GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **251 - 275** of **1070** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 7 Polyubiquitin-B Polyubiquitin-C Prostate transmembrane protein, androgen induced 1 Serine-threonine kinase receptor-associated protein TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein protein-tyrosine-phosphatase	A0A8I5Y0P5 A0A8I6A5Y3 A0A8I6AFY1 M0RCH9 O70436 O88406 P0CG51 P17246 P38438 P62982 P80204 P84025 Q5XIG8 Q63429 Q91XN4	Bambi LOC100360645 Madh2 Madh3 Madh7 Mtmr4 Pmepa1 Rps27a Smad2 Smad3 Smad7 Smurf2 Strap Tgfb1 Tgfbr1 Tgfbr2 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Unrip	Rattus norvegicus (Norway rat)
Downstream TCR signaling	3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 Caspase recruitment domain family, member 11 Histocompatibility 2, class II antigen E alpha Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta MALT1 paracaspase MHC class II beta chain Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator NF-kappa-B essential modulator Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Protein kinase C theta type Proto-oncogene tyrosine-protein kinase LCK RT1 class II, H alpha RT1 class II, locus Hb, pseudogene 1 Rano class II histocompatibility antigen, B alpha chain Rano class II histocompatibility antigen, B-1 beta chain Rano class II histocompatibility antigen, D-1 beta chain Receptor-interacting serine/threonine-protein kinase 2 T cell receptor associated transmembrane adaptor 1 T cell receptor beta, variable 16 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TNF receptor-associated factor 6	A0A023IKK2 A0A0G2K344 A0A8I5ZPF9 A0A8I6A4Z0 A0A8I6AA96 A0A8I6AAG4 A0A8I6AH74 A0A8I6ANR6 A0A8I6AU71 A0A8I6G8N5 A0A8I6GKC3 B5DF45 D3ZND8 D4A980 F7F6T0 G3V783 M0R576 M0RE10 O55173 P05540 P0C8E4 P18211 P19377 P20037 P29826 P97573 Q01621 Q5U303 Q63787 Q63788 Q64159 Q6MG98 Q6MGB1 Q6TMG5 Q9QY78 Q9QYN5 Q9WTQ0 Q9Z1L0	AABR07044416.1 Arrb2-ps Bcl10 Card11 Cd247 Cd3d Cd3e Cd3g Cd4 Chuk DA1 Db2 ENSRNOG00000065769 ENSRNOG00000065908 ENSRNOG00000065955 ENSRNOG00000070909 H2-Ea Hla-dma Hla-dmb Ikbkb Ikbkg Ikkb Inpp5d LOC100911800 Lck Malt1 Map3k7 Map3k7ip2 Nemo Pdk1 Pdpk1 Pik3ca Pik3cb Pik3r1 Pik3r2 Pkcq Prkcq Psmb9 Pten RT1-Ba RT1-Bb RT1-DOb RT1-Da RT1-Db1 RT1-Db2 RT1-Ha RT1-Hb-ps1 Ripk2 Ship Ship1 T3d Tab2 Tap1 Tap2 Tesb Traf6 Trat1 Trbv16	Rattus norvegicus (Norway rat)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Crk-like protein Cytoplasmic protein Cytoplasmic protein GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B (Fragment) Proto-oncogene tyrosine-protein kinase Src Rap guanine nucleotide exchange factor 1 Ras GTPase-activating protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Signal