GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **701 - 725** of **1070** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
Protein lipoylation	Acyl carrier protein Adrenodoxin, mitochondrial Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Glycine cleavage system H protein, mitochondrial Lipoyl synthase, mitochondrial Lipoyltransferase 1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Octanoyl-[acyl-carrier-protein]	A0A8I5ZRJ8 B2GV15 D3Z9Z2 D3ZA85 D3ZF13 P08461 P24483 Q01205 Q5I0P2 Q5XIH4	Dbt Dlat Dlst Fdx1 Gcsh Lias Lipt1 Lipt2 Ndufab1 Nfu1	Rattus norvegicus (Norway rat)
Protein methylation	Calmodulin-3 Calmodulin-lysine N-methyltransferase EEF1A lysine methyltransferase 1 Electron transfer flavoprotein beta subunit lysine methyltransferase Electron transfer flavoprotein subunit beta Elongation factor 1-alpha 1 Elongation factor 2 Eukaryotic elongation factor 2 lysine methyltransferase Heat shock cognate 71 kDa protein Kin17 DNA and RNA binding protein Methyltransferase 22, Kin17 lysine Protein N-lysine methyltransferase METTL21A Protein arginine N-methyltransferase 3 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS5	A0A096MKD1 B0K012 D3Z8P8 D3Z9R2 D3ZRI6 D3ZT78 D4A8Z5 O70467 P05197 P0DP31 P27952 P62630 P63018 Q68FU3 Q6P7Q0	AABR07029195.1 CaMIII Calm3 Cam3 Camc Camkmt Clnmt EEF1AKMT1 Eef1a Eef1a1 Eef1akmt1 Eef2 Eef2kmt Etfb Etfbkmt Fam86a Hrmt1l3 Hsc70 Hsc73 Hspa8 Kin LOC102553119 Mettl20 Mettl21a Mettl22 N6AMT2 Prmt3 Rps2	Rattus norvegicus (Norway rat)
Proton-coupled monocarboxylate transport	Basigin Embigin Monocarboxylate transporter 1 Monocarboxylate transporter 2 Monocarboxylate transporter 3 Monocarboxylate transporter 4	O35910 O70461 O88775 P26453 P53987 Q63344	Bsg Emb Gp70 Mct1 Mct2 Mct3 Mct4 Slc16a1 Slc16a3 Slc16a7 Slc16a8	Rattus norvegicus (Norway rat)
Proton-coupled neutral amino acid transporters	Proton-coupled amino acid transporter 1 Proton-coupled amino acid transporter 2	Q8K415 Q924A5	Lyaat1 Pat2 Slc36a1 Slc36a2 Tramd1	Rattus norvegicus (Norway rat)
Proton/oligopeptide cotransporters	Solute carrier family 15 member 1 Solute carrier family 15 member 2 Solute carrier family 15 member 3 Solute carrier family 15 member 4	O09014 P51574 Q63424 Q924V4	Pept1 Pept2 Pht1 Pht2 Slc15a1 Slc15a2 Slc15a3 Slc15a4	Rattus norvegicus (Norway rat)
Purine catabolism	5', 3'-nucleotidase, cytosolic 5'-nucleotidase, cytosolic IA 5'-nucleotidase, cytosolic IB 5'-nucleotidase 5-hydroxymethyl-dUMP N-hydrolase Cytosolic purine 5'-nucleotidase Guanine deaminase Inosine triphosphate pyrophosphatase Purine nucleoside phosphorylase Xanthine dehydrogenase/oxidase	A0A0G2JX78 A0A8I5ZYY7 D3ZMY7 D3ZW55 D3ZWR1 O35820 P21588 P22985 P85973 Q9WTT6	Dnph1 Gda Itpa Np Nt5 Nt5c Nt5c1a Nt5c1b Nt5c2 Nt5e Nte Pnp Rcl Xdh	Rattus norvegicus (Norway rat)
Purine salvage	AMP deaminase 1 AMP deaminase 2 AMP deaminase 3 Adenine phosphoribosyltransferase Adenosine deaminase Adenosine kinase Deoxycytidine kinase Deoxyguanosine kinase GMP reductase 1 GMP reductase Hypoxanthine-guanine phosphoribosyltransferase Purine nucleoside phosphorylase	A0A0G2K478 O09178 P10759 P27605 P36972 P48769 P85973 Q02356 Q5FVP6 Q64640 Q920P6 Q9Z244	Ada Adk Ampd1 Ampd2 Ampd3 Aprt Dck Dguok GMPR Gmpr Gmpr1 Gmpr2 Hprt Hprt1 Np Pnp	Rattus norvegicus (Norway rat)
Pyrimidine catabolism	5', 3'-nucleotidase, cytosolic 5',3'-nucleotidase, mitochondrial 5'-nucleotidase, cytosolic IA 5'-nucleotidase 5'-nucleotidase Beta-ureidopropionase Dihydropyrimidinase Dihydropyrimidine dehydrogenase [NADP(+)] Thymidine phosphorylase Uridine phosphorylase Uridine phosphorylase	A0A8I5ZYY7 A0A8I6AHB0 D3ZWR1 D4A5J2 D4A9N9 F7F0D5 O89000 P21588 Q03248 Q5FVR2 Q63150	Bup1 DPD Dpyd Dpys Ecgf1 Nt5 Nt5c Nt5c1a Nt5c3a Nt5e Nt5m Nte Tymp Upb1 Upp1 Upp2	Rattus norvegicus (Norway rat)
Pyroptosis	Apoptosis regulator BAX BCL2-antagonist/killer 1 Caspase-1 Caspase-3 Charged multivesicular body protein 2B Charged multivesicular body protein 2a Charged multivesicular body protein 3 Charged multivesicular body protein 4B Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cytochrome c domain-containing protein Cytochrome c, somatic Elastase, neutrophil expressed Gasdermin D Gasdermin E Granzyme B High mobility group protein B1 High mobility group protein B1 High mobility group protein B1 High mobility group protein B1 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 Similar to Cytochrome c, somatic	A0A096MJ11 A0A0G2K6P4 A0A8I5Y7D7 A0A8I5ZP83 A0A8I5ZY10 A0A8I6AB52 A0A8I6AQ75 A0A8I6GBU6 D3ZXV2 D4A488 D4A5L9 D4A7H9 F1MAG0 F7EQF3 P16598 P18291 P43527 P55213 P62898 P63159 P97636 Q569C1 Q63264 Q63690 Q8CGS4	AC128290.1 Bak1 Bax Casp1 Casp3 Chmp2a Chmp2b Chmp3 Chmp4b Chmp4c Chmp6 Chmp7 Cpp32 Cycs Cycsl2 Cycsl3 Elane Gsdmd Gsdme Gzmb Hmg-1 Hmg1 Hmgb1 Hmgb1-ps33 Hmgb1-ps4 Hmgb1l1 Hmgb1l2 Hmgb1l3 Hmgb1l5 Igif Il18 Il1a Il1b Il1bc Il1bce LOC108349189 LOC108350839 LOC690675 RGD1562558 Vps24	Rattus norvegicus (Norway rat)
