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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 19 | ABCA1 | ATP binding cassette subfamily A member 1 | |
| 111 | ADCY5 | adenylate cyclase 5 | |
| 133 | ADM | adrenomedullin | |
| 142 | PARP1 | poly(ADP-ribose) polymerase 1 | |
| 150 | ADRA2A | adrenoceptor alpha 2A | |
| 154 | ADRB2 | adrenoceptor beta 2 | |
| 155 | ADRB3 | adrenoceptor beta 3 | |
| 177 | AGER | advanced glycosylation end-product specific receptor | |
| 183 | AGT | angiotensinogen | |
| 186 | AGTR2 | angiotensin II receptor type 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 13982 | Esr1 | estrogen receptor 1 (alpha) | |
| 14061 | F2 | coagulation factor II | |
| 14066 | F3 | coagulation factor III | |
| 14068 | F7 | coagulation factor VII | |
| 14069 | F8 | coagulation factor VIII | |
| 14071 | F9 | coagulation factor IX | |
| 14103 | Fasl | Fas ligand | |
| 14118 | Fbn1 | fibrillin 1 | |
| 14161 | Fga | fibrinogen alpha chain | |
| 14234 | Foxc2 | forkhead box C2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24152 | Asip | agouti signaling protein | |
| 24179 | Agt | angiotensinogen | |
| 24182 | Agtr2 | angiotensin II receptor, type 2 | |
| 24185 | Akt1 | AKT serine/threonine kinase 1 | |
| 24192 | Akr1b1 | aldo-keto reductase family 1 member B1 | |
| 24221 | Avp | arginine vasopressin | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24241 | Calca | calcitonin-related polypeptide alpha | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24310 | Ace | angiotensin I converting enzyme |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31234 | Pdfr | Pigment-dispersing factor receptor | |
| 31248 | sgg | shaggy | |
| 31271 | w | white | |
| 31806 | Ogg1 | 8-oxoguanine DNA glycosylase | |
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 32442 | Rab3-GEF | Rab3 GDP-GTP exchange factor | |
| 32974 | Zw | Zwischenferment | |
| 33007 | Dop2R | Dopamine 2-like receptor | |
| 33496 | lilli | lilliputian | |
| 34091 | Spn28Dc | Serpin 28Dc |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 403310 | cacna1da | calcium channel, voltage-dependent, L type, alpha 1D subunit, a | |
| 406731 | ugt1ab | UDP glucuronosyltransferase 1 family a, b | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 560788 | parp1 | poly (ADP-ribose) polymerase 1 | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 100004455 | epoa | erythropoietin a | |
| 100384891 | ugt1a7 | UDP glucuronosyltransferase 1 family, polypeptide A7 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378695 | ins.L | insulin L homeolog | Xenopus laevis (African clawed frog) | |
| 378696 | ins.S | insulin S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 394283 | sdc2.S | syndecan 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 398006 | insr.L | insulin receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 178672 | srp-3 | Serpin domain-containing protein | |
| 178748 | zmp-3 | Matrix metalloproteinase-C | |
| 179053 | cpr-4 | Cathepsin B-like cysteine proteinase 4 | |
| 179195 | srp-7 | Serpin domain-containing protein | |
| 179197 | cri-2 | Putative metalloproteinase inhibitor tag-225 | |
| 179347 | dop-2 | Dopamine receptor 2 | |
| 179412 | egl-3 | Neuroendocrine convertase 2 | |
| 179663 | enpp-1 | Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein | |
| 179665 | C27A7.3 | Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 | |
| 179763 | anp-1 | Aminopeptidase |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850369 | ADP1 | putative ATP-dependent permease ADP1 | |
| 850391 | NPP1 | nucleotide diphosphatase/phosphodiesterase NPP1 | |
| 850614 | HXK1 | hexokinase 1 | |
| 850645 | BPT1 | ATP-binding cassette bilirubin transporter BPT1 | |
| 850678 | YBT1 | bile acid-transporting ATPase YBT1 | |
| 850886 | ATG26 | sterol 3-beta-glucosyltransferase | |
| 850979 | PIG1 | protein phosphatase regulator PIG1 | |
| 851006 | ECM38 | gamma-glutamyltransferase | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000855 | Insulin resistance |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 2645 | GCK | glucokinase |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 3990 | LIPC | lipase C, hepatic type |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
