GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **376 - 400** of **1070** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
Sodium/Calcium exchangers	Calmodulin-3 Mitochondrial sodium/calcium exchanger protein Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sodium/potassium/calcium exchanger 1 Sodium/potassium/calcium exchanger 2 Sodium/potassium/calcium exchanger 3 (Fragment) Solute carrier family 24 member 4 Solute carrier family 24 member 5 Sorcin	A0A0G2K3S9 A0A8I5Y9M9 A0A8I6GB53 O54701 P0DP31 P48768 P70549 Q01728 Q6AXS0 Q9EPQ0 Q9QZM6	CaMIII Calm3 Cam3 Camc Nckx1 Nckx2 Nckx3 Nckx6 Nclx Ncx1 Ncx2 Ncx3 Slc24a1 Slc24a2 Slc24a3 Slc24a4 Slc24a5 Slc24a6 Slc8a1 Slc8a2 Slc8a3 Slc8b1 Sri	Rattus norvegicus (Norway rat)
Lysosome Vesicle Biogenesis	ADP-ribosylation factor 1 AP complex subunit beta AP complex subunit sigma AP complex subunit sigma AP complex subunit sigma AP-1 complex subunit beta-1 AP-1 complex subunit gamma AP-1 complex subunit gamma AP-1 complex subunit mu-1 AP-1 complex subunit mu-2 AP-4 complex subunit epsilon AP-4 complex subunit mu-1 Adaptor related protein complex 1 subunit sigma 1 Amyloid-beta precursor protein Beta-arrestin-1 Biogenesis of lysosome-related organelles complex 1 subunit 1 Cathepsin Z Cation-dependent mannose-6-phosphate receptor Charged multivesicular body protein 2a Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Clavesin-1 Clavesin-2 Deoxyribonuclease-2-alpha DnaJ heat shock protein family (Hsp40) member C6 Dynamin-2 Endophilin-A1 Heat shock cognate 71 kDa protein Hepatocyte growth factor-regulated tyrosine kinase substrate N-acetylglucosamine-6-sulfatase Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 protein disulfide-isomerase	A0A0G2K410 A0A8I5Y697 A0A8I5ZVG9 A0A8I5ZY10 A0A8I6A896 A0A8I6AAZ1 A0A8I6AMT9 A6JFQ6 A6JUQ6 D3ZGW2 D3ZKU7 D3ZRP6 D3ZX21 D3ZZC1 F7EZ57 O35179 P08081 P08082 P08592 P11442 P29066 P39052 P52303 P63018 P63045 P84079 Q2PWT8 Q32KJ5 Q32Q06 Q6AY20 Q9JHW5 Q9JJ50 Q9QZK8 Q9R1T3 Q9WUF4	A4 AD1 Adtb1 Ap1b1 Ap1g1 Ap1g2 Ap1m1 Ap1m2 Ap1s1 Ap1s2 Ap1s3 Ap4b1 Ap4e1 Ap4m1 Ap4s1 App Arf1 Arrb1 Bloc1s1 Chmp2a Clta Cltb Cltc Clvs1 Clvs2 Ctsy Ctsz Dnajc6 Dnase2 Dnase2a Dnl2 Dnm2 Dyn2 Gns Hgs Hrs Hrs2 Hsc70 Hsc73 Hspa8 M6pr Rlbp1l1 Rlbp1l2 Sh3d2a Sh3gl2 Sh3p4 Syb2 Sybl1 Txndc5 Vamp2 Vamp7 Vamp8	Rattus norvegicus (Norway rat)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	26S proteasome regulatory subunit 4 Autocrine motility factor receptor Derlin Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 homolog B Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	A0A0G2K437 A0A8I6A5Y3 D4AE03 P0CG51 P46462 P62193 P62982 Q499N6 Q4KMA2 Q5RKH9 Q5XI55 Q63429	Amfr Derl1 Engase LOC100360645 Ngly1 Psmc1 Rad23b Rps27a Saks1 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ubxn1 Vcp	Rattus norvegicus (Norway rat)	G03934XO G25577BM G28233ME G51034LA G86419OL
