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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 7099 | TLR4 | toll like receptor 4 | |
| 7124 | TNF | tumor necrosis factor | |
| 7132 | TNFRSF1A | TNF receptor superfamily member 1A | |
| 7225 | TRPC6 | transient receptor potential cation channel subfamily C member 6 | |
| 7351 | UCP2 | uncoupling protein 2 | |
| 7352 | UCP3 | uncoupling protein 3 | |
| 7412 | VCAM1 | vascular cell adhesion molecule 1 | |
| 7422 | VEGFA | vascular endothelial growth factor A | |
| 7466 | WFS1 | wolframin ER transmembrane glycoprotein | |
| 7515 | XRCC1 | X-ray repair cross complementing 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11303 | Abca1 | ATP-binding cassette, sub-family A member 1 | |
| 11421 | Ace | angiotensin I converting enzyme | |
| 11450 | Adipoq | adiponectin, C1Q and collagen domain containing | |
| 11491 | Adam17 | a disintegrin and metallopeptidase domain 17 | |
| 11551 | Adra2a | adrenergic receptor, alpha 2a | |
| 11556 | Adrb3 | adrenergic receptor, beta 3 | |
| 11596 | Ager | advanced glycosylation end product-specific receptor | |
| 11601 | Angpt2 | angiopoietin 2 | |
| 11609 | Agtr2 | angiotensin II receptor, type 2 | |
| 11625 | Ahsg | alpha-2-HS-glycoprotein |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24152 | Asip | agouti signaling protein | |
| 24179 | Agt | angiotensinogen | |
| 24182 | Agtr2 | angiotensin II receptor, type 2 | |
| 24185 | Akt1 | AKT serine/threonine kinase 1 | |
| 24192 | Akr1b1 | aldo-keto reductase family 1 member B1 | |
| 24221 | Avp | arginine vasopressin | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24241 | Calca | calcitonin-related polypeptide alpha | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24310 | Ace | angiotensin I converting enzyme |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31234 | Pdfr | Pigment-dispersing factor receptor | |
| 31248 | sgg | shaggy | |
| 31271 | w | white | |
| 31806 | Ogg1 | 8-oxoguanine DNA glycosylase | |
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 32442 | Rab3-GEF | Rab3 GDP-GTP exchange factor | |
| 32974 | Zw | Zwischenferment | |
| 33007 | Dop2R | Dopamine 2-like receptor | |
| 33496 | lilli | lilliputian | |
| 34091 | Spn28Dc | Serpin 28Dc |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30173 | nog3 | noggin 3 | |
| 30174 | nog1 | noggin 1 | |
| 30262 | ins | preproinsulin | |
| 30667 | mtnr1aa | melatonin receptor 1A a | |
| 30668 | mtnr1bb | melatonin receptor 1Bb | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 321664 | aldob | aldolase b, fructose-bisphosphate | |
| 337685 | ogt.1 | O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 | |
| 393807 | ppp1r3cb | protein phosphatase 1, regulatory subunit 3Cb |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378695 | ins.L | insulin L homeolog | Xenopus laevis (African clawed frog) | |
| 378696 | ins.S | insulin S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 394283 | sdc2.S | syndecan 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 398006 | insr.L | insulin receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 180812 | scav-1 | SCAVenger receptor (CD36 family) related | |
| 180836 | W01C8.5 | DM13 domain-containing protein | |
| 180931 | cpr-6 | Cathepsin B-like cysteine proteinase 6 | |
| 181041 | adm-4 | Disintegrin and metalloproteinase domain-containing protein 17 homolog | |
| 181178 | gpx-5 | Glutathione peroxidase | |
| 181259 | sdn-1 | Syndecan;putative syndecan | |
| 181285 | pbo-4 | Na(+)/H(+) exchanger protein 7 | |
| 181326 | pgp-3 | Multidrug resistance protein pgp-3 | |
| 181563 | csq-1 | Calsequestrin | |
| 181579 | dpf-2 | Dipeptidyl peptidase family member 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 851974 | YPR1 | trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 | |
| 851977 | CTS2 | putative chitinase | |
| 852128 | EMI2 | putative glucokinase | |
| 852543 | VVS1 | Vvs1p | |
| 852639 | HXK2 | hexokinase 2 | |
| 853671 | STE6 | ATP-binding cassette a-factor transporter STE6 | |
| 854287 | GCY1 | glycerol 2-dehydrogenase (NADP(+)) GCY1 | |
| 854350 | GAC1 | protein phosphatase regulator GAC1 | |
| 854529 | PYK2 | pyruvate kinase PYK2 | |
| 854651 | GUT2 | glycerol-3-phosphate dehydrogenase |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000855 | Insulin resistance |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 2645 | GCK | glucokinase |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 3990 | LIPC | lipase C, hepatic type |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
