multiple sclerosis

Summary
Synonym
  • Generalized multiple sclerosis
  • insular sclerosis
Definition
A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Super Class
autoimmune disease of central nervous system demyelinating disease
Disease Ontology
DOID:2377
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 21 - 30 of 55 in total
Gene ID Gene Symbol Description Source
3456 IFNB1 interferon beta 1
3458 IFNG interferon gamma
3559 IL2RA interleukin 2 receptor subunit alpha
3565 IL4 interleukin 4
3566 IL4R interleukin 4 receptor
3569 IL6 interleukin 6
3663 IRF5 interferon regulatory factor 5
4155 MBP myelin basic protein
4179 CD46 CD46 molecule
4261 CIITA class II major histocompatibility complex transactivator
Displaying all 2 entries
Gene ID Gene Symbol Description Source
18646 Prf1 perforin 1 (pore forming protein)
21926 Tnf tumor necrosis factor

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 8, 2025