GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **426 - 450** of **1070** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Amphiregulin Betacellulin CD19 molecule CD86 molecule Cd80 molecule Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-1 receptor accessory protein Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Myeloid differentiation primary response protein MyD88 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide-3-kinase adaptor protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B (Fragment) Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase LCK Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RPTOR independent companion of MTOR, complex 2 Rac family small GTPase 2 Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein phosphatase non-receptor type 11 non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A0G2JW59 A0A0G2JYX9 A0A0G2K210 A0A0G2K344 A0A8I5Y1H8 A0A8I5Y949 A0A8I5ZNG4 A0A8I6A1P8 A0A8I6AQ55 A0A8I6B5D5 A0A8I6G1H3 B5DF45 D3Z8T6 D3ZAL7 D4A244 F1LNH2 F1LSG7 F1LSQ8 F1M784 F1MAL5 F7F6T0 G3V671 G3V6K6 O35531 O35569 O54769 O55173 O88182 P01134 P06211 P06494 P07522 P13109 P17945 P20786 P21581 P24338 P28576 P31042 P35570 P36364 P41499 P42346 P43322 P47196 P47197 P48807 P54100 P61149 P62994 P63076 P70483 P70492 P97523 Q01621 Q02195 Q04589 Q05028 Q05030 Q06175 Q06226 Q32PX6 Q498D6 Q566R0 Q5FVG6 Q62611 Q62799 Q62844 Q62986 Q63116 Q63484 Q63621 Q63787 Q63788 Q63789 Q66H70 Q6AYF1 Q6RUV5 Q6Y1S1 Q8R5L5 Q8R5L9 Q8VI79 Q8VI81 Q8VI82 Q9EQH1 Q9EST9 Q9R1T7 Q9WTQ6 Q9WUD9 Q9Z0L5 Q9Z1L0 Q9Z2K5 Q9Z2Y9	Ailim Akt1 Akt2 Akt3 Areg Ash Btc Cd19 Cd28 Cd80 Cd86 Dtr Egf Egfr Erbb2 Erbb3 Erbeta Ereg Esr Esr1 Esr2 Estr FGF15 FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr1 Fgfr2 Fgfr3 Fgfr4 Fit1 Flg Flt3 Frap1 Frs2 Fyn Gab1 Gab2 Gbl Grb2 Hbegf Hegfl Hgf Icos Il1rap Il1rl1 Il33 Irak1 Irak4 Irs-1 Irs1 Irs2 KIT Kgf Kit Kitl Kitlg Kl Klb LOC100361758 Lck Lst8 Mapkap1 Met Mgf Mip1 Mlst8 Mtor Myd88 Ndf Neu Nipk Nr3a1 Nr3a2 Nrg1 Nrg2 Nrg3 Ntak Pdgfa Pdgfb Pdgfr Pdgfr1 Pdgfra Pdgfrb Pdk1 Pdpk1 Pik3ap1 Pik3ca Pik3cb Pik3cd Pik3r1 Pik3r2 Pik3r3 Protor1 Prr5 Ptpn11 Rac Rac1 Rac2 Raft1 Rhog Rictor Rpa1 Sdgf Sgk Sgk1 Sin1 Src Strn Tgfa Them4 Traf6 Trat1 Trib3 Vav Vav1	Rattus norvegicus (Norway rat)
PI3K events in ERBB4 signaling	Betacellulin Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor	A0A0G2K344 A0A8I5Y1H8 A0A8I6AQ55 O35569 P43322 Q06175 Q63787 Q9Z0L5	Btc Dtr Ereg Hbegf Hegfl Ndf Nrg1 Nrg2 Nrg3 Ntak Pik3ca Pik3r1	Rattus norvegicus (Norway rat)
PI3K events in ERBB2 signaling	Betacellulin GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3	A0A0G2K344 A0A8I5Y1H8 A0A8I6AQ55 D3ZAL7 G3V6K6 O35569 P06494 P07522 P43322 P62994 Q06175 Q62799 Q63787 Q9Z0L5	Ash Btc Dtr Egf Egfr Erbb2 Erbb3 Ereg Gab1 Grb2 Hbegf Hegfl Ndf Neu Nrg1 Nrg2 Nrg3 Ntak Pik3ca Pik3r1	Rattus norvegicus (Norway rat)