Pyruvate metabolism	Alanine aminotransferase 1 Hydroxyacylglutathione hydrolase, mitochondrial L-lactate dehydrogenase A chain L-lactate dehydrogenase B chain L-lactate dehydrogenase C chain L-lactate dehydrogenase Lactoylglutathione lyase Malic enzyme Malic enzyme NADP-dependent malic enzyme Oxaloacetate decarboxylase, mitochondrial Pyruvate carboxylase, mitochondrial Pyruvate kinase PKLR Pyruvate kinase Voltage-dependent anion-selective channel protein 1	A0A0G2K502 F1M5N4 M0RD14 O35952 P04642 P12928 P13697 P19629 P25409 P42123 P52873 Q6AYQ8 Q6P7Q4 Q7TNA8 Q9Z2L0	Aat1 Fahd1 Glo1 Gpt Gpt1 Hagh LOC100362738 Ldh-1 Ldh-2 Ldh-3 Ldh1 Ldh2 Ldh3 Ldha Ldhal6b Ldhb Ldhc Me1 Me2 Me3 Mod-1 Mod1 Pc Pklr Pkml1 Rsp29 Vdac1	Rattus norvegicus (Norway rat)
RA biosynthesis pathway	Alcohol dehydrogenase 1 Aldehyde dehydrogenase 1A1 Aldehyde dehydrogenase 8 family, member A1 Aldo-keto reductase family 1 member C21 Aldo-keto reductase family 1, member C1 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Cellular retinoic acid-binding protein 1 Cytochrome P450 26A1 Cytochrome P450 26B1 Cytochrome P450, family 26, subfamily C, polypeptide 1 Dehydrogenase/reductase SDR family member 4 Dehydrogenase/reductase SDR family member 9 LRRGT00111 Retinal dehydrogenase 2 Retinaldehyde dehydrogenase 3 Retinol dehydrogenase 10 Retinol dehydrogenase 13 Retinol dehydrogenase 14 Retinol dehydrogenase 7 Short chain dehydrogenase/reductase family 16C, member 5	D3ZFR9 D3ZS85 D3ZUY0 D3ZXY4 D4AAL3 G3V7X8 G3V861 P06757 P51647 P55006 P62966 Q3MHS3 Q63639 Q64563 Q6AYQ2 Q6TUD3 Q80ZF7 Q8K4D8 Q8VD48 Q8VID1	Adh-1 Adh1 Adh2 Adh4 Akr1c1 Akr1c21 Aldh Aldh1a1 Aldh1a2 Aldh1a3 Aldh6 Aldh8a1 Crabp1 Cyp26a1 Cyp26b1 Cyp26c1 Dhrs4 Dhrs9 Hsd17b5 LOC683474 Raldh2 Raldh3 Rdh10 Rdh11 Rdh13 Rdh14 Rdh3 Rdh7 Sdr16c5 eRolDH	Rattus norvegicus (Norway rat)
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal like Alsin Ankyrin repeat domain 27 CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated DENN domain containing 1A DENN domain containing 1B DENN domain containing 1C DENN domain containing 2A DENN domain containing 2B DENN domain containing 2C DENN domain containing 2D DENN domain containing 3 DENN domain containing 4A DENN domain containing 4B DENN domain containing 4C DENN domain containing 5B DENN domain containing 6A DENN domain containing 6B DENN domain-containing protein 5A GTPase activating protein and VPS9 domains 1 Guanine nucleotide exchange factor for Rab-3A HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 MAP kinase-activating death domain protein Protein RIC1 homolog RAB guanine nucleotide exchange factor 1 RAB39A, member RAS oncogene family RAB6B, member RAS oncogene family RAB9B, member RAS oncogene family RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RGP1 homolog, RAB6A GEF complex partner 1 Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit (Fragments) Rab3 GTPase-activating protein non-catalytic subunit Rab7b, member RAS oncogene family Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-35 Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-6A Ras-related protein Rab-7a Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab SET binding factor 1 SET binding factor 2 Serine/threonine-protein kinase Trafficking protein particle complex 2 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Trafficking protein particle complex subunit Vacuolar fusion protein MON1 homolog Vacuolar fusion protein MON1 homolog small monomeric GTPase small monomeric GTPase	A0A0G2JT78 A0A0G2JUB1 A0A0G2K089 A0A0G2K0G9 A0A0G2K1K5 A0A0G2K6J1 A0A0G2K7U7 A0A8I5ZRE4 A0A8I5ZT12 A0A8I5ZYV2 A0A8I6A009 A0A8I6A6X2 A0A8I6AAJ7 A0A8I6ACY0 A0A8I6AEI1 A0A8I6AEV4 A0A8I6ANG7 A0A8I6G3S1 A0A8J8YPH6 A1L1J8 B0BNE3 B0BNK1 B1WC06 B2RYU6 D3Z8F6 D3ZAE3 D3ZE49 D3ZES2 D3ZLQ1 D3ZMG0 D3ZP15 D3ZP73 D3ZX30 D3ZZP2 D4A224 D4A2H4 D4A3S0 D4A518 D4A544 D4A6C4 D4A7A8 E9PU02 F1LTT7 F1M9W9 F1MAQ4 G3V631 G3V7Q0 M0RAP5 M0RBQ8 M0RC99 O08873 P09527 P0C5Y8 P10536 P23640 P35280 P35281 P35284 P35286 P37727 P47196 P47197 P50398 P50399 P61107 P62260 P63012 P69735 P70550 P97680 Q2KMM2 Q5BJL8 Q5EB77 Q5M887 Q5U1Z0 Q5U1Z2 Q5U316 Q62739 Q63483 Q63484 Q69BT7 Q6AXT5 Q6GQP4 Q6NYB7 Q99NH3 Q99P74 Q99P75 Q9WVB1	AABR07042915.1 Akt1 Akt2 Akt3 Als2 Als2cl Ankrd27 Ccz1 Ccz1b Chm Chml Dennd1a Dennd1b Dennd1c Dennd2a Dennd2b Dennd2c Dennd2d Dennd3 Dennd4a Dennd4b Dennd4c Dennd5a Dennd5b Dennd6a Dennd6b Gapvd1 Gdi1 Gdi2 Gdi3 Grab Hps1 Hps4 LOC100909916 Madd Mon1a Mon1b RGD1310016 RGD1562639 RGD1564492 Rab1 Rab10 Rab12 Rab13 Rab14 Rab18 Rab1A Rab1b Rab21 Rab27 Rab27a Rab27b Rab31 Rab35 Rab38 Rab39a Rab3a Rab3gap Rab3gap1 Rab3gap2 Rab3il1 Rab3ip Rab5a Rab5b Rab5c Rab6 Rab6a Rab6b Rab7 Rab7a Rab7b Rab8 Rab8a Rab8b Rab9 Rab9a Rab9b Rabgdia Rabgef1 Rabin3 Rabin8 Rep1 Rgp1 Ric1 Rin1 Rin2 Rin3 Rinl Sbdn Sbf1 Sbf2 Trappc1 Trappc10 Trappc11 Trappc12 Trappc13 Trappc2 Trappc2l Trappc2ll1 Trappc3 Trappc4 Trappc5 Trappc6a Trappc6b Trappc8 Trappc9 Ttc15 Ulk1 Ywhae	Rattus norvegicus (Norway rat)
