GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **226 - 250** of **1070** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism
Aggrephagy	ADP-ribosylation factor like GTPase 13B Centrin 1 Cystic fibrosis transmembrane conductance regulator Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 ubiquitin-protein ligase parkin Intraflagellar transport 88 Parkinson disease protein 7 homolog Pericentrin Polyubiquitin-B Polyubiquitin-C Ubiquitin B-like Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I5ZPQ6 A0A8I6A3Q1 A0A8I6A5Y3 D3ZMY8 G3V832 M0RDU9 O88767 P0CG51 P34158 P38650 P62982 P63170 Q62698 Q62871 Q63100 Q63429 Q78P75 Q9JK66 Q9QXU8	Abcc7 Arl13b Cap1 Cetn1 Cftr Dhc1 Dlc2 Dnch1 Dnchc1 Dnci1 Dnci2 Dncic1 Dncic2 Dncl1 Dnclc1 Dncli1 Dncli2 Dnec1 Dyhc Dync1h1 Dync1i1 Dync1i2 Dync1li1 Dync1li2 Dynll1 Dynll2 ENSRNOG00000067007 Ift88 LOC100360645 LOC309692 Map1c Park2 Park7 Pcnt Pin Prkn Rps27a Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1	Rattus norvegicus (Norway rat)
Retrograde transport at the Trans-Golgi-Network	ADP-ribosylation factor-like protein 1 ADP-ribosylation factor-related protein 1 Alpha-soluble NSF attachment protein Arfaptin-2 Beta-soluble NSF attachment protein Cation-dependent mannose-6-phosphate receptor Conserved oligomeric Golgi complex subunit 1 Conserved oligomeric Golgi complex subunit 2 Conserved oligomeric Golgi complex subunit 3 Conserved oligomeric Golgi complex subunit 4 Conserved oligomeric Golgi complex subunit 5 Conserved oligomeric Golgi complex subunit 6 Conserved oligomeric Golgi complex subunit 7 GRIP and coiled-coil domain containing 1 GRIP and coiled-coil domain-containing protein 2 Gamma-soluble NSF attachment protein Golgin A1 Golgin subfamily A member 4 Insulin-like growth factor 2 receptor Protein RIC1 homolog RAB6B, member RAS oncogene family RAB9B, member RAS oncogene family RGP1 homolog, RAB6A GEF complex partner 1 Rab9 effector protein with kelch motifs Ras-related protein Rab-43 Ras-related protein Rab-6A Ras-related protein Rab-9A Rho-related BTB domain containing 3 Short coiled-coil protein Syntaxin 16 Syntaxin-6 Sys1 golgi trafficking protein TATA element modulatory factor 1 Trans-Golgi network integral membrane protein TGN38 USP6 N-terminal like Vacuolar protein sorting-associated protein 51 homolog Vacuolar protein sorting-associated protein 52 homolog Vacuolar protein sorting-associated protein 53 homolog Vacuolar protein sorting-associated protein 54 Vesicle transport through interaction with t-SNAREs homolog 1A Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-fusing ATPase	A0A096MJ99 A0A0G2JT78 A0A0G2JZ48 A0A0G2K350 A0A0G2K528 A0A0G2K9P5 A0A8I5ZYV2 A0A8I6AFV4 A0A8I6AQS5 A0A8I6AU01 A0A8I6AXD4 A0A8I6GJ60 D3ZP15 D3ZPA1 D3ZT01 D3ZW90 D3ZZL9 D3ZZM3 D4A224 D4A6K4 F1M4I4 G3V824 O55166 P19814 P54921 P61212 P63025 P85969 Q3T1G7 Q4V8F4 Q53B90 Q5RJZ6 Q5U4E6 Q63055 Q63635 Q68FP9 Q6AY20 Q6AY65 Q99P75 Q9JI51 Q9JMK8 Q9QUL6 Q9WVB1	Are1 Arf7 Arfip2 Arfrp1 Arl1 Arp1 Cog1 Cog2 Cog3 Cog4 Cog5 Cog6 Cog7 Dbndd2 Erg1 Gcc1 Gcc185 Gcc2 Golga1 Golga4 Igf2r M6pr Napa Napb Napg Nsf RGD1310016 Rab43 Rab6 Rab6a Rab6b Rab9 Rab9a Rab9b Rabepk Rgp1 Rhobtb3 Ric1 Sacm2l Scoc Scoco Snap Snapa Snapb Stx16 Stx6 Syb3 Sys1 Tmf1 Ttgn1 Usp6nl Vamp3 Vamp4 Vps51 Vps52 Vps53 Vps54 Vps54l Vti1a Vti1l2	Rattus norvegicus (Norway rat)