PI3K Cascade	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11 receptor protein-tyrosine kinase	A0A0G2JW59 A0A0G2K210 A0A0G2K344 A0A8I6B5D5 D3Z8T6 D3ZAL7 D4A244 F1LSG7 F1LSQ8 F1MAL5 M0RAA8 O54769 O88182 O88763 P0C0R5 P13109 P35570 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q02195 Q04589 Q498D6 Q63787 Q63788 Q8R5L5 Q8R5L9 Q8VI79 Q8VI81 Q8VI82 Q9EQH1 Q9EST9 Q9Z1L0 Q9Z2Y9	Ash FGF15 FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr1 Fgfr2 Fgfr3 Fgfr4 Flg Flt3 Frs2 Gab1 Gab2 Grb2 Irs-1 Irs1 Irs2 Kgf Kl Klb Pik3c3 Pik3ca Pik3cb Pik3r1 Pik3r2 Pik3r4 Ptpn11 Tlr9 Vps34	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR4	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Klotho beta Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3Z8T6 D3ZAL7 D4A244 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P61149 P62994 P63076 Q498D6 Q63787 Q8R5L5 Q8VI81 Q8VI82 Q9EST9	Ash FGF15 FGF6 Fgf-1 Fgf-2 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf23 Fgf4 Fgf6 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr4 Frs2 Gab1 Grb2 Klb Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K210 A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P48807 P61149 P62994 P63076 Q63787 Q8VI82 Q9EST9	Ash Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf23 Fgf4 Fgf5 Fgf7a Fgf8 Fgf9 Fgfa Fgfr3 Frs2 Gab1 Grb2 Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSG7 F1LSQ8 O54769 O88182 P13109 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q02195 Q63787 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr2 Frs2 Gab1 Grb2 Kgf Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
PI-3K cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated binding protein 1 Growth factor receptor-bound protein 2 Klotho Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	A0A0G2K344 A0A8I6B5D5 D3ZAL7 D4A244 F1LSQ8 P13109 P36364 P41499 P48807 P61149 P62994 P63076 P70492 Q04589 Q63787 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Frs2 Gab1 Grb2 Kl Pik3ca Pik3r1 Ptpn11	Rattus norvegicus (Norway rat)
PI Metabolism	TNF alpha induced protein 8 like 3 Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 2 Tumor necrosis factor alpha-induced protein 8	A0A8I5ZY03 D4A9G3 F1LX20 Q6AYJ8	Tnfaip8 Tnfaip8l1 Tnfaip8l2 Tnfaip8l3	Rattus norvegicus (Norway rat)
PERK regulates gene expression	Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3, X-linked Eukaryotic translation initiation factor 2-alpha kinase 3	A0A8I6G5P0 P68101 P81795 Q9Z1Z1	Eif2a Eif2ak3 Eif2g Eif2s1 Eif2s2 Eif2s3 Eif2s3x Pek Perk	Rattus norvegicus (Norway rat)
