SMAC (DIABLO) binds to IAPs
|
|
|
- APAF1
- API3
- BIRC4
- CASP3
- CASP7
- CASP9
- CPP32
- CYC
- CYCS
- DIABLO
- IAP3
- KIAA0413
- MCH3
- MCH6
- SMAC
- XIAP
|
|
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
|
|
|
- APAF1
- API3
- BIRC4
- CASP3
- CASP7
- CASP9
- CPP32
- CYC
- CYCS
- DIABLO
- IAP3
- KIAA0413
- MCH3
- MCH6
- SMAC
- XIAP
|
|
SMAC, XIAP-regulated apoptotic response
|
|
|
- API3
- BIRC4
- CASP3
- CASP7
- CPP32
- DIABLO
- IAP3
- MCH3
- SMAC
- XIAP
|
|
SMAD2/3 MH2 Domain Mutants in Cancer
|
|
|
- DPC4
- MADH2
- MADH3
- MADH4
- MADR2
- SMAD2
- SMAD3
- SMAD4
|
|
SMAD2/3 Phosphorylation Motif Mutants in Cancer
|
|
|
- ALK5
- MADH2
- MADH3
- MADR2
- SKR4
- SMAD2
- SMAD3
- TGFB
- TGFB1
- TGFBR1
- TGFBR2
|
|
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
|
|
|
- BHLHE39
- CCNC
- CCNK
- CCNT1
- CCNT2
- CDC2L4
- CDK8
- CDK9
- CDKN2B
- COL1A2
- CPR4
- DP1
- DP2
- DPC4
- E2F4
- E2F5
- EP300
- ERK1
- ERK2
- FUR
- FURIN
- HDAC1
- JUNB
- MADH2
- MADH3
- MADH4
- MADH7
- MADH8
- MADR2
- MAPK1
- MAPK3
- MEN1
- MTS2
- MYC
- NSEP1
- P300
- PACE
- PAI1
- PCSK3
- PLANH1
- PRKM1
- PRKM2
- PRKM3
- RBL1
- RNF111
- RPD3L1
- RPS27A
- SCG2
- SERPINE1
- SMAD2
- SMAD3
- SMAD4
- SMAD7
- SP1
- TAK
- TAZ
- TFDP1
- TFDP2
- TGIF
- TGIF1
- TGIF2
- TSFP1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WWTR1
- YB1
- YBX1
|
|
SMAD4 MH2 Domain Mutants in Cancer
|
|
|
- DPC4
- MADH2
- MADH3
- MADH4
- MADR2
- SMAD2
- SMAD3
- SMAD4
|
|
SOS-mediated signalling
|
|
|
- HRAS
- HRAS1
- IRS1
- IRS2
- NRAS
- SOS1
|
|
SRP-dependent cotranslational protein targeting to membrane
|
|
|
- BBC1
- CCG2
- D11S2243E
- D6S218E
- DDOST
- DXS648E
- EC45
- FAU
- FTE1
- KIAA0102
- KIAA0115
- LAMBR
- LAMR1
- MFTL
- MPS1
- NEDD6
- OST48
- QM
- RIG
- RPL1
- RPL10
- RPL10A
- RPL10L
- RPL11
- RPL12
- RPL13
- RPL13A
- RPL14
- RPL15
- RPL17
- RPL18
- RPL18A
- RPL19
- RPL21
- RPL22
- RPL22L1
- RPL23
- RPL23A
- RPL24
- RPL26
- RPL26L1
- RPL26P1
- RPL27
- RPL27A
- RPL28
- RPL29
- RPL3
- RPL30
- RPL31
- RPL32
- RPL34
- RPL35
- RPL35A
- RPL36
- RPL36A
- RPL36AL
- RPL37
- RPL37A
- RPL38
- RPL39
- RPL39L
- RPL39L1
- RPL3L
- RPL4
- RPL41
- RPL44
- RPL5
- RPL6
- RPL7
- RPL7A
- RPL8
- RPL9
- RPL9P7
- RPL9P8
- RPL9P9
- RPLP0
- RPLP1
- RPLP2
- RPN1
- RPN2
- RPP2
- RPS10
- RPS11
- RPS12
- RPS13
- RPS14
- RPS15
- RPS15A
- RPS16
- RPS17
- RPS17L
- RPS18
- RPS19
- RPS2
- RPS20
- RPS21
- RPS23
- RPS24
- RPS25
- RPS26
- RPS27
- RPS27A
- RPS27L
- RPS28
- RPS29
- RPS3
- RPS3A
- RPS4
- RPS4X
- RPS4Y
- RPS4Y1
- RPS4Y2
- RPS4Y2P
- RPS5
- RPS6
- RPS7
- RPS8
- RPS9
- RPSA
- RRP1
- SCAR
- SEC11A
- SEC11C
- SEC11L1
- SEC11L3
- SEC61A
- SEC61A1
- SEC61A2
- SEC61B
- SEC61G
- SPC12
- SPC18
- SPC21
- SPC22
