GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1526 - 1550** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲
Defective B3GAT3 causes JDSSDHD	Agrin Basement membrane-specific heparan sulfate proteoglycan core protein Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 Glypican-1 Glypican-2 Glypican-3 Glypican-4 Glypican-5 Glypican-6 Neurocan core protein Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Versican core protein	O00468 O14594 O75056 O75487 O94766 O95196 P07585 P13611 P18827 P21810 P31431 P34741 P35052 P51654 P78333 P98160 Q6UVK1 Q8N158 Q96GW7 Q9Y625	AGRIN AGRN B3GAT3 BCAN BEHAB BGN CALEB CSPG2 CSPG3 CSPG4 CSPG5 CSPG7 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG1 HSPG2 KIAA0468 MCSP NCAN NEUR NGC OCI5 SDC SDC1 SDC2 SDC3 SDC4 SLRR1A SLRR1B VCAN	Homo sapiens (human)
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)	Solute carrier family 22 member 12	Q96S37	OATL4 SLC22A12 URAT1	Homo sapiens (human)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P31749 P31946 P49137 Q06265 Q07352 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 BERG36 BRF1 CML28 CSL4 DCP1A DCP2 DIS3 ERF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KIAA0116 KIAA1008 MAPKAPK2 MTR3 NUDT20 OIP2 PKB PMSCL1 RAC RNF162B RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11B XRN1 YWHAB ZFP36L1	Homo sapiens (human)
APC/C:Cdc20 mediated degradation of Cyclin B	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Polyubiquitin-B Polyubiquitin-C Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00762 P06493 P0CG47 P0CG48 P14635 P30260 P51668 P51965 P60006 P62979 P62987 Q12834 Q13042 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CCNB CCNB1 CDC16 CDC2 CDC20 CDC23 CDC26 CDC27 CDC28A CDK1 CDKN1 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 P34CDC2 RPS27A SFT TSG24 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Processing of Capped Intron-Containing Pre-mRNA	Cleavage and polyadenylation specificity factor subunit 1 Cleavage and polyadenylation specificity factor subunit 2 Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage and polyadenylation specificity factor subunit 7 Cleavage stimulation factor subunit 1 Cleavage stimulation factor subunit 2 tau variant Cleavage stimulation factor subunit 2 Cleavage stimulation factor subunit 3 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A3 Heterogeneous nuclear ribonucleoprotein D0 Heterogeneous nuclear ribonucleoprotein F Heterogeneous nuclear ribonucleoprotein H2 Heterogeneous nuclear ribonucleoprotein H Heterogeneous nuclear ribonucleoprotein K Heterogeneous nuclear ribonucleoprotein L Heterogeneous nuclear ribonucleoprotein M Heterogeneous nuclear ribonucleoprotein R Heterogeneous nuclear ribonucleoprotein U Heterogeneous nuclear ribonucleoproteins A2/B1 Heterogeneous nuclear ribonucleoproteins C1/C2 N6-adenosine-methyltransferase catalytic subunit N6-adenosine-methyltransferase non-catalytic subunit Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Poly(A) polymerase alpha Poly(rC)-binding protein 1 Poly(rC)-binding protein 2 Polyadenylate-binding protein 2 Polypyrimidine tract-binding protein 1 Polyribonucleotide 5'-hydroxyl-kinase Clp1 Pre-mRNA 3'-end-processing factor FIP1 Pre-mRNA cleavage complex 2 protein Pcf11 Pre-mRNA-splicing