GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **376 - 400** of **1070** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
SHC1 events in EGFR signaling	Amphiregulin Betacellulin GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha Receptor protein-tyrosine kinase SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6AQ55 D4A3T0 G3V6K6 P01134 P07522 P08644 P20171 P24338 P62994 Q04970 Q06175 Q5M824 Q9Z0L5	Areg Ash Btc Dtr Egf Egfr Ereg Grb2 Hbegf Hegfl Hras Hras1 Kras Kras2 Nras Sdgf Shc1 Sos1 Tgfa	Rattus norvegicus (Norway rat)
Signaling by EGFR	Amphiregulin Angio-associated, migratory cell protein Betacellulin Family with sequence similarity 83, member A Family with sequence similarity 83, member B Family with sequence similarity 83, member D Leucine-rich repeats and immunoglobulin-like domains 1 Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha Receptor protein-tyrosine kinase	A0A8I6AQ55 D3ZF70 D3ZQN0 D4ABG0 G3V6K6 G3V7V2 M0RB60 P01134 P07522 P24338 Q06175 Q9WUD9 Q9Z0L5	Aamp Areg Btc Dtr Egf Egfr Ereg Fam83a Fam83b Fam83d Hbegf Hegfl Lrig1 Sdgf Src Tgfa	Rattus norvegicus (Norway rat)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	25-hydroxycholesterol 7-alpha-hydroxylase (Fragment) 3 beta-hydroxysteroid dehydrogenase type 7 Aldo-keto reductase family 1 member C21 Aldo-keto reductase family 1 member D1 Aldo-keto reductase family 1, member C1 Bile acid receptor Cytochrome P450 7A1 Cytochrome P450 family 8 subfamily B member 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	A0A8I6APA0 G3V8J2 O35048 P17178 P18125 P31210 Q05343 Q3MHS3 Q62735 Q62969 Q63688 Q6AYQ2 Q9WUI9	Akr1c1 Akr1c21 Akr1d1 Bar Cca2 Cyp27 Cyp27a1 Cyp7 Cyp7a1 Cyp7b1 Cyp8 Cyp8b1 Fxr Hsd17b5 Hsd3b7 Ncoa1 Ncoa2 Nr1h4 Nr2b1 Ptgis Rip14 Rxra Tif2	Rattus norvegicus (Norway rat)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	25-hydroxycholesterol 7-alpha-hydroxylase (Fragment) 3 beta-hydroxysteroid dehydrogenase type 7 Acyl-coenzyme A thioesterase 8 Aldo-keto reductase family 1 member C21 Aldo-keto reductase family 1 member D1 Aldo-keto reductase family 1, member C1 Alpha-methylacyl-CoA racemase Bile acid receptor Bile acid-CoA Bile salt export pump Cytochrome P450 7A1 Cytochrome P450 family 8 subfamily B member 1 Long-chain fatty acid transport protein 2 Long-chain fatty acid transport protein 5 Nuclear receptor coactivator 2 Nuclear receptor coactivator Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal multifunctional enzyme type 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial Sterol carrier protein 2	A0A8I6APA0 G3V8J2 O35048 O70127 P11915 P17178 P18125 P31210 P70473 P97524 P97562 P97852 Q05343 Q3MHS3 Q62735 Q62969 Q63276 Q63688 Q6AYQ2 Q8VHK0 Q9ES38 Q9WUI9	Abcb11 Acot8 Acox2 Acsb Acsvl1 Akr1c1 Akr1c21 Akr1d1 Amacr Baat Bar Bsep Cca2 Cyp27 Cyp27a1 Cyp7 Cyp7a1 Cyp7b1 Cyp8 Cyp8b1 Edh17b4 Facvl1 Fatp2 Fatp5 Fxr Hsd17b4 Hsd17b5 Hsd3b7 Ncoa1 Ncoa2 Nr1h4 Nr2b1 Pte1 Ptgis Rip14 Rxra Scp-2 Scp2 Slc27a2 Slc27a5 Spgp Thcox Tif2 Vlacs Vlacsr Vlcs	Rattus norvegicus (Norway rat)