- SPC25
- SPCS1
- SPCS2
- SPCS3
- SPCS4A
- SPCS4C
- SRP14
- SRP19
- SRP54
- SRP68
- SRP72
- SRP9
- SRPR
- SRPRA
- SRPRB
- SSR1
- SSR2
- SSR3
- SSR4
- SURF-3
- SURF3
- TRAM
- TRAM1
- TRAPA
- TRAPB
- TRAPD
- TRAPG
- TXREB1
- UBA52
- UBA80
- UBCEP1
- UBCEP2
|
|
STAT3 nuclear events downstream of ALK signaling
|
|
|
- AIM
- APRF
- B7H1
- BHLHE78
- BLIMP1
- CD274
- CXXC9
- DNMT
- DNMT1
- EP300
- HDAC1
- HDAC2
- HDAC3
- HIF1A
- IL2RG
- MOP1
- P300
- PASD8
- PDCD1L1
- PDCD1LG1
- PDL1
- PRDM1
- RPD3L1
- SIN3A
- STAT3
|
|
STAT5 Activation
|
|
|
- CD135
- FLK2
- FLT3
- FLT3LG
- GAB2
- KIAA0571
- PTP2C
- PTPN11
- SHPTP2
- STAT5
- STAT5A
- STAT5B
- STK1
|
|
STAT5 activation downstream of FLT3 ITD mutants
|
|
|
- ASH
- BCL2L
- BCL2L1
- BCLX
- CAP20
- CD135
- CDKN1
- CDKN1A
- CIP1
- FLK2
- FLT3
- GAB2
- GRB2
- KIAA0571
- MDA6
- NOX4
- PIC1
- PIM1
- PTP2C
- PTPN11
- RENOX
- SDI1
- SHPTP2
- STAT5
- STAT5A
- STAT5B
- STK1
- WAF1
|
|
STAT6-mediated induction of chemokines
|
|
|
- ERIS
- MITA
- NAK
- STAT6
- STING
- STING1
- TBK1
- TMEM173
|
|
STING mediated induction of host immune responses
|
|
|
- ABS
- C6orf150
- CGAS
- DDX41
- ERIS
- IFI16
- IFNGIP1
- MB21D1
- MITA
- RNF81
- RO52
- SSA1
- STING
- STING1
- TMEM173
- TRIM21
|
|
SUMO is conjugated to E1 (UBA2:SAE1)
|
|
|
- AOS1
- SAE1
- SAE2
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUA1
- SUMO1
- SUMO2
- SUMO3
- UBA2
- UBL1
- UBLE1A
- UBLE1B
|
|
SUMO is proteolytically processed
|
|
|
- KIAA1331
- SENP1
- SENP2
- SENP5
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUMO1
- SUMO2
- SUMO3
- UBL1
|
|
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
|
|
|
- AOS1
- RSUME
- RWDD3
- SAE1
- SAE2
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUA1
- SUMO1
- SUMO2
- SUMO3
- UBA2
- UBC9
- UBCE9
- UBE2I
- UBL1
- UBLE1A
- UBLE1B
|
|
SUMOylation of DNA damage response and repair proteins
|
|
|
- AAAS
- ADPRT
- ADRACALA
- BAM
- BAP1
- BLM
- BMH
- BMI1
- BRCA1
- C10orf86
- C7orf14
- C8orf36
- CAIN
- CALT
- CAN
- CBX2
- CBX4
- CBX8
- CDKN2
- CDKN2A
- CEN2
- CETN2
- CG1
- CSPG6
- D3S1231E
- DDXBP1
- DING
- DXS423E
- EDR1
- EDR2
- EDR3
- EID3
- HCA4
- HDAC7
- HDAC7A
- HERC2
- HIPI3
- HR21
- KIAA0023
- KIAA0078
- KIAA0095
- KIAA0169
- KIAA0170
- KIAA0178
- KIAA0197
- KIAA0225
- KIAA0594
- KIAA0618
- KIAA0791
- KIAA0906
- MAGEG1
- MDC1
- MEL18
- MLM
- MMS21
- MP44
- MRNP41
- MYL
- NDC1
- NDNL2
- NFBD1
- NPAP60L
- NSMCE1
- NSMCE2
- NSMCE3
- NSMCE4A
- NUP107
- NUP120
- NUP121
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP358
- NUP37
- NUP42
- NUP43
- NUP50
- NUP53
- NUP54
- NUP62
- NUP75
- NUP85
- NUP88
- NUP93
- NUPL2
- NXP1
- PARP1
- PC3
- PCGF2
- PCGF4
- PCNT1
- PH1
- PH2
- PH3
- PHC1
- PHC2