PECAM1 interactions	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Integrin beta-3 Integrin subunit alpha V Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Platelet endothelial cell adhesion molecule Proto-oncogene tyrosine-protein kinase LCK Proto-oncogene tyrosine-protein kinase Src Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	F1LM93 F1LZX9 P10686 P41499 P81718 P97573 Q01621 Q07014 Q3SWT0 Q62844 Q8R2H2 Q9WUD9	Fyn Inpp5d Itgav Itgb3 Lck Lyn Pecam Pecam1 Plcg1 Ptph6 Ptpn11 Ptpn6 Ship Ship1 Src Yes1	Rattus norvegicus (Norway rat)
PDH complex synthesizes acetyl-CoA from PYR	Ac1164 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	D4A5G8 P08461 P26284 P49432 Q06437 Q6P6R2 Q7TQ85	Dlat Dld LOC311254 Pdha1 Pdha1l1 Pdha2 Pdhb Pdhx	Rattus norvegicus (Norway rat)
PD-1 signaling	CD274 molecule Histocompatibility 2, class II antigen E alpha Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II beta chain Programmed cell death 1 ligand 2 Programmed cell death 1 Proto-oncogene tyrosine-protein kinase LCK RT1 class II, H alpha RT1 class II, locus Hb, pseudogene 1 Rano class II histocompatibility antigen, B alpha chain Rano class II histocompatibility antigen, B-1 beta chain Rano class II histocompatibility antigen, D-1 beta chain T cell receptor beta, variable 16 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase CSK Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	A0A023IKK2 A0A8I5ZPF9 A0A8I6A4Z0 A0A8I6AAG4 A0A8I6G8N5 A0A8I6GKC3 D3ZIN8 D3ZND8 D4AAV6 D4AE25 M0R576 M0RE10 P05540 P18211 P19377 P20037 P29826 P32577 P41499 P81718 Q01621 Q64159 Q6MG98 Q6MGB1	AABR07044416.1 Arrb2-ps Cd247 Cd274 Cd3d Cd3e Cd3g Cd4 Csk DA1 Db2 ENSRNOG00000065769 ENSRNOG00000065908 ENSRNOG00000065955 ENSRNOG00000070909 H2-Ea Hla-dma Hla-dmb LOC100911800 Lck Pdcd1 Pdcd1lg2 Psmb9 Ptph6 Ptpn11 Ptpn6 RT1-Ba RT1-Bb RT1-DOb RT1-Da RT1-Db1 RT1-Db2 RT1-Ha RT1-Hb-ps1 T3d Tap1 Tap2 Tesb Trbv16	Rattus norvegicus (Norway rat)
PCP/CE pathway	Dishevelled associated activator of morphogenesis 1 Dishevelled segment polarity protein 2 Dishevelled segment polarity protein 3 Frizzled class receptor 3 Frizzled class receptor 7 Frizzled-1 Frizzled-6 Profilin-1 Protein Wnt-4 Protein Wnt-5a Protein Wnt Protein Wnt Protein Wnt Rac family small GTPase 2 Ras-related C3 botulinum toxin substrate 1 Segment polarity protein dishevelled homolog DVL-1 Transforming protein RhoA	A0A8I6A1P8 A0A8I6GKX7 A0A8I6GM04 B1WBR9 D3ZB71 D4A9J2 D4ACM8 G3V6L1 G3V819 M0RCN5 P61589 P62963 Q08463 Q6RUV5 Q9QXQ5 Q9QXQ7 Q9WVB9	Arha Arha2 Daam1 Dvl1 Dvl2 Dvl3 Fzd1 Fzd3 Fzd6 Fzd7 LOC100361515 Pfn1 Rac Rac1 Rac2 Rhoa Wnt-4 Wnt-5a Wnt1 Wnt11 Wnt4 Wnt5a Wnt5b	Rattus norvegicus (Norway rat)