transducer and activator of transcription Tyrosine-protein phosphatase non-receptor type 11	A0A0G2JX93 A0A0G2K2M3 A0A0G2K344 B2RZ33 D4A3M8 D4A3T0 F1M8L9 P08644 P10686 P20171 P20786 P28576 P41499 P50904 P52631 P52632 P62994 Q04970 Q05028 Q05030 Q5U2U2 Q62771 Q63767 Q63768 Q63787 Q63788 Q9QZC5 Q9WUD9 Q9Z1L0	Ash Bcar1 Cas Crk Crkas Crkl Crko Grb2 Grb7 Hras Hras1 Kras Kras2 Mgf Nck1 Nck2 Nras Pdgfa Pdgfb Pdgfr Pdgfr1 Pdgfra Pdgfrb Pik3ca Pik3cb Pik3r1 Pik3r2 Plcg1 Ptpn11 Rapgef1 Rasa Rasa1 Rpa1 Sos1 Src Stat1 Stat3 Stat4 Stat5a Stat5b Stat6	Rattus norvegicus (Norway rat)
Downstream signaling of activated FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibronectin leucine rich transmembrane protein 1 Klotho Leucine-rich repeat transmembrane protein FLRT2 Leucine-rich repeat transmembrane protein FLRT3	A0A8I6B5D5 B1H234 D3ZTV3 D4AC39 F1LSQ8 P13109 P36364 P48807 P61149 P63076 P70492 Q04589 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Flrt1 Flrt2 Flrt3 Kl	Rattus norvegicus (Norway rat)
Drug-mediated inhibition of ERBB2 signaling	Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2	P06494 P82995 Q63692	Cdc37 Erbb2 Hsp86 Hsp90aa1 Hspca Neu	Rattus norvegicus (Norway rat)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	P17945 P97523	Hgf Met	Rattus norvegicus (Norway rat)
E3 ubiquitin ligases ubiquitinate target proteins	B-cell lymphoma/leukemia 10 CTR9 homolog, Paf1/RNA polymerase II complex component DNA-dependent protein kinase catalytic subunit E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E3 ubiquitin protein ligase E3 ubiquitin-protein ligase BRE1B E3 ubiquitin-protein ligase RNF181 Histone H2B type 1-A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Parafibromin Peroxisomal membrane protein PEX14 Peroxisomal targeting signal 1 receptor Peroxisome assembly protein 12 Peroxisome biogenesis factor 2 Polyubiquitin-B Polyubiquitin-C RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein LEO1 Superkiller complex protein 8 Ubiquitin B-like Ubiquitin-conjugating enzyme E2 B Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2A Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing adaptor with coiled-coil	A0A0G2JXI9 A0A8I5ZSA8 A0A8I6A0W5 A0A8I6A2W1 A0A8I6A5Y3 A0A8I6A7P3 A0A8I6A8J6 A0A8I6AFP4 A0A8I6AFW8 D3Z8W5 D3ZC81 D3ZDK2 D3ZTN0 D3ZYQ9 F1LW69 F1M3L4 G3V9C7 O88177 P0CG51 P24392 P61078 P62839 P62982 P63149 Q00729 Q2M2R8 Q4V7A0 Q4V886 Q4V8C8 Q63429 Q641X2 Q642G4 Q6AXU4 Q8CJB9 Q9QYN5	Bcl10 Bre1b Cdc73 Ctr9 ENSRNOG00000064540 ENSRNOG00000066901 ENSRNOG00000068034 H2bc1 H2bc12l1 H2bc6 H2bcl1 H2bcl2 Hist1h2ba Hist1h2bc Hist1h2bg Hist1h2bo Hist1h2bq Hrpt2 LOC100360645 LOC100365043 LOC100366017 LOC100910200 LOC684797 Leo1 NEWGENE_1308361 Paf1 Paf3 Pex10 Pex12 Pex14 Pex2 Pex5 Pex5_predicted Pmp35 Prkdc Pxmp3 RGD1562407 Rad6b Rnf144a Rnf181 Rnf20 Rnf40 Rps27a Skic8 Th2b Uba80 Ubb Ubbl1 Ubc Ubc4 Ubcep1 Ubch4 Ubch5b Ubcl1 Ube2a Ube2b Ube2d1 Ube2d2 Ube2d3 Ube2e1 Ube2l3 WAC Wac Wdr61	Rattus norvegicus (Norway rat)
