GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **26 - 50** of **1070** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID ▼
Lewis blood group biosynthesis	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 Alpha-(1,3)-fucosyltransferase 10 Alpha-(1,3)-fucosyltransferase 11 Alpha-(1,3)-fucosyltransferase 4 Alpha-(1,3)-fucosyltransferase 7 Beta-1,3-galactosyltransferase 4 Beta-1,4-N-acetyl-galactosaminyl transferase 2 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 Galactoside alpha-(1,2)-fucosyltransferase 2 Hexosyltransferase Hexosyltransferase Hexosyltransferase ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Type 2 lactosamine alpha-2,3-sialyltransferase	A0A8I6AAQ3 D3ZPD8 D4A950 D4AB20 M0R3S4 O88178 P61131 P61943 Q02734 Q10984 Q5F2L1 Q62994 Q68FV3 Q712G6 Q99JB3	B3galt1 B3galt2 B3galt4 B3galt5 B4galnt2 Ftb Fut10 Fut11 Fut2 Fut4 Fut7 Fut9 Rfuc-t Sec1 Siat10 Siat4c Siat6 St3gal3 St3gal4 St3gal6 St6galnac6	Rattus norvegicus (Norway rat)	G39211DH G83633HB G90387AM G98173LG
Hyaluronan uptake and degradation	Beta-glucuronidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta CD44 antigen Calcineurin B homologous protein 1 Hyaluronidase-1 Hyaluronidase-2 Hyaluronidase-3 Sodium/hydrogen exchanger 1	P06760 P26051 P26431 P61023 Q641X3 Q6AXR4 Q76HM9 Q76HN1 Q9Z2Q3	Cd44 Chp Chp1 Gus Gusb Hexa Hexb Hyal1 Hyal2 Hyal3 Nhe1 Slc9a1	Rattus norvegicus (Norway rat)	G35674CY
Hyaluronan biosynthesis and export	ATP-binding cassette sub-family C member 5 Cell migration inducing hyaluronidase 1 Hyaluronan synthase 2 hyaluronan synthase hyaluronan synthase	D3ZWI0 O35776 Q8CH92 Q8CH93 Q9QYM0	Abcc5 Cemip HAS1 HAS3 Has1 Has2 Has3 LOC282821 Mrp5 RGD1305254	Rattus norvegicus (Norway rat)	G35674CY
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Glucose-6-phosphate 1-dehydrogenase Phosphoglucomutase 2 Ribokinase Ribulose-phosphate 3-epimerase Transaldolase Transketolase deoxyribose-phosphate aldolase ribose-5-phosphate isomerase	A0A8I6A8V2 A0A8I6G4T5 A0A8I6GEB4 D4A7L6 F7FLB2 P05370 P50137 P85968 P85971 Q9EQS0	Dera G6pd G6pdx Pgd Pgls Pgm2 RBKS Rbks Rpe Rpia Taldo1 Tkt	Rattus norvegicus (Norway rat)	G31080DL
CS/DS degradation	Alpha-L-iduronidase Arylsulfatase B Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Hyaluronidase-1 Hyaluronidase-3 Iduronate 2-sulfatase Neurocan core protein Versican core protein (Fragments)	D3ZE16 F1LLW8 P47853 P50430 P55067 P55068 Q00657 Q01129 Q641X3 Q6AXR4 Q76HM9 Q76HN1 Q9ERB4 Q9ERQ6	Arsb Bcan Behab Bgn Caleb Cspg2 Cspg3 Cspg4 Cspg5 Dcn Hexa Hexb Hyal1 Hyal3 Ids Idua LOC100363795 Ncan Ng2 Ngc Vcan	Rattus norvegicus (Norway rat)	G27025MB
