95YD5 Q9N5A0 Q9TYW1 Q9XW92 Q9XXU9	cup-5 fus-1 rdy-1 spe-5 unc-32 vha-10 vha-11 vha-12 vha-13 vha-14 vha-15 vha-16 vha-17 vha-19 vha-2 vha-3 vha-4 vha-5 vha-6 vha-7 vha-8 vha-9	Caenorhabditis elegans
Ion transport by P-type ATPases	Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium/calmodulin-dependent protein kinase type II Cation-transporting ATPase catp-5 Cation-transporting ATPase EF-hand domain-containing protein P-type Cu(+) transporter Phospholipid-transporting ATPase tat-1 Phospholipid-transporting ATPase Phospholipid-transporting ATPase Phospholipid-transporting ATPase Phospholipid-transporting ATPase Plasma membrane calcium-transporting ATPase mca-1 Probable cation-transporting ATPase W08D2.5 Probable manganese-transporting ATPase catp-8 Probable phospholipid-transporting ATPase tat-5	G5EBH1 G5EDU1 G5EE14 G5EEK8 G5EFR6 O18182 O62305 P90747 P91203 Q18136 Q21286 Q27533 Q7JPE3 Q95XP5 Q9N323 Q9TYP9 Q9U280 U4PBV8	W08D2.5 cal-5 catp-5 catp-7 catp-8 cua-1 mca-1 mca-2 mca-3 mca-4 pmr-1 sca-1 tat-1 tat-2 tat-3 tat-4 tat-5 tat-6 unc-43	Caenorhabditis elegans
Ion homeostasis	Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium/calmodulin-dependent protein kinase type II Calx-beta domain-containing protein Calx-beta domain-containing protein EF-hand domain-containing protein Inositol 1,4,5-trisphosphate receptor itr-1 Plasma membrane calcium-transporting ATPase mca-1 Stromal interaction molecule 1 Transient receptor ion channel domain-containing protein Troponin I 1 Troponin I 2 Troponin I 3 Troponin I 4 cAMP-dependent protein kinase catalytic subunit	G5EEK8 G5EF08 G5EF60 G5EFR6 H2KYP2 O44572 O62305 P21137 Q18136 Q20334 Q8I6Y9 Q95XP5 Q9GYF1 Q9TYP9 Q9XUN9 Q9Y0A1	cal-5 dec-4 itr-1 kin-1 lfe-1 mca-1 mca-2 mca-3 mca-4 ncx-1 ncx-2 sca-1 stim-1 tni-1 tni-2 tni-3 tni-4 trp-2 unc-27 unc-43	Caenorhabditis elegans
Reduction of cytosolic Ca++ levels	Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calx-beta domain-containing protein Calx-beta domain-containing protein EF-hand domain-containing protein Plasma membrane calcium-transporting ATPase mca-1	G5EEK8 G5EF08 G5EFR6 H2KYP2 Q18136 Q95XP5 Q9TYP9	cal-5 mca-1 mca-2 mca-3 mca-4 ncx-1 ncx-2 sca-1	Caenorhabditis elegans
HSF1-dependent transactivation	Calcium/calmodulin-dependent protein kinase type II DAF-15 DUF148 domain-containing protein Heat shock factor-binding protein 1 Heat shock protein 90 Heat shock protein Hsp-12.2 Heat shock protein hsp-1 Heat shock transcription factor hsf-1 Target of rapamycin complex subunit lst8 Target of rapamycin homolog	G5EC99 G5EFT5 O62305 P09446 P34328 P91040 Q18688 Q68TI8 Q95Q95 Q9U3B7	CELE_F11F1.1 CeTor daf-15 daf-21 hsb-1 hsf-1 hsp-1 hsp-12.2 hsp12-2 hsp70a let-363 mlst-8 unc-43	Caenorhabditis elegans
Calnexin/calreticulin cycle	Calnexin Calreticulin Protein disulfide-isomerase	G5ED07 P27798 P34652	cnx-1 crt-1 pdi-3	Caenorhabditis elegans
Nephrin family interactions	Calponin-homology (CH) domain-containing protein NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family SH2 domain-containing protein Synaptogenesis protein syg-1 Synaptogenesis protein syg-2 Tyrosine protein-kinase src-1	B1Q236 G5EE56 O17772 Q95PX0 Q95XA9 Q9U3P2	gap-3 nck-1 pes-7 src-1 syg-1 syg-2	Caenorhabditis elegans
