ERKs are inactivated
|
|
|
- Bmk1
- Dusp3
- Dusp4
- Dusp6
- Dusp7
- Erk1
- Erk2
- Erk5
- Mapk
- Mapk1
- Mapk3
- Mapk7
- Mkp2
- Mkp3
- Mkpx
- Ppp2ca
- Ppp2cb
- Ppp2r1a
- Ppp2r1b
- Ppp2r5d
- Prkm1
- Prkm3
- Vrk3
|
|
ERK/MAPK targets
|
|
|
- Bmk1
- Csbp1
- Csbp2
- Erk1
- Erk2
- Erk5
- Mapk
- Mapk1
- Mapk11
- Mapk14
- Mapk3
- Mapk7
- Mapkapk1a
- Ppp2ca
- Ppp2cb
- Ppp2r1a
- Ppp2r1b
- Ppp2r5d
- Prkm1
- Prkm3
- Rps6ka1
- Rps6ka2
- Rps6ka3
- Rps6ka5
- Rsk1
|
|
ERBB2 Regulates Cell Motility
|
|
|
- Arha
- Arha2
- Btc
- Diap1
- Diaph1
- Dtr
- Egf
- Egfr
- Erbb2
- Erbb3
- Ereg
- Hbegf
- Hegfl
- Memo1
- Ndf
- Neu
- Nrg1
- Nrg2
- Nrg3
- Ntak
- Rhoa
|
|
ERBB2 Activates PTK6 Signaling
|
|
|
- Btc
- Dtr
- Egf
- Egfr
- Erbb2
- Erbb3
- Ereg
- Hbegf
- Hegfl
- Ndf
- Neu
- Nrg1
- Nrg2
- Nrg3
- Ntak
- Ptk6
|
|
ER-Phagosome pathway
|
- Antigen peptide transporter 1
- Antigen peptide transporter 2
- Beta-2-microglobulin
- Calreticulin
- HLA class I histocompatibility antigen, A-24 alpha chain-like
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- MHC class Ib antigen
- Protein disulfide-isomerase A3
- RT1 class I, M1, 5
- RT1 class I, M1, gene 2
- RT1 class I, M10, gene 1
- RT1 class I, locus CE14
- RT1 class I, locus CE16
- RT1 class I, locus CE16
- RT1 class I, locus CE3
- RT1 class I, locus M1, gene 4
- RT1 class Ia, locus A1
- RT1 class Ia, locus A2
- RT1 class Ib, locus M3, gene 1
- RT1 class Ib, locus M5
- RT1 class Ib, locus N3
- RT1 class Ib, locus S3
- Synaptosomal-associated protein 23
- Syntaxin-4
- Tapasin
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 8
- Vesicle-trafficking protein SEC22b
|
|
- 1700031A10Rik
- 2781a1
- 2788a1a2
- 2795a1
- 2800a1a2
- 2812a1a2
- 2824a1
- 2829a1a2
- 2846a1a2
- 2860a1
- 2865a2
- 2869a1a2
- 2879a1
- 2886a1-a1a2
- 2901a1a2
- 2906a1
- 2920a1a2
- 2927a1
- 2941a1a2
- 2945a1a2
- 2950a1
- 2953a1a2
- 2959a1
- 2976a1
- 2981a1a2
- 2984a1a2
- 2994a1
- 3082ex4-5
- 3252a3
- 3258a2
- 3281a3
- 3298a3
- AABR07044308.2
- AABR07044362.1
- AABR07072807.1
- AC120486.1
- Abcb2
- Abcb3
- B2m
- Calr
- ENSRNOG00000064836
- ENSRNOG00000069480
- Erp60
- Grp58
- H2-M10.6
- H2-M10.6l
- LOC102546590
- LOC120093125
- Mtp1
- Mtp2
- Nerg-ps11
- Nerg-ps12
- Nerg-ps13
- Nerg-ps14
- Nerg-ps15