ECM proteoglycans	Aa1018 Aggrecan core protein Agrin Biglycan Brevican core protein Cartilage oligomeric matrix protein Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Hyaluronan and proteoglycan link protein 1 Integrin alpha-7 Integrin beta-1 Integrin beta-3 Integrin beta-6 Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 2b Integrin subunit alpha 8 Integrin subunit alpha 9 Integrin subunit alpha V Integrin subunit alpha X Matrilin 1 Matrilin 3 Matrilin 4 Neurocan core protein Plasminogen activator inhibitor 1 SPARC Tenascin C Tenascin N Tenascin-R Tenascin-X Versican core protein (Fragments)	A0A0G2JYF9 A0A0G2K470 A0A8I5ZWP3 A0A8I6AJ44 A0A8I6AQL1 A0A8I6ARC1 A0A8I6GGN2 D3ZK14 D3ZMS3 D3ZN51 F1LZX9 F7F1E3 P03994 P07897 P16975 P20961 P25304 P35444 P47853 P49134 P55067 P55068 P98193 Q01129 Q05546 Q5XI24 Q62598 Q63258 Q6AYF4 Q7TQ11 Q8R2H2 Q9ERB4	AABR07044388.2 Acan Agc Agc1 Agrin Agrn Bcan Behab Bgn Comp Crtl1 Cspg2 Cspg3 Dcn Dmp1 Dspp Hapln1 Itga2 Itga2b Itga7 Itga8 Itga9 Itgav Itgax Itgb1 Itgb3 Itgb5 Itgb6 Matn1 Matn3 Matn4 Ncan Pai1 Planh1 Rdsp2 Serpine1 Sparc Tnc Tnn Tnr Tnxb Vcan Vtn	Rattus norvegicus (Norway rat)
EGFR Transactivation by Gastrin	GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Proheparin-binding EGF-like growth factor Protein kinase C alpha type Receptor protein-tyrosine kinase SOS Ras/Rac guanine nucleotide exchange factor 1 Stromelysin-1	D4A3T0 G3V6K6 P03957 P05696 P08644 P20171 P62994 Q04970 Q06175	Ash Dtr Egfr Grb2 Hbegf Hegfl Hras Hras1 Kras Kras2 Mmp3 Nras Pkca Prkca Sos1	Rattus norvegicus (Norway rat)
EGFR downregulation	Amphiregulin Betacellulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor pathway substrate 15-like 1 Epidermal growth factor receptor pathway substrate 15 Epsin-1 Growth factor receptor-bound protein 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor protein-tyrosine kinase Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 2 Signal transducing adaptor molecule Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I5YC99 A0A8I6A5Y3 A0A8I6A726 A0A8I6AQ55 A0A8I6G3R2 B5DF55 B5DFH3 F1LQQ5 G3V6K6 G3V7Q4 O35179 O35180 O35964 O55043 O88339 P01134 P07522 P0CG51 P24338 P62982 P62994 Q06175 Q5HZA2 Q5XHY7 Q63429 Q8CFN2 Q925Q9 Q9JJ50 Q9Z0L5	Areg Arhgef7 Ash Btc Cbl Cdc42 Dtr Egf Egfr Epn1 Eps15 Eps15l1 Ereg Grb2 Hbegf Hegfl Hgs Hrs Hrs2 LOC100360645 Pak3bp Pixb Ptpn12 Ptpn3 Rps27a Ruk Sdgf Seta Sh3d2a Sh3d2c1 Sh3gl1 Sh3gl2 Sh3gl3 Sh3kbp1 Sh3p13 Sh3p4 Sh3p8 Spry1 Spry2 Stam Stam2 Tgfa Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1	Rattus norvegicus (Norway rat)