Glycosphingolipid catabolism	Acid ceramidase Alpha-galactosidase Arylsulfatase A Arylsulfatase B Arylsulfatase E Arylsulfatase G Arylsulfatase I Arylsulfatase K Arylsulfatase family, member J Beta-galactosidase-1-like protein 3 Beta-galactosidase Beta-galactosidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta Carboxypeptidase Cation-dependent mannose-6-phosphate receptor Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 Galactocerebrosidase Galactosidase, beta 1-like Ganglioside GM2 activator Glucosylceramidase beta 3 Glucosylceramidase Neutral ceramidase Non-lysosomal glucosylceramidase Prosaposin Sialidase-1 Sialidase-2 Sialidase-3 Sphingomyelin phosphodiesterase 2 Sphingomyelin phosphodiesterase 3 Sphingomyelin phosphodiesterase 4 Sphingomyelin phosphodiesterase Steryl-sulfatase Sulfatase modifying factor 1 Sulfatase modifying factor 2 exo-alpha-sialidase	A0A0G2JVP8 A0A1W2Q645 A0A8I5Y144 A0A8I6A5G9 A0A8I6AML4 A0A8I6ARV9 A0A8I6B4V4 B1WBS6 D3ZJF9 D3ZUM4 D3ZWB7 D4A7I8 F7ETC0 M0R3L8 O35049 P10960 P15589 P50430 Q32KJ2 Q32KJ7 Q32KJ8 Q32KJ9 Q32KK0 Q32KK2 Q5EZ72 Q5M868 Q5XIL5 Q641X3 Q64627 Q6AXR4 Q6AY20 Q6P7S1 Q91XT9 Q99PW3 Q99PW5 Q9ET64	AABR07013255.1 Arsa Arsb Arse Arsg Arsi Arsj Arsk Arsl Asah1 Asah2 Cca1 Ctsa Enpp7 Galc Gba Gba1 Gba2 Gba3 Gla Glb1 Glb1l Glb1l2 Glb1l3 Gm2a Hexa Hexb M6pr Neu1 Neu2 Neu3 Neu4 Psap Sgp1 Smpd1 Smpd2 Smpd3 Smpd4 Sts Sumf1 Sumf2	Rattus norvegicus (Norway rat)	G09546QO G27025MB G58161NS
Keratan sulfate degradation	Aggrecan core protein Beta-galactosidase-1-like protein 3 Beta-galactosidase Beta-galactosidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta Fibromodulin Galactosidase, beta 1-like Keratocan Lumican N-acetylglucosamine-6-sulfatase Osteomodulin Prolargin	A0A8I5Y144 B1WBS6 D3ZUM4 D3ZVD7 P07897 P50609 P51886 Q32KJ5 Q5XIL5 Q641X3 Q6AXR4 Q9EQP5 Q9Z1S7	Acan Agc Agc1 Fmod Glb1 Glb1l Glb1l2 Glb1l3 Gns Hexa Hexb Kera Lcn Ldc Lum Omd Prelp	Rattus norvegicus (Norway rat)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	26S proteasome regulatory subunit 4 Autocrine motility factor receptor Derlin Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 homolog B Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	A0A0G2K437 A0A8I6A5Y3 D4AE03 P0CG51 P46462 P62193 P62982 Q499N6 Q4KMA2 Q5RKH9 Q5XI55 Q63429	Amfr Derl1 Engase LOC100360645 Ngly1 Psmc1 Rad23b Rps27a Saks1 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ubxn1 Vcp	Rattus norvegicus (Norway rat)	G03934XO G25577BM G28233ME G51034LA G86419OL
HS-GAG degradation	Agrin Alpha-L-iduronidase Beta-galactosidase-1-like protein 3 Beta-galactosidase Beta-galactosidase Beta-glucuronidase Galactosidase, beta 1-like Glypican 4 Glypican 5 Glypican 6 Glypican-1 Glypican-2 Glypican-3 Heparanase 2 (inactive) Heparanase Iduronate 2-sulfatase N-acetyl-alpha-glucosaminidase N-sulfoglucosamine sulfohydrolase Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4	A0A8I5Y144 A0A8I5ZZ84 A0A8I6A609 A0A8I6ACQ6 A0A8I6AN52 B1WBS6 D3ZE16 D3ZUM4 D3ZZL3 F1LLW8 P06760 P13265 P25304 P26260 P33671 P34900 P34901 P35053 P51653 Q5XIL5 Q642B0 Q71RP1	Agrin Agrn Glb1 Glb1l Glb1l2 Glb1l3 Gpc1 Gpc2 Gpc3 Gpc4 Gpc5 Gpc6 Gus Gusb Hep Hpse Hpse2 Hspg1 Ids Idua LOC100363795 Naglu Sdc1 Sdc2 Sdc3 Sdc4 Sgsh Synd1 Synd2 Synd3 Synd4	Rattus norvegicus (Norway rat)	G01550VL G09546QO