regulator WTAP RNA-binding motif protein, X chromosome RNA-binding protein 10 RNA-binding protein FUS Serine/arginine-rich splicing factor 10 Serine/arginine-rich splicing factor 11 Serine/arginine-rich splicing factor 12 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 3 Serine/arginine-rich splicing factor 4 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Serine/arginine-rich splicing factor 8 Serine/arginine-rich splicing factor 9 Symplekin Transformer-2 protein homolog beta Y-box-binding protein 1 pre-mRNA 3' end processing protein WDR33	O15514 O43390 O43809 O75494 O94913 O95639 P07910 P09651 P13984 P14866 P19387 P19388 P22626 P24928 P26599 P30876 P31943 P33240 P35269 P35637 P36954 P38159 P51003 P51991 P52272 P52298 P52434 P52435 P52597 P53803 P55795 P61218 P61978 P62487 P62875 P62995 P67809 P84103 P98175 Q00839 Q01130 Q05048 Q05519 Q07955 Q08170 Q09161 Q10570 Q12996 Q13242 Q13243 Q13247 Q14103 Q15007 Q15365 Q15366 Q16629 Q6UN15 Q86U42 Q86U44 Q8N684 Q8WXF0 Q92797 Q92989 Q9BRL6 Q9C0J8 Q9H0L4 Q9HCE5 Q9P2I0 Q9UKF6	ASF AUF1 C1orf199 CBP20 CBP80 CFIM25 CLP1 CPSF1 CPSF100 CPSF160 CPSF2 CPSF25 CPSF3 CPSF30 CPSF4 CPSF5 CPSF7 CPSF73 CSTF1 CSTF2 CSTF2T CSTF3 DXS8237E FIP1 FIP1L1 FTP3 FUS FUSIP1 FUSIP2 GPATC9 GPATCH9 GTF2F1 GTF2F2 HEAB HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRPA1 HNRPA2B1 HNRPA3 HNRPC HNRPD HNRPF HNRPG HNRPH HNRPH1 HNRPH2 HNRPK HNRPL HNRPM HNRPR HNRPU HRS KIAA0105 KIAA0122 KIAA0689 KIAA0824 KIAA1367 KIAA1627 METTL14 METTL3 MTA70 NAGR1 NAR NCBP NCBP1 NCBP2 NEB1 NSEP1 NUDT21 PAB2 PABP2 PABPN1 PAP PAPOLA PCBP1 PCBP2 PCF11 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PTB PTBP1 RAP30 RAP74 RBM10 RBMX RBMXP1 RHE RPB7 SAFA SF2 SF2P33 SFRS1 SFRS10 SFRS11 SFRS13A SFRS13B SFRS19 SFRS2 SFRS2B SFRS3 SFRS4 SFRS5 SFRS6 SFRS7 SFRS9 SPK SRP20 SRP30C SRP40 SRP46 SRP55 SRP75 SRRP35 SRSF1 SRSF10 SRSF11 SRSF12 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 SYMPK TASR TLS TRA2B U21.1 WDC146 WDR33 WTAP YB1 YBX1	Homo sapiens (human)
Presynaptic function of Kainate receptors	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Glutamate receptor ionotropic, kainate 3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5	O14610 O14775 O60262 P16520 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 Q00722 Q01970 Q13003 Q9HAV0 Q9NQ66 Q9P2W3 Q9UBI6 Q9UK08	GLUR7 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GRIK3 KIAA0581 PLCB1 PLCB2 PLCB3	Homo sapiens (human)
Maturation of hRSV A proteins	Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Exportin-1 Furin Fusion glycoprotein F0 Importin subunit beta-1 Matrix protein Non-structural protein 1 Non-structural protein 2 Nucleoprotein Phosphoprotein Protein M2-1 RNA-directed RNA polymerase L Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Signal peptidase complex catalytic subunit SEC11A Signal peptidase complex catalytic subunit SEC11C Signal peptidase complex subunit 1 Signal peptidase complex subunit 2 Signal peptidase complex subunit 3	O14980 P03418 P03420 P03421 P04543 P04545 P09958 P0DOE7 P0DOE9 P19784 P28887 P36873 P61009 P62136 P62140 P67812 P67870 P68400 P70168 Q15005 Q9BY50 Q9Y6A9	1B 1C CK2A1 CK2A2 CK2N CRM1 CSNK2A1 CSNK2A2 CSNK2B F FUR FURIN G5A Impnb KIAA0102 Kpnb1 L M M2-1 N NS1 NS2 P PACE PCSK3 PPP1A PPP1CA PPP1CB PPP1CC SEC11A SEC11C SEC11L1 SEC11L3 SPC12 SPC18 SPC21 SPC22 SPC25 SPCS1 SPCS2 SPCS3 SPCS4A SPCS4C XPO1	Homo sapiens (human)