Recycling of bile acids and salts	ATP-binding cassette sub-family C member 3 Albumin Bile acid receptor Bile acid-CoA Bile salt export pump Gastrotropin Hepatic sodium/bile acid cotransporter Ileal sodium/bile acid cotransporter Long-chain fatty acid transport protein 5 Nuclear receptor coactivator 2 Nuclear receptor coactivator Retinoic acid receptor RXR-alpha Solute carrier family 51 subunit alpha Solute carrier family 51 subunit beta Solute carrier organic anion transporter family member 1A4 Solute carrier organic anion transporter family member 1B2 StAR-related lipid transfer domain containing 5	A0A8I6APA0 D3ZN38 D3ZYJ2 D4AC81 O35913 O70127 O88563 P02770 P26435 P80020 Q05343 Q62633 Q62735 Q63276 Q9ES38 Q9QZX8 Q9WUI9	Abcb11 Abcc3 Acsb Alb Baat Bar Bsep Cmoat2 Fabp6 Fatp5 Fxr Ilbp Illbp Mlp2 Mrp3 Ncoa1 Ncoa2 Nr1h4 Nr2b1 Ntcp Ntcp2 Oatp1a4 Oatp1b2 Oatp2 Rip14 Rxra Slc10a1 Slc10a2 Slc21a10 Slc21a5 Slc27a5 Slc51a Slc51b Slco1a4 Slco1b2 Spgp Stard5 Tif2 Vlacsr	Rattus norvegicus (Norway rat)
Endogenous sterols	25-hydroxycholesterol 7-alpha-hydroxylase (Fragment) Adrenodoxin, mitochondrial Aromatase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Bile acid receptor Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B2, mitochondrial Cytochrome P450 11B3, mitochondrial Cytochrome P450 1B1 Cytochrome P450 4V2 Cytochrome P450 7A1 Cytochrome P450, family 39, subfamily a, polypeptide 1 Cytochrome P450, family 46, subfamily a, polypeptide 1 Ferredoxin-2, mitochondrial Lanosterol 14-alpha demethylase NADPH Nuclear receptor coactivator 2 Nuclear receptor coactivator Pro-opiomelanocortin Retinoic acid receptor RXR-alpha Steroid 21-hydroxylase Sterol 26-hydroxylase, mitochondrial	A0A8I6APA0 A2RRT9 D4A8N2 D4AE09 F7EN52 P01194 P14137 P15393 P17178 P18125 P22443 P24483 P30099 P30100 P41738 P41739 P56522 Q05343 Q62735 Q63688 Q64562 Q64654 Q64678 Q75NT5 Q78E60 Q9WUI9	Ahr Ahrr Arnt Arnt2 Arom Bar Cyp11a Cyp11a-1 Cyp11a1 Cyp11b-1 Cyp11b-2 Cyp11b-3 Cyp11b1 Cyp11b2 Cyp11b3 Cyp19 Cyp19a1 Cyp1b1 Cyp21 Cyp21a1 Cyp27 Cyp27a1 Cyp39a1 Cyp46a1 Cyp4v2 Cyp4v3 Cyp51 Cyp51a1 Cyp7 Cyp7a1 Cyp7b1 Fdx1 Fdx1l Fdx2 Fdxr Fxr Ncoa1 Ncoa2 Nr1h4 Nr2b1 Pomc Pomc2 Rip14 Rxra Tif2	Rattus norvegicus (Norway rat)
TNF signaling	BAG cochaperone 4 Disintegrin and metalloproteinase domain-containing protein 17 Receptor interacting serine/threonine kinase 1 TNF receptor-associated factor Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	A0A8I6AP78 B5DFH7 D3ZYL0 D3ZZC5 P16599 P22934 Q9Z1K9	Adam17 Bag4 Ripk1 Tace Tnf Tnfa Tnfr-1 Tnfr1 Tnfrsf1a Tnfsf2 Tradd Traf2	Rattus norvegicus (Norway rat)