- Pbp-ps
- Pdia3
- Ppid-ps
- Ppp1cb-ps
- RT1-A1
- RT1-A2
- RT1-CE1
- RT1-CE11
- RT1-CE14
- RT1-CE16
- RT1-CE2
- RT1-M1-1
- RT1-M1-2
- RT1-M1-3
- RT1-M1-4
- RT1-M1-5
- RT1-M10-1
- RT1-M10-2
- RT1-M10-3
- RT1-M10-4
- RT1-M2
- RT1-M3-1
- RT1-M5
- RT1-M7
- RT1-M8
- RT1-N3
- RT1-O1l1
- RT1-P2
- RT1-S3
- Rcrg1-ps25
- Rcrg1-ps26
- Rcrg1-ps27
- Rcrg1-ps28
- Rcrg1-ps29
- Rcrg1-ps30
- Rcrg1-ps31
- Rcrg1-ps32
- Rcrg1-ps33
- Rcrg1-ps34
- Rcrg1-ps35
- Rcrg1-ps36
- Rcrg1-ps37
- Rcrg1-ps38
- Rcrg1-ps39
- Rcrg1-ps40
- Rpl39-ps
- Sec22b
- Sec22l1
- Snap23
- Stx4
- Stx4a
- Syb3
- Tap1
- Tap2
- Tapbp
- Trim15
- Trim31
- Trim39-ps
- Vamp3
- Vamp8
|
|
EPHB-mediated forward signaling
|
|
|
- Actb
- Actg
- Actg1
- Actr2
- Actr3
- Arha
- Arha2
- Arhgef28
- Arp2
- Arp3
- Arpc1a
- Arpc1b
- Arpc2
- Arpc3
- Arpc4
- Arpc5
- Cdc42
- Duo
- Ehsh1
- Fak
- Fak1
- Fyn
- Grin1
- Grin2b
- Hapip
- Hras
- Hras1
- Hspg1
- Itsn
- Itsn1
- Kalrn
- Lyn
- Nmdar1
- Pak1
- Ptk2
- Rac
- Rac1
- Rasa
- Rasa1
- Rgnef
- Rhoa
- Rock1
- Rock2
- Sdc2
- Src
- Synd2
- Tiam1
- Yes1
|
|
EPH-ephrin mediated repulsion of cells
|
|
|
- Aph1a
- Efnb1
- Efnb3
- Elk
- Ephb1
- Ephb2
- Ephb3
- Ephb4
- Ephb6
- Eplg2
- Epth2
- Fyn
- LOC686310
- Lerk2
- Lyn
- Mmp2
- Mmp9
- Ncstn
- Ps2
- Psen1
- Psen2
- Psenen
- Psnl1
- Psnl2
- Rac
- Rac1
- Src
- Tiam1
- Vav2
- Vav3
- Yes1
|
|
EPH-Ephrin signaling
|
|
|
- Efna1
- Efna2
- Efna3
- Efna4
- Efna5
- Efnb1
- Efnb3
- Ehk-1
- Ehk-2
- Ehk-3
- Ehk2
- Ehk3
- Ekh1
- Elk
- Epgl1
- Epha1
- Epha10
- Epha2
- Epha3
- Epha4
- Epha5
- Epha6
- Epha7
- Ephb1
- Ephb2
- Ephb3
- Ephb4
- Ephb6
- Eplg2
- Eplg7
- Epth2
- LOC686310
- Lerk1
- Lerk2
- Lerk7
- Rek4
- Rek7
- Tyro4
|
|
EML4 and NUDC in mitotic spindle formation
|
|
|
- Ahctf1
- Aik2
- Aim1
- Airk2
- Ark2
- Aurkb
- B9d2
- Birc5
- Bub1
- Bub1b
- Ccdc99
- Cdc20
- Cdca1
- Cdca8
- Cenpc
- Cenpc1
- Cenpe
- Cenpf
- Cenph
- Cenpi
- Cenpk
- Cenpl
- Cenpm
- Cenpn
- Cenpo
- Cenpp
- Cenpq
- Cenpr
- Cenpt
- Cenpu
- Ckap5
- Clasp1
- Clasp2
- Clip1
- Crm1
- Cyln1
- Dhc1
- Dlc2
- Dnch1
- Dnchc1
- Dnci1
- Dnci2
- Dncic1
- Dncic2
- Dncl1
- Dnclc1
- Dncli1
- Dncli2
- Dnec1
- Dsn1
- Dyhc
- Dync1h1
- Dync1i1
- Dync1i2
- Dync1li1
- Dync1li2
- Dynll1
- Dynll2
- Eml4
- Ercc6l
- Fam33a
- Fshprh1