RAS processing	ADP-ribosylation factor-like protein 2 Acyl-protein thioesterase 1 Alpha/beta hydrolase domain-containing protein 17A Alpha/beta hydrolase domain-containing protein 17B Alpha/beta hydrolase domain-containing protein 17C Bcl-2-like protein 1 CAAX prenyl protease 2 Calmodulin-3 GTPase HRas GTPase KRas GTPase NRas Golgin subfamily A member 7 Palmitoyltransferase Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Protein kinase C theta type Protein-S-isoprenylcysteine O-methyltransferase Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase cGMP-dependent protein kinase 2	A0A8I5ZMP6 A0A8I5ZS01 A0A8I6AGE4 A0A8I6AMA7 B0BMW8 B5DFK7 D3ZRD3 F7F533 O08697 P08644 P0DP31 P20171 P53563 P70470 Q02293 Q04631 Q04970 Q5XIJ5 Q64595 Q6AY17 Q6AYQ1 Q9WTQ0 Q9WVM4	Abhd17a Abhd17b Abhd17c Apt1 Arl184 Arl2 Bcl2l1 Bclx Blc2l CaMIII Calm3 Cam3 Camc ENSRNOG00000064803 ENSRNOG00000067432 Fnta Fntb Golga7 Hras Hras1 Icmt Kras Kras2 LOC100910107 LOC120097921 LOC120098474 Lypla1 Nras Pde6d Pkcq Prkcq Prkg2 Rce1 Usp17l Usp17l8 Usp17la Usp17la2 Usp17lh Usp17li Zdhhc9	Rattus norvegicus (Norway rat)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	ADP-ribosylation factor-like protein 2-binding protein ADP-ribosylation factor-like protein 2 ADP/ATP translocase 1 ADP/ATP translocase 2 Equilibrative nucleoside transporter 1 Equilibrative nucleoside transporter 2 Equilibrative nucleoside transporter 3 Sodium/nucleoside cotransporter 1 Sodium/nucleoside cotransporter 2 Solute carrier family 28 member 3 Solute carrier family 29 member 4	F1M2Y4 O08697 O54698 O54699 Q05962 Q09073 Q4V8C5 Q62674 Q62773 Q80WK7 Q8VIH3	Aac1 Ant1 Ant2 Arl184 Arl2 Arl2bp Bart Bart1 Cnt1 Cnt2 Cnt3 Ent1 Ent2 Ent3 Slc25a4 Slc25a5 Slc28a1 Slc28a2 Slc28a3 Slc29a1 Slc29a2 Slc29a3 Slc29a4 Spnt	Rattus norvegicus (Norway rat)
BBSome-mediated cargo-targeting to cilium	ADP-ribosylation factor-like protein 6 Bardet-Biedl syndrome 1 Bardet-Biedl syndrome 2 protein homolog Bardet-Biedl syndrome 4 Bardet-Biedl syndrome 7 protein homolog Bardet-Biedl syndrome 9 Leucine zipper transcription factor-like protein 1 Melanin-concentrating hormone receptor 1 Protein smoothened Rab-3A-interacting protein Somatostatin receptor type 3 Tetratricopeptide repeat domain 8	A0A1P8YVD0 A0A8I6AHB5 A0A8I6GF94 D4A4U2 F1M285 P30936 P97639 P97698 Q562C6 Q62739 Q66H90 Q99MH9	Arl6 Bbs1 Bbs2 Bbs4 Bbs7 Bbs9 Gpr24 Lztfl1 Mchr1 Rab3ip Rabin3 Rabin8 Slc1 Smo Smoh Sstr3 Ttc8	Rattus norvegicus (Norway rat)