Cell-extracellular matrix interactions	Calponin-homology (CH) domain-containing protein Integrin-linked protein kinase homolog pat-4 LIM domain-containing protein pin-2 LIM domain-containing protein unc-97 Paralyzed arrest at two-fold protein 6 Protein unc-112 UNC-34 Zyxin	G5EG53 O16785 P50464 Q18685 Q19157 Q9TZC4 Q9U3F4 U4PBJ9	fln-1 pat-4 pat-6 pin-2 unc-112 unc-34 unc-97 zyx-1	Caenorhabditis elegans
Sodium/Calcium exchangers	Calx-beta domain-containing protein Calx-beta domain-containing protein EF-hand domain-containing protein Putative sodium/calcium exchanger 7 Sodium/calcium exchanger membrane region domain-containing protein Sodium/calcium exchanger membrane region domain-containing protein	G5EC02 G5EF08 H2KYP2 P34322 P90858 Q18136	cal-5 ncx-1 ncx-2 ncx-4 ncx-5 ncx-7	Caenorhabditis elegans
Physiological factors	Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Gut esterase 1 NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family Neprilysin-11 Neprilysin-1 Neprilysin-21 Neprilysin-2 Neprilysin Neprilysin Neprilysin Neprilysin Neprilysin Peptidase M13 C-terminal domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 N-terminal domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13_N domain-containing protein	A0A131MCS3 A0A1C3NSL8 A0A5S9MNU9 G5ED52 G5EDJ7 H2KYL1 H2KZE5 H2L0K7 H9G2Y9 O01302 O16607 O16636 O16652 O16789 O16790 O16795 O16796 O44857 O45311 O45569 P92016 Q04457 Q18673 Q21266 Q22008 Q22523 Q22763 Q23268 Q23427 Q400M1 Q4LDP0 Q8MQ23 Q9U2T0 Q9U2T1 Q9XW75	CELE_F41C6.4 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 ges-1 nep-1 nep-10 nep-11 nep-12 nep-13 nep-16 nep-17 nep-18 nep-2 nep-20 nep-21 nep-22 nep-23 nep-24 nep-25 nep-26 nep-3 nep-4 nep-6 nep-8 nep-9	Caenorhabditis elegans
MHC class II antigen presentation	Carboxypeptidase Carboxypeptidase Carboxypeptidase Cathepsin F Cathepsin L-like GILT-like protein F37H8.5 Peptidase C1A papain C-terminal domain-containing protein Serine carboxypeptidase ctsa-1.1 Serine carboxypeptidase ctsa-1.2 Serine carboxypeptidase ctsa-3.1 Serine carboxypeptidase ctsa-3.2 Serine carboxypeptidase ctsa-4.1	K8ESM2 O16454 O17861 O45734 O76725 P52714 P52715 P52716 P52717 Q09991 Q20950 Q94269	CELE_Y16B4A.2 F37H8.5 cpl-1 cpr-9 ctsa-1 ctsa-1.1 ctsa-1.2 ctsa-2 ctsa-3.1 ctsa-3.2 ctsa-4.1 ctsa-4.2 drd-7 tag-196	Caenorhabditis elegans
Signal transduction by L1	Casein kinase II subunit alpha Casein kinase II subunit beta Dual specificity mitogen-activated protein kinase kinase mek-2 Ig-like domain-containing protein Integrin alpha pat-2 Integrin beta pat-3 Mitogen-activated protein kinase mpk-1 Myoblast growth factor receptor egl-15 Protein vav-1 Ras-related protein ced-10 Receptor tyrosine-protein kinase let-23 Serine/threonine-protein kinase pak-1 Uncharacterized integrin beta-like protein C05D9.3	P18334 P24348 P28548 P34446 P39745 Q03206 Q10656 Q10664 Q17850 Q27874 Q45FX5 Q5WRR1 Q9GYK2	C05D9.3 ced-10 egl-15 kin-10 kin-3 kin-5 kin-7 let-23 mek-2 mpk-1 pak-1 pat-2 pat-3 rac-1 sur-1 vav-1 wrk-1	Caenorhabditis elegans