Lysosomal oligosaccharide catabolism	Ab2-450 Alpha-mannosidase 2C1 Alpha-mannosidase Beta-mannosidase	F7FG85 P21139 Q4FZV0 Q7TP34	Man2b1 Man2b2 Man2c1 Manba Mrfap1	Rattus norvegicus (Norway rat)	G00027MO G25577BM G28233ME G70323CJ G90333CG
Acyl chain remodeling of DAG and TAG	Acyltransferase Acyltransferase Diacylglycerol O-acyltransferase 1 Diacylglycerol O-acyltransferase 2 Monoglyceride lipase Patatin-like phospholipase domain containing 3 Patatin-like phospholipase domain-containing protein 2	D3Z9J9 D3ZTG7 D4A598 P0C548 Q5FVP8 Q8R431 Q9ERM3	Atgl Awat2 Dgat Dgat1 Dgat2 Dgat2l6 Mgl2 Mgll Pnpla2 Pnpla3	Rattus norvegicus (Norway rat)
Opsins	Medium-wave-sensitive opsin 1 Melanopsin Opsin 3 Opsin 5 Retinal G protein coupled receptor Retinal pigment epithelium derived rhodopsin homolog Rhodopsin Short-wave-sensitive opsin 1	A0A1W2Q6H2 A0A8J8YD44 D3ZFS1 D3ZG87 O35476 P51489 Q63652 Q8R456	Bcp Gcp Opn1mw Opn1sw Opn3 Opn4 Opn5 Rgr Rho Rrh	Rattus norvegicus (Norway rat)
Golgi Associated Vesicle Biogenesis	ADP-ribosylation factor 1 AP complex subunit beta AP complex subunit sigma AP complex subunit sigma AP-1 complex subunit beta-1 AP-1 complex subunit gamma AP-1 complex subunit mu-1 AP-1 complex subunit mu-2 AP-3 complex subunit beta AP-4 complex subunit epsilon Adaptin ear-binding coat-associated protein 1 Adaptor related protein complex 1 subunit sigma 1 Adaptor related protein complex 3 subunit sigma 1 Alpha-soluble NSF attachment protein Beta-arrestin-1 Biogenesis of lysosomal organelles complex 1 subunit 4 Biogenesis of lysosome-related organelles complex 1 subunit 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 Biogenesis of lysosome-related organelles complex 1 subunit 6 Carboxypeptidase D Clathrin heavy chain 1 Clathrin interactor 1 Clathrin light chain A Cyclin-G-associated kinase DnaJ heat shock protein family (Hsp40) member C6 Dynamin-2 Dysbindin Endophilin-A1 Ferritin heavy chain Ferritin light chain 1 Ferritin Ferritin Golgi resident protein GCP60 Golgin B1 Heat shock cognate 71 kDa protein Huntingtin interacting protein 1 related Inositol polyphosphate 5-phosphatase OCRL Insulin-like growth factor 2 receptor Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Phosphatidylinositol-binding clathrin assembly protein Protein YIPF6 Pumilio homolog 1 SH3 domain containing 19 SNARE-associated protein Snapin Sortilin Sorting nexin 9 Sorting nexin-2 Sorting nexin-5 TBC1 domain family member 8B TPD52 like 1 Trans-Golgi network integral membrane protein TGN38 Transferrin receptor protein 1 Tumor protein D52 Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 protein disulfide-isomerase small monomeric GTPase	A0A0G2K865 A0A0G2K9M5 A0A8I5Y697 A0A8I5Y9G0 A0A8I5ZU81 A0A8I5ZVG9 A0A8I6A086 A0A8I6A678 A0A8I6A896 A0A8I6AAZ1 A0A8I6AMT9 A0A8I6GJY7 B0BNK1 B1H267 D3Z8L5 D3ZGS3 D3ZIF5 D3ZKU7 D3ZRP6 D3ZTF6 D3ZX21 D3ZZC1 D4A3V6 F1LML7 F1M5T1 F7EZ57 