PKMTs methylate histone lysines	AE binding protein 2 ASH1 like histone lysine methyltransferase ASH2 like histone lysine methyltransferase complex subunit Actin-histidine N-methyltransferase Activating transcription factor 7 interacting protein Embryonic ectoderm development Euchromatic histone lysine methyltransferase 1 Euchromatic histone lysine methyltransferase 2 Histone H3.1 Histone H3 Histone H4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase KMT5B Histone-lysine N-methyltransferase KMT5C Histone-lysine N-methyltransferase PRDM9 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase, H3 lysine-79 specific Histone-lysine N-methyltransferase Histone-lysine N-methyltransferase Histone-lysine N-methyltransferase N-lysine methyltransferase SETD6 N-lysine methyltransferase SMYD2 Nuclear factor kappa B subunit 2 Nuclear receptor binding SET domain protein 1 Nuclear receptor binding SET domain protein 2 Nuclear receptor binding SET domain protein 3 PR/SET domain 16 RB binding protein 4, chromatin remodeling factor RB binding protein 5, histone lysine methyltransferase complex subunit RELA proto-oncogene, NF-kB subunit SET domain bifurcated histone lysine methyltransferase 1 SET domain containing 1A, histone lysine methyltransferase SET domain containing 1B, histone lysine methyltransferase SUZ12 polycomb repressive complex 2 subunit WD repeat-containing protein 5 [histone H3]-lysine(36) N-trimethyltransferase [histone H3]-lysine(4) N-methyltransferase [histone H3]-lysine(4) N-methyltransferase [histone H3]-lysine(4) N-trimethyltransferase [histone H4]-lysine(20) N-methyltransferase	A0A096MKA6 A0A0G2K001 A0A0G2K1E3 A0A0G2K6T6 A0A0G2K889 A0A8I5ZMV7 A0A8I5ZRT2 A0A8I6A054 A0A8I6A0F7 A0A8I6A1E5 A0A8I6A3A4 A0A8I6A4Z1 A0A8I6A5I9 A0A8I6AIG5 A0A8I6AMN8 A0A8I6ANV4 A0A8I6AQI0 A0A8I6G6F3 A0A8I6GKG3 A0A8J8XWH8 A0A8J8YPE2 B5DFE2 D3ZC01 D3ZIH5 D3ZJ08 D3ZS88 D3ZSK5 D3ZTV7 D4A081 D4A9J4 F1M0L3 G3V6U9 M0R6H5 P0C2N5 P0C2N6 P0C6Y7 P62804 Q498M4 Q4V8B9 Q6LED0 Q71UF4 Q7M6Z3	Aebp2 Ash1l Ash2l Atf7ip Dot1l Eed Ehmt1 Ehmt2 Ezh2 H3c13 H4c16 H4c2 H4f16 H4ft Hist1h4b Hist1h4m Hist2h3c2 Hist4 Hist4h4 Kmt2a Kmt2b Kmt2c Kmt5a Kmt5b Kmt5c LOC120093163 LOC498295 Mll Mll1 Nfkb2 Nsd1 Nsd2 Nsd3 Prdm16 Prdm9 Rbbp4 Rbbp5 Rbbp7 Rela Setd1a Setd1b Setd2 Setd3 Setd6 Setd7 Setdb1 Setdb2 Smyd2 Smyd3 Suv39h1 Suv39h2 Suv420h1 Suv420h2 Suz12 Wdr5 Whsc1 Whsc1l1	Rattus norvegicus (Norway rat)
PRC2 methylates histones and DNA	AE binding protein 2 DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5-)-methyltransferase Embryonic ectoderm development Histone H2A type 2-A Histone H2A.J Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B type 1-A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H3.1 Histone H3.3 Histone H3 Histone H4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Jumonji and AT-rich interaction domain containing 2 Metal response element binding transcription factor 2 PHD finger protein 19 PHD finger protein 1 RB binding protein 4, chromatin remodeling factor SUZ12 polycomb repressive complex 2 subunit	A0A0G2JXI9 A0A0G2K557 A0A8I5ZSA8 A0A8I5ZSG2 A0A8I5ZYY0 A0A8I6A054 A0A8I6A2W1 A0A8I6A7P3 A0A8I6AFW8 A0A8I6AIG5 A0A8I6AQI0 A0A8I6AWT3 A0A8I6G659 A0A8J8XG14 A0A8J8YPE2 A9UMV8 B5DFE2 D3ZJ08 D3ZVK7 D3ZXP3 D4ACM0 F1M1Y4 G3V9C7 M0RBQ5 M0RBV7 P0CC09 P62804 P84245 Q00729 Q1LZ53 Q6LED0 Q71UF4 Q9Z330	Aebp2 Dnmt1 Dnmt3a Dnmt3b ENSRNOG00000062927 ENSRNOG00000064540 ENSRNOG00000066901 ENSRNOG00000068034 Eed Ezh2 H2ab3 H2ac10 H2ac18 H2ac4 H2afb3 H2afx H2aj H2ax H2az2 H2bc1 H2bc12l1 H2bc6 H2bcl1 H2bcl2 H2bu1 H3-3b H3.3b H3c13 H3f3b H4c16 H4c2 H4f16 H4ft Hist1h2ba Hist1h2bc Hist1h2bg Hist1h2bo Hist1h2bq Hist1h4b Hist1h4m Hist2h2aa3 Hist2h3c2 Hist4 Hist4h4 Jarid2 LOC100365043 LOC100910200 LOC120097726 LOC681740 LOC684797 Mtf2 Phf1 Phf19 Rbbp4 Rbbp7 Suz12 Th2b	Rattus norvegicus (Norway rat)
