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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 5288 | PIK3C2G | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | |
| 5291 | PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | |
| 5293 | PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | |
| 5313 | PKLR | pyruvate kinase L/R | |
| 5327 | PLAT | plasminogen activator, tissue type | |
| 5329 | PLAUR | plasminogen activator, urokinase receptor | |
| 5443 | POMC | proopiomelanocortin | |
| 5444 | PON1 | paraoxonase 1 | |
| 5445 | PON2 | paraoxonase 2 | |
| 5467 | PPARD | peroxisome proliferator activated receptor delta |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 18976 | Pomc | pro-opiomelanocortin-alpha | |
| 18979 | Pon1 | paraoxonase 1 | |
| 19016 | Pparg | peroxisome proliferator activated receptor gamma | |
| 19017 | Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | |
| 19045 | Ppp1ca | protein phosphatase 1 catalytic subunit alpha | |
| 19047 | Ppp1cc | protein phosphatase 1 catalytic subunit gamma | |
| 19099 | Mapk8ip1 | mitogen-activated protein kinase 8 interacting protein 1 | |
| 19215 | Ptgds | prostaglandin D2 synthase (brain) | |
| 19225 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | |
| 19266 | Ptprd | protein tyrosine phosphatase receptor type D |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24152 | Asip | agouti signaling protein | |
| 24179 | Agt | angiotensinogen | |
| 24182 | Agtr2 | angiotensin II receptor, type 2 | |
| 24185 | Akt1 | AKT serine/threonine kinase 1 | |
| 24192 | Akr1b1 | aldo-keto reductase family 1 member B1 | |
| 24221 | Avp | arginine vasopressin | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24241 | Calca | calcitonin-related polypeptide alpha | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24310 | Ace | angiotensin I converting enzyme |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 37131 | Pepck1 | Phosphoenolpyruvate carboxykinase 1 | |
| 37420 | Ugt49B1 | UDP-glycosyltransferase family 49 member B1 | |
| 37447 | Sdc | Syndecan | |
| 38109 | Glut1 | Glucose transporter 1 | |
| 38726 | Mdr65 | Multi drug resistance 65 | |
| 38868 | Snmp2 | Sensory neuron membrane protein 2 | |
| 39557 | Hsp110 | Heat shock protein 110 | |
| 39836 | st | scarlet | |
| 40079 | Ugt316A1 | UDP-glycosyltransferase family 316 member A1 | |
| 41334 | Ugt35A1 | UDP-glycosyltransferase family 35 member A1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30173 | nog3 | noggin 3 | |
| 30174 | nog1 | noggin 1 | |
| 30262 | ins | preproinsulin | |
| 30667 | mtnr1aa | melatonin receptor 1A a | |
| 30668 | mtnr1bb | melatonin receptor 1Bb | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 266751 | adra2b | adrenoceptor alpha 2B | |
| 321664 | aldob | aldolase b, fructose-bisphosphate | |
| 337685 | ogt.1 | O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 | |
| 393807 | ppp1r3cb | protein phosphatase 1, regulatory subunit 3Cb |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373759 | cnr1.S | cannabinoid receptor 1 (brain) S homeolog | Xenopus laevis (African clawed frog) | |
| 378584 | drd2.L | dopamine receptor D2 L homeolog | Xenopus laevis (African clawed frog) | |
| 378695 | ins.L | insulin L homeolog | Xenopus laevis (African clawed frog) | |
| 378696 | ins.S | insulin S homeolog | Xenopus laevis (African clawed frog) | |
| 379783 | akt2.L | v-akt murine thymoma viral oncogene homolog 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 380341 | pon2.L | paraoxonase 2 L homeolog | Xenopus laevis (African clawed frog) | |
| 394283 | sdc2.S | syndecan 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397750 | hmgcr.L | 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 398006 | insr.L | insulin receptor L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171619 | C53D5.5 | Gamma-glutamyltranspeptidase 1 | |
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171905 | ace-2 | Carboxylic ester hydrolase | |
| 171999 | poml-2 | Arylesterase | |
| 172085 | ugt-26 | UDP-glucuronosyltransferase | |
| 172509 | gpdh-3 | putative glycerol-3-phosphate dehydrogenase, mitochondrial | |
| 173297 | F49B2.6 | Aminopeptidase | |
| 174685 | ptp-3 | Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase | |
| 175076 | ace-3 | Carboxylic ester hydrolase | |
| 175182 | ver-1 | Protein ver-1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850369 | ADP1 | putative ATP-dependent permease ADP1 | |
| 850391 | NPP1 | nucleotide diphosphatase/phosphodiesterase NPP1 | |
| 850614 | HXK1 | hexokinase 1 | |
| 850645 | BPT1 | ATP-binding cassette bilirubin transporter BPT1 | |
| 850678 | YBT1 | bile acid-transporting ATPase YBT1 | |
| 850886 | ATG26 | sterol 3-beta-glucosyltransferase | |
| 850979 | PIG1 | protein phosphatase regulator PIG1 | |
| 851006 | ECM38 | gamma-glutamyltransferase | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000855 | Insulin resistance |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 2645 | GCK | glucokinase |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 3990 | LIPC | lipase C, hepatic type |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