EGFR interacts with phospholipase C-gamma	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Amphiregulin Betacellulin Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha Receptor protein-tyrosine kinase	A0A8I6AQ55 G3V6K6 P01134 P07522 P10686 P24338 Q06175 Q9Z0L5	Areg Btc Dtr Egf Egfr Ereg Hbegf Hegfl Plcg1 Sdgf Tgfa	Rattus norvegicus (Norway rat)
EML4 and NUDC in mitotic spindle formation	AT hook containing transcription factor 1 Aurora kinase B B9 domain-containing protein 2 BUB1 mitotic checkpoint serine/threonine kinase B BUB1 mitotic checkpoint serine/threonine kinase Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 2 Cell division cycle protein 20 homolog Centromere protein C Centromere protein E Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein T Centromere protein U Centromere/kinetochore protein zw10 homolog Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoplasmic linker associated protein 1 Cytoskeleton associated protein 5 DSN1 component of MIS12 kinetochore complex Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic EMAP like 4 ERCC excision repair 6 like, spindle assembly checkpoint helicase Exportin-1 Inner centromere protein Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinesin-like protein Kinetochore associated 1 Kinetochore protein NDC80 Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 LOC683983 protein Microtubule-associated protein RP/EB family member 1 Mitotic arrest deficient 1 like 1 Mitotic arrest deficient 2 like 1 NSL1 component of MIS12 kinetochore complex Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup98-Nup96 Nucleoporin 133 Nucleoporin 160 Nucleoporin 37 Platelet-activating factor acetylhydrolase IB subunit alpha Polyamine-modulated factor 1 Protein MIS12 homolog Protein SEC13 homolog Protein Spindly Protein phosphatase 2 scaffold subunit A alpha Protein zwilch RAN GTPase activating protein 1 RAN binding protein 2 Regulator of chromosome condensation 2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 Spindle and kinetochore-associated protein 2 ZW10 interactor	A0A0G2JW74 A0A0G2K160 A0A0G2K254 A0A0G2K2Z0 A0A0G2K3M4 A0A0G2K5R3 A0A1W2Q6F6 A0A8I5YC36 A0A8I5ZMG6 A0A8I5ZRC2 A0A8I5ZZ56 A0A8I6A3Y0 A0A8I6A596 A0A8I6A6K6 A0A8I6ADJ6 A0A8I6AEZ5 A0A8I6ALB1 A0A8I6G7C3 A0A8I6G9X6 B0BN28 B0BNB5 D3Z896 D3Z8B2 D3ZBL6 D3ZDI7 D3ZEH8 D3ZG58 D3ZV60 D3ZWI4 D4A0G9 D4A1C5 D4A5D3 D4A624 D4A9X9 D4AC25 D4ACM2 E9PSW8 E9PT83 F1LMI1 F1LVV4 F1M389 F1M3N2 O55099 O88664 P0C5J3 P38650 P49793 P52590 P62716 P63004 P63088 P63170 P63331 Q3KR99 Q3ZAU7 Q4QQS8 Q4QQT4 Q4V8C2 Q4V8G7 Q561R1 Q5I0J4 Q5M856 Q5U1Z7 Q5U2W4 Q5XFW8 Q5XI34 Q5XI51 Q62623 Q62673 Q62698 