GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **426 - 450** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism
Succinyl-CoA Biosynthesis	2-oxoglutarate dehydrogenase complex component E1 Alpha-ketoglutarate dehydrogenase component 4 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	P09622 P36957 P82909 Q02218	DLD DLST DLTS GCSL KGD4 LAD MRPS36 OGDH PHE3	Homo sapiens (human)
PDH complex synthesizes acetyl-CoA from PYR	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial	O00330 P08559 P09622 P10515 P11177 P29803	DLAT DLD DLTA GCSL LAD PDHA1 PDHA2 PDHAL PDHB PDHX PDX1 PHE1A PHE1B PHE3	Homo sapiens (human)
Regulation of pyruvate dehydrogenase (PDH) complex	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Maleylacetoacetate isomerase NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial	O00330 O43708 P08559 P09622 P10515 P11177 P29803 Q15118 Q15119 Q15120 Q16654 Q8NCN5 Q9P0J1 Q9P2J9 Q9Y6E7	DLAT DLD DLTA GCSL GSTZ1 KIAA1348 KIAA1990 LAD MAAI PDHA1 PDHA2 PDHAL PDHB PDHK1 PDHK2 PDHK3 PDHK4 PDHX PDK1 PDK2 PDK3 PDK4 PDP PDP1 PDP2 PDPR PDX1 PHE1A PHE1B PHE3 PPM2C SIR2L4 SIRT4	Homo sapiens (human)
Signaling by LRP5 mutants	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5	O75197 O94907 Q8NCW0 Q96MU8 Q9UBT3 Q9UBU2	DKK1 DKK2 DKK4 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP7	Homo sapiens (human)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Protein Wnt-3a Protein Wnt-4 Protein Wnt-5a Protein Wnt-9a Sclerostin Secreted frizzled-related protein 1 Secreted frizzled-related protein 2 Wnt inhibitory factor 1	O14904 O75197 O75581 O94907 P41221 P56704 P56705 Q8N474 Q8NCW0 Q96HF1 Q96MU8 Q9BQB4 Q9UBT3 Q9UBU2 Q9Y5W5	DKK1 DKK2 DKK4 FRP FRP1 FRP2 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP6 LRP7 SARP1 SARP2 SFRP1 SFRP2 SOST WIF1 WNT14 WNT3A WNT4 WNT5A WNT9A	Homo sapiens (human)
Translesion synthesis by POLK	DNA polymerase kappa DNA polymerase zeta catalytic subunit DNA repair protein REV1 Mitotic spindle assembly checkpoint protein MAD2B Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60673 P0CG47 P0CG48 P12004 P15927 P27694 P35244 P35249 P35250 P35251 P40937 P40938 P62979 P62987 Q9UBT6 Q9UBZ9 Q9UI95	DINB1 MAD2B MAD2L2 PCNA POLK POLZ REPA1 REPA2 REPA3 REV1 REV1L REV3 REV3L REV7 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Sulfide oxidation to sulfate	Mitochondrial dicarboxylate carrier Persulfide dioxygenase ETHE1, mitochondrial Sulfide Sulfite oxidase, mitochondrial Thiosulfate sulfurtransferase Thiosulfate	O95571 P51687 Q16762 Q8NFU3 Q9UBX3 Q9Y6N5	DIC ETHE1 HSCO KAT SLC25A10 SQOR SQRDL SUOX TST TSTD1	Homo sapiens (human)
Hypusinylation	Deoxyhypusine hydroxylase Deoxyhypusine synthase Eukaryotic translation initiation factor 5A-1 Eukaryotic translation initiation factor 5A-2	P49366 P63241 Q9BU89 Q9GZV4	DHPS DOHH DS EIF5A EIF5A2 HLRC1	Homo sapiens (human)
HHAT G278V doesn't palmitoylate Hh-Np	Desert hedgehog protein Indian hedgehog protein Protein-cysteine N-palmitoyltransferase HHAT Sonic hedgehog protein	O43323 Q14623 Q15465 Q5VTY9	DHH HHAT IHH MART2 SHH SKI1	Homo sapiens (human)
