GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1026 - 1050** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Death domain-associated protein 6 Transcriptional regulator ATRX	P46100 Q9UER7	ATRX BING2 DAP6 DAXX RAD54L XH2
Defective PAPSS2 causes SEMD-PA	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	ATPSK2 PAPSS2
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Thioredoxin reductase 1, cytoplasmic	O43252 O95340 Q16881	ATPSK1 ATPSK2 GRIM12 KDRF PAPSS PAPSS1 PAPSS2 TXNRD1
Transport and synthesis of PAPS	Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate anion transporter 1 Sulfate transporter	O43252 O95340 P50443 Q8TB61 Q9H1N7 Q9H2B4	ATPSK1 ATPSK2 C6orf196 DTD DTDST PAPSS PAPSS1 PAPSS2 PAPST1 PAPST2 SAT1 SLC26A1 SLC26A2 SLC35B2 SLC35B3
Synthesis of diphthamide-EEF2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Diphthamide biosynthesis protein 3 Diphthine methyl ester synthase Diphthine methyltransferase Diphthine--ammonia ligase DnaJ homolog subfamily C member 24 Elongation factor 2	P13639 Q6P3W2 Q7L8W6 Q96FX2 Q9BQC3 Q9BTV6 Q9BZG8 Q9H2P9	ATPBD4 C9orf112 DESR1 DNAJC24 DPH1 DPH2 DPH2L DPH2L1 DPH2L2 DPH3 DPH4 DPH5 DPH6 DPH7 EEF2 EF2 OVCA1 WDR85 ZCSL2 ZCSL3
Blockage of phagosome acidification	Low molecular weight protein-tyrosine phosphatase A V-type proton ATPase subunit H	P9WIA1 Q9UI12	ATP6V1H mptpA ptpA
Amino acids regulate mTORC1	Cytosolic arginine sensor for mTORC1 subunit 1 Cytosolic arginine sensor for mTORC1 subunit 2 Folliculin-interacting protein 1 Folliculin-interacting protein 2 Folliculin GATOR1 complex protein DEPDC5 GATOR1 complex protein NPRL2 GATOR1 complex protein NPRL3 GATOR2 complex protein MIOS GATOR2 complex protein WDR24 GATOR2 complex protein WDR59 GTP-binding protein Rheb KICSTOR complex protein ITFG2 KICSTOR complex protein SZT2 KICSTOR complex protein kaptin KICSTOR subunit 2 Neutral amino acid transporter 9 Nucleoporin SEH1 Protein SEC13 homolog Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR S-adenosylmethionine sensor upstream of mTORC1 SH3 domain-binding protein 4 Serine/threonine-protein kinase mTOR Sestrin-1 Sestrin-2 Target of rapamycin complex subunit LST8 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	A6NHX0 O15342 O43504 O75140 O75348 O95670 P15313 P21281 P21283 P27449 P36543 P38606 P42345 P55735 P58004 P61421 Q0VGL1 Q12980 Q13488 Q15382 Q16864 Q1RMZ1 Q5T011 Q5VZM2 Q6IAA8 Q6PJI9 Q7L523 Q8N122 Q8N8Y2 Q8NBW4 Q8NEY4 Q8NFG4 Q8NHE4 Q8TF40 Q8WTW4 Q8WTX7 Q969R8 Q96A05 Q96EE3 Q96LB4 Q96MD2 Q96S15 Q99437 Q9BVC4 Q9HB90 Q9NQL2 Q9NXC5 Q9P0V3 Q9P278 Q9UHA4 Q9UI12 Q9Y2Q5 Q9Y5K8 Q9Y664 Q9Y6P5	ATP6A1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6J ATP6L ATP6M ATP6N1C ATP6S14 ATP6V0A3 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL BHD BMT2 BOG25 C11orf59 C12orf66 C16orf21 C16orf35 C1orf84 C7orf32 C7orf59 C7orf60 CASTOR1 CASTOR2 CGTHBA D3S1231E DEPDC5 EHB10 FLCN FNIP1 FNIP2 FNIPL FRAP FRAP1 FRAP2 GATSL1 GATSL2 GATSL3 GBL HBXIP Hi95 ITFG2 KIAA0467 KIAA0645 KIAA1303 KIAA1450 KIAA1923 KIAA1961 KICS2 KPTN LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MAPO1 MARE MIOS MLST8 MTOR NG38 NPRL2 NPRL3 PA26 PDRO RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SAMTOR SEC13 SEC13A SEC13L SEC13L1 SEC13R SEH1 SEH1L SESN1 SESN2 SEST1 SEST2 SH3BP4 SLC38A9 SZT2 TCIRG1 TTP TUSC4 URLC11 VATB VATC VATD VATF VPATPD VPP2 VPP3 WDR24 WDR59 XIP
ROS and RNS production in phagocytes	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Natural resistance-associated macrophage protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Nitric oxide synthase 1 Nitric oxide synthase 3 Nitric oxide synthase, inducible Ras-related C3 botulinum toxin substrate 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2 Voltage-gated hydrogen channel 1	O15342 O75348 O95670 P04839 P13498 P14598 P15153 P15313 P19878 P21281 P21283 P27449 P29474 P29475 P35228 P36543 P38606 P49279 P61421 Q13488 Q15080 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96D96 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 CYBA CYBB HVCN1 LSH NCF1 NCF2 NCF4 NG38 NOS1 NOS2 NOS2A NOS3 NOX2 NOXA2 NOXO2 NRAMP NRAMP1 P67PHOX RAC2 SH3PXD1A SH3PXD4 SLC11A1 TCIRG1 VATB VATC VATD VATF VPATPD VPP1 VPP2 VPP3 VSOP