Aspirin ADME	ATP-binding cassette sub-family C member 2 ATP-binding cassette sub-family C member 3 Acyl-coenzyme A synthetase ACSM2A, mitochondrial Acyl-coenzyme A synthetase ACSM2B, mitochondrial Acyl-coenzyme A synthetase ACSM4, mitochondrial Acyl-coenzyme A synthetase ACSM5, mitochondrial Albumin Basigin Cholinesterase Cocaine esterase Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2E1 Cytochrome P450 3A4 Glycine N-acyltransferase-like protein 1 Glycine N-acyltransferase-like protein 2 Glycine N-acyltransferase-like protein 3 Glycine N-acyltransferase Liver carboxylesterase 1 Monocarboxylate transporter 1 Solute carrier family 22 member 7 UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 1A7 UDP-glucuronosyltransferase 1A8 UDP-glucuronosyltransferase 1A9 UDP-glucuronosyltransferase 2A1 UDP-glucuronosyltransferase 2A2 UDP-glucuronosyltransferase 2A3 UDP-glucuronosyltransferase 2B10 UDP-glucuronosyltransferase 2B11 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B28 UDP-glucuronosyltransferase 2B4 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase 3A1 UDP-glucuronosyltransferase 3A2	O00748 O15438 O60656 O75310 O75795 P02768 P05181 P06133 P06276 P08684 P0C7M7 P0DTE4 P0DTE5 P10632 P10635 P11712 P16662 P19224 P22309 P22310 P23141 P33261 P35503 P35504 P35613 P36537 P53985 P54855 Q08AH3 Q3SY77 Q5SZD4 Q68CK6 Q6IB77 Q6NUN0 Q6NUS8 Q6UWM9 Q8WU03 Q92887 Q969I3 Q9BY64 Q9HAW7 Q9HAW9 Q9Y694	ABCC2 ABCC3 ACGNAT ACSM2 ACSM2A ACSM2B ACSM4 ACSM5 ALB BCHE BSG C6orf140 CAT CES1 CES2 CHE1 CMOAT CMOAT1 CMOAT2 CMRP CYP2C10 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2DL1 CYP2E CYP2E1 CYP3A3 CYP3A4 GAT GLYAT GLYATL1 GLYATL2 GLYATL3 GNAT GNT1 ICE MACS2 MACS3 MCT1 MLP2 MRP2 MRP3 NLT OAT2 SES1 SLC16A1 SLC22A7 UGT1 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT2B8 UGT3A1 UGT3A2 UGTB2B9	Homo sapiens (human)
PINK1-PRKN Mediated Mitophagy	Autophagy protein 5 E3 ubiquitin-protein ligase parkin Microtubule-associated proteins 1A/1B light chain 3A Microtubule-associated proteins 1A/1B light chain 3B Mitochondrial import receptor subunit TOM20 homolog Mitochondrial import receptor subunit TOM22 homolog Mitochondrial import receptor subunit TOM40 homolog Mitochondrial import receptor subunit TOM5 homolog Mitochondrial import receptor subunit TOM6 homolog Mitochondrial import receptor subunit TOM7 homolog Mitochondrial import receptor subunit TOM70 Mitofusin-1 Mitofusin-2 Polyubiquitin-B Polyubiquitin-C Sequestosome-1 Serine/threonine-protein kinase PINK1, mitochondrial Transcription termination factor 3, mitochondrial Ubiquitin-like protein ATG12 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Voltage-dependent anion-selective channel protein 1	O60260 O94817 O94826 O95140 O96008 P0CG47 P0CG48 P21796 P62979 P62987 Q13501 Q15388 Q8IWA4 Q8N4H5 Q96B49 Q96E29 Q9BXM7 Q9GZQ8 Q9H1Y0 Q9H492 Q9NS69 Q9P0U1	APG12 APG12L APG5L ASP ATG12 ATG5 C19orf1 C9orf105 CPRP1 KIAA0016 KIAA0214 KIAA0719 MAP1ALC3 MAP1LC3A MAP1LC3B MFN1 MFN2 MTERF3 MTERFD1 OBTP ORCA OSIL PARK2 PEREC1 PINK1 PRKN RPS27A SQSTM1 TOM22 TOM40 TOM5 TOM6 TOM7 TOM70 TOMM07 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TOMM70A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VDAC VDAC1	Homo sapiens (human)