RAB geranylgeranylation	GTP-binding protein Rab-3D Geranylgeranyl transferase type-2 subunit alpha Geranylgeranyl transferase type-2 subunit beta Protein tyrosine phosphatase type IVA 2 RAB17, member RAS oncogene family RAB20, member RAS oncogene family RAB22A, member RAS oncogene family RAB23, member RAS oncogene family RAB2B, member RAS oncogene family RAB30, member RAS oncogene family RAB33A, member RAS oncogene family RAB33B, member RAS oncogene family RAB36, member RAS oncogene family RAB37, member RAS oncogene family RAB39A, member RAS oncogene family RAB44, member RAS oncogene family RAB6B, member RAS oncogene family RAB9B, member RAS oncogene family Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A Rab40b, member RAS oncogene family Rab40c, member RAS oncogene family Rab7b, member RAS oncogene family Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-11B Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-15 Ras-related protein Rab-18 Ras-related protein Rab-19 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-26 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-2A Ras-related protein Rab-31 Ras-related protein Rab-34 Ras-related protein Rab-35 Ras-related protein Rab-3A Ras-related protein Rab-3B Ras-related protein Rab-3C Ras-related protein Rab-43 Ras-related protein Rab-4A Ras-related protein Rab-4B Ras-related protein Rab-5A Ras-related protein Rab-6A Ras-related protein Rab-7L1 Ras-related protein Rab-7a Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab small monomeric GTPase small monomeric GTPase	A0A0G2JT78 A0A0G2JTT4 A0A8I5YC69 A0A8I5ZKQ1 A0A8I5ZWU0 A0A8I6AAJ7 A0A8I6AES5 A0A8I6ALE4 A1L1J8 B0BNK1 B2RZ46 B5DF78 D3ZCU8 D3ZP15 D3ZRM5 D3ZZP2 D4A7A8 D4AAE6 F1LW77 F1M8M0 M0RC99 O35509 P05712 P05714 P09527 P10536 P23640 P35280 P35281 P35284 P35286 P35289 P37727 P51146 P51156 P61107 P62494 P62824 P63012 P70550 Q08602 Q08603 Q53B90 Q5EB77 Q5M7U5 Q5U1Y1 Q5U316 Q63481 Q63483 Q63941 Q63942 Q6AXT5 Q6GQP4 Q6NYB7 Q6P9X4 Q99P74 Q99P75 Q9WVB1	Chm Chml Ggta Ggtb Prl2 Ptp4a2 Rab1 Rab10 Rab11 Rab11a Rab11b Rab12 Rab13 Rab14 Rab15 Rab16 Rab17 Rab18 Rab19 Rab1A Rab1b Rab2 Rab20 Rab21 Rab22a Rab23 Rab26 Rab27 Rab27a Rab27b Rab29 Rab2a Rab2b Rab30 Rab31 Rab33a Rab33b Rab34 Rab35 Rab36 Rab37 Rab38 Rab39a Rab3a Rab3b Rab3c Rab3d Rab4 Rab40b Rab40c Rab43 Rab44 Rab4a Rab4b Rab5a Rab5b Rab5c Rab6 Rab6a Rab6b Rab7 Rab7a Rab7b Rab7l1 Rab8 Rab8a Rab8b Rab9 Rab9a Rab9b Rabggta Rabggtb Rep1	Rattus norvegicus (Norway rat)
RAC1 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl-interactor 2 Actin-binding protein WASF1 Active breakpoint cluster region-related protein Alsin Amphoterin-induced protein 2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 BAR/IMD domain-containing adapter protein 2-like 1 BAR/IMD domain-containing adapter protein 2 BRICK1 subunit of SCAR/WAVE actin nucleating complex Beta-chimaerin Breakpoint cluster region protein CDC42 effector protein 4 Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Chimaerin Citron rho-interacting kinase Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein Cytoplasmic FMR1-interacting protein DEF6 guanine nucleotide exchange factor DEP domain containing 1B Dedicator of cyto-kinesis 3 Dedicator of cytokinesis 10 Dedicator of cytokinesis 11 Dedicator of cytokinesis 2 Dedicator of cytokinesis 4 Dedicator of cytokinesis 5 Dedicator of cytokinesis 6 Dedicator of cytokinesis 7 Dedicator of cytokinesis 8 Delta(14)-sterol reductase LBR Emerin Ephexin-1 Epithelial cell transforming 2 Extended synaptotagmin-1 FERM domain containing kindlin 2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 FERM, ARHGEF and pleckstrin domain-containing protein 1 FYVE, RhoGEF and PH domain containing 5 Family with sequence similarity 13, member A Family with sequence similarity 13, member B Formin-like 1 Gem-interacting protein Granule associated Rac and RHOG effector 1 Guanine nucleotide exchange factor DBS Guanine nucleotide-binding protein subunit alpha-13 IQ motif containing GTPase activating protein 1 IQ motif containing GTPase activating protein 2 IQ motif containing GTPase activating protein 3 Integrin beta-1 Kalirin Kinectin 1 MAGUK p55 subfamily member 7 MCF.2 cell line derived transforming sequence NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 NCK associated protein 1 like NHS actin remodeling regulator Nck-associated protein 1 Neutral amino acid transporter B(0) Neutrophil cytosol factor 2 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 4 Nischarin Oligophrenin-1 Partitioning defective 6 homolog alpha Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Phospholipase D1 Phospholipase D2 Pleckstrin homology and RhoGEF domain containing G1 Pleckstrin homology and RhoGEF domain containing G2 Pleckstrin homology and RhoGEF domain containing G3 Pleckstrin homology and RhoGEF domain containing G6 Protein diaphanous homolog 3 Protein jagged-1 Proto-oncogene vav RNA binding motif protein 39 Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 RalA-binding protein 1 Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-7a Ras-specific guanine