Degradation of the extracellular matrix	Cathepsin L-like Contactin rig-6 Disintegrin and metalloproteinase domain-containing protein adm-2 Disintegrin and metalloproteinase domain-containing protein unc-71 Ig-like domain-containing protein Kringle domain-containing protein MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Peptidase M12B domain-containing protein Peptidase metallopeptidase domain-containing protein Titin homolog Uncharacterized protein Zinc metalloproteinase nas-39	C6KRM7 G4SLH0 G5EBU3 G5ECC4 G5EDW5 G5EFD5 G5EGM1 H2KZ60 O17913 O44836 O45734 P91823 Q20176 Q21182 Q9N5X7	CELE_K03B8.6 CELE_T22A3.6 adm-1 adm-2 cpl-1 nas-39 rig-5 rig-6 tag-275 ttn-1 unc-71 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
Activation of Matrix Metalloproteinases	Cathepsin L-like Furin-like protease kpc-1 Kringle domain-containing protein MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C NTR domain-containing protein Peptidase metallopeptidase domain-containing protein Putative metalloproteinase inhibitor tag-225 Uncharacterized protein	G5EBU3 G5ECC4 G5EGM1 O17798 O17913 O44836 O45734 P91823 Q21182 Q21265 Q21267	CELE_K03B8.6 CELE_T22A3.6 cpl-1 kpc-1 tag-225 timp-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Cathepsin L-like SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein	A9Z1L1 G5ECY2 G5EE40 G5EFH4 O17365 O45520 O45734 Q18287 Q19651 Q9XVQ1	C28G1.2 CELE_F15D3.4 CELE_F44G3.7 cpl-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8	Caenorhabditis elegans
Cargo concentration in the ER	Cathepsin Z-1 ERGIC-53-like protein Fibronectin type-III domain-containing protein GLutamate Receptor family (AMPA) GLutamate Receptor family (AMPA) GLutamate Receptor family (AMPA) Glutamate receptor 1 Glutamate receptor 2 Glutamate receptor ionotropic, kainate 2 Glutamate receptor ionotropic, kainate glr-3 Golgi SNAP receptor complex member 2 homolog memb-1 L-type lectin-like domain-containing protein Protein cornichon homolog 1 Protein transport protein SEC23 Protein transport protein Sec24C Putative syntaxin-5 SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Small COPII coat GTPase SAR1 Vesicle-trafficking protein SEC22b Yeast SEC homolog	A0A1T5HUM0 A9Z1L1 G5ECY2 G5EDE8 G5EE40 G5EFH4 G5EGA4 G5EGP8 O01623 O17365 O45520 P34299 P41941 Q10914 Q17697 Q18287 Q19371 Q19651 Q20797 Q21415 Q22170 Q22361 Q23368 Q23445 Q8MXV8 Q94241 Q9U2Z1 Q9XVQ1	C28G1.2 CELE_F15D3.4 CELE_F44G3.7 cle-1 cni-1 cnih-2 cpz-1 glr-1 glr-2 glr-3 glr-4 glr-5 glr-6 glr-7 gosr-2.1 ile-1 ile-2 memb-1 sar-1 sec-22 sec-23 sec-24.1 sec-24.2 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 syn-3 syx-5	Caenorhabditis elegans
Metal ion SLC transporters	Cation diffusion facilitator family protein 1 Copper transport protein NRAMP-like transporter smf-1 NRAMP-like transporter smf-2 NRAMP-like transporter smf-3 SLC41A/MgtE integral membrane domain-containing protein SLC41A/MgtE integral membrane domain-containing protein SLC41A/MgtE integral membrane domain-containing protein	O02340 O44196 O45182 Q19936 Q21433 Q21434 Q95QW4 Q95XG8	CELE_F31E8.4 CELE_K07H8.2 CELE_ZK1053.6 CELE_ZK185.2 cdf-1 smf-1 smf-2 smf-3	Caenorhabditis elegans