Aspartate and asparagine metabolism	60 kDa lysophospholipase Acidic amino acid decarboxylase GADL1 Asparagine synthetase [glutamine-hydrolyzing] Aspartate aminotransferase, cytoplasmic Aspartate aminotransferase, mitochondrial Aspartoacylase Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial Glutamate carboxypeptidase 2 N-acetylaspartate synthetase N-acetylated-alpha-linked acidic dipeptidase 2 Putative N-acetylated-alpha-linked acidic dipeptidase	O75746 P00505 P08243 P17174 P45381 Q04609 Q6ZQY3 Q86U10 Q8N9F0 Q9HBA9 Q9UJS0 Q9Y3Q0	ACY2 AGC1 ARALAR1 ASNS ASP ASPA ASPG C14orf76 CML3 FOLH FOLH1 FOLH1B GADL1 GOT1 GOT2 KYAT4 NAALAD1 NAALAD2 NAT8L PSM PSMA PSMAL SLC25A12 SLC25A13 TS11	Homo sapiens (human)
CHL1 interactions	Ankyrin-1 Contactin-6 Heat shock cognate 71 kDa protein Integrin alpha-10 Integrin alpha-1 Integrin alpha-2 Integrin beta-1 Neural cell adhesion molecule L1-like protein Neuropilin-1	O00533 O14786 O75578 P05556 P11142 P16157 P17301 P56199 Q9UQ52	ANK ANK1 CALL CD49B CHL1 CNTN6 FNRB HSC70 HSP73 HSPA10 HSPA8 ITGA1 ITGA10 ITGA2 ITGB1 MDF2 MSK12 NRP NRP1 VEGF165R	Homo sapiens (human)
PI and PC transport between ER and Golgi membranes	Phosphatidylinositol transfer protein beta isoform	P48739	PITPNB	Homo sapiens (human)
Stabilization of p53	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q13315 Q8N726 Q9BVI0	ATM C20orf104 CDKN2 CDKN2A CDS1 CHEK2 CHK2 GLEA2 HCA58 MDM2 MDM4 MDMX MLM NZF P53 PHF20 RAD53 RPS27A TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Presynaptic phase of homologous DNA pairing and strand exchange	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1	O14757 O15315 O43502 O43543 O60671 O60921 O60934 O75771 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CHEK1 CHK1 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RAD9A RAD9B RBBP8 REC1 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN XRCC2	Homo sapiens (human)
Gap-filling DNA repair synthesis and ligation in GG-NER	DNA ligase 1 DNA ligase 3 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair protein XRCC1 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P12004 P15927 P18858 P18887 P27694 P28340 P35244 P35249 P35250 P35251 P40937 P40938 P49005 P49916 P56282 P62979 P62987 Q07864 Q15054 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6	CHRAC17 DINB1 DPE2 KIAA0039 LIG1 LIG3 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XRCC1	Homo sapiens (human)
Citric acid cycle (TCA cycle)	Aconitate hydratase, mitochondrial Citrate synthase, mitochondrial Fumarate hydratase, mitochondrial Heat shock protein 75 kDa, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Malate dehydrogenase, mitochondrial NAD(P) transhydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	O14521 O43837 O75390 P07954 P21912 P31040 P40926 P48735 P50213 P51553 P53597 Q12931 Q13423 Q96I99 Q99643 Q99798 Q9P2R7	ACO2 CS CYB560 FH HSP75 HSPC5 IDH2 IDH3A IDH3B IDH3G MDH2 NNT SDH SDH1 SDH2 SDH3 SDH4 SDHA SDHB SDHC SDHD SDHF SUCLA2 SUCLG1 SUCLG2 TRAP1	Homo sapiens (human)