Syndecan interactions	Aa1018 Fibroblast growth factor 2 Integrin beta-1 Integrin beta-3 Integrin beta-4 Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 6 Integrin subunit alpha V Protein kinase C alpha type Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Transforming growth factor beta-1 proprotein	A0A0G2K470 A0A8I6AJE9 A0A8I6AQL1 F1LZX9 P05696 P13109 P17246 P26260 P33671 P34900 P34901 P49134 Q64632 Q7TQ11 Q8R2H2	Fgf-2 Fgf2 Hspg1 Itga2 Itga6 Itgav Itgb1 Itgb3 Itgb4 Itgb5 Pkca Prkca Sdc1 Sdc2 Sdc3 Sdc4 Synd1 Synd2 Synd3 Synd4 Tgfb1 Vtn	Rattus norvegicus (Norway rat)
MET activates PTK2 signaling	Focal adhesion kinase 1 Hepatocyte growth factor receptor Hepatocyte growth factor Integrin alpha 3 variant B Integrin beta-1 Integrin subunit alpha 2 Laminin subunit alpha 4 Multiple epidermal growth factor-like domains protein 6 Proto-oncogene tyrosine-protein kinase Src	A0A0G2K470 F1LTF8 I4DUB5 O35346 O88281 P17945 P49134 P97523 Q9WUD9	Egfl3 Fak Fak1 Hgf ITGA3B Itga2 Itga3 Itgb1 Lama4 Megf6 Met Ptk2 Src	Rattus norvegicus (Norway rat)
Purine salvage	AMP deaminase 1 AMP deaminase 2 AMP deaminase 3 Adenine phosphoribosyltransferase Adenosine deaminase Adenosine kinase Deoxycytidine kinase Deoxyguanosine kinase GMP reductase 1 GMP reductase Hypoxanthine-guanine phosphoribosyltransferase Purine nucleoside phosphorylase	A0A0G2K478 O09178 P10759 P27605 P36972 P48769 P85973 Q02356 Q5FVP6 Q64640 Q920P6 Q9Z244	Ada Adk Ampd1 Ampd2 Ampd3 Aprt Dck Dguok GMPR Gmpr Gmpr1 Gmpr2 Hprt Hprt1 Np Pnp	Rattus norvegicus (Norway rat)
A tetrasaccharide linker sequence is required for GAG synthesis	Agrin Beta-1,4-galactosyltransferase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 Glypican 4 Glypican 5 Glypican 6 Glypican-1 Glypican-2 Glypican-3 Hexosyltransferase Neurocan core protein Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Versican core protein (Fragments) Xylosyltransferase 1 (Fragment) Xylosyltransferase 2	A0A0G2K4C0 A0A8I6A609 A0A8I6ACQ6 D3ZQC1 O35789 P13265 P25304 P26260 P33671 P34900 P34901 P35053 P47853 P51653 P55067 P55068 Q00657 Q01129 Q642B0 Q9EPI0 Q9EPI1 Q9ERB4 Q9ERQ6 Q9Z137	Agrin Agrn B3galt6 B3gat1 B3gat2 B4galt7 Bcan Behab Bgn Caleb Cspg2 Cspg3 Cspg4 Cspg5 Dcn Glcats Gpc1 Gpc2 Gpc3 Gpc4 Gpc5 Gpc6 Hspg1 Ncan Ng2 Ngc Sdc1 Sdc2 Sdc3 Sdc4 Synd1 Synd2 Synd3 Synd4 Vcan Xylt1 Xylt2	Rattus norvegicus (Norway rat)
Intrinsic Pathway of Fibrin Clot Formation	Ac2-248 Alpha-2-macroglobulin Coagulation factor IX Coagulation factor VIII Coagulation factor X Coagulation factor XI Coagulation factor XII Complement component 1 Q subcomponent-binding protein, mitochondrial Glia-derived nexin Glycoprotein 9 Glycoprotein Ib platelet subunit alpha Heparin cofactor 2 Kininogen-1 Plasma kallikrein Plasma protease C1 inhibitor Platelet glycoprotein Ib beta chain Platelet glycoprotein V Prolylcarboxypeptidase Prothrombin Serpin family A member 5 Vitamin K-dependent protein C Vitamin K-dependent protein S	A0A0G2K4I9 D3ZEB1 D3ZQU7 D3ZTE0 D4AA31 F7EMJ6 O08770 O35796 P06238 P07092 P08934 P14272 P16296 P18292 P31394 P53813 Q4AEG0 Q63207 Q64268 Q6P734 Q7TPI9 Q9JJM7	A2m A2m1 C1qbp Cf9 F10 F11 F12 F2 F8 F9 Gc1qbp Gp1ba Gp1bb Gp5 Gp9 Hcf2 Klk3 Klkb1 Kng Kng1 Pi7 Pk Pn1 Prcp Proc Pros Pros1 Serpina5 Serpinc1 Serpind1 Serpine2 Serping1	Rattus norvegicus (Norway rat)