- Incenp
- Itgb3bp
- Kif18a
- Kif2
- Kif2a
- Kif2b
- Kif2c
- Knl1
- Kntc1
- Krp2
- LOC100909468
- LOC102555739
- LOC679342
- LOC681185
- LOC683983
- Lis-1
- Lis1
- Lrpr1
- Mad1l1
- Mad2l1
- Map1c
- Mapre1
- Mis12
- Mlf1ip
- Ndc80
- Nde1
- Ndel1
- Nrif3
- Nsl1
- Nudc
- Nude
- Nude1
- Nude2
- Nudel
- Nuf2
- Nup107
- Nup133
- Nup160
- Nup37
- Nup43
- Nup85
- Nup98
- Pafah1b1
- Pafaha
- Pcnt1
- Pin
- Plk
- Plk1
- Pmf1
- Ppp1cc
- Ppp2ca
- Ppp2cb
- Ppp2r1a
- Ppp2r1b
- Ppp2r5a
- Ppp2r5b
- Ppp2r5c
- Ppp2r5d
- Ppp2r5e
- Ranbp2
- Rangap1
- Rcc2
- Rps27
- Rsn
- S27-1
- Sec13
- Sec13l1
- Sgo1
- Sgo2
- Sip30
- Ska1
- Ska2
- Ska2l1
- Spbc25
- Spc24
- Spc24-ps1
- Spc25
- Spdl1
- Stk1
- Stk12
- Stk5
- Tao1
- Taok1
- Xpo1
- Zw10
- Zwilch
- Zwint
|
|
EGFR interacts with phospholipase C-gamma
|
|
|
- Areg
- Btc
- Dtr
- Egf
- Egfr
- Ereg
- Hbegf
- Hegfl
- Plcg1
- Sdgf
- Tgfa
|
|
EGFR downregulation
|
|
|
- Areg
- Arhgef7
- Ash
- Btc
- Cbl
- Cdc42
- Dtr
- Egf
- Egfr
- Epn1
- Eps15
- Eps15l1
- Ereg
- Grb2
- Hbegf
- Hegfl
- Hgs
- Hrs
- Hrs2
- LOC100360645
- Pak3bp
- Pixb
- Ptpn12
- Ptpn3
- Rps27a
- Ruk
- Sdgf
- Seta
- Sh3d2a
- Sh3d2c1
- Sh3gl1
- Sh3gl2
- Sh3gl3
- Sh3kbp1
- Sh3p13
- Sh3p4
- Sh3p8
- Spry1
- Spry2
- Stam
- Stam2
- Tgfa
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubcep1
- Ubcl1
|
|
EGFR Transactivation by Gastrin
|
|
|
- Ash
- Dtr
- Egfr
- Grb2
- Hbegf
- Hegfl
- Hras
- Hras1
- Kras
- Kras2
- Mmp3
- Nras
- Pkca
- Prkca
- Sos1
|
|
ECM proteoglycans
|
|
|
- AABR07044388.2
- Acan
- Agc
- Agc1
- Agrin
- Agrn
- Bcan
- Behab
- Bgn
- Comp
- Crtl1
- Cspg2
- Cspg3
- Dcn
- Dmp1
- Dspp
- Hapln1
- Itga2
- Itga2b
- Itga7
- Itga8
- Itga9
- Itgav
- Itgax
- Itgb1
- Itgb3
- Itgb5
- Itgb6
- Matn1
- Matn3
- Matn4
- Ncan
- Pai1
- Planh1
- Rdsp2
- Serpine1
- Sparc
- Tnc
- Tnn
- Tnr
- Tnxb
- Vcan
- Vtn
|
|
E3 ubiquitin ligases ubiquitinate target proteins
|
|
|
- Bcl10
- Bre1b
- Cdc73
- Ctr9
- ENSRNOG00000064540
- ENSRNOG00000066901
- ENSRNOG00000068034
- H2bc1
- H2bc12l1
- H2bc6
- H2bcl1
- H2bcl2
- Hist1h2ba
- Hist1h2bc
- Hist1h2bg
- Hist1h2bo
- Hist1h2bq
- Hrpt2
- LOC100360645
- LOC100365043
- LOC100366017
- LOC100910200
- LOC684797
- Leo1
- NEWGENE_1308361
- Paf1
- Paf3
- Pex10
- Pex12
- Pex14
- Pex2
- Pex5