F7FE56 G3V6A8 G3V6R9 G3V824 G3V9Y9 O35179 O54861 O55012 P02793 P08081 P11442 P19132 P19814 P29066 P39052 P52303 P54921 P60192 P63018 P63045 P69682 P84079 P97874 Q32Q06 Q4QQU5 Q4V8A6 Q5M834 Q7TNY6 Q99376 Q9JHW1 Q9JHW5 Q9WUF4	AABR07054189.1 Acbd3 Adtb1 Ap1b1 Ap1g1 Ap1m1 Ap1m2 Ap1s1 Ap1s2 Ap1s3 Ap3b1 Ap3s1 Ap4b1 Ap4e1 Arf1 Arrb1 Bloc1s1 Bloc1s3 Bloc1s4 Bloc1s6 Bloc1s7 Bloc1s8 Calm Clint1 Clta Cltc Cpd Dnajc6 Dnm2 Dtnbp1 Dyn2 Fth Fth1 Fth1-ps5 Ftl Ftl1 Ftl1l2 Gak Gcp60 Golgb1 Hip1r Hsc70 Hsc73 Hspa8 Igf2r LOC100359668 Napa Necap1 Ocrl Picalm Pik3c2a Pldn Pum1 Rab5c Sh3d19 Sh3d2a Sh3gl2 Sh3p4 Snap Snap25bp Snapa Snapap Snapin Snx2 Snx5 Snx9 Sort1 Syb2 Sybl1 Tbc1d8b Tfrc Tpd52 Tpd52l1 Trfr Ttgn1 Txndc5 Vamp2 Vamp7 Vamp8 Yipf6	Rattus norvegicus (Norway rat)
RAF/MAP kinase cascade	Actinin alpha 2 Amphiregulin Angiopoietin-1 Artemin Astrocytic phosphoprotein PEA-15 Betacellulin Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-3 Colony stimulating factor 2 receptor subunit beta Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Focal adhesion kinase 1 GDNF family receptor alpha 3 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-4 GTPase HRas GTPase KRas GTPase NRas Glial cell line-derived neurotrophic factor Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2D Granulocyte-macrophage colony-stimulating factor Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin 3 receptor subunit alpha Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 Interleukin-5 Kit ligand Klotho beta Klotho Leucine-rich repeat-containing protein 7 Linker for activation of T-cells family member 1 Mast/stem cell growth factor receptor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Neuregulin 3 Neurofilament light polypeptide Neurturin Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B (Fragment) Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase receptor Ret Protransforming growth factor alpha RAS guanyl releasing protein 3 RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 4 Ral guanine nucleotide dissociation stimulator,-like 1 Ral guanine nucleotide dissociation stimulator-like 2 Ral guanine nucleotide dissociation stimulator Ran-binding protein 9 Rap guanine nucleotide exchange factor 2 Ras-specific guanine nucleotide-releasing factor 1 Ras-specific guanine nucleotide-releasing factor 2 RasGEF domain family, member 1A Receptor protein-tyrosine kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Receptor-type tyrosine-protein phosphatase alpha SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain Spectrin beta chain Spectrin beta chain Spectrin, alpha, erythrocytic 1 Spectrin, beta, non-erythrocytic 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A0G2JW59 A0A0G2JY25 A0A0G2K210 A0A0G2K344 A0A0G2K677 A0A0G2KAU4 A0A0U1RS29 A0A8I5Y176 A0A8I5Y1H8 A0A8I5ZN92 A0A8I5ZW61 A0A8I6AM23 A0A8I6AQ55 A0A8I6AWM3 A0A8I6B3J9 A0A8I6B5D5 D3Z8T6 D3ZS31 D3ZZV7 D4A244 D4A3T0 D4A678 E9PSX4 F1LSG7 F1LSQ8 