nucleotide-releasing factor 2 Rho GDP dissociation inhibitor beta Rho GDP-dissociation inhibitor 1 Rho GTPase activating protein 10 Rho GTPase activating protein 12 Rho GTPase activating protein 1 Rho GTPase activating protein 21 Rho GTPase activating protein 22 Rho GTPase activating protein 23 Rho GTPase activating protein 25 Rho GTPase activating protein 30 Rho GTPase activating protein 31 Rho GTPase activating protein 32 Rho GTPase activating protein 33 Rho GTPase activating protein 42 Rho GTPase activating protein 45 Rho GTPase activating protein 4 Rho GTPase activating protein 5 Rho GTPase activating protein 9 Rho GTPase-activating protein 15 Rho GTPase-activating protein 17 Rho GTPase-activating protein 20 Rho GTPase-activating protein 24 Rho GTPase-activating protein 26 Rho GTPase-activating protein 27 Rho GTPase-activating protein 29 Rho GTPase-activating protein 35 Rho GTPase-activating protein 44 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 SH3 domain-binding protein 1 SLIT-ROBO Rho GTPase activating protein 1 SLIT-ROBO Rho GTPase activating protein 3 SLIT-ROBO Rho GTPase-activating protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 SOS Ras/Rho guanine nucleotide exchange factor 2 Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase TAO3 Spermatogenesis associated 13 Switching B-cell complex subunit SWAP70 Synapse defective Rho GTPase homolog 2 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 T-cell activation RhoGTPase activating protein TIAM Rac1 associated GEF 1 TIAM Rac1 associated GEF 2 Transferrin receptor protein 1 Triple functional domain protein Tyrosine-protein kinase Unconventional myosin-IXb Vang-like protein Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 Vesicle-associated membrane protein 3 Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase receptor protein-tyrosine kinase	A0A096MK16 A0A0G2JTR4 A0A0G2JTU0 A0A0G2JV16 A0A0G2JVF0 A0A0G2JVP1 A0A0G2JVX3 A0A0G2JXJ0 A0A0G2JYR5 A0A0G2JYU6 A0A0G2K344 A0A0G2K3H2 A0A0G2K7N9 A0A0G2KA11 A0A8I5ZK89 A0A8I5ZKS6 A0A8I5ZL97 A0A8I5ZLD3 A0A8I5ZMC4 A0A8I5ZNF3 A0A8I5ZNR8 A0A8I5ZPB5 A0A8I5ZRM9 A0A8I5ZRT6 A0A8I5ZS98 A0A8I5ZXI2 A0A8I6A4W2 A0A8I6A829 A0A8I6A9Q4 A0A8I6AC12 A0A8I6ADN8 A0A8I6AEP6 A0A8I6AH32 A0A8I6AHL8 A0A8I6AM38 A0A8I6AN18 A0A8I6ANH8 A0A8I6AP97 A0A8I6APD0 A0A8I6APL5 A0A8I6APV4 A0A8I6AQA1 A0A8I6G699 A0A8I6GDA1 A0A8I6GLR6 A0A8J8XFB5 A0A8J8XIU8 A1A5P0 A7E3N2 A7E3N7 B0BN40 B1WC33 B5DF62 D3ZA02 D3ZA21 D3ZA46 D3ZBN3 D3ZCI3 D3ZCK4 D3ZCS4 D3ZFJ3 D3ZFK8 D3ZGL1 D3ZJ25 D3ZKC8 D3ZMS5 D3ZQ51 D3ZRE7 D3ZUD0 D3ZUP5 D3ZWB4 D3ZXG5 D3ZYG0 D4A208 D4A280 D4A3T0 D4A646 D4A8H8 D4A987 D4A9G6 D4AA32 D4ABR1 D4ACU5 D4AE81 E9PSL7 E9PT59 F1LQX4 F1LVD8 F1LVW7 F1LXF1 F1LYQ8 F1M0N1 F1M0Z1 F1M287 F1M2D4 F1M4N6 F1M5M9 F1M707 F1MAI3 F1MAK3 F7EUE3 G3V7Q7 G3V9A0 M0R3X3 M0R7F3 O08874 O54874 O55043 O70377 P09527 P0C5Y8 P0CAX5 P35465 P41350 P49134 P54100 P55161 P63025 P70496 P70498 P81128 P97924 Q03070 Q3KR97 Q4G017 Q53UA7 Q5BJU7 Q5BKC9 Q5EGY4 Q5FWU0 Q5PQJ5 Q5U2Y3 Q5U2Z7 Q5XI73 Q5XXR3 Q62737 Q62796 Q62829 Q63190 Q63358 Q63406 Q63433 Q63722 Q63744 Q63787 Q63788 Q63789 Q64303 Q66H91 Q672K1 Q6AYC5 Q6B4M5 Q6GMN2 Q6P720 Q6P791 Q6Q7Y5 Q6REY9 Q6RUV5 Q6TLK4 Q7TNJ4 Q8CFN2 Q99376 Q99JE4 Q99N37 Q9EPF2 Q9ERL1 Q9ES67 Q9QZM5 Q9WV87 Q9Z1X1 Q9Z272	AABR07021955.1 AABR07032856.1 Abi1 Abi2 Abl2 Abr Ali1 Als2 Amigo2 Arap1 Arap2 Arap3 Arg357 Arhgap1 Arhgap10 Arhgap12 Arhgap15 Arhgap17 Arhgap20 Arhgap21 Arhgap22 Arhgap23 Arhgap24 Arhgap25 Arhgap26 Arhgap27 Arhgap29 Arhgap3 Arhgap30 Arhgap31 Arhgap32 Arhgap33 Arhgap35 Arhgap4 Arhgap42 Arhgap44 Arhgap45 Arhgap5 Arhgap7 Arhgap9 Arhgdia Arhgdib Arhgef10 Arhgef11 Arhgef15 Arhgef19 Arhgef25 Arhgef39 Arhgef5 Arhgef6 Arhgef7 Baiap2 Baiap2l1 Bch Bcr Borg5 Brk1 CRIK Camgap1 Cav Cav1 Cdc42 Cdc42bpa Cdc42ep1 Cdc42ep4 Chn2 Cit Cyba Cybb Cyfip1 Cyfip2 Def6 Depdc1b Diaph3 Dlc1 Dock10 Dock11 Dock2 Dock3 Dock4 Dock5 Dock6 Dock7 Dock8 Duo Ect2 Emd Epha2 Esyt1 Fam13a Fam13b Fam62a Farp1 Farp2 Fermt2 Fgd5 Fmnl1 Garre1 Geft Git1 Git2 Gmip Gna13 Grf2 Grlf1 Hapip Hem2 Iqgap1 Iqgap2 Iqgap3 Itgb1 Jag1 Jik Kalrn Ktn1 Lamtor1 Lbr Mbc2 Mcam Mcf2 Mcf2l Mox1 Mpp7 Muc18 Myo9b Myr5 Nap1 Ncf1 Ncf2 Ncf4 Nckap1 Nckap1l Ngef Nhs Nisch Noh1 Nox1 Nox3 Noxa1 Noxo1 Ophn1 Ost P190A Pak1 Pak2 Pak3 Pak3bp Pak4 Pak5 Pak6 Pak7 Par-6a Par6a Pard6a Pik3ca Pik3r1 Pik3r2 Pik3r3 Pixb Pk428 Pkn Pkn1 Pkn2 Pld1 Pld2 Plekhg1 Plekhg2 Plekhg3 Plekhg6 Prex1 Prex2 Prk1 Prk2 Prkcl1 Prkcl2 RGD1565043 Rab7 Rab7a Rac Rac1 Racgap1 Ralbp1 Rasgrf2 Rbm39 Rhogap Rich2 Sh3bp1 Slc1a5 Snap23 Sos1 Sos2 Spata13 Srgap1 Srgap2 Srgap3 Stard12 Swap70 Syb3 Syde2 Tagap Taok3 Tfrc Tiam1 Tiam2 Trfr Trio Vamp3 Vangl1 Vav Vav1 Vav2 Vav3 Vrk2 Wasf1 Wasf2 Wasf3 Wave1 Ykt6 p190ARHOGAP	Rattus norvegicus (Norway rat)