TP53 Regulates Metabolic Genes	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 Cytochrome c domain-containing protein Cytochrome c oxidase assembly factor COX18 Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase copper chaperone COX11 Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6C-2 Cytochrome c oxidase subunit 7A2 like Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit Cytochrome c, somatic DNA damage-inducible transcript 4 protein Fructose-2,6-bisphosphatase TIGAR GTP-binding protein Rheb Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Glutathione peroxidase 2 Glutathione reductase (Fragment) Hamartin Leucine-rich PPR motif-containing protein, mitochondrial Neutral amino acid transporter 9 Peroxiredoxin-1 Peroxiredoxin-2 Peroxiredoxin-5, mitochondrial Protein kinase AMP-activated non-catalytic subunit gamma 2 Protein kinase AMP-activated non-catalytic subunit gamma 3 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein Ras-related GTP-binding protein Regulatory associated protein of MTOR, complex 1 Roadblock/LAMTOR2 domain-containing protein Serine/threonine-protein kinase mTOR Sestrin 1 Sestrin 2 Sestrin 3 Similar to Cytochrome c, somatic Stratifin Surfeit locus protein 1 Synthesis of cytochrome C oxidase 1 Target of rapamycin complex subunit LST8 Thioredoxin reductase 1, cytoplasmic Thioredoxin Thymidine phosphorylase Translational activator of cytochrome c oxidase 1 Tuberin	A0A0G2K4P1 A0A0G2K8S8 A0A140UHX4 A0A8I5ZSY5 A0A8I5ZWG1 A0A8I6A0N4 A0A8I6A8X0 A0A8I6AAY1 A0A8I6ADH7 B2GUV6 B2RYT9 B2RZ38 D3Z8B0 D3ZDU2 D3ZF11 D3ZNJ0 D3ZXV2 D4A568 D4A5L9 D4A7E4 D4AD29 G3V985 G3V9A3 O89049 P00406 P05370 P05503 P05505 P10818 P10888 P11232 P11240 P11951 P12075 P13264 P28492 P35213 P35704 P42346 P47196 P47197 P49816 P54645 P61983 P62260 P62898 P63102 P68255 P68511 P70619 P80385 P80386 P80431 P80432 P80433 P83645 Q0D2L6 Q3B8Q3 Q5SGE0 Q5U204 Q5XFV8 Q62639 Q63484 Q63486 Q63487 Q63716 Q6P6V0 Q6P791 Q8VHZ9 Q9QXU2 Q9QZH4 Q9R063 Q9Z136 Q9Z2K5	AC128290.1 Akt1 Akt2 Akt3 Ampk1 COX2 Ccdc44 Coi Coii Coiii Cox11 Cox14 Cox16 Cox18 Cox4 Cox4a Cox4i1 Cox5a Cox5b Cox6a1 Cox6al Cox6b1 Cox6c Cox6c2 Cox7a2l Cox7b Cox7c Cox7c1 Cox8 Cox8a Cox8l Cycs Cycsl2 Cycsl3 Ddit4 ENSRNOG00000066475 Frap1 G6pd G6pdx Ga Gbl Gls Gls2 Gpi Gpx2 Gsr LOC120096563 LOC690675 Lamtor1 Lamtor3 Lamtor4 Lamtor5 Lrp157 Lrpprc Lst8 Map2k1ip1 Mlst8 Msfs1 Mt-co1 Mt-co2 Mt-co3 Mtco1 Mtco2 Mtco3 Mtor Prdx1 Prdx2 Prdx5 Prkaa1 Prkab1 Prkab2 Prkag1 Prkag2 Prkag3 RGD1562558 Raft1 Redd1 Rheb Rptor RragB Rraga Rragc Rragc_predicted Rragd Rtp801 Sco1 Sesn1 Sesn2 Sesn3 Sfn Slc38a9 Surf-1 Surf1 Taco1 Tdpx1 Tdpx2 Tigar Trxr1 Tsc1 Tsc2 Txn Txn1 Txnrd1 Tymp Ywhab Ywhae Ywhag Ywhah Ywhaq Ywhaz	Rattus norvegicus (Norway rat)