Ion channel transport	V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P15313 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 NG38 TCIRG1 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3
Transferrin endocytosis and recycling	Hereditary hemochromatosis protein Metalloreductase STEAP3 Metalloreductase STEAP4 Mucolipin-1 Serotransferrin Transferrin receptor protein 1 Transferrin receptor protein 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P02786 P02787 P15313 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q30201 Q658P3 Q687X5 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9GZU1 Q9HBG4 Q9UI12 Q9UP52 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 HFE HLAH MCOLN1 ML4 NG38 STAMP2 STEAP3 STEAP4 TCIRG1 TF TFR2 TFRC TNFAIP9 TRPML1 TSAP6 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3
Insulin receptor recycling	Cathepsin D Insulin receptor Insulin-degrading enzyme Insulin Receptor-type tyrosine-protein phosphatase F Tyrosine-protein phosphatase non-receptor type 1 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P01308 P06213 P07339 P10586 P14735 P15313 P18031 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 CPSD CTSD IDE INS INSR LAR NG38 PTP1B PTPN1 PTPRF TCIRG1 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3
Formation of ATP by chemiosmotic coupling	ATP synthase F(0) complex subunit B1, mitochondrial ATP synthase F(0) complex subunit C1, mitochondrial ATP synthase F(0) complex subunit C2, mitochondrial ATP synthase F(0) complex subunit C3, mitochondrial ATP synthase protein 8 ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit delta, mitochondrial ATP synthase subunit e, mitochondrial ATP synthase subunit epsilon, mitochondrial ATP synthase subunit f, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase subunit s, mitochondrial ATP synthase-coupling factor 6, mitochondrial	O75947 O75964 P00846 P03928 P05496 P06576 P18859 P24539 P25705 P30049 P36542 P48047 P48201 P56134 P56381 P56385 Q06055 Q99766	ATP5A ATP5A1 ATP5AL2 ATP5B ATP5C ATP5C1 ATP5CL1 ATP5D ATP5E ATP5F1 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5JL ATP5K ATP5L ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5MF ATP5MG ATP5O ATP5PB ATP5PD ATP5PF ATP5PO ATP5S ATP6 ATP8 ATPASE6 ATPASE8 ATPM ATPMB ATPO ATPSB ATPW DMAC2L MT-ATP6 MT-ATP8 MTATP6 MTATP8
Pre-NOTCH Processing in Golgi	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Beta-1,3-N-acetylglucosaminyltransferase manic fringe Beta-1,3-N-acetylglucosaminyltransferase radical fringe Beta-1,4-galactosyltransferase 1 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 Furin Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 3 Neurogenic locus notch homolog protein 4 Protein sel-1 homolog 1 Ras-related protein Rab-6A Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Transmembrane emp24 domain-containing protein 2 Type 2 lactosamine alpha-2,3-sialyltransferase	O00587 O14983 P09958 P15291 P16615 P20340 P46531 Q04721 Q11203 Q11206 Q15363 Q8NES3 Q93084 Q99466 Q9UBV2 Q9UM47 Q9Y274 Q9Y644	ATP2A1 ATP2A2 ATP2A3 ATP2B B4GALT1 CGS23 FUR FURIN GGTB2 INT3 LFNG MFNG NANTA3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PACE PCSK3 RAB6 RAB6A RFNG RNP24 SEL1L SIAT10 SIAT4C SIAT6 ST3GAL3 ST3GAL4 ST3GAL6 STZ TAN1 TMED2 TSA305
Reduction of cytosolic Ca++ levels	Calmodulin-1 Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sorcin	O14983 P0DP23 P16615 P20020 P23634 P30626 P32418 P57103 Q01814 Q16720 Q93084 Q9UPR5	ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM CALM1 CAM CAM1 CNC KIAA1087 MXRA1 NCX1 NCX2 NCX3 PMCA1 PMCA2 SLC8A1 SLC8A2 SLC8A3 SRI