RAC2 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl-interactor 2 Active breakpoint cluster region-related protein Ankyrin repeat and LEM domain-containing protein 2 Armadillo repeat-containing X-linked protein 3 BAR/IMD domain-containing adapter protein 2-like 1 BRICK1 subunit of SCAR/WAVE actin nucleating complex Breakpoint cluster region protein CDC42 effector protein 4 Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein DEF6 guanine nucleotide exchange factor DEP domain containing 1B Dedicator of cyto-kinesis 3 Dedicator of cytokinesis 10 Dedicator of cytokinesis 2 Dedicator of cytokinesis 4 Delta(14)-sterol reductase LBR Desmoglein 2 Emerin Extended synaptotagmin-1 Granule associated Rac and RHOG effector 1 IQ motif containing GTPase activating protein 1 Integrin beta-1 MAGUK p55 subfamily member 7 MCF.2 cell line derived transforming sequence Membrane-associated progesterone receptor component 2 Metaxin-1 NCK associated protein 1 like NHS actin remodeling regulator Nck-associated protein 1 Neutrophil cytosol factor 2 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 4 Oligophrenin-1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Phospholipase D2 Protein ERGIC-53 Protein diaphanous homolog 3 Proto-oncogene vav RNA binding motif protein 39 Rac GTPase-activating protein 1 Rac family small GTPase 2 Ragulator complex protein LAMTOR1 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 1 Rho GTPase activating protein 1 Rho GTPase activating protein 21 Rho GTPase activating protein 32 Rho GTPase activating protein 42 Rho GTPase-activating protein 17 Rho GTPase-activating protein 26 Rho GTPase-activating protein 35 Rho GTPase-activating protein SYDE1 SLIT and NTRK-like family, member 5 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase TAO3 Sorting and assembly machinery component 50 homolog Starch-binding domain-containing protein 1 Switching B-cell complex subunit SWAP70 TIAM Rac1 associated GEF 1 Transferrin receptor protein 1 Triple functional domain protein Vang-like protein Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein-associated protein B Wiskott-Aldrich syndrome protein family member non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase receptor protein-tyrosine kinase	A0A0G2JTR4 A0A0G2JU49 A0A0G2JVP1 A0A0G2JXJ0 A0A0G2JYR5 A0A0G2K344 A0A8I5ZLD3 A0A8I5ZNF3 A0A8I5ZNR8 A0A8I5ZPB5 A0A8I5ZRT6 A0A8I5ZS98 A0A8I6A1P8 A0A8I6A9Q4 A0A8I6AC12 A0A8I6ADN8 A0A8I6AEP6 A0A8I6AG90 A0A8I6AH32 A0A8I6APL5 A0A8I6APV4 A0A8I6GDA1 A0A8I6GLR6 A0A8J8XFB5 A0A8J8XIU8 A1A5P0 A7E3N2 B1WC33 B5DF62 D3ZBN3 D3ZCK4 D3ZKC8 D3ZRE7 D3ZUP5 D3ZYG0 D3ZZN9 D4A8H8 D4AA32 F1LVW7 F1LXF1 F1M0Z1 F1M4N6 F1M707 F1MAK3 G3V7Q7 M0R9U3 P09527 P0CAX5 P35465 P41350 P49134 P54100 P55161 P63025 P70498 P81128 Q3KR97 Q53UA7 Q5FVN1 Q5FWU0 Q5U2Y3 Q5XI73 Q5XID7 Q5XIU9 Q62737 Q62902 Q63190 Q63787 Q63788 Q63789 Q64303 Q66H91 Q6AXV4 Q6P791 Q7TP65 Q8CFN2 Q99376 Q99N37 Q9EPF2 Q9ERL1 Q9QZM5 Q9Z1X1 Q9Z269 Q9Z272	AABR07021955.1 Abi1 Abi2 Abr Ankle2 Arg357 Arhgap1 Arhgap17 Arhgap21 Arhgap26 Arhgap32 Arhgap35 Arhgap42 Arhgdia Armcx3 Baiap2l1 Bcr Borg5 Brk1 Cav Cav1 Cdc42 Cdc42ep1 Cdc42ep4 Cyba Cybb Cyfip1 Def6 Depdc1b Diaph3 Dock10 Dock2 Dock3 Dock4 Dsg2 Emd Epha2 Ergic53 Esyt1 Fam62a Garre1 Git1 Git2 Grlf1 Hem2 Iqgap1 Itgb1 Jik Lamtor1 Lbr Lem4 Lman1 Mbc2 Mcam Mcf2 Mpp7 Mtx1 Muc18 Nap1 Ncf1 Ncf2 Ncf4 Nckap1 Nckap1l Nhs Ophn1 P190A Pak1 Pak2 Pak4 Pgrmc2 Pik3ca Pik3r1 Pik3r2 Pik3r3 Pld2 Prex1 Rab7 Rab7a Rac2 Racgap1 Rbm39 Samm50 Slitrk5 Stbd1 Swap70 Syb3 Syde1 Taok3 Tfrc Tiam1 Trfr Trio Vamp3 Vangl1 Vapb Vav Vav1 Vav2 Vav3 Vrk2 Wasf2 p190ARHOGAP	Rattus norvegicus (Norway rat)
RAF activation	14-3-3 protein beta/alpha BRCA1 associated protein Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-3 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 GTPase HRas GTPase KRas GTPase NRas Kinase suppressor of ras 1 Leucine-rich repeat protein SHOC-2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase kinase kinase 11 Prohibitin 1 Protein phosphatase 2 scaffold subunit A alpha Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Tyrosine-protein kinase JAK2 non-specific serine/threonine protein kinase	A0A8I5Y120 A0A8I5ZMG6 A0A8I5ZQW6 A0A8I5ZRC2 A0A8I6A6K6 A0A8I6ATH0 D3ZDI7 P08413 P08644 P0DP31 P11275 P11345 P11730 P14056 P15791 P20171 P35213 P36506 P62142 P62716 P63088 P63331 P67779 P97538 Q01986 Q04970 Q4QQT4 Q5XI34 Q62689 Q66HA1 Q6AYI5 Q80W83 Q8VHF0 Q9WUD9	A-raf Araf Araf1 Braf Brap CaMIII Calm3 Cam3 Camc Camk2a Camk2b Camk2d Camk2g Hras Hras1 Jak2 Kras Kras2 Ksr1 LOC100909468 Map2k1 Map2k2 Map3k11 Mark3 Mek1 Mek2 Mkk2 Mlk3 Mras Nras Phb Phb1 Ppp1cb Ppp1cc Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5a Ppp2r5b Ppp2r5c Ppp2r5d Ppp2r5e Prkmk1 Prkmk2 Raf Raf1 Rras3 Shoc2 Src Ywhab	Rattus norvegicus (Norway rat)
RAF-independent MAPK1/3 activation	Astrocytic phosphoprotein PEA-15 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 protein-serine/threonine phosphatase protein-serine/threonine phosphatase protein-serine/threonine phosphatase protein-tyrosine-phosphatase	A0A8I6AJQ7 D3ZBG7 D3ZNK9 D4A3W6 O54838 P21708 P63086 Q2YDV1 Q5U318 Q62767 Q63340 Q64346 Q64623	Cl100 Dusp1 Dusp10 Dusp16 Dusp4 Dusp5 Dusp6 Dusp7 Dusp8 Dusp9 ENSRNOG00000069024 Erk1 Erk2 Mapk Mapk1 Mapk3 Mkp1 Mkp2 Mkp3 Mkpx Pea15 Prkm1 Prkm3 Ptpn16	Rattus norvegicus (Norway rat)