Aspirin ADME	ATP-binding cassette sub-family C member 2 ATP-binding cassette sub-family C member 3 Acyl-coenzyme A synthetase ACSM2, mitochondrial Acyl-coenzyme A synthetase ACSM4, mitochondrial Acyl-coenzyme A synthetase ACSM5, mitochondrial Albumin Basigin Carboxylesterase 1D Carboxylic ester hydrolase Carboxylic ester hydrolase Cytochrome P450 2C26-like Cytochrome P450 2D4 Cytochrome P450 2E1 Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A Glycine N-acyltransferase-like protein Glycine N-acyltransferase Monocarboxylate transporter 1 Solute carrier family 22 member 7 Solute carrier organic anion transporter family member 2B1 UDP-glucuronosyltransferase 1-2 UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 1A7 UDP-glucuronosyltransferase 1A8 UDP-glucuronosyltransferase 2A1 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B1 UDP-glucuronosyltransferase 2B2 UDP-glucuronosyltransferase 2B37 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase glucuronosyltransferase	A0A0G2K4R2 A0A0G2K5K4 A0A8I6AFV7 A0A8J8XQI9 D3ZHY4 F1LTB8 M0R9W7 O70490 O88563 P02770 P04800 P05182 P05183 P08430 P08541 P08542 P09875 P16303 P19488 P20720 P26453 P36510 P36511 P51538 P53987 Q5PQT3 Q5RLM2 Q62789 Q63120 Q64550 Q64581 Q64633 Q64634 Q64637 Q64638 Q64680 Q6AYT9 Q7TN78 Q9JHI3	Abcc2 Abcc3 Acsm2 Acsm4 Acsm5 Alb Bche Bsg Ces1d Ces2b Ces3 Cmoat Cmoat2 Cmrp Cyp2c66 Cyp2d-18 Cyp2d-4 Cyp2d18 Cyp2d4 Cyp2e Cyp2e-1 Cyp2e1 Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 Glyat Glyatl3 Ks LOC100912265 LOC679149 Macs3 Mct1 Mlp2 Mrp2 Mrp3 Nlt Oat2 Oatp2b1 Omacs RGD1559459 Slc16a1 Slc21a9 Slc22a7 Slco2b1 Udpgtr2 Ugt1 Ugt1a1 Ugt1a2 Ugt1a3 Ugt1a5 Ugt1a6 Ugt1a7 Ugt1a7c Ugt1a8 Ugt2a-1 Ugt2a1 Ugt2b Ugt2b1 Ugt2b12 Ugt2b15 Ugt2b17 Ugt2b2 Ugt2b3 Ugt2b34l1 Ugt2b36 Ugt2b37 Ugt2b4 Ugt2b5 Ugt2b6 Ugt2b7 Ugt2b8 Ugt3a1 Ugt3a2	Rattus norvegicus (Norway rat)
Glucuronidation	Palmitoyl-protein thioesterase ABHD10, mitochondrial UDP-glucuronosyltransferase 1-2 UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 1A7 UDP-glucuronosyltransferase 1A8 UDP-glucuronosyltransferase 2A1 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B1 UDP-glucuronosyltransferase 2B2 UDP-glucuronosyltransferase 2B37 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase glucuronosyltransferase	A0A0G2K4R2 F1LTB8 P08430 P08541 P08542 P09875 P19488 P20720 P36510 P36511 Q5I0K5 Q62789 Q64550 Q64633 Q64634 Q64637 Q64638	Abhd10 RGD1559459 Udpgtr2 Ugt1 Ugt1a1 Ugt1a2 Ugt1a3 Ugt1a5 Ugt1a6 Ugt1a7 Ugt1a7c Ugt1a8 Ugt2a-1 Ugt2a1 Ugt2b Ugt2b1 Ugt2b12 Ugt2b15 Ugt2b17 Ugt2b2 Ugt2b3 Ugt2b34l1 Ugt2b36 Ugt2b37 Ugt2b4 Ugt2b5 Ugt2b6 Ugt2b7 Ugt2b8 Ugt3a1 Ugt3a2	Rattus norvegicus (Norway rat)
Miscellaneous transport and binding events	Alpha-adducin Beta-adducin Cystinosin, lysosomal cystine transporter Dematin actin binding protein Gamma-adducin Leucine rich repeat containing 8 VRAC subunit B Lysosomal amino acid transporter 1 homolog Magnesium transporter MRS2 homolog, mitochondrial Magnesium transporter protein 1 Mineralization regulator ANKH NIPA magnesium transporter 1 NIPA magnesium transporter 2 NIPA-like domain containing 1 NIPA-like domain containing 2 NIPA-like domain containing 3 NIPA-like domain containing 4 Prolactin-inducible protein homolog Tumor suppressor candidate 3 Volume-regulated anion channel subunit LRRC8A Volume-regulated anion channel