F1M386 F1MAL5 F7F1M3 G3V608 G3V6K6 G3V6S0 G3V9H8 O35346 O35460 O35569 O54769 O70142 O70143 O70301 O70601 O88182 P01134 P04823 P06494 P07522 P08413 P08644 P0DP31 P11275 P11730 P13109 P13596 P15791 P16086 P17108 P17945 P19527 P20171 P20786 P21581 P21708 P24338 P26896 P26897 P28576 P28818 P31016 P35439 P35570 P36364 P43322 P48750 P48807 P61149 P62994 P63076 P63086 P70492 P70587 P97523 Q00960 Q02195 Q03348 Q03386 Q04589 Q04970 Q05028 Q05030 Q06175 Q07731 Q08125 Q498D6 Q52RG8 Q5M824 Q5U318 Q62645 Q62689 Q62696 Q62799 Q62844 Q62936 Q62997 Q63116 Q63272 Q63622 Q63787 Q63788 Q6AYE8 Q811Q5 Q8R5I4 Q8R5L5 Q8R5L9 Q8VI79 Q8VI81 Q8VI82 Q99JE4 Q9EPI2 Q9EST9 Q9QWN8 Q9R1K8 Q9Z0L5 Q9Z1L0 Q9Z2Y9	Actn2 Angpt1 Areg Artn Ash Btc CaMIII Calm3 Cam3 Camc Camk2a Camk2b Camk2d Camk2g Csf2 Csf2rb Csfgm Dlg1 Dlg2 Dlg3 Dlg4 Dlgh1 Dlgh2 Dlgh3 Dlgh4 Dtr Egf Egfr Erbb2 Erbb3 Ereg Erk1 Erk2 FGF15 FGF22 FGF6 Fak Fak1 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf19 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf8a Fgf9 Fgfa Fgfr1 Fgfr2 Fgfr3 Fgfr4 Flg Flt3 Frs2 Frs3 Fyn Gdnf Gdnfra Gfra1 Gfra2 Gfra3 Gfra4 GluN2D Grb2 Grf2 Grin1 Grin2b Grin2d Hbegf Hegfl Hgf Hras Hras1 Il-2 Il-3 Il-5 Il2 Il2ra Il2rb Il3 Il3ra Il5 Irs-1 Irs1 Irs2 Jak1 Jak2 Jak3 KIT Kgf Kit Kitl Kitlg Kl Klb Kras Kras2 Lap1 Lat Lrp Lrrc7 Mapk Mapk1 Mapk3 Met Mgf Ncam Ncam1 Ndf Nefl Neu Nf68 Nfl Nmdar1 Nras Nrg1 Nrg2 Nrg3 Nrtn Nshc Ntak Pdgfa Pdgfb Pdgfr Pdgfr1 Pdgfra Pdgfrb Pdzgef1 Pea15 Pik3ca Pik3cb Pik3r1 Pik3r2 Prkm1 Prkm3 Psd95 Pspn Ptk2 Ptpra Ralgds Ralgdsl1 Ralgdsl2 Ranbp9 Rapgef2 Rasgef1a Rasgrf1 Rasgrf2 Rasgrp Rasgrp1 Rasgrp3 Rasgrp4 Ret Retl1 Rgl1 Rgl2 Rpa1 Sck Sdgf Shc1 Shc2 Shc3 Shcc Snt2 Sos1 Spna2 Spnb3 Spta1 Spta2 Sptan1 Sptb Sptbn1 Sptbn2 Sptbn4 Sptbn5 Tek Tgfa Trnr1	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 Klotho SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6B5D5 D4A3T0 F1LSQ8 P08644 P13109 P20171 P36364 P48807 P61149 P62994 P63076 P70492 Q04589 Q04970 Q5M824 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9 Q9Z2Y9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr1 Flg Grb2 Hras Hras1 Kl Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
Regulation of TP53 Activity through Acetylation	Bromodomain and PHD finger containing, 1 Bromodomain and PHD finger containing, 3 Bromodomain containing 1 Bromodomain containing 7 Cellular tumor antigen p53 Chromatin modification-related protein MEAF6 DNA helicase DNA helicase GATA zinc finger domain containing 2A GATA zinc finger domain containing 2B Histone acetyltransferase KAT6A Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP7 Inhibitor of growth family, member 5 Metastasis associated 1 family, member 2 Methyl-CpG binding domain protein 3 PML nuclear body scaffold RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RB binding protein 4, chromatin remodeling factor histone acetyltransferase	A0A0G2JTM7 A0A0U1RRW8 A0A8I6AC37 A0A8I6AFB3 A0A8I6AMU4 A0A8I6AQI0 A0A8I6G641 A0A8I6GIY0 A0A8I6GKJ6 D3ZUW8 D4A411 E9PU01 F7ENH8 F7EY92 F7F888 G3V8R7 P10361 P47196 P47197 Q4QQW4 Q5TKR9 Q63484 Q71UF4	Akt1 Akt2 Akt3 Brd1 Brd7 Brpf1 Brpf3 Chd3 Chd4 Ep300 Gatad2a Gatad2b Hdac1 Hdac2 Ing5 Kat6a Mbd3 Meaf6 Moz Mta2 Myst3 P53 Pml Rbbp4 Rbbp7 Tp53	Rattus norvegicus (Norway rat)