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	CREB-binding protein Hepatocyte nuclear factor 1-beta Hepatocyte nuclear factor 6 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 1 Neurogenin-3 One cut domain family member 3 Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Transcription factor HES-1	O60422 P35680 P46531 Q06330 Q09472 Q13495 Q13573 Q14469 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9UBC0 Q9Y4Z2	ATOH5 BHLHA7 BHLHB39 CBP CG1 CREBBP CXorf6 EP300 GCN5 GCN5L2 HES1 HL HNF1B HNF6 HNF6A HRY IGKJRB IGKJRB1 KAT2A KAT2B KIAA0200 KIAA1816 KIAA1819 MAML1 MAML2 MAML3 MAMLD1 NEUROG3 NGN3 NOTCH1 ONECUT1 ONECUT3 P300 PCAF RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 TAN1 TCF2
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	Homeobox protein Nkx-2.2 Insulinoma-associated protein 1 Neurogenic differentiation factor 1 Neurogenin-3 Paired box protein Pax-4	O43316 O95096 Q01101 Q13562 Q9Y4Z2	ATOH5 BHLHA3 BHLHA7 IA1 INSM1 NEUROD NEUROD1 NEUROG3 NGN3 NKX2-2 NKX2.2 NKX2B PAX4
Sensing of DNA Double Strand Breaks	DNA repair protein RAD50 Double-strand break repair protein MRE11 Histone acetyltransferase KAT5 Importin subunit alpha-1 Nibrin Serine-protein kinase ATM	O60934 P49959 P52292 Q13315 Q92878 Q92993	ATM HNGS1 HTATIP KAT5 KPNA2 MRE11 MRE11A NBN NBS NBS1 P95 RAD50 RCH1 SRP1 TIP60
Autodegradation of the E3 ubiquitin ligase COP1	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cellular tumor antigen p53 E3 ubiquitin-protein ligase COP1 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P04637 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 Q06323 Q13200 Q13315 Q14997 Q15008 Q16401 Q8NHY2 Q8TAA3 Q92530 Q99436 Q99460 Q9UL46 Q9UNM6	ATM C7orf76 COP1 DSS1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU P53 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RING10 RING12 RNF200 RPS27A SEM1 SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TP53 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Stabilization of p53	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q13315 Q8N726 Q9BVI0	ATM C20orf104 CDKN2 CDKN2A CDS1 CHEK2 CHK2 GLEA2 HCA58 MDM2 MDM4 MDMX MLM NZF P53 PHF20 RAD53 RPS27A TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Meiotic recombination	Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 DNA endonuclease RBBP8 DNA mismatch repair protein Mlh1 DNA mismatch repair protein Mlh3 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 3 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.1t Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase PRDM9 Homologous-pairing protein 2 homolog Meiotic nuclear division protein 1 homolog Meiotic recombination protein DMC1/LIM15 homolog Meiotic recombination protein SPO11 MutS protein homolog 4 MutS protein homolog 5 Nibrin RecQ-like DNA helicase BLM Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Testis-expressed protein 15	O15457 O43196 O43502 O60814 O60934 P04908 P06899 P0C5Y9 P11802 P15927 P16104 P20671 P23527 P24941 P27694 P33778 P35244 P38398 P40692 P49959 P51587 P54132 P57053 P58876 P62805 P62807 P68431 P84243 Q06609 Q13315 Q13472 Q14565 Q16695 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q92878 Q93077 Q93079 Q96A08 Q99708 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9BWT6 Q9BXT5 Q9NQV7 Q9P2W1 Q9UHC1 Q9Y5K1	ATM BLM BRCA1 BRCA2 CDK2 CDK4 CDKN2 COCA2 CTIP DMC1 DMC1H FACD FANCD1 GAJ H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3-4 H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HOP2 LIM15 MLH1 MLH3 MND1 MRE11 MRE11A MSH4 MSH5 NBN NBS NBS1 P95 PFM6 PRDM9 PSMC3IP RAD50 RAD51 RAD51A RAD51C RAD51L2 RBBP8 RECA RECQ2 RECQL3 REPA1 REPA2 REPA3 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SPO11 TBPIP TEX15 TOP3 TOP3A TSH2B
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Impaired BRCA2 binding to PALB2	BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C9orf76 CTIP DNA2 DNA2L EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 TIP60 TOP3 TOP3A WRN XRCC2
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2

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