subunit LRRC8C Volume-regulated anion channel subunit LRRC8D Volume-regulated anion channel subunit LRRC8E Zinc-alpha-2-glycoprotein	A0A0G2K4T6 A0A8I5ZXT2 A0A8I6GMM8 B0BMY1 D3ZA72 D3ZG79 D3ZKE2 D3ZUV1 D4A758 F1M5J3 O35777 O70417 P58366 Q05764 Q3KRC6 Q498T9 Q4V8I7 Q5U308 Q62847 Q63028 Q63678 Q6AY49 Q9ET09	Add1 Add2 Add3 Ank Ankh Azgp1 Ctns Dmtn Iag2 Lrrc5 Lrrc8 Lrrc8a Lrrc8b Lrrc8c Lrrc8d Lrrc8e Magt1 Mrs2 Mrs2l Nipa1 Nipa2 Nipal1 Nipal2 Nipal3 Nipal4 Pip Pqlc2 Rpt Slc66a1 Tusc3	Rattus norvegicus (Norway rat)
Ovarian tumor domain proteases	Adenomatous polyposis coli protein Cellular tumor antigen p53 Cyclin-dependent kinase 1 Deubiquitinating protein VCPIP1 Estrogen receptor NF-kappa-B essential modulator NF-kappa-B essential modulator Nucleotide-binding oligomerization domain containing 1 Nucleotide-binding oligomerization domain containing 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyubiquitin-B Polyubiquitin-C Receptor interacting serine/threonine kinase 1 Receptor-interacting serine/threonine-protein kinase 2 Ring finger protein 128 TNF receptor-associated factor 6 TNF receptor-associated factor TNFAIP3 interacting protein 1 TNFAIP3 interacting protein 2 Transforming protein RhoA Transitional endoplasmic reticulum ATPase Ubiquitin B-like Ubiquitin thioesterase OTU1 Ubiquitin thioesterase OTUB1 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A0G2K4Z7 A0A0G2K5N0 A0A0G2K7X2 A0A8I6A5Y3 A0A8I6AH74 A0A8I6AL23 A0A8I6AU71 B2RYG6 B2RZ84 B5DF45 D3ZAR8 D3ZDK2 D3ZHV1 D3ZYL0 D4A3I0 D4A7M3 D4ABZ4 D4ADT7 G3V783 G3V7R6 P06211 P0CG51 P10361 P39951 P46462 P61589 P62982 P70478 Q32Q05 Q63429 Q6TMG5 Q8CF97	Apc Arha Arha2 Cdc2 Cdc2a Cdk1 Cdkn1 Esr Esr1 Estr Hshin7 Ikbkg LOC100360606 LOC100360645 Nemo Nod1 Nod2 Nr3a1 Otub1 Otub2 Otud3 Otud7a Otud7b P53 Pten Rhoa Ripk1 Ripk2 Rnf128 Rps27a Tnfaip3 Tnip1 Tnip2 Tp53 Traf3 Traf6 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ube2d1 Vcip135 Vcp Vcpip1 Yod1 Zranb1	Rattus norvegicus (Norway rat)
Pyruvate metabolism	Alanine aminotransferase 1 Hydroxyacylglutathione hydrolase, mitochondrial L-lactate dehydrogenase A chain L-lactate dehydrogenase B chain L-lactate dehydrogenase C chain L-lactate dehydrogenase Lactoylglutathione lyase Malic enzyme Malic enzyme NADP-dependent malic enzyme Oxaloacetate decarboxylase, mitochondrial Pyruvate carboxylase, mitochondrial Pyruvate kinase PKLR Pyruvate kinase Voltage-dependent anion-selective channel protein 1	A0A0G2K502 F1M5N4 M0RD14 O35952 P04642 P12928 P13697 P19629 P25409 P42123 P52873 Q6AYQ8 Q6P7Q4 Q7TNA8 Q9Z2L0	Aat1 Fahd1 Glo1 Gpt Gpt1 Hagh LOC100362738 Ldh-1 Ldh-2 Ldh-3 Ldh1 Ldh2 Ldh3 Ldha Ldhal6b Ldhb Ldhc Me1 Me2 Me3 Mod-1 Mod1 Pc Pklr Pkml1 Rsp29 Vdac1	Rattus norvegicus (Norway rat)