Q62871 Q62909 Q63100 Q63517 Q63525 Q66H02 Q66HR2 Q6AXW0 Q6AYL9 Q71TY3 Q78P75 Q78PB6 Q7TQ72 Q80U96 Q80W83 Q8VIL3 Q99JD4 Q9ES39 Q9JHY7 Q9JK25 Q9QXU8 Q9WV63	Ahctf1 Aik2 Aim1 Airk2 Ark2 Aurkb B9d2 Birc5 Bub1 Bub1b Ccdc99 Cdc20 Cdca1 Cdca8 Cenpc Cenpc1 Cenpe Cenpf Cenph Cenpi Cenpk Cenpl Cenpm Cenpn Cenpo Cenpp Cenpq Cenpr Cenpt Cenpu Ckap5 Clasp1 Clasp2 Clip1 Crm1 Cyln1 Dhc1 Dlc2 Dnch1 Dnchc1 Dnci1 Dnci2 Dncic1 Dncic2 Dncl1 Dnclc1 Dncli1 Dncli2 Dnec1 Dsn1 Dyhc Dync1h1 Dync1i1 Dync1i2 Dync1li1 Dync1li2 Dynll1 Dynll2 Eml4 Ercc6l Fam33a Fshprh1 Incenp Itgb3bp Kif18a Kif2 Kif2a Kif2b Kif2c Knl1 Kntc1 Krp2 LOC100909468 LOC102555739 LOC679342 LOC681185 LOC683983 Lis-1 Lis1 Lrpr1 Mad1l1 Mad2l1 Map1c Mapre1 Mis12 Mlf1ip Ndc80 Nde1 Ndel1 Nrif3 Nsl1 Nudc Nude Nude1 Nude2 Nudel Nuf2 Nup107 Nup133 Nup160 Nup37 Nup43 Nup85 Nup98 Pafah1b1 Pafaha Pcnt1 Pin Plk Plk1 Pmf1 Ppp1cc Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5a Ppp2r5b Ppp2r5c Ppp2r5d Ppp2r5e Ranbp2 Rangap1 Rcc2 Rps27 Rsn S27-1 Sec13 Sec13l1 Sgo1 Sgo2 Sip30 Ska1 Ska2 Ska2l1 Spbc25 Spc24 Spc24-ps1 Spc25 Spdl1 Stk1 Stk12 Stk5 Tao1 Taok1 Xpo1 Zw10 Zwilch Zwint	Rattus norvegicus (Norway rat)
EPH-Ephrin signaling	EPH receptor A10 Ephrin A2 Ephrin A3 Ephrin A4 Ephrin B3 Ephrin type-A receptor 3 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-B receptor 1 Ephrin type-B receptor 3 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A5 Ephrin-B1 receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A0G2JV56 D3ZBN3 D3ZDH4 D3ZEN1 D3ZH39 D3ZZK3 F1LX55 F1MA19 F1MAJ0 G3V7D4 M0RDA4 O08680 P09759 P0C0K7 P52796 P54757 P54758 P54759 P97553 P97605	Efna1 Efna2 Efna3 Efna4 Efna5 Efnb1 Efnb3 Ehk-1 Ehk-2 Ehk-3 Ehk2 Ehk3 Ekh1 Elk Epgl1 Epha1 Epha10 Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Eplg2 Eplg7 Epth2 LOC686310 Lerk1 Lerk2 Lerk7 Rek4 Rek7 Tyro4	Rattus norvegicus (Norway rat)
EPH-ephrin mediated repulsion of cells	72 kDa type IV collagenase Ephrin B3 Ephrin type-B receptor 1 Ephrin type-B receptor 3 Ephrin type-B receptor 6 Ephrin-B1 Gamma-secretase subunit APH-1 Gamma-secretase subunit PEN-2 Matrix metalloproteinase-9 Nicastrin Presenilin-1 Presenilin-2 Proto-oncogene tyrosine-protein kinase Src Ras-related C3 botulinum toxin substrate 1 TIAM Rac1 associated GEF 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Vav guanine nucleotide exchange factor 2 Vav guanine nucleotide exchange factor 3 receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A8I5ZPB5 A0A8I6AC12 D3ZH39 D3ZYG0 F1LM93 F1MAJ0 F7EYZ3 G3V7D4 M0RDA4 O88777 P09759 P0C0K7 P33436 P50282 P52796 P97887 Q07014 Q62844 Q6QI68 Q6RUV5 Q8CGU6 Q9WUD9	Aph1a Efnb1 Efnb3 Elk Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Eplg2 Epth2 Fyn LOC686310 Lerk2 Lyn Mmp2 Mmp9 Ncstn Ps2 Psen1 Psen2 Psenen Psnl1 Psnl2 Rac Rac1 Src Tiam1 Vav2 Vav3 Yes1	Rattus norvegicus (Norway rat)