InlB-mediated entry of Listeria monocytogenes into host cell	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Internalin B Internalin B Polyubiquitin-B Polyubiquitin-C SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P0DQD2 P0DQD3 P22681 P42566 P62979 P62987 Q92783 Q96B97 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 EPS15 HBP HGS HRS MET RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 inlB	Homo sapiens (human)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O60825 P16118 P17612 P22612 P22694 P30153 P30154 P62714 P67775 Q14738 Q16875 Q16877	F6PK PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFRX PKACA PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG	Homo sapiens (human)
Hypusinylation	Deoxyhypusine hydroxylase Deoxyhypusine synthase Eukaryotic translation initiation factor 5A-1 Eukaryotic translation initiation factor 5A-2	P49366 P63241 Q9BU89 Q9GZV4	DHPS DOHH DS EIF5A EIF5A2 HLRC1	Homo sapiens (human)
Cyclin A:Cdk2-associated events at S phase entry	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Fizzy-related protein homolog Histone-binding protein RBBP4 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	P01106 P06400 P20248 P24941 P30291 P30304 P30305 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 P78396 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9UM11 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCN1 CCNA CCNA1 CCNA2 CCNH CDC25A CDC25B CDC25HU2 CDH1 CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 FYR FZR FZR1 KIAA1242 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27	Homo sapiens (human)
p75NTR negatively regulates cell cycle via SC1	Beta-nerve growth factor Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 PR domain zinc finger protein 4 Tumor necrosis factor receptor superfamily member 16	O15379 P01138 P08138 Q13547 Q92769 Q9UKN5	HDAC1 HDAC2 HDAC3 NGF NGFB NGFR PFM1 PRDM4 RPD3L1 TNFRSF16	Homo sapiens (human)
Resolution of AP sites via the single-nucleotide replacement pathway	DNA ligase 3 DNA polymerase beta DNA repair protein XRCC1	P06746 P18887 P49916	LIG3 POLB XRCC1	Homo sapiens (human)
PI5P Regulates TP53 Acetylation	Cellular tumor antigen p53 Dual specificity mitogen-activated protein kinase kinase 6 Histone acetyltransferase p300 Inhibitor of growth protein 2 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	P04637 P48426 P52564 P78356 Q09472 Q13526 Q86T03 Q8TBX8 Q9H160	C14orf9 EP300 ING1L ING2 MAP2K6 MEK6 MKK6 P300 P53 PI5P4KA PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP5K2 PIP5K2A PIP5K2B PIP5K2C PRKMK6 SKK3 TMEM55B TP53	Homo sapiens (human)
DNA methylation	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3-like DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B E3 ubiquitin-protein ligase UHRF1 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4	O60814 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q96T88 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9UJW3 Q9Y6K1	AIM CXXC9 DNMT DNMT1 DNMT3A DNMT3B DNMT3L H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 ICBP90 NP95 RNF106 TSH2B UHRF1	Homo sapiens (human)
MET activates RAS signaling	GTPase HRas GTPase NRas Hepatocyte growth factor receptor Hepatocyte growth factor Mucin-20 Ran-binding protein 10 Ran-binding protein 9 Son of sevenless homolog 1	P01111 P01112 P08581 P14210 Q07889 Q6VN20 Q8N307 Q96S59	HGF HPTA HRAS HRAS1 KIAA1359 KIAA1464 MET MUC20 NRAS RANBP10 RANBP9 RANBPM SOS1	Homo sapiens (human)

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