Intracellular oxygen transport	Cytoglobin Myoglobin Neuroglobin	Q921A4 Q99JA8 Q9QZ76	Cygb Mb Ngb Stap	Rattus norvegicus (Norway rat)
Unblocking of NMDA receptors, glutamate binding and activation	Actinin alpha 2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-3 Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Glutamate receptor 1 Glutamate receptor 2 Glutamate receptor 3 Glutamate receptor 4 Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic, NMDA 2D Leucine-rich repeat-containing protein 7 Neurofilament light polypeptide	A0A8I5ZN92 P08413 P0DP31 P11275 P11730 P15791 P19490 P19491 P19492 P19493 P19527 P31016 P35439 P70587 Q00959 Q00960 Q00961 Q62645 Q62696 Q62936 Q63622	Actn2 CaMIII Calm3 Cam3 Camc Camk2a Camk2b Camk2d Camk2g Dlg1 Dlg2 Dlg3 Dlg4 Dlgh1 Dlgh2 Dlgh3 Dlgh4 GluA1 GluA2 GluA3 GluN2D Glur1 Glur2 Glur3 Glur4 Gria1 Gria2 Gria3 Gria4 Grin1 Grin2a Grin2b Grin2c Grin2d Lap1 Lrrc7 Nefl Nf68 Nfl Nmdar1 Psd95	Rattus norvegicus (Norway rat)
Methylation	Adenosylhomocysteinase Arsenite methyltransferase Catechol O-methyltransferase Cytochrome P450 1A2 Glutathione S-transferase omega-1 Methionine adenosyltransferase 2 subunit beta Methionine synthase reductase Methionine synthase Nicotinamide N-methyltransferase S-adenosylmethionine synthase isoform type-1 S-adenosylmethionine synthase isoform type-2 Thiopurine S-methyltransferase	D4A605 P04799 P10760 P13444 P18298 P22734 Q498R1 Q5U2R0 Q8VHT6 Q9Z0T0 Q9Z2Q4 Q9Z339	Ahcy Ams1 Ams2 As3mt Comt Cyp1a-2 Cyp1a2 Cyt19 Gsto1 Mat1a Mat2a Mat2b Mtr Mtrr Nnmt Tpmt	Rattus norvegicus (Norway rat)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Alpha-actinin-1 Alpha-parvin Dual specificity testis-specific protein kinase 1 LIM and senescent cell antigen-like-containing domain protein Parvin, beta Paxillin Ras suppressor protein 1 Rho guanine nucleotide exchange factor 6	A0A8I5Y6N4 A0A8I6A6W3 D4A8F2 Q5XXR3 Q63572 Q66H76 Q9HB97 Q9Z1P2	Actn1 Actp Arhgef6 Lims1 Parva Parvb Pxn Rsu1 Tesk1	Rattus norvegicus (Norway rat)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	B5DF45 Q5XIC2 Q62925	Ecsit Map3k1 Mekk Mekk1 Traf6	Rattus norvegicus (Norway rat)
FOXO-mediated transcription of cell cycle genes	Forkhead box O3 Forkhead box O4 Forkhead box protein G1 Forkhead box protein O1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4	D3ZBQ1 D4A433 G3V7R4 O70436 O70437 P84025 Q00939	Fkhl1 Foxg1 Foxg1b Foxo1 Foxo1a Foxo3 Foxo4 Madh2 Madh3 Madh4 Smad2 Smad3 Smad4	Rattus norvegicus (Norway rat)