RAF/MAP kinase cascade	Actinin alpha 2 Amphiregulin Angiopoietin-1 Artemin Astrocytic phosphoprotein PEA-15 Betacellulin Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-3 Colony stimulating factor 2 receptor subunit beta Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Focal adhesion kinase 1 GDNF family receptor alpha 3 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-4 GTPase HRas GTPase KRas GTPase NRas Glial cell line-derived neurotrophic factor Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2D Granulocyte-macrophage colony-stimulating factor Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin 3 receptor subunit alpha Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 Interleukin-5 Kit ligand Klotho beta Klotho Leucine-rich repeat-containing protein 7 Linker for activation of T-cells family member 1 Mast/stem cell growth factor receptor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Neuregulin 3 Neurofilament light polypeptide Neurturin Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B (Fragment) Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase receptor Ret Protransforming growth factor alpha RAS guanyl releasing protein 3 RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 4 Ral guanine nucleotide dissociation stimulator,-like 1 Ral guanine nucleotide dissociation stimulator-like 2 Ral guanine nucleotide dissociation stimulator Ran-binding protein 9 Rap guanine nucleotide exchange factor 2 Ras-specific guanine nucleotide-releasing factor 1 Ras-specific guanine nucleotide-releasing factor 2 RasGEF domain family, member 1A Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Receptor-type tyrosine-protein phosphatase alpha SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain Spectrin beta chain Spectrin beta chain Spectrin, alpha, erythrocytic 1 Spectrin, beta, non-erythrocytic 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A0G2JW59 A0A0G2JY25 A0A0G2K210 A0A0G2K344 A0A0G2K677 A0A0G2KAU4 A0A0U1RS29 A0A8I5Y176 A0A8I5Y1H8 A0A8I5ZN92 A0A8I5ZW61 A0A8I6AM23 A0A8I6AQ55 A0A8I6AWM3 A0A8I6B3J9 A0A8I6B5D5 D3Z8T6 D3ZS31 D3ZZV7 D4A244 D4A3T0 D4A678 E9PSX4 F1LSG7 F1LSQ8 F1M386 F1MAL5 F7F1M3 G3V608 G3V6K6 G3V6S0 G3V9H8 O35346 O35460 O35569 O54769 O70142 O70143 O70301 O70601 O88182 P01134 P04823 P06494 P07522 P08413 P08644 P0DP31 P11275 P11730 P13109 P13596 P15791 P16086 P17108 P17945 P19527 P20171 P20786 P21581 P21708 P24338 P26896 P26897 P28576 P28818 P31016 P35439 P35570 P36364 P43322 P48750 P48807 P61149 P62994 P63076 P63086 P70492 P70587 P97523 Q00960 Q02195 Q03348 Q03386 Q04589 Q04970 Q05028 Q05030 Q06175 Q07731 Q08125 Q498D6 Q52RG8 Q5M824 Q5U318 Q62645 Q62689 Q62696 Q62799 Q62844 Q62936 Q62997 Q63116 Q63272 Q63622 Q63787 Q63788 Q6AYE8 Q811Q5 Q8R5I4 Q8R5L5 Q8R5L9 Q8VI79 Q8VI81 Q8VI82 Q99JE4 Q9EPI2 Q9EST9 Q9QWN8 Q9R1K8 Q9Z0L5 Q9Z1L0 Q9Z2Y9	Actn2 Angpt1 Areg Artn Ash Btc CaMIII Calm3 Cam3 Camc Camk2a Camk2b Camk2d Camk2g Csf2 Csf2rb Csfgm Dlg1 Dlg2 Dlg3 Dlg4 Dlgh1 Dlgh2 Dlgh3 Dlgh4 Dtr Egf Egfr Erbb2 Erbb3 Ereg Erk1 Erk2 FGF15 FGF22 FGF6 Fak Fak1 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr1 Fgfr2 Fgfr3 Fgfr4 Flg Flt3 Frs2 Frs3 Fyn Gdnf Gdnfra Gfra1 Gfra2 Gfra3 Gfra4 GluN2D Grb2 Grf2 Grin1 Grin2b Grin2d Hbegf Hegfl Hgf Hras Hras1 Il-2 Il-3 Il-5 Il2 Il2ra Il2rb Il3 Il3ra Il5 Irs-1 Irs1 Irs2 Jak1 Jak2 Jak3 KIT Kgf Kit Kitl Kitlg Kl Klb Kras Kras2 Lap1 Lat Lrp Lrrc7 Mapk Mapk1 Mapk3 Met Mgf Ncam Ncam1 Ndf Nefl Neu Nf68 Nfl Nmdar1 Nras Nrg1 Nrg2 Nrg3 Nrtn Nshc Ntak Pdgfa Pdgfb Pdgfr Pdgfr1 Pdgfra Pdgfrb Pdzgef1 Pea15 Pik3ca Pik3cb Pik3r1 Pik3r2 Prkm1 Prkm3 Psd95 Pspn Ptk2 Ptpra Ralgds Ralgdsl1 Ralgdsl2 Ranbp9 Rapgef2 Rasgef1a Rasgrf1 Rasgrf2 Rasgrp Rasgrp1 Rasgrp3 Rasgrp4 Ret Retl1 Rgl1 Rgl2 Rpa1 Sck Sdgf Shc1 Shc2 Shc3 Shcc Snt2 Sos1 Spna2 Spnb3 Spta1 Spta2 Sptan1 Sptb Sptbn1 Sptbn2 Sptbn4 Sptbn5 Tek Tgfa Trnr1	Rattus norvegicus (Norway rat)
RAS processing	ADP-ribosylation factor-like protein 2 Acyl-protein thioesterase 1 Alpha/beta hydrolase domain-containing protein 17A Alpha/beta hydrolase domain-containing protein 17B Alpha/beta hydrolase domain-containing protein 17C Bcl-2-like protein 1 CAAX prenyl protease 2 Calmodulin-3 GTPase HRas GTPase KRas GTPase NRas Golgin subfamily A member 7 Palmitoyltransferase Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Protein kinase C theta type Protein-S-isoprenylcysteine O-methyltransferase Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase cGMP-dependent protein kinase 2	A0A8I5ZMP6 A0A8I5ZS01 A0A8I6AGE4 A0A8I6AMA7 B0BMW8 B5DFK7 D3ZRD3 F7F533 O08697 P08644 P0DP31 P20171 P53563 P70470 Q02293 Q04631 Q04970 Q5XIJ5 Q64595 Q6AY17 Q6AYQ1 Q9WTQ0 Q9WVM4	Abhd17a Abhd17b Abhd17c Apt1 Arl184 Arl2 Bcl2l1 Bclx Blc2l CaMIII Calm3 Cam3 Camc ENSRNOG00000064803 ENSRNOG00000067432 Fnta Fntb Golga7 Hras Hras1 Icmt Kras Kras2 LOC100910107 LOC120097921 LOC120098474 Lypla1 Nras Pde6d Pkcq Prkcq Prkg2 Rce1 Usp17l Usp17l8 Usp17la Usp17la2 Usp17lh Usp17li Zdhhc9	Rattus norvegicus (Norway rat)