Replication of the SARS-CoV-2 genome	Probable ATP-dependent RNA helicase DDX5 Replicase polyprotein 1a Replicase polyprotein 1ab Retinoblastoma-associated protein Zinc finger CCHC-type and RNA-binding motif-containing protein 1 von Hippel-Lindau disease tumor suppressor	P06400 P0DTC1 P0DTD1 P17844 P40337 Q8TBF4	DDX5 G17P1 HELR HLR1 RB1 VHL ZCRB1 rep	Homo sapiens (human)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	ATP-dependent DNA/RNA helicase DHX36 ATP-dependent RNA helicase A Interferon regulatory factor 7 Myeloid differentiation primary response protein MyD88 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Transcription factor p65	P19838 Q00653 Q04206 Q08211 Q92985 Q99836 Q9H2U1	DDX36 DDX9 DHX36 DHX9 IRF7 KIAA1488 LKP LYT10 MLEL1 MYD88 NDH2 NFKB1 NFKB2 NFKB3 RELA RHAU	Homo sapiens (human)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E Eukaryotic translation initiation factor 4H	P06730 P23588 P60842 Q04637 Q13541 Q14240 Q15056	DDX2A DDX2B EIF4A EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI EIF4H KIAA0038 WBSCR1 WSCR1	Homo sapiens (human)
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	DIS3-like exonuclease 2 Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic initiation factor 4A-III Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E Polyadenylate-binding protein 1 Polyadenylate-binding protein 2 Polyadenylate-binding protein-interacting protein 1 Terminal uridylyltransferase 4 Terminal uridylyltransferase 7	P06730 P11940 P23588 P38919 P60842 Q04637 Q14240 Q5TAX3 Q5VYS8 Q86U42 Q8IYB7 Q9H074	DDX2A DDX2B DDX48 DIS3L2 EIF4A EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FAM6A HS2 KIAA0111 KIAA0191 KIAA1711 PAB1 PAB2 PABP PABP1 PABP2 PABPC1 PABPC2 PABPN1 PAIP1 TUT4 TUT7 ZCCHC11 ZCCHC6	Homo sapiens (human)
Essential pentosuria	L-xylulose reductase	Q7Z4W1	DCXR SDR20C1	Homo sapiens (human)
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	Natural resistance-associated macrophage protein 2	P49281	DCT1 DMT1 NRAMP2 SLC11A2	Homo sapiens (human)
Synthesis of glycosylphosphatidylinositol (GPI)	Dolichol phosphate-mannose biosynthesis regulatory protein GPI ethanolamine phosphate transferase 1 GPI ethanolamine phosphate transferase 2 GPI ethanolamine phosphate transferase 3 GPI mannosyltransferase 1 GPI mannosyltransferase 2 GPI mannosyltransferase 3 GPI mannosyltransferase 4 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Phosphatidylinositol N-acetylglucosaminyltransferase subunit H Phosphatidylinositol N-acetylglucosaminyltransferase subunit P Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Phosphatidylinositol-glycan biosynthesis class F protein Phosphatidylinositol-glycan biosynthesis class W protein Phosphatidylinositol-glycan biosynthesis class X protein	O94777 O95427 P37287 P57054 Q07326 Q14442 Q3MUY2 Q5H8A4 Q7Z7B1 Q86VD9 Q8TBF5 Q8TEQ8 Q92521 Q92535 Q9H3S5 Q9NUD9 Q9Y2B2	DCRC DPM2 DSCR5 DSCRC GPI2 GPI7 MCD4 PIGA PIGB PIGC PIGF PIGG PIGH PIGL PIGM PIGN PIGO PIGP PIGV PIGW PIGX PIGY PIGZ SMP3	Homo sapiens (human)