P2Y receptors	Lysophosphatidic acid receptor 4 Lysophosphatidic acid receptor 6 P2Y purinoceptor 12 P2Y purinoceptor 13 P2Y purinoceptor 14 P2Y purinoceptor 1 P2Y purinoceptor 2 P2Y purinoceptor 4 P2Y purinoceptor 6 P2Y receptor family member 10 Uracil nucleotide/cysteinyl leukotriene receptor	A0A8I5ZW42 D3ZHA3 O35811 O35881 P41232 P49651 Q09QM4 Q4G072 Q63371 Q6GUG4 Q9EPX4	Gpr105 Gpr17 Lpar4 Lpar6 P2ru1 P2ry1 P2ry10 P2ry12 P2ry13 P2ry14 P2ry2 P2ry4 P2ry5 P2ry6 P2y12 P2y4 P2y5	Rattus norvegicus (Norway rat)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin 2 Egl nine homolog 1 (Fragment) Elongin-B Elongin-C Endothelial PAS domain-containing protein 1 Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 3-alpha LIM domain-containing protein 1 LIM domain-containing protein ajuba Polyubiquitin-B Polyubiquitin-C Prolyl hydroxylase EGLN2 Prolyl hydroxylase EGLN3 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Ring-box 1 Ubiquitin B-like Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eS31 fusion protein WT1 interacting protein von Hippel-Lindau disease tumor suppressor	A0A0G2JSL0 A0A0G2JUC8 A0A0G2KAX0 A0A8I5ZM79 A0A8I5ZNE7 A0A8I6A5Y3 A0A8I6G8I6 B0BN93 B5DEH0 D3ZDK2 F1LMC1 F1LMQ3 F1LMZ8 F1M6I7 F7FGV7 G3V6W6 G3V8G2 O35800 O88761 P0CG51 P17220 P18420 P18421 P18422 P21670 P28064 P28073 P28075 P28077 P34064 P34067 P40112 P40307 P48004 P59722 P60901 P61078 P62193 P62198 P62839 P62870 P62982 P83941 Q4FZT9 Q4KM35 Q4V8E2 Q5U2Z2 Q5XIC6 Q5XIU5 Q62630 Q63347 Q63429 Q63569 Q63570 Q63797 Q63798 Q64259 Q6AYU4 Q9JHS1 Q9JHS2 Q9JHW0 Q9WTV5 Q9Z2X3	Ajuba Cul2 Egln1 Egln2 Egln3 Elob Eloc Epas1 Hif1a Hif2a Hif3a Jub LOC100360645 LOC100360846 LOC100365869 Limd1 Lmp10 Lmp2 Mecl1 Mss1 Psma1 Psma2 Psma3 Psma4 Psma5 Psma6 Psma7 Psma8 Psmb1 Psmb10 Psmb2 Psmb3 Psmb4 Psmb5 Psmb6 Psmb6l Psmb6l1 Psmb7 Psmb8 Psmb9 Psmc1 Psmc2 Psmc3 Psmc4 Psmc5 Psmc6 Psmd1 Psmd10 Psmd11 Psmd12 Psmd13 Psmd14 Psmd2 Psmd3 Psmd5 Psmd6 Psmd7 Psmd8 Psmd9 Psme1 Psme2 Psme4 Psmf1 Rbx1 Ring12 Rps27a Sm20 Sug1 Tbp1 Tbp7 Tceb1 Tceb2 Uba80 Ubb Ubbl1 Ubc Ubc4 Ubcep1 Ubch4 Ubch5b Ubcl1 Ube2d1 Ube2d2 Ube2d3 Vhl Wtip	Rattus norvegicus (Norway rat)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox 2 Chromobox 4 Chromobox 6 Chromobox 8 Cyclin dependent kinase inhibitor 2D Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Dual specificity mitogen-activated protein kinase kinase 7 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Embryonic ectoderm development Histone H2A type 2-A Histone H2A.J Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B type 1-A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H3.1 Histone H3.3 Histone H3 Histone H4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 MAP kinase-activated protein kinase 3 MAPK activated protein kinase 2 MAPK activated protein kinase 5 Mapk11 protein Misshapen-like kinase 1 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Polyhomeotic homolog 1 Polyhomeotic homolog 2 Polyhomeotic homolog 