Processing of SMDT1	AFG3 like matrix AAA peptidase subunit 2 ATP-dependent zinc metalloprotease YME1L1 Calcium uniporter protein Calcium uniporter regulatory subunit MCUb Calcium uptake protein 1, mitochondrial Calcium uptake protein 2, mitochondrial Essential MCU regulator, mitochondrial Mitochondrial calcium uptake family, member 3 Mitochondrial inner membrane m-AAA protease component paraplegin Mitochondrial-processing peptidase subunit alpha Mitochondrial-processing peptidase subunit beta Presenilin-associated rhomboid-like protein, mitochondrial Prohibitin 1 Prohibitin-2 Stomatin-like protein 2, mitochondrial m-AAA protease-interacting protein 1, mitochondrial	A0A0G2K059 A0A8I6A2H6 A0A8I6ASM9 F1LN92 F1LUQ0 P20069 P67779 Q03346 Q3B8P0 Q4FZT0 Q5XIH7 Q6AY04 Q6P6Q9 Q7TT47 Q925S8 Q99P63	Afg3l2 Bcap37 Cbara1 Efha1 Maip1 Mcu Mcub Micu1 Micu2 Micu3 Mppa Mppb Parl Phb Phb1 Phb2 Pmpca Pmpcb Psarl Smdt1 Smhs2 Spg7 Stoml2 Yme1l1	Rattus norvegicus (Norway rat)
Aryl hydrocarbon receptor signalling	AH receptor-interacting protein Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Heat shock protein HSP 90-beta Prostaglandin E synthase 3	P34058 P41738 P41739 P83868 Q5FWY5 Q75NT5 Q78E60	Ahr Ahrr Aip Arnt Arnt2 Hsp84 Hsp90ab1 Hspc3 Hspcb Ptges3 Tebp Xap2	Rattus norvegicus (Norway rat)
HSF1-dependent transactivation	AKT1 substrate 1 Alpha-crystallin B chain Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma DnaJ heat shock protein family (Hsp40) member B1 Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock factor-binding protein 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock protein beta-8 Heat shock transcription factor 1 Regulatory associated protein of MTOR, complex 1 Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	A0A8I5ZRQ9 D3ZDU2 D3ZUU5 F1MAF1 P08413 P0DMW0 P0DMW1 P11275 P11730 P15791 P23928 P34058 P42346 P55063 P63018 P82995 Q8K3X8 Q9EPX0 Q9Z2K5	Akt1s1 Camk2a Camk2b Camk2d Camk2g Cryab Cryac Dnajb1 Frap1 Gbl Hsbp1 Hsc70 Hsc73 Hsf1 Hsp22 Hsp70-1 Hsp70-2 Hsp70-3 Hsp84 Hsp86 Hsp90aa1 Hsp90ab1 Hspa1 Hspa1a Hspa1b Hspa1l Hspa2 Hspa8 Hspb8 Hspc3 Hspca Hspcb Lst8 Mlst8 Mtor Raft1 Rptor	Rattus norvegicus (Norway rat)