Basigin interactions	Caveolin-1 Caveolin-2 Contactin rig-6 Ig-like domain-containing protein Integrin alpha ina-1 MFS domain-containing protein MFS domain-containing protein MMP-like protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Peptidase metallopeptidase domain-containing protein Peptidyl-prolyl cis-trans isomerase 4 Peptidyl-prolyl cis-trans isomerase Probable sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta Uncharacterized integrin beta-like protein C05D9.3 Uncharacterized protein	G5EBU3 G5ECC4 G5ECR3 G5EGM1 H2KZ60 H2L0E6 O17328 O17913 O44836 P52012 Q03600 Q18879 Q21182 Q22109 Q2L6V8 Q5WRR1 Q93235 Q93896 Q94051 Q9GYK2 Q9UAT3 Q9XUG9 Q9XUY5	C05D9.3 CELE_K03B8.6 CELE_T22F3.12 cav-1 cav-2 cyn-4 cyp-4 ina-1 mct-1 mct-2 mct-3 mct-4 mct-5 mct-6 mog-6 nkb-1 nkb-2 nkb-3 rig-6 slcf-1 wrk-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
Downstream signal transduction	Cell death abnormality protein 2 Discoidin domain-containing receptor tyrosine kinase B NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Platelet-derived growth factor (PDGF) family profile domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Ras protein let-60 SH2 domain-containing protein Sex muscle abnormal protein 5 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Son of sevenless homolog Tyrosine protein-kinase src-1	A0A1I6CMA1 D3YT30 G5EDP9 G5EE56 P22981 P29355 Q20977 Q21046 Q94125 Q95PX0 Q95XA9 Q95ZV7 Q9N413 Q9N5D3 Q9NAD6 Q9NHC3	CELE_F59F5.3 CELE_T12G3.2 aap-1 age-1 ced-2 ddr-2 gap-3 kin-36 let-341 let-60 lin-34 nck-1 pvf-1 sem-5 sos-1 src-1 sta-1 sta-2 stat-b svh-4	Caenorhabditis elegans
Ligand-independent caspase activation via DCC	Cell death protein 3 Netrin receptor unc-40	G5EF96 P42573	ced-3 unc-40	Caenorhabditis elegans
EGFR downregulation	Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL EGF-like domain-containing protein EGF-like domain-containing protein EHS-1 ENTH domain-containing protein Endophilin-A homolog Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-A Receptor tyrosine-protein kinase let-23 SH3 domain-containing protein SH3 domain-containing protein Sex muscle abnormal protein 5 Signal transducing adapter molecule 1 Tyrosine-protein phosphatase 1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	B1V8A0 G5EFK8 O01498 O44191 P0CG71 P24348 P28191 P29355 P37165 P49632 Q05062 Q17796 Q19019 Q21430 Q6A573 Q9BI71 Q9BIF4	CELE_F14B4.1 cdap-2 cdc-42 ehs-1 epn-1 hgrs-1 kin-7 let-23 pix-1 pqn-19 ptp-1 rme-2 sem-5 sli-1 stam-1 ubia ubib ubl-1 ubq-1 ubq-2 unc-57	Caenorhabditis elegans
Glycosphingolipid biosynthesis	Ceramide glucosyltransferase 2 Ceramide kinase 1 Hexosyltransferase L-Fucosyltransferase Putative UDP-glucuronosyltransferase ugt-60	G5EC84 O61739 P34317 Q8MQG4 Q9TZI1	B0024.15 B0205.4 cerk-1 cgt-2 ugt-60	Caenorhabditis elegans
Sealing of the nuclear envelope (NE) by ESCRT-III	Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4b Charged multivesicular body protein 4b Charged multivesicular body protein 6 Charged multivesicular body protein 7 Coiled-coil and C2 domain-containing protein 1-like IST1 homolog Spastin homolog Vesicle-fusing ATPase	G5ECX8 O02208 Q18886 Q21959 Q22718 Q8MNV0 Q9BL60 Q9BL83 Q9GYK4 Q9U2F6 Q9U2M8	C01A2.4 CELE_R12C12.5 Y37H9A.3 chmp-7 istr-1 spas-1 vps-2 vps-20 vps-24 vps-32.1 vps-4	Caenorhabditis elegans

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