3 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein c-Fos RB binding protein 4, chromatin remodeling factor SUZ12 polycomb repressive complex 2 subunit Scm polycomb group protein like 2 Thioredoxin Transcription factor Jun Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein [histone H3]-trimethyl-L-lysine(27) demethylase mitogen-activated protein kinase kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A0G2JXI9 A0A0G2K2B0 A0A0G2K490 A0A8I5Y785 A0A8I5ZLV4 A0A8I5ZMG5 A0A8I5ZSA8 A0A8I5ZYY0 A0A8I6A2W1 A0A8I6A5Y3 A0A8I6A7P3 A0A8I6ACN6 A0A8I6AEL0 A0A8I6AFH2 A0A8I6AFW8 A0A8I6AHM8 A0A8I6AIG5 A0A8I6AQI0 A0A8I6AWT3 A0A8I6G5V3 A0A8I6G659 A0A8J8YPE2 A9UMV8 B5DFE2 D3ZJ08 D3ZRL8 D3ZVK7 D3ZXP3 D4A0M3 D4A3U7 D4ACM0 F1LN87 F1LP90 F1MA87 G3V9C7 M0R7E7 M0RBQ5 M0RE14 P0CC09 P0CG51 P10361 P11232 P12841 P17325 P21708 P35426 P49185 P49186 P49187 P55272 P62804 P62982 P63086 P70618 P84245 Q00729 Q4KLY4 Q4KSH7 Q5XIN1 Q63429 Q66H84 Q6LED0 Q6MGB6 Q6P4Z7 Q71UF4 Q80ZF4 Q925D6 S4VP54	Cbx2 Cbx4 Cbx6 Cbx8 Cdk4 Cdk6 Cdkn2b Cdkn2d Csbp1 Csbp2 ENSRNOG00000062927 ENSRNOG00000064540 ENSRNOG00000066901 ENSRNOG00000068034 Eed Erk1 Erk2 Ezh2 Fos H2ab3 H2ac10 H2ac18 H2ac4 H2afb3 H2afx H2aj H2ax H2az2 H2bc1 H2bc12l1 H2bc6 H2bcl1 H2bcl2 H2bu1 H3-3b H3.3b H3c13 H3f3b H4c16 H4c2 H4f16 H4ft Hist1h2ba Hist1h2bc Hist1h2bg Hist1h2bo Hist1h2bq Hist1h4b Hist1h4m Hist2h2aa3 Hist2h3c2 Hist4 Hist4h4 Ink4 Jnk1 Jnk2 Jnk3 Jun Kdm6b LOC100360645 LOC100365043 LOC100910200 LOC120097726 LOC684797 Map2k3 Map2k4 Map2k6 Map2k7 Map3k5 Map4k4 Map4k6 Mapk Mapk1 Mapk10 Mapk11 Mapk14 Mapk3 Mapk8 Mapk9 Mapkapk2 Mapkapk3 Mapkapk5 Mdm2 Mdm4 Mdmx Mink Mink1 Mkk6 P53 Phc1 Phc2 Phc3 Prkm1 Prkm10 Prkm3 Prkm8 Prkm9 Rbbp4 Rbbp7 Ring1 Ring1b Rjg-9 Rnf1 Rnf2 Rps27a Scml2 Suz12 Th2b Tnik Tp53 Txn Txn1 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1	Rattus norvegicus (Norway rat)
Ovarian tumor domain proteases	Adenomatous polyposis coli protein Cellular tumor antigen p53 Cyclin-dependent kinase 1 Deubiquitinating protein VCPIP1 Estrogen receptor NF-kappa-B essential modulator NF-kappa-B essential modulator Nucleotide-binding oligomerization domain containing 1 Nucleotide-binding oligomerization domain containing 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyubiquitin-B Polyubiquitin-C Receptor interacting serine/threonine kinase 1 Receptor-interacting serine/threonine-protein kinase 2 Ring finger protein 128 TNF receptor-associated factor 6 TNF receptor-associated factor TNFAIP3 interacting protein 1 TNFAIP3 interacting protein 2 Transforming protein RhoA Transitional endoplasmic reticulum ATPase Ubiquitin B-like Ubiquitin thioesterase OTU1 Ubiquitin thioesterase OTUB1 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A0G2K4Z7 A0A0G2K5N0 A0A0G2K7X2 A0A8I6A5Y3 