AKT phosphorylates targets in the cytosol	AKT1 substrate 1 Caspase-9 Cyclin-dependent kinase inhibitor 1A Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 Inhibitor of nuclear factor kappa-B kinase subunit alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RING-type E3 ubiquitin transferase Tuberin	A0A0G2QC40 A0A8I5ZRQ9 A0A8I5ZZ18 A0A8I6ANR6 A0A8I6G5V3 O08769 P47196 P47197 P49816 Q63484 Q9JHK1	Akt1 Akt1s1 Akt2 Akt3 Casp9 Cdkn1a Cdkn1b Chuk Mdm2 Mkrn1 RNCASP9 Tsc2 p27Kip1	Rattus norvegicus (Norway rat)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase Alpha-1,3-glucosyltransferase Alpha-1,3/1,6-mannosyltransferase ALG2 Dol-P-Man Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Mannose-P-dolichol utilization defect 1 Mannosyltransferase Mannosyltransferase UDP-N-acetylglucosamine transferase subunit ALG13 UDP-N-acetylglucosamine transferase subunit ALG14 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	A0A8I6B3Y3 B1WBY3 D3ZCW5 D4A5S6 E9PT91 F7EMK2 G3V6U3 M0R7D2 Q3T1L5 Q5I0K7 Q6AY85	Alg1 Alg12 Alg13 Alg14 Alg2 Alg3 Alg6 Alg8 Alg9 Dpagt1 Mpdu1	Rattus norvegicus (Norway rat)
Signaling by LTK	ALK and LTK ligand 1 ALK and LTK ligand 2 Activated CDC42 kinase 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase receptor	A0A0G2K344 A0A8I6GCV6 B2RZ42 D4A3T0 M0R9C8 P35570 P62994 Q5M824 Q5U2X5 Q63787 Q63788 Q9Z1L0	Ack1 Alkal1 Alkal2 Ash Fam150a Grb2 Irs-1 Irs1 LOC100910984 Ltk Pik3ca Pik3cb Pik3r1 Pik3r2 Shc1 Sos1 Tnk2	Rattus norvegicus (Norway rat)
Purine salvage	AMP deaminase 1 AMP deaminase 2 AMP deaminase 3 Adenine phosphoribosyltransferase Adenosine deaminase Adenosine kinase Deoxycytidine kinase Deoxyguanosine kinase GMP reductase 1 GMP reductase Hypoxanthine-guanine phosphoribosyltransferase Purine nucleoside phosphorylase	A0A0G2K478 O09178 P10759 P27605 P36972 P48769 P85973 Q02356 Q5FVP6 Q64640 Q920P6 Q9Z244	Ada Adk Ampd1 Ampd2 Ampd3 Aprt Dck Dguok GMPR Gmpr Gmpr1 Gmpr2 Hprt Hprt1 Np Pnp	Rattus norvegicus (Norway rat)
Cargo recognition for clathrin-mediated endocytosis	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma AP2-associated protein kinase 1 Adaptin ear-binding coat-associated protein 1 Adaptin ear-binding coat-associated protein 2 Amphiregulin Apolipoprotein B-100 Arf-GAP domain and FG repeat-containing protein 1 Beta-2 adrenergic receptor Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Betacellulin COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 6 COP9 signalosome complex subunit 8 COP9 signalosome subunit 5 COP9 signalosome subunit 7A COP9 signalosome subunit 7B Cation-dependent mannose-6-phosphate receptor Clathrin coat assembly protein AP180 Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Cystic fibrosis transmembrane conductance regulator Disabled homolog 2 Dishevelled segment polarity protein 2 Dyslexia-associated protein KIAA0319 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor pathway substrate 15-like 1 Epidermal growth factor receptor pathway substrate 15 Epsin-1 Epsin-2 F-BAR domain only protein 2 FCH and mu domain containing endocytic adaptor 1 Frizzled-4 G protein-coupled receptor kinase 3 Growth factor receptor-bound protein 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Insulin-like growth factor 2 receptor Interleukin-7 receptor subunit alpha Intersectin 2 Intersectin-1 Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Low-density lipoprotein receptor Lysosome membrane protein 2 Muscarinic acetylcholine receptor M2 NEDD8 Phosphatidylinositol-binding