Formyl peptide receptors bind formyl peptides and many other ligands	Amyloid-beta precursor protein Annexin A1 C-C motif chemokine 6 C-C motif chemokine ligand 9 Formyl peptide receptor 2 like 2 Formyl peptide receptor 2 Heme-binding protein 1 fMet-Leu-Phe receptor	A0A8I6AM80 B4F7C7 D4A7Q2 D4A942 P07150 P08592 Q5FVN3 Q68FP3	A4 AD1 Anx1 Anxa1 App Ccl6 Ccl9 Fpr1 Fpr2 Fpr2l3 Hebp1	Rattus norvegicus (Norway rat)
Interleukin-2 signaling	Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Protein-tyrosine kinase 2-beta Proto-oncogene tyrosine-protein kinase LCK SHC-transforming protein 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK3 Tyrosine-protein kinase SYK Tyrosine-protein kinase	A0A8I6AM23 P17108 P26896 P26897 P52632 P70600 Q01621 Q5M824 Q62771 Q63272 Q64725	Fak2 Il-2 Il2 Il2ra Il2rb Jak1 Jak3 Lck Mgf Ptk2b Pyk2 Shc1 Stat5a Stat5b Syk	Rattus norvegicus (Norway rat)
IFNG signaling activates MAPKs	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 RAF proto-oncogene serine/threonine-protein kinase Tyrosine-protein kinase JAK2 Tyrosine-protein kinase	A0A8I6AM23 D4A109 F7FHZ1 P01581 P11345 P21708 P63086 Q62689	Erk1 Erk2 Ifng Ifngr1 Ifngr2 Jak1 Jak2 Mapk Mapk1 Mapk3 Prkm1 Prkm3 Raf Raf1	Rattus norvegicus (Norway rat)
MAPK1 (ERK2) activation	Dual specificity mitogen-activated protein kinase kinase 2 Interleukin-6 receptor subunit alpha Interleukin-6 receptor subunit beta Interleukin-6 Mitogen-activated protein kinase 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11	A0A8I6AM23 D3ZD03 P20607 P22273 P36506 P40190 P41499 P63086 Q62689	Erk2 Il-6 Il6 Il6r Il6ra Il6st Jak1 Jak2 Map2k2 Mapk Mapk1 Mek2 Mkk2 Prkm1 Prkmk2 Ptpn11 Tyk2	Rattus norvegicus (Norway rat)
MAPK3 (ERK1) activation	Cyclin-dependent kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Interleukin-6 receptor subunit alpha Interleukin-6 receptor subunit beta Interleukin-6 Mitogen-activated protein kinase 3 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11	A0A8I6AM23 D3ZD03 P20607 P21708 P22273 P39951 P40190 P41499 Q01986 Q62689	Cdc2 Cdc2a Cdk1 Cdkn1 Erk1 Il-6 Il6 Il6r Il6ra Il6st Jak1 Jak2 Map2k1 Mapk3 Mek1 Prkm3 Prkmk1 Ptpn11 Tyk2	Rattus norvegicus (Norway rat)
Interleukin-12 signaling	Interleukin 12 receptor subunit beta 1 Interleukin 12 receptor subunit beta 2 Interleukin-12 subunit alpha Interleukin-12 subunit beta Protein disulfide-isomerase Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein kinase Vesicle-associated membrane protein 7	A0A8I6AM23 D3ZD03 E9PSU7 E9PU71 F1LRH7 P04785 Q62689 Q9JHW5 Q9R103	IL12B Il12a Il12b Il12rb1 Il12rb2 Jak1 Jak2 P4hb Pdia1 Sybl1 Tyk2 Vamp7	Rattus norvegicus (Norway rat)
Interleukin-10 signaling	Interleukin 10 receptor subunit alpha Interleukin 10 receptor subunit beta Interleukin-10 Signal transducer and activator of transcription 3 Tyrosine-protein kinase Tyrosine-protein kinase	A0A8I6AM23 D3ZD03 D3ZM36 G3V830 P29456 P52631	Il-10 Il10 Il10ra Il10rb Jak1 Stat3 Tyk2	Rattus norvegicus (Norway rat)
Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll-like receptor 7	A0A8I6AM21	Tlr7	Rattus norvegicus (Norway rat)
Trafficking and processing of endosomal TLR	Canopy FGF signaling regulator 3 Cathepsin B Cathepsin K Cathepsin S Endoplasmin Legumain Procathepsin L Similar to Cathepsin L precursor (Major excreted protein) (MEP) Toll-like receptor 7 Toll-like receptor 8 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A8I6AM21 A5H300 D3ZDJ4 D3ZKC3 G3V828 M0RAA8 O35186 P00787 P07154 Q02765 Q66HD0 Q9R0J8	Cnpy3 Cts7l2 Ctsb Ctsk Ctsl Ctsl1 Ctsll3 Ctss Grp94 Hsp90b1 Hspc4 Lgmn Prsc1 RGD1308751 Tlr7 Tlr8 Tlr9 Tra1 Unc93b1	Rattus norvegicus (Norway rat)
RAF-independent MAPK1/3 activation	Astrocytic phosphoprotein PEA-15 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 protein-serine/threonine phosphatase protein-serine/threonine phosphatase protein-serine/threonine phosphatase protein-tyrosine-phosphatase	A0A8I6AJQ7 D3ZBG7 D3ZNK9 D4A3W6 O54838 P21708 P63086 Q2YDV1 Q5U318 Q62767 Q63340 Q64346 Q64623	Cl100 Dusp1 Dusp10 Dusp16 Dusp4 Dusp5 Dusp6 Dusp7 Dusp8 Dusp9 ENSRNOG00000069024 Erk1 Erk2 Mapk Mapk1 Mapk3 Mkp1 Mkp2 Mkp3 Mkpx Pea15 Prkm1 Prkm3 Ptpn16	Rattus norvegicus (Norway rat)
Laminin interactions	Integrin alpha 3 variant B Integrin alpha-7 Integrin beta-1 Integrin beta-4 Integrin subunit alpha 6 Laminin subunit alpha 4 Multiple epidermal growth factor-like domains protein 6 Nidogen-2	A0A8I6AJE9 B5DFC9 F1LTF8 I4DUB5 O88281 P49134 Q63258 Q64632	Egfl3 ITGA3B Itga3 Itga6 Itga7 Itgb1 Itgb4 Lama4 Megf6 Nid2	Rattus norvegicus (Norway rat)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	CCR4-NOT transcription complex subunit 10 CCR4-NOT transcription complex subunit 11 CCR4-NOT transcription complex subunit 6 CCR4-NOT transcription complex subunit 9 CCR4-NOT transcription complex, subunit 1 CCR4-NOT transcription complex, subunit 2 CCR4-NOT transcription complex, subunit 3 CCR4-NOT transcription complex, subunit 4 Centromere protein J M-phase inducer phosphatase Nucleophosmin Protein BTG2 Serine/threonine-protein kinase PLK2 Serine/threonine-protein kinase PLK3 Tankyrase 1 binding protein 1 poly(A)-specific ribonuclease	A0A8I6AJD1 A0A8I6AL98 B0BNA9 D3ZF26 D3ZUV9 D4A194 D4ADT2 G3V7M0 P13084 P27049 Q498M7 Q5PQL2 Q5XIA4 Q6AXU9 Q9R011 Q9R012	Btg2 Ccr4 Cdc25c Cenpj Cnk Cnot1 Cnot10 Cnot11 Cnot2 Cnot3 Cnot4 Cnot6 Cnot6l Cnot9 Fnk Npm1 Pc3 Plk2 Plk3 Rcd1 Rqcd1 Snk Tnks1bp1	Rattus norvegicus (Norway rat)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Rabenosyn, RAB effector Toll-like receptor 9	A0A8I6AIN6 D3ZL11 M0RAA8 O88763 P0C0R5	Eea1 Pik3c3 Pik3r4 Rbsn Tlr9 Vps34 Zfyve20	Rattus norvegicus (Norway rat)
