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MIRAGE
obesity

Summary
Definition
An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Super Class
overnutrition
Disease Ontology
DOID:9970
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 72 in total
Gene ID Gene Symbol Description Source
19 ABCA1 ATP binding cassette subfamily A member 1
154 ADRB2 adrenoceptor beta 2
155 ADRB3 adrenoceptor beta 3
183 AGT angiotensinogen
347 APOD apolipoprotein D
367 AR androgen receptor
583 BBS2 Bardet-Biedl syndrome 2
886 CCKAR cholecystokinin A receptor
1268 CNR1 cannabinoid receptor 1
1312 COMT catechol-O-methyltransferase
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
12876 Cpe carboxypeptidase E
14738 Gpr12 G-protein coupled receptor 12
14917 Gucy2c guanylate cyclase 2c
16846 Lep leptin
16847 Lepr leptin receptor
17201 Mc3r melanocortin 3 receptor
17202 Mc4r melanocortin 4 receptor
17977 Ncoa1 nuclear receptor coactivator 1
18166 Npy1r neuropeptide Y receptor Y1
18548 Pcsk1 proprotein convertase subtilisin/kexin type 1
Displaying entries 1 - 10 of 25 in total
Gene ID Gene Symbol Description Source
24217 Atp4b ATPase H+/K+ transporting subunit beta
24232 C3 complement C3
24385 Gck glucokinase
24464 Hp haptoglobin
24536 Lepr leptin receptor
24539 Lpl lipoprotein lipase
24889 Cckar cholecystokinin A receptor
24890 Esr1 estrogen receptor 1
25058 Hk1 hexokinase 1
25116 Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1
Displaying all 3 entries
Gene ID Gene Symbol Description Source
173169 eif-6 Eukaryotic translation initiation factor 6
176286 glp-1 glp-1/Notch intracellular domain
177850 gon-1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein
Related Glycoprotein
The Human Phenotype Ontology
Displaying all 5 entries
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0010982 Polygenic inheritance
HP:0000006 Autosomal dominant inheritance
HP:0012340 Decreased resting energy expenditure
HP:0001513 Obesity
Displaying all 2 entries
Gene ID Gene Symbol Description
5167 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
9672 SDC3 syndecan 3
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025