RET signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Artemin Docking protein 1 Docking protein 2 Docking protein 4 Docking protein 5 Docking protein 6 Fibroblast growth factor receptor substrate 2 GDNF family receptor alpha 3 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-4 GRB2-associated binding protein 1 GRB2-associated-binding protein 2 Glial cell line-derived neurotrophic factor Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Insulin receptor substrate 2 Mitogen-activated protein kinase 7 Neurturin PDZ and LIM domain protein 7 Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Protein kinase C alpha type Proto-oncogene tyrosine-protein kinase Src Proto-oncogene tyrosine-protein kinase receptor Ret Rap1 GTPase-activating protein SH3 and multiple ankyrin repeat domains protein 3 SHC-transforming protein 1 SHC-transforming protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0G2K344 A0A8I5Y949 A0A8I6A882 A0A8I6ALT5 A0A8I6B3J9 D3ZAL7 D4A244 D4A3T0 F1LV89 F1M038 F1MAL5 F7F1M3 F7FET5 G3V9H8 O70143 O70301 P05696 P0C865 P0CE43 P10686 P27791 P41499 P62994 P68182 Q07731 Q4QQV2 Q5M824 Q62997 Q63787 Q63788 Q63789 Q6AYE8 Q811Q5 Q9EPI2 Q9EQH1 Q9JLU4 Q9QZC5 Q9WUD9 Q9Z1L0 Q9Z1Z9	Artn Ash Bmk1 Dok1 Dok2 Dok4 Dok5 Dok6 Enigma Erk5 Frs2 Gab1 Gab2 Gdnf Gdnfra Gfra1 Gfra2 Gfra3 Gfra4 Grb10 Grb2 Grb7 Irs2 Lim1 Mapk7 Nrtn Nshc Pdlim7 Pik3ca Pik3cb Pik3cd Pik3r1 Pik3r2 Pik3r3 Pkacb Pkca Plcg1 Prkaca Prkacb Prkca Prosap2 Pspn Ptpn11 Rap1gap Ret Retl1 Shank3 Shc1 Shc3 Shcc Sos1 Src Trnr1	Rattus norvegicus (Norway rat)
RHO GTPases Activate Formins	AT hook containing transcription factor 1 Actin, cytoplasmic 1 Actin, cytoplasmic 2 Aurora kinase B B9 domain-containing protein 2 BUB1 mitotic checkpoint serine/threonine kinase B BUB1 mitotic checkpoint serine/threonine kinase Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 2 Cell division control protein 42 homolog Cell division cycle protein 20 homolog Centromere protein C Centromere protein E Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein T Centromere protein U Centromere/kinetochore protein zw10 homolog Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoplasmic linker associated protein 1 Cytoskeleton associated protein 5 DSN1 component of MIS12 kinetochore complex Dishevelled associated activator of morphogenesis 1 Dishevelled segment polarity protein 2 Dishevelled segment polarity protein 3 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic ERCC excision repair 6 like, spindle assembly checkpoint helicase Ena/VASP-like protein Exportin-1 Formin-like 1 Formin-like 2 Inner centromere protein Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinesin-like protein Kinetochore associated 1 Kinetochore protein NDC80 Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 LOC683983 protein Microtubule-associated protein RP/EB family member 1 Mitotic arrest deficient 1 like 1 Mitotic arrest deficient 2 like 1 Myocardin related transcription factor A NSL1 component of MIS12 kinetochore complex Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup98-Nup96 Nucleoporin 133 Nucleoporin 160 Nucleoporin 37 Platelet-activating factor acetylhydrolase IB subunit alpha Polyamine-modulated factor 1 Profilin-1 Profilin-2 Protein MIS12 homolog Protein SCAI Protein SEC13 homolog Protein Spindly Protein diaphanous homolog 1 Protein diaphanous homolog 3 Protein phosphatase 2 scaffold subunit A alpha Protein zwilch Proto-oncogene tyrosine-protein kinase Src RAN GTPase activating protein 1 RAN binding protein 2 Ras homolog family member D Ras-related C3 botulinum toxin substrate 1 Regulator of chromosome condensation 2 Rho-related GTP-binding protein RhoB SLIT-ROBO Rho GTPase-activating protein 2 Segment polarity protein dishevelled homolog DVL-1 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Serum response factor Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 Spindle and kinetochore-associated protein 2 Transforming protein RhoA ZW10 interactor	A0A0G2JW74 A0A0G2JXC5 A0A0G2JYU6 A0A0G2K160 A0A0G2K254 A0A0G2K3M4 A0A0G2K5R3 A0A1W2Q6F6 A0A8I5YC36 A0A8I5ZMG6 A0A8I5ZRC2 A0A8I5ZZ56 A0A8I6A3Y0 A0A8I6A596 A0A8I6A6K6 A0A8I6ADJ6 A0A8I6AEZ5 A0A8I6AKV5 A0A8I6ALB1 A0A8I6G7C3 A0A8I6G9X6 A0A8I6GB80 A0A8I6GKV0 A0A8I6GKX7 A0A8I6GM04 B0BN28 B0BNB5 D3Z896 D3Z8B2 D3ZB71 D3ZBL6 D3ZDI7 D3ZEH8 D3ZG58 D3ZHH8 D3ZV60 D3ZWI4 D4A0G9 D4A1C5 D4A208 D4A5D3 D4A624 D4A9X9 D4AC25 D4ACM2 E9PSW8 E9PT83 F1LMI1 F1LVV4 F1LVW7 F1M389 F1M3N2 F1M775 O08719 O55099 O88664 P0C5J3 P38650 P49793 P52590 P60711 P61589 P62716 P62747 P62963 P63004 P63088 P63170 P63259 P63331 Q3KR99 Q3ZAU7 Q4QQS8 Q4QQT4 Q4V8C2 Q4V8G7 Q561R1 Q5I0J4 Q5M856 Q5U1Z7 Q5U2W4 Q5XFW8 Q5XI34 Q5XI51 Q62623 Q62673 Q62698 Q62871 Q62909 Q63100 Q63517 Q63525 Q66H02 Q66HR2 Q6AXW0 Q6AYL9 Q6RUV5 Q71TY3 Q78P75 Q78PB6 Q7TQ72 Q80U96 Q80W83 Q8CFN2 Q8VIL3 Q99JD4 Q9EPC6 Q9ES39 Q9JHY7 Q9JK25 Q9QXU8 Q9WUD9 Q9WV63 Q9WVB9	Actb Actg Actg1 Ahctf1 Aik2 Aim1 Airk2 Arha Arha2 Arhb Ark2 Aurkb B9d2 Birc5 Bub1 Bub1b Ccdc99 Cdc20 Cdc42 Cdca1 Cdca8 Cenpc