- Pex5_predicted
- Pmp35
- Prkdc
- Pxmp3
- RGD1562407
- Rad6b
- Rnf144a
- Rnf181
- Rnf20
- Rnf40
- Rps27a
- Skic8
- Th2b
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubc4
- Ubcep1
- Ubch4
- Ubch5b
- Ubcl1
- Ube2a
- Ube2b
- Ube2d1
- Ube2d2
- Ube2d3
- Ube2e1
- Ube2l3
- WAC
- Wac
- Wdr61
|
|
Drug-mediated inhibition of MET activation
|
|
|
|
|
Drug-mediated inhibition of ERBB2 signaling
|
|
|
- Cdc37
- Erbb2
- Hsp86
- Hsp90aa1
- Hspca
- Neu
|
|
Downstream signaling of activated FGFR1
|
|
|
- FGF22
- FGF6
- Fgf-1
- Fgf-2
- Fgf-5
- Fgf-9
- Fgf1
- Fgf10
- Fgf17
- Fgf2
- Fgf20
- Fgf22
- Fgf23
- Fgf3
- Fgf4
- Fgf5
- Fgf5c
- Fgf5d
- Fgf6
- Fgf7a
- Fgf7b
- Fgf8
- Fgf9
- Fgfa
- Fgfr1
- Flg
- Flrt1
- Flrt2
- Flrt3
- Kl
|
|
Downstream signal transduction
|
|
|
- Ash
- Bcar1
- Cas
- Crk
- Crkas
- Crkl
- Crko
- Grb2
- Grb7
- Hras
- Hras1
- Kras
- Kras2
- Mgf
- Nck1
- Nck2
- Nras
- Pdgfa
- Pdgfb
- Pdgfr
- Pdgfr1
- Pdgfra
- Pdgfrb
- Pik3ca
- Pik3cb
- Pik3r1
- Pik3r2
- Plcg1
- Ptpn11
- Rapgef1
- Rasa
- Rasa1
- Rpa1
- Sos1
- Src
- Stat1
- Stat3
- Stat4
- Stat5a
- Stat5b
- Stat6
|
|
Downstream TCR signaling
|
- 3-phosphoinositide-dependent protein kinase 1
- B-cell lymphoma/leukemia 10
- Caspase recruitment domain family, member 11
- Histocompatibility 2, class II antigen E alpha
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Ig-like domain-containing protein
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- MALT1 paracaspase
- MHC class II beta chain
- Mitogen-activated protein kinase kinase kinase 7
- NF-kappa-B essential modulator
- NF-kappa-B essential modulator
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Protein kinase C theta type
- Proto-oncogene tyrosine-protein kinase LCK
- RT1 class II, H alpha
- RT1 class II, locus Hb, pseudogene 1
- Rano class II histocompatibility antigen, B alpha chain
- Rano class II histocompatibility antigen, B-1 beta chain
- Rano class II histocompatibility antigen, D-1 beta chain
- Receptor-interacting serine/threonine-protein kinase 2
- T cell receptor associated transmembrane adaptor 1
- T cell receptor beta, variable 16
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD3 zeta chain
- T-cell surface glycoprotein CD4