EPHB-mediated forward signaling	Actin related protein 2/3 complex, subunit 3 Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin-related protein 2/3 complex subunit 1A Actin-related protein 2/3 complex subunit 1B Actin-related protein 2/3 complex subunit 2 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin-related protein 3 Cell division control protein 42 homolog Focal adhesion kinase 1 GTPase HRas Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Intersectin-1 Kalirin Proto-oncogene tyrosine-protein kinase Src Ras GTPase-activating protein 1 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor 28 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Serine/threonine-protein kinase PAK 1 Syndecan-2 TIAM Rac1 associated GEF 1 Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	A0A8I5Y5E8 A0A8I6AC12 A0A8I6AL89 F1LM93 O35346 O88656 P0C6P5 P20171 P34900 P35439 P35465 P50904 P60711 P61589 P63259 P85970 P97924 Q00960 Q07014 Q4KLF8 Q4V7C7 Q5M7U6 Q62844 Q62868 Q63644 Q6RUV5 Q8CFN2 Q99PD4 Q9WUD9 Q9WVE9	Actb Actg Actg1 Actr2 Actr3 Arha Arha2 Arhgef28 Arp2 Arp3 Arpc1a Arpc1b Arpc2 Arpc3 Arpc4 Arpc5 Cdc42 Duo Ehsh1 Fak Fak1 Fyn Grin1 Grin2b Hapip Hras Hras1 Hspg1 Itsn Itsn1 Kalrn Lyn Nmdar1 Pak1 Ptk2 Rac Rac1 Rasa Rasa1 Rgnef Rhoa Rock1 Rock2 Sdc2 Src Synd2 Tiam1 Yes1	Rattus norvegicus (Norway rat)
ER-Phagosome pathway	Antigen peptide transporter 1 Antigen peptide transporter 2 Beta-2-microglobulin Calreticulin HLA class I histocompatibility antigen, A-24 alpha chain-like Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class Ib antigen Protein disulfide-isomerase A3 RT1 class I, M1, 5 RT1 class I, M1, gene 2 RT1 class I, M10, gene 1 RT1 class I, locus CE14 RT1 class I, locus CE16 RT1 class I, locus CE16 RT1 class I, locus CE3 RT1 class I, locus M1, gene 4 RT1 class Ia, locus A1 RT1 class Ia, locus A2 RT1 class Ib, locus M3, gene 1 RT1 class Ib, locus M5 RT1 class Ib, locus N3 RT1 class Ib, locus S3 Synaptosomal-associated protein 23 Syntaxin-4 Tapasin Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 8 Vesicle-trafficking protein SEC22b	A0A0G2K1E1 A0A0G2K4S5 A0A0G2K881 A0A8I5YC56 A0A8I5ZLY7 A0A8I5ZTS2 A0A8I5ZYQ2 A0A8I6ADU9 A0A8I6AK64 A0A8I6ASE5 A0A8I6GE62 A0A8J8XB15 A0A8J8Y6P7 A0A8J8YPS9 E9PTZ7 E9PTZ9 F1LQF2 F1MAR7 O70377 P07151 P11598 P18418 P36370 P36372 P63025 Q08850 Q4KM74 Q6MFZ3 Q6MFZ4 Q6W9J5 Q9WUF4	1700031A10Rik 2781a1 2788a1a2 2795a1 2800a1a2 2812a1a2 2824a1 2829a1a2 2846a1a2 2860a1 2865a2 2869a1a2 2879a1 2886a1-a1a2 2901a1a2 2906a1 2920a1a2 2927a1 2941a1a2 2945a1a2 2950a1 2953a1a2 2959a1 2976a1 2981a1a2 2984a1a2 2994a1 3082ex4-5 3252a3 3258a2 3281a3 