Lysosphingolipid and LPA receptors	Lysophosphatidic acid receptor 1 Lysophosphatidic acid receptor 2 Lysophosphatidic acid receptor 3 Lysophosphatidic acid receptor 5 Phospholipid phosphatase related 5 Phospholipid phosphatase-related protein type 1 Phospholipid phosphatase-related protein type 2 Phospholipid phosphatase-related protein type 3 Phospholipid phosphatase-related protein type 4 Sphingosine 1-phosphate receptor 1 Sphingosine 1-phosphate receptor 2 Sphingosine 1-phosphate receptor 5 Sphingosine-1-phosphate receptor 3 Sphingosine-1-phosphate receptor 4	A0A0G2K505 A0A8I5ZVX2 D4ADR1 D4AEH8 F1M9D3 P47752 P48303 P61794 Q6W5G4 Q6WAY2 Q7TMB0 Q7TMB7 Q8K5E0 Q9JKM5	Edg1 Edg2 Edg5 Edg7 Edg8 Gpcr91 Lpa1 Lpa3 Lpar1 Lpar2 Lpar3 Lpar5 Lppr1 Lppr2 Lppr3 Lppr4 Nrg1 Php1 Plppr1 Plppr2 Plppr3 Plppr4 Plppr5 Prg1 Prg2 Prg3 Prg4 S1pr1 S1pr2 S1pr3 S1pr4 S1pr5	Rattus norvegicus (Norway rat)
Interconversion of nucleotide di- and triphosphates	Adenylate kinase 2, mitochondrial Adenylate kinase 4, mitochondrial Adenylate kinase 5 Adenylate kinase 7 Adenylate kinase 8 Adenylate kinase 8 Adenylate kinase isoenzyme 1 Adenylate kinase isoenzyme 6 CTP synthase 2 CTP synthase Deoxycytidylate deaminase Deoxyuridine 5'-triphosphate nucleotidohydrolase Glutaredoxin-1 Glutathione reductase (Fragment) NAD(+) diphosphatase Nucleoside diphosphate kinase A Nucleoside diphosphate kinase B Nucleoside diphosphate kinase Ribonucleoside-diphosphate reductase subunit M2 Ribonucleoside-diphosphate reductase Ribonucleotide reductase regulatory TP53 inducible subunit M2B Thioredoxin reductase 1, cytoplasmic Thioredoxin Thymidylate synthase UMP-CMP kinase dTMP kinase guanylate kinase	A0A0G2K524 A0A8I5Y915 A0A8I6A2B3 A0A8I6AFQ3 D4ADQ1 F1M632 F7F0L0 G3V816 M0R515 M0R7U1 O89049 P11232 P19804 P29410 P39069 P45352 P70583 P70619 Q05982 Q4KLN6 Q4KM73 Q5EB68 Q5M9G0 Q5U2N0 Q68FP8 Q9ESH6 Q9WUS0	Ak1 Ak2 Ak3l1 Ak4 Ak5 Ak6 Ak7 Ak8 Ak9 Akd2 Cinap Cmpk Cmpk1 Ctps1 Ctps2 Dctd Dtymk Dut Dutp Glrx Glrx1 Grx Gsr Guk1 Nme1 Nme2 Nme3 Nudt13 RGD1559879 Rrm1 Rrm2 Rrm2b Trxr1 Txn Txn1 Txnrd1 Tyms	Rattus norvegicus (Norway rat)
Phase 3 - rapid repolarisation	A-kinase anchoring protein 9 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E member 3 Potassium voltage-gated channel subfamily E regulatory subunit 4 Potassium voltage-gated channel subfamily E regulatory subunit 5 Potassium voltage-gated channel subfamily H member 2 Potassium voltage-gated channel subfamily KQT member 1	A0A0G2K548 A5HKJ1 O08962 P19024 P63161 Q71FD8 Q9JJV7 Q9Z0N7	Akap9 Erg Kcna5 Kcna9 Kcne1l Kcne2 Kcne3 Kcne4 Kcne5 Kcnh2 Kcnq1 Kvlqt1	Rattus norvegicus (Norway rat)
Phase 2 - plateau phase	A-kinase anchoring protein 9 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E member 3 Potassium voltage-gated channel subfamily E regulatory subunit 4 Potassium voltage-gated channel subfamily E regulatory subunit 5 Potassium voltage-gated channel subfamily KQT member 1 Voltage-dependent L-type calcium channel subunit alpha-1C Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit Voltage-dependent calcium channel subunit alpha-2/delta-2	A0A0G2K548 A5HKJ1 P22002 P54283 P62957 P63161 Q71FD8 Q8CFG6 Q8VGC3 Q8VHW5 Q8VHW7 Q8VHW9 Q9JJV7 Q9Z0N7	Akap9 Cach2 Cacn2 Cacna1c Cacna2d2 Cacnb1 Cacnb2 Cacng4 Cacng6 Cacng7 Cacng8 Cacnl1a1 Cacnlb1 Cacnlb2 Cchl1a1 Kcna9 Kcne1l Kcne2 Kcne3 Kcne4 Kcne5 Kcnq1 Kvlqt1	Rattus norvegicus (Norway rat)