Citric acid cycle (TCA cycle)	Aconitate hydratase, mitochondrial Citrate synthase, mitochondrial Fumarate hydratase, mitochondrial Heat shock protein 75 kDa, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial Malate dehydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial proton-translocating NAD(P)(+) transhydrogenase	A0A8I6AIH6 A0A8I6AQG5 F1LM47 P04636 P13086 P14408 P21913 P41565 P56574 Q5XHZ0 Q641Z9 Q68FX0 Q6PCT8 Q8VHF5 Q920L2 Q99NA5 Q9ER34	Aco2 Cs Fh Fh1 Hsp75 Hspc5 Idh2 Idh3B Idh3a Idh3g Mdh2 Mor1 Nnt SUCLA2 SUCLG2 Sdh1 Sdha Sdhb Sdhc Sdhd Sucla2 Suclg1 Suclg2 Trap1	Rattus norvegicus (Norway rat)
Chondroitin sulfate biosynthesis	Biglycan Brevican core protein Carbohydrate sulfotransferase 11 Carbohydrate sulfotransferase 15 Carbohydrate sulfotransferase 3 Carbohydrate sulfotransferase 7 Carbohydrate sulfotransferase Carbohydrate sulfotransferase Carbohydrate sulfotransferase Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Hexosyltransferase Hexosyltransferase Hexosyltransferase Hexosyltransferase Hexosyltransferase Hexosyltransferase Neurocan core protein Versican core protein (Fragments)	A0A8I6AI88 B5DEY9 D3ZPV0 D3ZRM3 D4A5Z0 F1M862 M0R6S5 P47853 P55067 P55068 P69478 Q00657 Q01129 Q498S0 Q5XIQ8 Q6XQG8 Q8CHI9 Q9ERB4 Q9ERQ6 Q9QZL2	Bcan Behab Bgn Caleb Chpf Chpf2 Chst11 Chst12 Chst13 Chst15 Chst3 Chst7 Chst9 Chsy1 Chsy3 Csgalnact1 Csgalnact2 Cspg2 Cspg3 Cspg4 Cspg5 Dcn Galnac4s6st Ncan Ng2 Ngc Vcan	Rattus norvegicus (Norway rat)
Synthesis of bile acids and bile salts	25-hydroxycholesterol 7-alpha-hydroxylase (Fragment) Bile acid receptor Cholesterol 25-hydroxylase Cytochrome P450 7A1 Nuclear receptor coactivator 2 Nuclear receptor coactivator Oxysterol-binding protein-related protein 1 Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Retinoic acid receptor RXR-alpha	A0A8I6AI28 A0A8I6ANM6 A0A8I6APA0 D3ZHZ3 D4A0F3 D4A0G0 D4A9D8 P18125 Q05343 Q4QQV7 Q62735 Q63688 Q8K4M9 Q9WUI9	Bar Ch25h Cyp7 Cyp7a1 Cyp7b1 Fxr Ncoa1 Ncoa2 Nr1h4 Nr2b1 Orp1 Osbp Osbpl1a Osbpl2 Osbpl3 Osbpl6 Osbpl7 Osbpl9 Rip14 Rxra Tif2	Rattus norvegicus (Norway rat)
Interleukin-15 signaling	Growth factor receptor-bound protein 2 Interleukin 15 receptor subunit alpha Interleukin-15 Interleukin-2 receptor subunit beta SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 SOS Ras/Rho guanine nucleotide exchange factor 2 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK3 Tyrosine-protein kinase	A0A8I6AI14 A0A8I6AM23 D4A3T0 F1MAI3 P26896 P52631 P52632 P62994 P97604 Q5M824 Q62771 Q63272	Ash Grb2 Il15 Il15ra Il2rb Jak1 Jak3 Mgf Shc1 Sos1 Sos2 Stat3 Stat5a Stat5b	Rattus norvegicus (Norway rat)
RHOT2 GTPase cycle	Mitochondrial Rho GTPase 2 Mitofusin-1 Mitofusin-2 Myosin XIX Trafficking kinesin protein 1 Trafficking kinesin-binding protein 2	A0A8I6AI05 D3Z8I9 Q7TSA0 Q8R2H7 Q8R4Z9 Q8R500	Als2cr3 Arht2 Fzo1a Fzo1b Grif1 Mfn1 Mfn2 Myo19 Oip98 Rhot2 Trak1 Trak2	Rattus norvegicus (Norway rat)

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