clathrin assembly protein Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protein Wnt-5a Protransforming growth factor alpha RALBP1 associated Eps domain containing 1 RALBP1 associated Eps domain containing 2 Receptor protein-tyrosine kinase SH3 domain-containing kinase-binding protein 1 Serotransferrin Signal transducing adapter molecule 2 Signal transducing adaptor molecule Solute carrier family 2, facilitated glucose transporter member 8 Stonin-1 Stonin-2 Substance-P receptor Synaptotagmin-11 Synaptotagmin-1 Synaptotagmin-2 Synaptotagmin-8 Synaptotagmin-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Torsin-1A Trans-Golgi network integral membrane protein TGN38 Transferrin receptor protein 1 Type-1 angiotensin II receptor A Ubiquilin 2 Ubiquilin-1 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 Vesicular acetylcholine transporter	A0A096MJ99 A0A8I5YBR2 A0A8I5YC99 A0A8I6A4J2 A0A8I6A5Y3 A0A8I6A726 A0A8I6A8K6 A0A8I6A974 A0A8I6AED1 A0A8I6AQ55 A0A8I6G3R2 A0A8I6GJC5 B5DF55 D3ZAR1 D3ZB71 D3ZIM5 D3ZU52 D3ZYR1 D4A3X8 D4AA63 D4AB66 F1MAA2 F7EUU4 G3V6K6 G3V824 O08835 O35179 O35180 O35964 O55012 O88339 O88797 P01134 P01186 P05540 P07522 P08081 P08082 P0C1X8 P0CG51 P0CI71 P10608 P10980 P11442 P12346 P14600 P18484 P19377 P19814 P21707 P24338 P25095 P26817 P26819 P27615 P29066 P29067 P29101 P34158 P35952 P61203 P62744 P62944 P62982 P62994 P63025 P63045 P69682 P84092 P97834 P98158 Q00788 Q05140 Q06175 Q4KLH5 Q5XHY7 Q62666 Q63429 Q64159 Q68FS2 Q68FW9 Q68G38 Q6AY20 Q6P4Z9 Q6P756 Q71UE8 Q7TMA5 Q925B4 Q925C0 Q925Q9 Q99376 Q9JHW5 Q9JJ50 Q9JJP9 Q9JJZ1 Q9QXQ7 Q9QZH0 Q9WUF4 Q9WVE9 Q9Z0L5 Q9Z1Z3	Aak1 Abcc7 Adrb2 Adrb2r Adrbk1 Adrbk2 Adtab Agfg1 Agfg1-ps1 Agtr1 Agtr1a Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Apob Areg Arh Arrb1 Arrb2 Ash At1a Avp Avpr2 Btc Calm Cbl Cd36l2 Cd3d Cd3g Cd4 Cftr Chrm-2 Chrm2 Clapb1 Claps2 Clta Cltb Cltc Cops1 Cops2 Cops3 Cops4 Cops5 Cops6 Cops7a Cops7b Cops8 Csn1 Csn2 Csn3 Csn4 Csn8 Da41 Dab2 Doc2 Dtr Dvl2 Dyt1 Egf Egfr Ehsh1 Epn1 Epn2 Eps15 Eps15l1 Ereg Fcho1 Fcho2 Fzd4 Glut8 Glutx1 Gps1 Grb2 Grk2 Grk3 Hbegf Hegfl Hgs Hrb Hrs Hrs2 Igf2r Il7r Itsn Itsn1 Itsn2 LOC100360645 LOC100361515 Ldlr Ldlrap1 Limpii Lrp2 M6pr Necap1 Necap2 Nedd8 Picalm Plic1 Reps1 Reps2 Rip Rps27a Ruk Scarb2 Sdgf Seta Sh3d2a Sh3d2c1 Sh3gl1 Sh3gl2 Sh3gl3 Sh3kbp1 Sh3p13 Sh3p4 Sh3p8 Slc18a3 Slc2a8 Snap91 Stam Stam2 Ston1 Ston2 Syb2 Syb3 Sybl1 Syt1 Syt11 Syt2 Syt5 Syt8 Syt9 T3d Tac1r Tacr1 Tf Tfrc Tgfa Tor1a Trfr Trip15 Ttgn1 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ubqln1 Ubqln2 Vacht Vamp2 Vamp3 Vamp4 Vamp7 Vamp8 Vat Wnt-5a Wnt5a	Rattus norvegicus (Norway rat)
LDL clearance	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Apolipoprotein B-100 Clathrin heavy chain 1 Clathrin light chain A Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor Lysosomal acid lipase/cholesteryl ester hydrolase NPC intracellular cholesterol transporter 1 NPC intracellular cholesterol transporter 2 Neutral cholesterol ester hydrolase 1 Proprotein convertase subtilisin/kexin type 9 Sterol O-acyltransferase 1 Sterol O-acyltransferase 2	A0A8I6A4J2 A0A8I6AWS0 B2GV54 D3ZAR1 G3V7K5 O70536 P08081 P11442 P18484 P35952 P59996 P62744 P62944 P84092 Q64194 Q7TMA5 Q7TQM4	Aadacl1 Acact Acat Acat2 Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Apob Arh Clapb1 Claps2 Clta Cltc Lal Ldlr Ldlrap1 Lip1 Lipa Narc1 Nceh1 Npc1 Npc2 Pcsk9 Soat1 Soat2	Rattus norvegicus (Norway rat)