A0A8I6AH74 A0A8I6AL23 A0A8I6AU71 B2RYG6 B2RZ84 B5DF45 D3ZAR8 D3ZDK2 D3ZHV1 D3ZYL0 D4A3I0 D4A7M3 D4ABZ4 D4ADT7 G3V783 G3V7R6 P06211 P0CG51 P10361 P39951 P46462 P61589 P62982 P70478 Q32Q05 Q63429 Q6TMG5 Q8CF97	Apc Arha Arha2 Cdc2 Cdc2a Cdk1 Cdkn1 Esr Esr1 Estr Hshin7 Ikbkg LOC100360606 LOC100360645 Nemo Nod1 Nod2 Nr3a1 Otub1 Otub2 Otud3 Otud7a Otud7b P53 Pten Rhoa Ripk1 Ripk2 Rnf128 Rps27a Tnfaip3 Tnip1 Tnip2 Tp53 Traf3 Traf6 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ube2d1 Vcip135 Vcp Vcpip1 Yod1 Zranb1	Rattus norvegicus (Norway rat)
Other semaphorin interactions	Cd72 molecule Plexin A1 Plexin C1 Plexin D1 Plexin-B3 Receptor-type tyrosine-protein phosphatase C Semaphorin 3E Semaphorin 4A Semaphorin 4D Semaphorin 6D Semaphorin 7A (John Milton Hagen blood group) Semaphorin-5A TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 2	A0A0G2JZC4 A0A8I5ZKT8 A0A8I6AGW9 A0A8I6G5Q1 D3Z8E2 D3ZLH5 D3ZQP6 D3ZTD8 D3ZZ89 D4AA77 F7F3I7 P04157 Q5BK59 Q6X9T7	Cd72 Dap12 Plxna1 Plxnb3 Plxnc1 Plxnd1 Ptprc Sema3e Sema4a Sema4d Sema5a Sema6d Sema7a Trem2 Tyrobp	Rattus norvegicus (Norway rat)
Other interleukin signaling	Caspase-3 Interleukin-34 Macrophage colony-stimulating factor 1 receptor Macrophage colony-stimulating factor 1 Pro-interleukin-16 Receptor-type tyrosine-protein phosphatase zeta Synaptosomal-associated protein 25 Syndecan-1 Syntaxin-1A Syntaxin-3 Syntaxin-4 Syntaxin-binding protein 2 T-cell surface glycoprotein CD4 Taxilin alpha Vesicle-associated membrane protein 2	A0A8I6AF93 B2GV14 P05540 P26260 P32851 P55213 P60881 P63045 Q00495 Q08849 Q08850 Q4KM46 Q62656 Q62753 Q8JZQ0	Casp3 Cd4 Cpp32 Csf1 Csf1r Csfm Csfmr Fms IL16 Il16 Il34 Ptprz Ptprz1 Ptpz Sap Sdc1 Snap Snap25 Stx1a Stx3 Stx3a Stx4 Stx4a Stxbp2 Syb2 Synd1 Txlna Unc18b Vamp2	Rattus norvegicus (Norway rat)
Organic cation transport	Organic cation/carnitine transporter 2 Runt-related transcription factor 1 Solute carrier family 22 member 16 Solute carrier family 22 member 18 Solute carrier family 22 member 1 Solute carrier family 22 member 2 Solute carrier family 22 member 3 Solute carrier family 22 member 4 Solute carrier family 22, member 15	A0A8I5ZMN2 D4A271 O70594 O88446 Q63046 Q63089 Q6AY78 Q9R0W2 Q9R141	Aml1 Cbfa2 Oct1 Oct2 Oct3 Octn1 Octn2 Orctl2 Runx1 Slc22a1 Slc22a15 Slc22a16 Slc22a18 Slc22a2 Slc22a3 Slc22a4 Slc22a5 Tssc5	Rattus norvegicus (Norway rat)
Organic anion transporters	Mitochondrial 2-oxoglutarate/malate carrier protein Mitochondrial dicarboxylate carrier Mitochondrial glutamate carrier 1 Mitochondrial glutamate carrier 2 Sodium-coupled monocarboxylate transporter 1 Sodium-dependent phosphate transport protein 1 Sodium/iodide cotransporter Tricarboxylate transport protein, mitochondrial Vesicular glutamate transporter 1 Vesicular glutamate transporter 2 Vesicular glutamate transporter 3	A0A0G2K5L2 A0A8I6A218 O89035 P32089 P97700 Q505J6 Q62634 Q62795 Q63008 Q7TSF2 Q9JI12	Bnpi Dnpi Gc1 Nis Npt1 Slc17a1 Slc17a6 Slc17a7 Slc17a8 Slc20a3 Slc20a4 Slc25a1 Slc25a10 Slc25a11 Slc25a18 Slc25a22 Slc5a5 Slc5a8 Vglut1 Vglut2 Vglut3	Rattus norvegicus (Norway rat)