Role of second messengers in netrin-1 signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Netrin receptor DCC Netrin-1 Phosphatidylinositol transfer protein alpha isoform Short transient receptor potential channel 1 Short transient receptor potential channel 3 Short transient receptor potential channel 4 Short transient receptor potential channel 5 Short transient receptor potential channel 6 Short transient receptor potential channel 7	O95631 P19174 P43146 P48995 Q00169 Q13507 Q9HCX4 Q9UBN4 Q9UL62 Q9Y210	DCC IGDCC1 NTN1 NTN1L PITPN PITPNA PLC1 PLCG1 TRP1 TRP3 TRP5 TRP6 TRP7 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7	Homo sapiens (human)
Netrin mediated repulsion signals	Netrin receptor DCC Netrin receptor UNC5A Netrin receptor UNC5B Netrin receptor UNC5C Netrin receptor UNC5D Netrin-1 Proto-oncogene tyrosine-protein kinase Src Tyrosine-protein phosphatase non-receptor type 11	O95185 O95631 P12931 P43146 Q06124 Q6UXZ4 Q6ZN44 Q8IZJ1	DCC IGDCC1 KIAA1777 KIAA1976 NTN1 NTN1L P53RDL1 PTP2C PTPN11 SHPTP2 SRC SRC1 UNC5A UNC5B UNC5C UNC5D UNC5H1 UNC5H2 UNC5H3 UNC5H4	Homo sapiens (human)
Regulation of commissural axon pathfinding by SLIT and ROBO	Netrin receptor DCC Netrin-1 Protein kinase C-binding protein NELL2 Proto-oncogene tyrosine-protein kinase Src Roundabout homolog 1 Roundabout homolog 2 Slit homolog 1 protein Slit homolog 2 protein Slit homolog 3 protein	O75093 O75094 O94813 O95631 P12931 P43146 Q99435 Q9HCK4 Q9Y6N7	DCC DUTT1 IGDCC1 KIAA0813 KIAA0814 KIAA1568 MEGF4 MEGF5 NELL2 NRP2 NTN1 NTN1L ROBO1 ROBO2 SLIL1 SLIL2 SLIL3 SLIT1 SLIT2 SLIT3 SRC SRC1	Homo sapiens (human)
DSCAM interactions	Cell adhesion molecule DSCAM Cell adhesion molecule DSCAML1 Netrin receptor DCC Netrin-1	O60469 O95631 P43146 Q8TD84	DCC DSCAM DSCAM2 DSCAML1 IGDCC1 KIAA1132 NTN1 NTN1L	Homo sapiens (human)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Sodium-dependent dopamine transporter	Q01959	DAT1 SLC6A3	Homo sapiens (human)
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Sodium-dependent dopamine transporter	Q01959	DAT1 SLC6A3	Homo sapiens (human)
Clearance of dopamine	Amine oxidase [flavin-containing] A Sodium-dependent dopamine transporter	P21397 Q01959	DAT1 MAOA SLC6A3	Homo sapiens (human)
Elastic fibre formation	Elastin Fibrillin-1 Fibrillin-2 Fibrillin-3 Fibulin-5 Furin Integrin alpha-5 Integrin alpha-V Integrin beta-1 Integrin beta-3 Integrin beta-6 Lysyl oxidase homolog 1 Lysyl oxidase homolog 2 Lysyl oxidase homolog 3 Lysyl oxidase homolog 4 Microfibrillar-associated protein 2 Microfibrillar-associated protein 5 Protein-lysine 6-oxidase	P05106 P05556 P06756 P08648 P09958 P15502 P18564 P28300 P35555 P35556 P55001 P58215 Q08397 Q13361 Q75N90 Q96JB6 Q9UBX5 Q9Y4K0	DANCE ELN FBLN5 FBN FBN1 FBN2 FBN3 FNRA FNRB FUR FURIN GP3A ITGA5 ITGAV ITGB1 ITGB3 ITGB6 KIAA1776 LOX LOXC LOXL LOXL1 LOXL2 LOXL3 LOXL4 MAGP1 MAGP2 MDF2 MFAP2 MFAP5 MSK12 MSK8 PACE PCSK3 VNRA VTNR	Homo sapiens (human)
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	Dystroglycan 1 Protein O-mannosyl-transferase 1 Protein O-mannosyl-transferase 2	Q14118 Q9UKY4 Q9Y6A1	DAG1 POMT1 POMT2	Homo sapiens (human)

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