- PHC3
- PIAS1
- PIAS4
- PIASG
- PML
- POM121
- POM121A
- POM121C
- PP8675
- PPOL
- RAD21
- RAD52
- RAE1
- RANBP2
- RC1
- RECQ2
- RECQ3
- RECQL2
- RECQL3
- REPA1
- RING1
- RING1A
- RING1B
- RNF1
- RNF110
- RNF168
- RNF2
- RNF51
- RNF53
- RNF71
- RPA1
- RPA70
- SA1
- SA2
- SB1.8
- SCC1
- SCC3
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SMC1
- SMC1A
- SMC1L1
- SMC3
- SMC3L1
- SMC5
- SMC5L1
- SMC6
- SMC6L1
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SP100
- STAG1
- STAG2
- SUMO1
- SUMO2
- SUMO3
- TDG
- TMEM48
- TPR
- TRIM19
- UBC9
- UBCE9
- UBE2I
- UBL1
- WRN
- XPC
- XPCC
- XRCC4
- ZNF144
|
|
SUMOylation of DNA methylation proteins
|
|
|
- AIM
- BAP1
- BMI1
- CBX2
- CBX4
- CBX8
- CXXC9
- DING
- DNMT
- DNMT1
- DNMT3A
- DNMT3B
- EDR1
- EDR2
- EDR3
- HIPI3
- MEL18
- PC3
- PCGF2
- PCGF4
- PH1
- PH2
- PH3
- PHC1
- PHC2
- PHC3
- RC1
- RING1
- RING1A
- RING1B
- RNF1
- RNF110
- RNF2
- RNF51
- SMT3C
- SMT3H3
- SUMO1
- UBC9
- UBCE9
- UBE2I
- UBL1
- ZNF144
|
|
SUMOylation of DNA replication proteins
|
|
|
- AAAS
- ADRACALA
- AIK
- AIK2
- AIM1
- AIRK1
- AIRK2
- API4
- ARK1
- ARK2
- AURA
- AURKA
- AURKB
- AYK1
- BIRC5
- BTAK
- C7orf14
- CAIN
- CAN
- CDCA8
- CG1
- D3S1231E
- IAK1
- IAP4
- INCENP
- KIAA0023
- KIAA0095
- KIAA0169
- KIAA0197
- KIAA0225
- KIAA0618
- KIAA0791
- KIAA0906
- KIAA1835
- MP44
- MRNP41
- NDC1
- NPAP60L
- NUP107
- NUP120
- NUP121
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP358
- NUP37
- NUP42
- NUP43
- NUP50
- NUP53
- NUP54
- NUP62
- NUP75
- NUP85
- NUP88
- NUP93
- NUPL2
- PCNA
- PCNT1
- PESCRG3
- PIAS3
- PIAS4
- PIASG
- POM121
- POM121A
- POM121C
- RAE1
- RANBP2
- RANGAP1
- SD
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- STK1
- STK12
- STK15
- STK5
- STK6
- SUMO1
- SUMO2
- SUMO3
- TMEM48
- TOP1
- TOP2
- TOP2A
- TOP2B
- TPR
- UBC9
- UBCE9
- UBE2I
- UBL1
|
|
SUMOylation of RNA binding proteins
|
|
|
- AAAS
- ADRACALA
- BAP1
- BMI1
- C7orf14
- CAIN
- CAN
- CBX2
- CBX4
- CBX8
- CG1
- D3S1231E
- DING
- EDR1
- EDR2
- EDR3
- HIPI3
- HNRNPC
- HNRNPK
- HNRPC
- HNRPK
- KIAA0023
- KIAA0095
- KIAA0169
- KIAA0197
- KIAA0225
- KIAA0618
- KIAA0791
- KIAA0906
- MEL18
- MP44
- MRNP41
- NDC1
- NOL5
- NOP5
- NOP58
- NPAP60L
- NUP107
- NUP120
- NUP121
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP358
- NUP37
- NUP42
- NUP43
- NUP50
- NUP53
- NUP54
- NUP62
- NUP75
- NUP85
- NUP88
- NUP93
- NUPL2
- PC3
- PCGF2
- PCGF4
- PCNT1
- PH1
- PH2
- PH3
- PHC1
- PHC2
- PHC3
- POM121
- POM121A
- POM121C
- RAE1
- RANBP2
- RC1
- RING1
- RING1A
- RING1B
- RNF1
- RNF110
- RNF2
- RNF51
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SMT3B
- SMT3C
- SMT3H2
- SMT3H3
- SUMO1
- SUMO2
- TMEM48
- TPR
- UBC9
- UBCE9
- UBE2I