Organic anion transport	Organic anion transporter 3 Solute carrier family 22 member 12 Solute carrier family 22 member 6 Solute carrier family 22 member 7	O35956 Q3ZAV1 Q5RLM2 Q9R1U7	Nlt Oat1 Oat2 Oat3 Slc22a12 Slc22a6 Slc22a7 Slc22a8 Urat1	Rattus norvegicus (Norway rat)
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Hypocretin neuropeptide precursor Neuropeptide FF receptor 1 Neuropeptide FF receptor 2 Orexigenic neuropeptide QRFP Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Pro-FMRFamide-related neuropeptide FF Pyroglutamylated RFamide peptide receptor like	A0A8I6AD76 O55232 P56718 P56719 P83860 Q9EP86 Q9EQD2 Q9WVA9	Gpr147 Gpr74 Hcrt Hcrtr1 Hcrtr2 Npff Npff1 Npff2 Npffr1 Npffr2 Npgpr Ox P518 Ppox Qrfp Qrfprl RGD1560028	Rattus norvegicus (Norway rat)
Orc1 removal from chromatin	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cell division control protein Chromatin licensing and DNA replication factor 1 Cullin 1 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 DNA helicase MCM8 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex, subunit 5 Origin recognition complex, subunit 6 Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Ring-box 1 S-phase kinase associated protein 2 S-phase kinase-associated protein 1 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein	A0A0G2JSL0 A0A0G2JUC8 A0A0G2JVY9 A0A0G2K6D6 A0A0G2KAX0 A0A8I5Y0H0 A0A8I5ZM79 A0A8I5ZNE7 A0A8I6A5Y3 A0A8I6AMP0 B0BN93 D3ZFP4 D3ZKD4 D3ZP96 D3ZRK7 D3ZVK1 E9PTS4 F1LMQ3 F1LMZ8 F1M6I7 F7FAH8 F7FGV7 G3V681 G3V6W6 G3V8G2 O88761 P0CG51 P17220 P18420 P18421 P18422 P21670 P28064 P28073 P28075 P28077 P34064 P34067 P40112 P40307 P48004 P60901 P62193 P62198 P62982 Q4FZT9 Q4KM35 Q4R180 Q4V8E2 Q5XIC6 Q5XIU5 Q63347 Q63429 Q63569 Q63570 Q63699 Q63797 Q63798 Q6AY13 Q6P9Z8 Q6PEC4 Q75PQ8 Q80Z32 Q9JHW0 Q9WTV5 Q9Z2X3	Ccna1 Ccna2 Cdc6 Cdk2 Cdkn2 Cdt1 Cul1 LOC100360645 LOC100360846 LOC100365869 Lmp10 Lmp2 Mcm2 Mcm3 Mcm4 Mcm5 Mcm8 Mecl1 Mss1 Orc1 Orc1l Orc2 Orc2l Orc3 Orc3l Orc4 Orc4l Orc5 Orc6 Psma1 Psma2 Psma3 Psma4 Psma5 Psma6 Psma7 Psma8 Psmb1 Psmb10 Psmb2 Psmb3 Psmb4 Psmb5 Psmb6 Psmb6l Psmb6l1 Psmb7 Psmb8 Psmb9 Psmc1 Psmc2 Psmc3 Psmc4 Psmc5 Psmc6 Psmd1 Psmd10 Psmd11 Psmd12 Psmd13 Psmd14 Psmd2 Psmd3 Psmd5 Psmd6 Psmd7 Psmd8 Psmd9 Psme1 Psme2 Psme4 Psmf1 Rbx1 Ring12 Rps27a Skp1 Skp1a Skp2 Sug1 Tbp1 Tbp7 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1	Rattus norvegicus (Norway rat)

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