Activation of Matrix Metalloproteinases	72 kDa type IV collagenase Anionic trypsin-2-like Anionic trypsin-2 Cathepsin G Cathepsin K Chymase Chymotrypsinogen B Collagen type XVIII alpha 1 chain Collagenase 3 (Fragment) Elastase, neutrophil expressed Furin Glandular kallikrein-10 Glandular kallikrein-12, submandibular/renal Glandular kallikrein-7, submandibular/renal Kallikrein-1 Matrilysin Matrix metallopeptidase 15 Matrix metallopeptidase 17 Matrix metallopeptidase 25 Matrix metalloproteinase-14 Matrix metalloproteinase-16 Matrix metalloproteinase-24 Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Metalloproteinase inhibitor 2 Neutrophil collagenase Plasma kallikrein Plasminogen Procathepsin L Prostatic glandular kallikrein-6 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 Serine protease 1 Similar to Anionic trypsin II precursor (Pretrypsinogen II) Stromelysin-1 Stromelysin-2 Stromelysin-3 Submandibular glandular kallikrein-9 Tonin Trypsin 10 Tryptase beta-2 interstitial collagenase tissue kallikrein tissue kallikrein tissue kallikrein tissue kallikrein tissue kallikrein tissue kallikrein trypsin trypsin	A0A8I5Y5M6 A0A8I5ZME9 A0A8I5ZXK8 A0A8I6ABC2 A0A8I6ALB4 A0A8I6AMA2 A0A8I6AMU8 A0A8I6APH4 A0A8I6GHE1 A0A8I6GLR1 B5DFD5 D3ZCG5 D3ZQV0 D3ZXJ0 D4A488 M0R3T3 M0R8E3 O35186 O35548 O88766 P00758 P00759 P00762 P00763 P03957 P07152 P07154 P07338 P07647 P14272 P17977 P23097 P23377 P30120 P30121 P33436 P36373 P36374 P36375 P36376 P50280 P50282 P50339 P50343 Q01177 Q10739 Q499S5 Q99PW6 W4VSR6	Cma1 Col18a1 Ctrb Ctrb1 Ctsg Ctsk Ctsl Ctsl1 ENSRNOG00000066972 ENSRNOG00000067174 ENSRNOG00000069479 ENSRNOG00000071144 Elane Fur Furin Klk-1 Klk-10 Klk-12 Klk-2 Klk-7 Klk-8 Klk-9 Klk1 Klk10 Klk12 Klk1c4 Klk1c6 Klk2 Klk3 Klk6 Klk7 Klk8 Klk9 Klkb1 Klks3 LOC100365995 LOC102554637 LOC683849 Mcp6 Mcpt3 Mcpt6 Mmp-7 Mmp1 Mmp10 Mmp11 Mmp13 Mmp14 Mmp15 Mmp16 Mmp17 Mmp1a Mmp2 Mmp24 Mmp25 Mmp3 Mmp7 Mmp8 Mmp9 Mt5mmp Mtmmp Ngfg Pcsk3 Pk Plg Prss1 Prss2 Prss2l1 Prss3 Spock3 Timp-1 Timp-2 Timp1 Timp2 Ton Tpsb2 Trp1 Try1 Try10 Try2 Try4 Try5 Tryp1	Rattus norvegicus (Norway rat)
Trafficking of AMPA receptors	A-kinase anchor protein 5 Band 4.1-like protein 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Disks large homolog 1 Disks large homolog 4 E3 ubiquitin-protein ligase Mdm2 Glutamate receptor 1 Glutamate receptor 3 Glutamate receptor 4 Unconventional myosin-VI Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-3 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A8I6ACM8 A0A8I6G5V3 P08413 P11275 P11730 P15791 P19490 P19492 P19493 P24587 P31016 Q62696 Q71RJ2 Q8VHW5 Q8VHW9 Q8VHX0 Q9WTP0	Akap150 Akap5 Cacng2 Cacng3 Cacng4 Cacng8 Camk2a Camk2b Camk2d Camk2g Dlg1 Dlg4 Dlgh1 Dlgh4 Epb4.1l1 Epb41l1 GluA1 GluA3 Glur1 Glur3 Glur4 Gria1 Gria3 Gria4 Mdm2 Myo6 Psd95 Stg	Rattus norvegicus (Norway rat)
betaKlotho-mediated ligand binding	Fibroblast growth factor receptor 4 Fibroblast growth factor Klotho beta	D3Z8T6 Q498D6 Q8VI81	FGF15 Fgf19 Fgf8a Fgfr4 Klb	Rattus norvegicus (Norway rat)

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