Cenpc1 Cenpe Cenpf Cenph Cenpi Cenpk Cenpl Cenpm Cenpn Cenpo Cenpp Cenpq Cenpr Cenpt Cenpu Ckap5 Clasp1 Clasp2 Clip1 Crm1 Cyln1 Daam1 Dhc1 Diap1 Diaph1 Diaph3 Dlc2 Dnch1 Dnchc1 Dnci1 Dnci2 Dncic1 Dncic2 Dncl1 Dnclc1 Dncli1 Dncli2 Dnec1 Dsn1 Dvl1 Dvl2 Dvl3 Dyhc Dync1h1 Dync1i1 Dync1i2 Dync1li1 Dync1li2 Dynll1 Dynll2 Ercc6l Evl Fam33a Fmnl1 Fmnl2 Fshprh1 Incenp Itgb3bp Kif18a Kif2 Kif2a Kif2b Kif2c Knl1 Kntc1 Krp2 LOC100361515 LOC100909468 LOC102555739 LOC679342 LOC681185 LOC683983 Lis-1 Lis1 Lrpr1 Mad1l1 Mad2l1 Map1c Mapre1 Mis12 Mkl1 Mlf1ip Mrtfa Ndc80 Nde1 Ndel1 Nrif3 Nsl1 Nudc Nude Nude1 Nude2 Nudel Nuf2 Nup107 Nup133 Nup160 Nup37 Nup43 Nup85 Nup98 Pafah1b1 Pafaha Pcnt1 Pfn1 Pfn2 Pin Plk Plk1 Pmf1 Ppp1cc Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5a Ppp2r5b Ppp2r5c Ppp2r5d Ppp2r5e Rac Rac1 Ranbp2 Rangap1 Rcc2 Rhoa Rhob Rhod Rnb6 Rps27 Rsn S27-1 Scai Sec13 Sec13l1 Sgo1 Sgo2 Sip30 Ska1 Ska2 Ska2l1 Spbc25 Spc24 Spc24-ps1 Spc25 Spdl1 Src Srf Srgap2 Stk1 Stk12 Stk5 Tao1 Taok1 Xpo1 Zw10 Zwilch Zwint	Rattus norvegicus (Norway rat)
RHO GTPases Activate NADPH Oxidases	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Mapk11 protein Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Neutrophil cytosol factor 2 Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 4 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Protein S100-A8 Protein S100-A9 Protein kinase C alpha type Protein kinase C beta type Protein kinase C delta type Protein kinase C zeta type Rac family small GTPase 2 Ras-related C3 botulinum toxin substrate 1 peptidylprolyl isomerase	A0A8I5ZNF3 A0A8I6A1P8 A0A8I6GJ67 A7E3N2 A7E3N7 D4A3U7 D4ACU5 F1M707 O88763 P05696 P09215 P09217 P0C0R5 P21708 P50115 P50116 P63086 P68403 P70618 Q62737 Q672K1 Q6RUV5 Q9ERL1 Q9WV87	Csbp1 Csbp2 Cyba Cybb Erk1 Erk2 Mapk Mapk1 Mapk11 Mapk14 Mapk3 Mox1 Mrp14 Mrp8 Ncf1 Ncf2 Ncf4 Noh1 Nox1 Nox3 Noxa1 Noxo1 Pik3c3 Pik3r4 Pin1 Pkca Pkcb Pkcd Pkcz Prkca Prkcb Prkcb1 Prkcd Prkcz Prkm1 Prkm3 Rac Rac1 Rac2 S100a8 S100a9 Vps34	Rattus norvegicus (Norway rat)
RHO GTPases Activate WASPs and WAVEs	Abl interactor 1 Abl-interactor 2 Actin related protein 2/3 complex, subunit 3 Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin-binding protein WASF1 Actin-related protein 2/3 complex subunit 1A Actin-related protein 2/3 complex subunit 1B Actin-related protein 2/3 complex subunit 2 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin-related protein 3 BAR/IMD domain-containing adapter protein 2 BRICK1 subunit of SCAR/WAVE actin nucleating complex Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein Cytoplasmic FMR1-interacting protein Cytoplasmic protein Focal adhesion kinase 1 Growth factor receptor-bound protein 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NCK associated protein 1 like NCK interacting protein with SH3 domain Nck-associated protein 1 Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase Tyrosine-protein kinase WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 3 Wiskott-Aldrich syndrome protein family member Wiskott-Aldrich syndrome protein family member	A0A0G2K6M9 A0A8I5Y5E8 A0A8I5ZLD3 A0A8I6AH32 A0A8I6AHL8 A0A8I6AL89 B2RZ33 D3ZUP5 D3ZWX4 D4A8H8 E9PT20 M0R7F3 O35346 O88656 P21708 P55161 P60711 P62994 P63086 P63259 P85970 Q4KLF8 Q4V7C7 Q5BJU7 Q5FWU0 Q5M7U6 Q6GMN2 Q6IN36 Q6RUV5 Q8CFN2 Q99PD4 Q9QZM5 Q9Z0G8	Abi1 Abi2 Abl1 Actb Actg Actg1 Actr2 Actr3 Arp2 Arp3 Arpc1a Arpc1b Arpc2 Arpc3 Arpc4 Arpc5 Ash Baiap2 Brk1 Btk Cdc42 Cr16 Cyfip1 Cyfip2 Erk1 Erk2 Fak Fak1 Grb2 Hem2 Mapk Mapk1 Mapk3 Nap1 Nck1 Nckap1 Nckap1l Nckipsd Prkm1 Prkm3 Ptk2 Rac Rac1 Wasf1 Wasf2 Wasf3 Waspip Wave1 Wip Wipf1 Wipf3	Rattus norvegicus (Norway rat)
RHO GTPases activate PAKs	Calmodulin-3 Cell division control protein 42 homolog Filamin A LIM domain kinase 1 Merlin (Fragment) Myosin heavy chain 14 Myosin light chain kinase, smooth muscle Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein phosphatase PP1-beta catalytic subunit	A0A8I5ZV49 A0A8I6AUI8 D3ZFU9 D3ZIC4 F1LNF0 P0DP31 P18666 P35465 P53669 P62142 Q10728 Q62812 Q62829 Q63648 Q64122 Q64303 Q6RUV5 Q8CFN2 Q9JLT0	CaMIII Calm3 Cam3 Camc Cdc42 Flna LOC685883 Limk Limk1 Mbs Mrlc2 Mrlcb Myh10 Myh14 Myh9 Myl12b Myl6 Myl9 Mylc2b Mylk Mypt1 Myrl2 Nf2 Pak1 Pak2 Pak3 Ppp1cb Ppp1r12a Ppp1r12b Rac Rac1	Rattus norvegicus (Norway rat)
RHO GTPases activate PKNs	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 M-phase inducer phosphatase Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 14A Protein phosphatase 1 regulatory subunit Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Stratifin Transforming protein RhoA	D3ZIC4 D4ADT2 G3V9A3 O08874 O55173 P35213 P61589 P61983 P62142 P62260 P62747 P63102 P68255 P68511 Q10728 Q63433 Q6RUV5 Q99MC0	Arha Arha2 Arhb Cdc25c Cpi Cpi17 Mbs Msfs1 Mypt1 Pak2 Pdk1 Pdpk1 Pkn Pkn1 Pkn2 Ppp1cb Ppp1r12a Ppp1r12b Ppp1r14a Prk1 Prk2 Prkcl1 Prkcl2 Rac Rac1 Rhoa Rhob Sfn Ywhab Ywhae Ywhag Ywhah Ywhaq Ywhaz	Rattus norvegicus (Norway rat)

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