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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
asthma
Summary
- Synonym
-
- bronchial hyperreactivity
- chronic obstructive asthma
- chronic obstructive asthma with acute exacerbation
- chronic obstructive asthma with status asthmaticus
- Definition
- A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
- Super Class
- bronchial disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 28 | ABO | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase | |
| 101 | ADAM8 | ADAM metallopeptidase domain 8 | |
| 128 | ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | |
| 134 | ADORA1 | adenosine A1 receptor | |
| 135 | ADORA2A | adenosine A2a receptor | |
| 142 | PARP1 | poly(ADP-ribose) polymerase 1 | |
| 154 | ADRB2 | adrenoceptor beta 2 | |
| 177 | AGER | advanced glycosylation end-product specific receptor | |
| 185 | AGTR1 | angiotensin II receptor type 1 | |
| 186 | AGTR2 | angiotensin II receptor type 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12064 | Bdnf | brain derived neurotrophic factor | |
| 12168 | Bmpr2 | bone morphogenetic protein receptor type 2 | |
| 12266 | C3 | complement component 3 | |
| 12267 | C3ar1 | complement component 3a receptor 1 | |
| 12273 | C5ar1 | complement component 5a receptor 1 | |
| 12475 | Cd14 | CD14 antigen | |
| 12477 | Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | |
| 12487 | Cd28 | CD28 antigen | |
| 12524 | Cd86 | CD86 antigen | |
| 12550 | Cdh1 | cadherin 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 170926 | Cysltr2 | cysteinyl leukotriene receptor 2 | |
| 192155 | Sftpb | surfactant protein B | |
| 246097 | Fas | Fas cell surface death receptor | |
| 260320 | F7 | coagulation factor VII | |
| 286934 | Havcr1 | hepatitis A virus cellular receptor 1 | |
| 286963 | Cyp2d5 | cytochrome P450, family 2, subfamily d, polypeptide 5 | |
| 287222 | Timd2 | T-cell immunoglobulin and mucin domain containing 2 | |
| 287287 | Il4 | interleukin 4 | |
| 287561 | Ccl7 | C-C motif chemokine ligand 7 | |
| 289211 | Fcgr2b | Fc gamma receptor 2B |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 58133 | ngfb | nerve growth factor b (beta polypeptide) | |
| 114424 | cdh1 | cadherin 1, type 1, E-cadherin (epithelial) | |
| 387303 | gbgt1l4 | globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4 | |
| 394082 | slc18a3b | solute carrier family 18 member 3b | |
| 406411 | rhoaa | ras homolog gene family, member Aa | |
| 406659 | rhoac | ras homolog gene family, member Ac | |
| 436718 | rhocb | ras homolog family member Cb | |
| 447881 | gbgt1l3 | globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 3 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 495825 | abo.3.L | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) L homeolog | Xenopus laevis (African clawed frog) | |
| 549437 | abo.3 | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) gene 3 | Xenopus tropicalis (tropical clawed frog) | |
| 549858 | abo.2 | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) gene 2 | Xenopus tropicalis (tropical clawed frog) | |
| 550054 | abo | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) gene 1 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 100337618 | cdh1.S | cadherin 1, type 1 S homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 172841 | 45566 | Organic cation transporter 1 | |
| 174044 | sma-6 | Serine/threonine-protein kinase receptor sma-6 | |
| 174462 | let-23 | Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase | |
| 175182 | ver-1 | Protein ver-1 | |
| 175383 | zmp-2 | Matrix metalloproteinase-B | |
| 175504 | pat-3 | Integrin beta pat-3 | |
| 177343 | skn-1 | BZIP domain-containing protein;Protein skinhead-1 | |
| 178118 | trpa-1 | Ion transport domain-containing protein;Transient receptor potential cation channel subfamily A member 1 homolog | |
| 178215 | pgp-1 | Multidrug resistance protein pgp-1 | |
| 178274 | cho-1 | High-affinity choline transporter 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850462 | GIT1 | Git1p | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
| 851977 | CTS2 | putative chitinase | |
| 853671 | STE6 | ATP-binding cassette a-factor transporter STE6 | |
| 853978 | NFT1 | putative multidrug transporter NFT1 | |
| 854394 | STE13 | Ste13p | |
| 854900 | HMG1 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 | |
| 856294 | RHO1 | Rho family GTPase RHO1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001426 | Non-Mendelian inheritance |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002099 | Asthma |
