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Standards Ontologies Notations
multiple sclerosis

Summary
Synonym
  • Generalized multiple sclerosis
  • insular sclerosis
Definition
A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Super Class
autoimmune disease of central nervous system demyelinating disease
Disease Ontology
DOID:2377
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 87 in total
Gene ID Gene Symbol Description Source
2 A2M alpha-2-macroglobulin
43 ACHE acetylcholinesterase (Yt blood group)
176 ACAN aggrecan
177 AGER advanced glycosylation end-product specific receptor
182 JAG1 jagged canonical Notch ligand 1
183 AGT angiotensinogen
335 APOA1 apolipoprotein A1
344 APOC2 apolipoprotein C2
355 FAS Fas cell surface death receptor
356 FASLG Fas ligand
Displaying entries 1 - 10 of 72 in total
Gene ID Gene Symbol Description Source
11423 Ache acetylcholinesterase
11450 Adipoq adiponectin, C1Q and collagen domain containing
11595 Acan aggrecan
11596 Ager advanced glycosylation end product-specific receptor
12064 Bdnf brain derived neurotrophic factor
12287 Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit
12477 Ctla4 cytotoxic T-lymphocyte-associated protein 4
12484 Cd24a CD24a antigen
12487 Cd28 CD28 antigen
12524 Cd86 CD86 antigen
Displaying entries 21 - 30 of 43 in total
Gene ID Gene Symbol Description Source
29146 Jag1 jagged canonical Notch ligand 1
29260 Tlr4 toll-like receptor 4
29333 Cd46 CD46 molecule
29393 Col1a1 collagen type I alpha 1 chain
29409 Mag myelin-associated glycoprotein
29499 Shh sonic hedgehog signaling molecule
58968 Acan aggrecan
60590 Grm8 glutamate metabotropic receptor 8
65196 B4galt6 beta-1,4-galactosyltransferase 6
81687 Mmp9 matrix metallopeptidase 9
Displaying all 10 entries
Gene ID Gene Symbol Description Source
32158 cac cacophony
36585 beta4GalNAcTA beta1,4-N-acetylgalactosaminyltransferase A
39443 Ptp69D Protein tyrosine phosphatase 69D
39984 Grd Glycine receptor
41625 Ace Acetylcholine esterase
41840 Hsc70-4 Heat shock protein 70 cognate 4
42490 Mvl Malvolio
43222 Tl Toll
43275 Ser Serrate
43425 beta4GalNAcTB beta1,4-N-acetylgalactosaminyltransferase B
Displaying all 8 entries
Gene ID Gene Symbol Description Source
114549 ache acetylcholinesterase (Yt blood group)
140421 jag1a jagged canonical Notch ligand 1a
393912 b4galt6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
406411 rhoaa ras homolog gene family, member Aa
406659 rhoac ras homolog gene family, member Ac
555941 cacna1ba calcium channel, voltage-dependent, N type, alpha 1B subunit, a
724080 b4galt5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
100006041 rhoab ras homolog gene family, member Ab
Displaying all 6 entries
Gene ID Gene Symbol Description Source Organism
446703 b4galt5.L UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 L homeolog Xenopus laevis (African clawed frog)
548965 b4galt6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Xenopus tropicalis (tropical clawed frog)
549139 b4galt5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 Xenopus tropicalis (tropical clawed frog)
779435 b4galt6.L UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 L homeolog Xenopus laevis (African clawed frog)
108695277 b4galt6.S UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 S homeolog Xenopus laevis (African clawed frog)
108702589 b4galt5.S UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 S homeolog Xenopus laevis (African clawed frog)
Displaying entries 1 - 10 of 20 in total
Gene ID Gene Symbol Description Source
175076 ace-3 Carboxylic ester hydrolase
176282 lin-12 lin-12/Notch intracellular domain
176286 glp-1 glp-1/Notch intracellular domain
177044 smf-3 NRAMP-like transporter smf-3
177372 cpi-1 Cystatin cpi-1
178748 zmp-3 Matrix metalloproteinase-C
179053 cpr-4 Cathepsin B-like cysteine proteinase 4
179991 zmp-4 Hemopexin;Peptidase metallopeptidase domain-containing protein
180033 cpr-3 Cathepsin B-like cysteine proteinase 3
180349 grd-2 Ground-like domain-containing protein
Displaying all 2 entries
Gene ID Gene Symbol Description Source
850721 SMF3 putative divalent metal ion transporter SMF3
856294 RHO1 Rho family GTPase RHO1
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024