3298a3 AABR07044308.2 AABR07044362.1 AABR07072807.1 AC120486.1 Abcb2 Abcb3 B2m Calr ENSRNOG00000064836 ENSRNOG00000069480 Erp60 Grp58 H2-M10.6 H2-M10.6l LOC102546590 LOC120093125 Mtp1 Mtp2 Nerg-ps11 Nerg-ps12 Nerg-ps13 Nerg-ps14 Nerg-ps15 Pbp-ps Pdia3 Ppid-ps Ppp1cb-ps RT1-A1 RT1-A2 RT1-CE1 RT1-CE11 RT1-CE14 RT1-CE16 RT1-CE2 RT1-M1-1 RT1-M1-2 RT1-M1-3 RT1-M1-4 RT1-M1-5 RT1-M10-1 RT1-M10-2 RT1-M10-3 RT1-M10-4 RT1-M2 RT1-M3-1 RT1-M5 RT1-M7 RT1-M8 RT1-N3 RT1-O1l1 RT1-P2 RT1-S3 Rcrg1-ps25 Rcrg1-ps26 Rcrg1-ps27 Rcrg1-ps28 Rcrg1-ps29 Rcrg1-ps30 Rcrg1-ps31 Rcrg1-ps32 Rcrg1-ps33 Rcrg1-ps34 Rcrg1-ps35 Rcrg1-ps36 Rcrg1-ps37 Rcrg1-ps38 Rcrg1-ps39 Rcrg1-ps40 Rpl39-ps Sec22b Sec22l1 Snap23 Stx4 Stx4a Syb3 Tap1 Tap2 Tapbp Trim15 Trim31 Trim39-ps Vamp3 Vamp8	Rattus norvegicus (Norway rat)
ERBB2 Activates PTK6 Signaling	Betacellulin Neuregulin 3 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Tyrosine-protein kinase	A0A8I5Y1H8 A0A8I6AQ55 D3ZDS3 G3V6K6 O35569 P06494 P07522 P43322 Q06175 Q62799 Q9Z0L5	Btc Dtr Egf Egfr Erbb2 Erbb3 Ereg Hbegf Hegfl Ndf Neu Nrg1 Nrg2 Nrg3 Ntak Ptk6	Rattus norvegicus (Norway rat)
ERBB2 Regulates Cell Motility	Betacellulin Neuregulin 3 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Protein MEMO1 Protein diaphanous homolog 1 Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Transforming protein RhoA	A0A8I5Y1H8 A0A8I6AQ55 F1M775 G3V6K6 O35569 P06494 P07522 P43322 P61589 Q06175 Q4QQR9 Q62799 Q9Z0L5	Arha Arha2 Btc Diap1 Diaph1 Dtr Egf Egfr Erbb2 Erbb3 Ereg Hbegf Hegfl Memo1 Ndf Neu Nrg1 Nrg2 Nrg3 Ntak Rhoa	Rattus norvegicus (Norway rat)
ERK/MAPK targets	Mapk11 protein Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Protein phosphatase 2 scaffold subunit A alpha Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase Ribosomal protein S6 kinase Ribosomal protein S6 kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	A0A8I6A6K6 A0A8I6A7D1 A0A8I6AR08 A0A8I6AWJ2 D4A3U7 P0C865 P21708 P62716 P63086 P63331 P70618 Q4QQT4 Q5XI34 Q63531	Bmk1 Csbp1 Csbp2 Erk1 Erk2 Erk5 Mapk Mapk1 Mapk11 Mapk14 Mapk3 Mapk7 Mapkapk1a Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5d Prkm1 Prkm3 Rps6ka1 Rps6ka2 Rps6ka3 Rps6ka5 Rsk1	Rattus norvegicus (Norway rat)
ERKs are inactivated	Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Protein phosphatase 2 scaffold subunit A alpha Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform VRK serine/threonine kinase 3	A0A8I6A6K6 A0A8I6AF61 F7F2H0 P0C865 P21708 P62716 P63086 P63331 Q4QQT4 Q5XI34 Q62767 Q63340 Q64346	Bmk1 Dusp3 Dusp4 Dusp6 Dusp7 Erk1 Erk2 Erk5 Mapk Mapk1 Mapk3 Mapk7 Mkp2 Mkp3 Mkpx Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5d Prkm1 Prkm3 Vrk3	Rattus norvegicus (Norway rat)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Peptidyl-prolyl cis-trans isomerase FKBP4 Prostaglandin E synthase 3 Serine/threonine-protein phosphatase 5 peptidylprolyl isomerase	F7EYK0 P06211 P34058 P53042 P82995 P83868 Q62986 Q9QVC8	Erbeta Esr Esr1 Esr2 Estr Fkbp4 Fkbp5 Fkbp52 Hsp84 Hsp86 Hsp90aa1 Hsp90ab1 Hspc3 Hspca Hspcb Nr3a1 Nr3a2 Ppp5c Ptges3 Tebp	Rattus norvegicus (Norway rat)