- UBL1
- ZNF144
|
|
SUMOylation of SUMOylation proteins
|
|
|
- AAAS
- ADRACALA
- C7orf14
- CAIN
- CAN
- CG1
- D3S1231E
- KIAA0023
- KIAA0095
- KIAA0169
- KIAA0197
- KIAA0225
- KIAA0618
- KIAA0791
- KIAA0906
- LUN
- MP44
- MRNP41
- NDC1
- NPAP60L
- NUP107
- NUP120
- NUP121
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP358
- NUP37
- NUP42
- NUP43
- NUP50
- NUP53
- NUP54
- NUP62
- NUP75
- NUP85
- NUP88
- NUP93
- NUPL2
- PCNT1
- PIAS4
- PIASG
- POM121
- POM121A
- POM121C
- RAE1
- RANBP2
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SMT3B
- SMT3C
- SMT3H2
- SMT3H3
- SUMO1
- SUMO2
- TMEM48
- TOPORS
- TP53BPL
- TPR
- UBC9
- UBCE9
- UBE2I
- UBL1
|
|
SUMOylation of chromatin organization proteins
|
|
|
- AAAS
- ADRACALA
- ALTE
- BAP1
- BMI1
- C7orf14
- CAIN
- CAN
- CBX2
- CBX4
- CBX5
- CBX8
- CG1
- CHD3
- CHET9
- D3S1231E
- DDXBP1
- DING
- DREF
- EDR1
- EDR2
- EDR3
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HDAC1
- HDAC2
- HDAC4
- HIPI3
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST4H4
- HP1A
- JJAZ1
- KIAA0023
- KIAA0095
- KIAA0160
- KIAA0169
- KIAA0197
- KIAA0225
- KIAA0288
- KIAA0618
- KIAA0785
- KIAA0791
- KIAA0906
- KIAA1034
- L3MBTL2
- MEL18
- MP44
- MRNP41
- NDC1
- NPAP60L
- NUP107
- NUP120
- NUP121
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP358
- NUP37
- NUP42
- NUP43
- NUP50
- NUP53
- NUP54
- NUP62
- NUP75
- NUP85
- NUP88
- NUP93
- NUPL2
- PC3
- PCGF2
- PCGF4
- PCNT1
- PH1
- PH2
- PH3
- PHC1
- PHC2
- PHC3
- PIAS1
- POM121
- POM121A
- POM121C
- RAE1
- RANBP2
- RC1
- RING1
- RING1A
- RING1B
- RNF1
- RNF110
- RNF2
- RNF51
- RPD3L1
- SATB1
- SATB2
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUMO1
- SUMO2
- SUMO3
- SUZ12
- TMEM48
- TPR
- TRAMP
- UBC9
- UBCE9
- UBE2I
- UBL1
- ZBED1
- ZNF144
- hDREF
|
|
SUMOylation of immune response proteins
|
|
|
- EIF2AK2
- FIP3
- IKBA
- IKBKE
- IKBKG
- IKKE
- IKKI
- KIAA0151
- LUN
- LYT10
- MAD3
- NEMO
- NFKB2
- NFKB3
- NFKBI
- NFKBIA
- PIAS3
- PIAS4
- PIASG
- PKR
- PRKR
- RELA
- SMT3A
- SMT3C
- SMT3H1
- SMT3H3
- SUMO1
- SUMO3
- TOPORS
- TP53BPL
- UBC9
- UBCE9
- UBE2I
- UBL1
|
|
SUMOylation of intracellular receptors
|
|
|
- AD4BP
- AR
- DDXBP1
- DHTR
- ERBA2
- ESR
- ESR1
- FTZF1
- GRL
- HDAC4
- KIAA0288
- LXRB
- MCR
- MLR
- NER
- NOT
- NR1A2
- NR1B1
- NR1C1
- NR1C3
- NR1F1
- NR1H2
- NR1I1
- NR2B1
- NR2C1
- NR3A1
- NR3C1
- NR3C2
- NR3C3
- NR3C4
- NR4A2
- NR5A1
- NURR1
- PGR
- PIAS1
- PIAS3
- PIAS4
- PIASG
- PPAR
- PPARA
- PPARG
- RARA
- RORA
- RXRA
- RZRA
- SF1
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUMO1
- SUMO2
- SUMO3
- THR1
- THRB
- TINUR
- TR2
- UBC9
- UBCE9
- UBE2I
- UBL1
- UNR
- VDR
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