WNT5A-dependent internalization of FZD4	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Beta-arrestin-2 Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Dishevelled segment polarity protein 2 Frizzled-4 Protein Wnt-5a Protein kinase C alpha type Protein kinase C beta type Protein kinase C gamma type	A0A8I6A4J2 D3ZB71 P05696 P08081 P08082 P11442 P18484 P29067 P62744 P62944 P63319 P68403 P84092 Q9QXQ7 Q9QZH0	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Arrb2 Clapb1 Claps2 Clta Cltb Cltc Dvl2 Fzd4 LOC100361515 Pkca Pkcb Pkcc Pkcg Prkca Prkcb Prkcb1 Prkcc Prkcg Wnt-5a Wnt5a	Rattus norvegicus (Norway rat)
Retrograde neurotrophin signalling	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Beta-nerve growth factor Clathrin heavy chain 1 Clathrin light chain A Dynein light chain Endophilin-A1 High affinity nerve growth factor receptor	A0A8I6A4J2 O35179 P08081 P11442 P18484 P25427 P35739 P62744 P62944 P84092 Q5PPH7	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Clapb1 Claps2 Clta Cltc Dnal4 Ngf Ngfb Ntrk1 Sh3d2a Sh3gl2 Sh3p4 Trk Trka	Rattus norvegicus (Norway rat)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Frizzled-2 Frizzled-5 Protein Wnt-5a Receptor tyrosine kinase-like orphan receptor 1 Receptor tyrosine kinase-like orphan receptor 2	A0A8I6A4J2 D3ZNY8 D3ZZ97 P08081 P08082 P11442 P18484 P62744 P62944 P84092 Q08464 Q8CHL0 Q9QXQ7	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Clapb1 Claps2 Clta Cltb Cltc Fzd2 Fzd5 Ror1 Ror2 Wnt-5a Wnt5a	Rattus norvegicus (Norway rat)
Recycling pathway of L1	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin light chain A Dihydropyrimidinase-related protein 2 Dynamin-1 Dynamin-2 Dynamin-3 Endophilin-A1 Ezrin Kinesin family member 4A Kinesin family member 4B Mitogen-activated protein kinase 1 Moesin Neural cell adhesion molecule L1 Protein numb homolog Proto-oncogene tyrosine-protein kinase Src Radixin	A0A8I6A4J2 A0A8I6GLI2 E9PSJ3 E9PT65 O35179 O35763 P08081 P11442 P18484 P21575 P31977 P39052 P47942 P62744 P62944 P63086 P84092 Q05695 Q08877 Q2LC84 Q9WUD9	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Caml1 Clapb1 Claps2 Clta Cltc Dnm Dnm1 Dnm2 Dnm3 Dpysl2 Dyn2 Dyn3 Erk2 Ezr Kif4a Kif4b L1cam Mapk Mapk1 Msn Numb Prkm1 Rdx Sh3d2a Sh3gl2 Sh3p4 Src Vil2	Rattus norvegicus (Norway rat)
VLDLR internalisation and degradation	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin light chain A E3 ubiquitin-protein ligase MYLIP Oxysterols receptor LXR-alpha Oxysterols receptor LXR-beta Polyubiquitin-B Polyubiquitin-C Proprotein convertase subtilisin/kexin type 9 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein Very low-density lipoprotein receptor	A0A8I6A4J2 A0A8I6A5Y3 D3ZDI6 P08081 P0CG51 P11442 P18484 P59996 P62744 P62944 P62982 P84092 P98166 Q62685 Q62755 Q63429	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Clapb1 Claps2 Clta Cltc LOC100360645 Lxra Lxrb Mylip Narc1 Nr1h2 Nr1h3 Pcsk9 Rps27a Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Vldlr	Rattus norvegicus (Norway rat)