Synthesis of glycosylphosphatidylinositol (GPI)	Dolichol phosphate-mannose biosynthesis regulatory protein Dolichol phosphate-mannose biosynthesis regulatory protein GPI ethanolamine phosphate transferase 1 GPI ethanolamine phosphate transferase 2 GPI mannosyltransferase 1 GPI mannosyltransferase 2 Mannosyltransferase N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Phosphatidylinositol glycan anchor biosynthesis, class F Phosphatidylinositol glycan anchor biosynthesis, class H Phosphatidylinositol glycan anchor biosynthesis, class P Phosphatidylinositol glycan anchor biosynthesis, class Q Phosphatidylinositol-glycan biosynthesis class W protein Phosphatidylinositol-glycan biosynthesis class X protein phosphatidylinositol N-acetylglucosaminyltransferase	A0A0G2K579 A0A8I5ZK79 A0A8I6A044 A0A8I6AHS9 D3ZYY8 D4AAY7 E9PTA5 M0R9J2 O35790 Q5KR61 Q5PQQ4 Q60GF7 Q642B8 Q7TSN4 Q9EQY6 Q9Z325	Dpm2 Piga Pigb Pigc Pigf Pigg Pigh Pigl Pigm Pign Pigp Pigq Pigv Pigw Pigx	Rattus norvegicus (Norway rat)
Regulation of pyruvate metabolism	Armadillo repeat-containing protein 8 E3 ubiquitin-protein transferase MAEA GID complex subunit 4 GID complex subunit 8 homolog L-lactate dehydrogenase A chain Muskelin NADP-dependent malic enzyme Polyubiquitin-B Polyubiquitin-C Pyruvate kinase RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase Ran-binding protein 9 Serine/threonine-protein phosphatase PGAM5, mitochondrial Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein WD repeat-containing protein 26 non-specific serine/threonine protein kinase	A0A0G2K5C7 A0A8I5Y176 A0A8I6A5Y3 A0A8I6AAM6 D3ZWU9 F1LTR1 F1M943 M0RD14 P04642 P0CG51 P13697 P62982 Q562B5 Q566Q9 Q5RKJ1 Q63429 Q6YDN8 Q99PV3	Armc8 Gid4 Gid8 LOC100360645 LOC100362738 Ldh-1 Ldh1 Ldha Maea Me1 Mkln1 Mod-1 Mod1 Msk Nek1 Pgam5 Pkml1 Ranbp9 Rmnd5a Rmnd5b Rps27a Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Wdr26	Rattus norvegicus (Norway rat)
Aflatoxin activation and detoxification	Aflatoxin B1 aldehyde reductase member 2 Aflatoxin B1 aldehyde reductase member 3 Aminoacylase-1A Cytochrome P450 1A2 Cytochrome P450 2A3 Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A Dipeptidase 1 Dipeptidase 2 Dipeptidase 3 Glutathione hydrolase 1 proenzyme Glutathione hydrolase 5 proenzyme Glutathione hydrolase 6 Glutathione hydrolase 7 Microsomal glutathione S-transferase 1 Microsomal glutathione S-transferase 2 Microsomal glutathione S-transferase 3 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)	A0A0G2K5K4 A0A8I5ZLK2 A0A8I6AAX9 P04799 P04800 P05183 P07314 P08011 P20812 P31430 P38918 P51538 Q5M872 Q5M876 Q5U2X4 Q64581 Q6AYS7 Q6IE08 Q8CG45 Q99MZ4 Q9QWE9	Acy1 Acy1a Acy3 Afar Afar2 Aiar Akr7a1 Akr7a2 Akr7a3 Cyp1a-2 Cyp1a2 Cyp2a-3 Cyp2a3 Cyp2a3a Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 Dpep1 Dpep2 Dpep3 Ggt Ggt1 Ggt5 Ggt6 Ggt7 Ggtl3 Ggtla1 Gst12 Mgst1 Mgst2 Mgst3 Mgst3l1 Rdp	Rattus norvegicus (Norway rat)