Effects of PIP2 hydrolysis	Diacylglycerol kinase alpha Diacylglycerol kinase beta Diacylglycerol kinase gamma Diacylglycerol kinase iota Diacylglycerol kinase theta Diacylglycerol kinase zeta Diacylglycerol kinase Diacylglycerol kinase Diacylglycerol kinase Diacylglycerol kinase Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Protein kinase C delta type Protein kinase C epsilon type Protein kinase C eta type Protein kinase C theta type Short transient receptor potential channel 3 Transient receptor potential cation channel, subfamily C, member 7	A0A096UWG9 D3ZEY4 D3ZSZ6 F1LQF7 F1LZW2 F1M5T2 F1MAB7 O08560 P09215 P09216 P29994 P29995 P49620 P49621 P51556 Q63269 Q64617 Q9JMI9 Q9WTQ0	Dagk Dagk1 Dagk2 Dagk3 Dagk6 Dgka Dgkb Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Insp3r Itpr1 Itpr2 Itpr3 Pkcd Pkce Pkch Pkcq Prkcd Prkce Prkch Prkcq Trpc3 Trpc7 Trrp3	Rattus norvegicus (Norway rat)
Elastic fibre formation	Elastin Fibrillin 1 Fibulin-5 Furin Integrin beta-1 Integrin beta-3 Integrin beta-6 Integrin subunit alpha 5 Integrin subunit alpha V Lysyl oxidase homolog 2 Lysyl oxidase homolog Microfibril associated protein 2 Microfibril associated protein 5 Protein-lysine 6-oxidase protein-lysine 6-oxidase protein-lysine 6-oxidase	A0A0G2K1E2 A0A0G2K9S8 B5DF27 D3Z952 D3ZP82 D4A9V5 F1LZX9 G3V9M6 P16636 P23377 P49134 Q5FWS5 Q6AYF4 Q8R2H2 Q99372 Q9WVH8	Dance Eln Fbln5 Fbn1 Fur Furin Itga5 Itgav Itgb1 Itgb3 Itgb6 Lox Loxl1 Loxl2 Loxl3 Loxl4 Mfap2 Mfap5 Pcsk3	Rattus norvegicus (Norway rat)
Electric Transmission Across Gap Junctions	Gap junction delta-2 protein Gap junction gamma-1 protein Gap junction protein Pannexin-1 Pannexin-2	A4GG66 F1LPI3 O70610 P60570 P60571	Gja10 Gja7 Gja9 Gjc1 Gjd2 Panx1 Panx2 Px1 Px2	Rattus norvegicus (Norway rat)
Elevation of cytosolic Ca2+ levels	Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 P2X purinoceptor 1 P2X purinoceptor 2 P2X purinoceptor 3 P2X purinoceptor 4 P2X purinoceptor 5 P2X purinoceptor 6 P2X purinoceptor 7 Short transient receptor potential channel 3 Transient receptor potential cation channel, subfamily C, member 7	F1LQF7 P29994 P29995 P47824 P49653 P49654 P51577 P51578 P51579 Q63269 Q64663 Q9JMI9	Insp3r Itpr1 Itpr2 Itpr3 P2rx1 P2rx2 P2rx3 P2rx4 P2rx5 P2rx6 P2rx7 P2rxl1 Trpc3 Trpc7 Trrp3	Rattus norvegicus (Norway rat)

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