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- TNF receptor-associated factor 6
|
|
- AABR07044416.1
- Arrb2-ps
- Bcl10
- Card11
- Cd247
- Cd3d
- Cd3e
- Cd3g
- Cd4
- Chuk
- DA1
- Db2
- ENSRNOG00000065769
- ENSRNOG00000065908
- ENSRNOG00000065955
- ENSRNOG00000070909
- H2-Ea
- Hla-dma
- Hla-dmb
- Ikbkb
- Ikbkg
- Ikkb
- Inpp5d
- LOC100911800
- Lck
- Malt1
- Map3k7
- Map3k7ip2
- Nemo
- Pdk1
- Pdpk1
- Pik3ca
- Pik3cb
- Pik3r1
- Pik3r2
- Pkcq
- Prkcq
- Psmb9
- Pten
- RT1-Ba
- RT1-Bb
- RT1-DOb
- RT1-Da
- RT1-Db1
- RT1-Db2
- RT1-Ha
- RT1-Hb-ps1
- Ripk2
- Ship
- Ship1
- T3d
- Tab2
- Tap1
- Tap2
- Tesb
- Traf6
- Trat1
- Trbv16
|
|
Downregulation of TGF-beta receptor signaling
|
|
|
- Bambi
- LOC100360645
- Madh2
- Madh3
- Madh7
- Mtmr4
- Pmepa1
- Rps27a
- Smad2
- Smad3
- Smad7
- Smurf2
- Strap
- Tgfb1
- Tgfbr1
- Tgfbr2
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubcep1
- Ubcl1
- Unrip
|
|
Downregulation of SMAD2/3:SMAD4 transcriptional activity
|
|
|
- Adprt
- Atp1b4
- Erk1
- Erk2
- Hdac1
- LOC100360645
- Madh2
- Madh3
- Madh4
- Mapk
- Mapk1
- Mapk3
- Ncor2
- Nedd4l
- Parp1
- Pp2c1
- Ppm1a
- Pppm1a
- Prkm1
- Prkm3
- Rps27a
- Ski
- Skil
- Smad2
- Smad3
- Smad4
- Smurf2
- Snw1
- Tgif1
- Trim33
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubcep1
- Ubcl1
- Ube2d1
- Ube2d3
|
|
Downregulation of ERBB2:ERBB3 signaling
|
|
|
- Akt1
- Akt2
- Akt3
- Erbb2
- Erbb3
- LOC100360645
- Ndf
- Neu
- Nrg1
- Nrg2
- Ntak
- Rnf41
- Rps27a
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubcep1
- Ubcl1
- Usp8
|
|
Downregulation of ERBB2 signaling
|
|
|
- Batk
- Btc
- Cdc37
- Ctk
- Cul5
- Dtr
- Egf
- Egfr
- Erbb2
- Erbb3
- Ereg
- Hbegf
- Hegfl
- Hsp86
- Hsp90aa1
- Hspca
- LOC100360645
- Matk
- Ndf
- Neu
- Nrg1
- Nrg2
- Nrg3
- Ntak
- Ptpn12
- Ptpn18
- Rps27a
- Uba80
- Ubb
- Ubbl1
- Ubc
- Ubcep1
- Ubcl1
- Vacm1
|
|
Dopamine receptors
|
|
|
|
|
Dopamine Neurotransmitter Release Cycle
|
|
|
- Apba1
- Bzrap1
- Cask
- Cplx1
- Lin7a
- Lin7b
- Lin7c
- Mals1
- Mals2
- Mals3
- Mint1
- Ppfia1
- Ppfia2
- Ppfia3
- Ppfia4
- Rab3a
- Rbp1
- Rim1
- Rims1
- Sap
- Slc18a2
- Snap
- Snap25
- Stx1a
- Stxbp1
- Svat
- Syb2
- Syn1
- Syn2
- Syn3
- Syt1
- Tspoap1
- Unc13b
- Unc13h2
- Unc18a
- Vamp2
- Veli1
- Veli1a
- Veli2
- Veli3
- Vmat2
- X11
|
|