Biosynthesis of maresin-like SPMs	Cytochrome P450 1A2 Cytochrome P450 2C26-like Cytochrome P450 2D4 Cytochrome P450 2E1 Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A	A0A0G2K5K4 A0A8I6AFV7 P04799 P04800 P05182 P05183 P51538 Q64581 Q64680	Cyp1a-2 Cyp1a2 Cyp2c66 Cyp2d-18 Cyp2d-4 Cyp2d18 Cyp2d4 Cyp2e Cyp2e-1 Cyp2e1 Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 LOC100912265	Rattus norvegicus (Norway rat)
Phase I - Functionalization of compounds	Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase [copper-containing] 3 Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like Carbonyl reductase [NADPH] 3 Carboxylesterase 1D Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A Cytochrome P450 Cytochrome b5 type B Diamine oxidase [copper-containing] Epoxide hydrolase 1 Mitochondrial amidoxime reducing component 2 NADH-cytochrome b5 reductase 3 Ribosyldihydronicotinamide dehydrogenase [quinone]	A0A0G2K5K4 B2GV72 F7FBS0 G3V9D2 M0R9W7 O08590 O88994 P04166 P04800 P05183 P07687 P11883 P16303 P20070 P36633 P41738 P41739 P51538 Q64581 Q6AY80 Q75NT5 Q78E60 Q7TP52 Q9QZH8	Aada Aadac Abp1 Ahr Ahrr Aldd Aldh3 Aldh3a1 Aoc1 Aoc3 Arnt Arnt2 Bphl Cbr3 Ces1d Ces2b Ces3 Cmbl Cyb5b Cyb5m Cyb5r3 Cyp2b21 Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 Dia1 Eph-1 Ephx1 LOC679149 Marc2 Mg87 Mosc2 Mtarc2 Nqo2 Omb5	Rattus norvegicus (Norway rat)
Prednisone ADME	11-beta-hydroxysteroid dehydrogenase 1 11-beta-hydroxysteroid dehydrogenase type 2 ATP-dependent translocase ABCB1 Albumin Aldo-keto reductase family 1 member C21 Aldo-keto reductase family 1, member C1 Corticosteroid-binding globulin Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A UDP-glucuronosyltransferase 1-2 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B1 UDP-glucuronosyltransferase 2B2 UDP-glucuronosyltransferase 2B37 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase	A0A0G2K5K4 F1LTB8 P02770 P04800 P05183 P08541 P08542 P09875 P16232 P19488 P20720 P31211 P36511 P43245 P50233 P51538 Q3MHS3 Q62789 Q64581 Q64637 Q64638 Q6AYQ2	Abcb1 Akr1c1 Akr1c21 Alb Cbg Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 Hsd11 Hsd11b1 Hsd11b2 Hsd11k Hsd17b5 Mdr1 Mdr1b Pgy1 RGD1559459 Serpina6 Udpgtr2 Ugt1 Ugt1a2 Ugt1a3 Ugt1a5 Ugt2b Ugt2b1 Ugt2b12 Ugt2b15 Ugt2b17 Ugt2b2 Ugt2b3 Ugt2b34l1 Ugt2b36 Ugt2b37 Ugt2b4 Ugt2b5 Ugt2b6 Ugt2b7 Ugt2b8	Rattus norvegicus (Norway rat)
Atorvastatin ADME	ATP-binding cassette sub-family C member 2 ATP-dependent translocase ABCB1 Cytochrome P450 3A18 Cytochrome P450 3A1 Cytochrome P450 3A2 Cytochrome P450 3A9 Cytochrome P450 3A Serum paraoxonase/arylesterase 1 Serum paraoxonase/lactonase 3 Solute carrier organic anion transporter family member 1B2 Solute carrier organic anion transporter family member 2B1 UDP-glucuronosyltransferase 1-2 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A5	A0A0G2K5K4 P04800 P05183 P20720 P43245 P51538 P55159 Q63120 Q64581 Q64637 Q64638 Q68FP2 Q9JHI3 Q9QZX8	Abcb1 Abcc2 Cmoat Cmrp Cyp3a-1 Cyp3a-2 Cyp3a1 Cyp3a11 Cyp3a13 Cyp3a18 Cyp3a2 Cyp3a62 Cyp3a9 Mdr1 Mdr1b Mrp2 Oatp1b2 Oatp2b1 Pgy1 Pon Pon1 Pon3 Slc21a10 Slc21a9 Slco1b2 Slco2b1 Ugt1 Ugt1a2 Ugt1a3 Ugt1a5	Rattus norvegicus (Norway rat)

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