Trafficking of GluR2-containing AMPA receptors	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Glutamate receptor 1 Glutamate receptor 2 Glutamate receptor 3 Glutamate receptor 4 Glutamate receptor-interacting protein 1 Glutamate receptor-interacting protein 2 PRKCA-binding protein Protein kinase C alpha type Protein kinase C beta type Protein kinase C gamma type Tetraspanin Vesicle-fusing ATPase	A0A8I6A4J2 B0BNE7 P05696 P18484 P19490 P19491 P19492 P19493 P62744 P62944 P63319 P68403 P84092 P97879 Q9EP80 Q9QUL6 Q9WTW1	Adtab Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Clapb1 Claps2 Erg1 GluA1 GluA2 GluA3 Glur1 Glur2 Glur3 Glur4 Gria1 Gria2 Gria3 Gria4 Grip1 Grip2 Nsf Pick1 Pkca Pkcb Pkcc Pkcg Prkca Prkcabp Prkcb Prkcb1 Prkcc Prkcg Tspan7	Rattus norvegicus (Norway rat)
Gap junction degradation	AP-2 complex subunit mu Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Disabled homolog 2 Dynamin-1 Dynamin-2 Gap junction alpha-1 protein Unconventional myosin-VI	A0A8I6ACM8 O88797 P08050 P08081 P08082 P11442 P21575 P39052 P84092	Ap2m1 Clta Cltb Cltc Cxn-43 Dab2 Dnm Dnm1 Dnm2 Doc2 Dyn2 Gja1 Myo6	Rattus norvegicus (Norway rat)
Formation of annular gap junctions	AP-2 complex subunit mu Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Disabled homolog 2 Dynamin-1 Dynamin-2 Gap junction alpha-1 protein	O88797 P08050 P08081 P08082 P11442 P21575 P39052 P84092	Ap2m1 Clta Cltb Cltc Cxn-43 Dab2 Dnm Dnm1 Dnm2 Doc2 Dyn2 Gja1	Rattus norvegicus (Norway rat)
Disassembly of the destruction complex and recruitment of AXIN to the membrane	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Caveolin-1 Dishevelled segment polarity protein 2 Dishevelled segment polarity protein 3 FRAT regulator of WNT signaling pathway 1 FRAT regulator of WNT signaling pathway 2 Frizzled-1 Frizzled-2 Frizzled-5 Glycogen synthase kinase-3 beta Low-density lipoprotein receptor-related protein Low-density lipoprotein receptor-related protein Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein phosphatase 2 scaffold subunit A alpha Segment polarity protein dishevelled homolog DVL-1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	A0A0G2K0H3 A0A8I5ZMG6 A0A8I5ZRC2 A0A8I6A4C8 A0A8I6A6K6 A0A8I6G721 A0A8I6GKX7 D3ZB71 D3ZCP6 D3ZDI7 D3ZND6 D4A9D7 D4A9J2 F1M077 M0R5Z2 O70239 P18266 P41350 P62716 P63331 P70478 P97633 Q08463 Q08464 Q4QQT4 Q5XI34 Q80W83 Q8CHL0 Q9WU82 Q9WVB9	Amer1 Apc Axin Axin1 Catnb Cav Cav1 Csnk1a1 Ctnnb1 Dvl1 Dvl2 Dvl3 Frat1 Frat2 Fzd1 Fzd2 Fzd5 Gsk3b LOC100361515 LOC100909468 LOC679110 Lrp5 Lrp6 Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5a Ppp2r5b Ppp2r5c Ppp2r5d Ppp2r5e Wnt1 Wnt3a Wnt8a Wnt8b	Rattus norvegicus (Norway rat)

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