GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **526 - 550** of **2090** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Aladin E3 SUMO-protein ligase RanBP2 Glucokinase regulatory protein Hexokinase-4 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Protein SEC13 homolog mRNA export factor RAE1	A8CG34 O15504 O75694 P12270 P35557 P35658 P37198 P49790 P49792 P55735 P57740 P78406 Q12769 Q14397 Q5SRE5 Q7Z3B4 Q8N1F7 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q96HA1 Q99567 Q9BTX1 Q9BW27 Q9NRG9 Q9UKX7	AAAS ADRACALA C7orf14 CAIN CAN CG1 D3S1231E GCK GCKR KIAA0023 KIAA0095 KIAA0169 KIAA0197 KIAA0225 KIAA0618 KIAA0791 KIAA0906 MP44 MRNP41 NDC1 NPAP60L NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 PCNT1 POM121 POM121A POM121C RAE1 RANBP2 SEC13 SEC13A SEC13L1 SEC13R TMEM48 TPR
Defective UGT1A1 causes hyperbilirubinemia	UDP-glucuronosyltransferase 1A1	P22309	GNT1 UGT1 UGT1A1
Defective UGT1A4 causes hyperbilirubinemia	UDP-glucuronosyltransferase 1A4	P22310	GNT1 UGT1 UGT1A4
Defective VWF binding to collagen type I	von Willebrand factor	P04275	F8VWF VWF
Defective VWF cleavage by ADAMTS13 variant	A disintegrin and metalloproteinase with thrombospondin motifs 13 von Willebrand factor	P04275 Q76LX8	ADAMTS13 C9orf8 F8VWF VWF
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1C G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Retinoblastoma-associated protein Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3	O00716 O96020 P06400 P11802 P24385 P24864 P24941 P30279 P30281 P38936 P46527 P49918 Q00534 Q01094 Q14186 Q14188 Q14209	BCL1 CAP20 CCND1 CCND2 CCND3 CCNE CCNE1 CCNE2 CDK2 CDK4 CDK6 CDKN1 CDKN1A CDKN1B CDKN1C CDKN2 CDKN6 CIP1 DP1 DP2 E2F1 E2F2 E2F3 KIAA0075 KIP1 KIP2 MDA6 PIC1 PRAD1 RB1 RBBP3 SDI1 TFDP1 TFDP2 WAF1 p27
Defective binding of VWF variant to GPIb:IX:V	Platelet glycoprotein IX Platelet glycoprotein Ib alpha chain Platelet glycoprotein Ib beta chain Platelet glycoprotein V von Willebrand factor	P04275 P07359 P13224 P14770 P40197	F8VWF GP1BA GP1BB GP5 GP9 VWF
Defective cofactor function of FVIIIa variant	Coagulation factor IX Coagulation factor VIII Coagulation factor X	P00451 P00740 P00742	F10 F8 F8C F9
Defective factor IX causes thrombophilia	Coagulation factor IX Coagulation factor VIII Coagulation factor X	P00451 P00740 P00742	F10 F8 F8C F9
Defective factor XII causes hereditary angioedema	Coagulation factor XII Plasma kallikrein Prothrombin	P00734 P00748 P03952	F12 F2 KLK3 KLKB1
Defective gamma-carboxylation of F9	Coagulation factor IX Vitamin K-dependent gamma-carboxylase	P00740 P38435	F9 GC GGCX
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Defective pro-SFTPB causes SMDP1 and RDS	Pulmonary surfactant-associated protein B	P07988	SFTP3 SFTPB
Defective pyroptosis	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA primase large subunit DNA primase small subunit Gasdermin-E Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Polycomb protein EED Polycomb protein SUZ12	O60443 O60814 O75530 P04908 P06899 P09884 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P49642 P49643 P57053 P58876 P62805 P62807 P68431 P84243 Q09028 Q14181 Q15022 Q15910 Q16576 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9Y6K1	AIM CHET9 CXXC9 DFNA5 DNMT DNMT1 DNMT3A DNMT3B EED EZH2 GSDME H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 ICERE1 JJAZ1 KIAA0160 KMT6 POLA POLA1 POLA2 PRIM1 PRIM2 PRIM2A RBAP46 RBAP48 RBBP4 RBBP7 SUZ12 TSH2B
Defective regulation of TLR7 by endogenous ligand	Toll-like receptor 7	Q9NYK1	TLR7
Defective translocation of RB1 mutants to the nucleus	Retinoblastoma-associated protein	P06400	RB1
Defensins	Beta-defensin (Fragment) Beta-defensin 103 Beta-defensin 104 Beta-defensin 105 Beta-defensin 106 Beta-defensin 107 Beta-defensin 108B Beta-defensin 110 Beta-defensin 112 Beta-defensin 113 Beta-defensin 114 Beta-defensin 115 Beta-defensin 116 Beta-defensin 119 Beta-defensin 121 Beta-defensin 123 Beta-defensin 124 Beta-defensin 125 Beta-defensin 126 Beta-defensin 127 Beta-defensin 128 Beta-defensin 129 Beta-defensin 130A Beta-defensin 130B Beta-defensin 131A Beta-defensin 132 Beta-defensin 133 Beta-defensin 134 Beta-defensin 135 Beta-defensin 1 Defensin alpha 4 Defensin alpha 5 Defensin beta 118 Defensin beta 136 Defensin beta 4A Defensin-6 Neutrophil defensin 1 Neutrophil defensin 3	O15263 P0DP73 P0DP74 P12838 P59665 P59666 P59861 P60022 P81534 Q01523 Q01524 Q30KP8 Q30KP9 Q30KQ1 Q30KQ3 Q30KQ4 Q30KQ5 Q30KQ6 Q30KQ7 Q30KQ8 Q30KQ9 Q4QY38 Q5J5C9 Q7Z7B7 Q7Z7B8 Q8IZN7 Q8N104 Q8N687 Q8N688 Q8N690 Q8NES8 Q8NET1 Q8NG35 Q8WTQ1 Q96PH6 Q9BYW3 Q9H1M3 Q9H1M4	BD1 BD3 BD5 BD6 C20orf63 C20orf73 C20orf8 C20orf87 DEF1 DEF3 DEF4 DEF5 DEF6 DEFA1 DEFA1B DEFA2 DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB10 DEFB102 DEFB103 DEFB103A DEFB103B DEFB104 DEFB104A DEFB104B DEFB105 DEFB105A DEFB105B DEFB106 DEFB106A DEFB106B DEFB107 DEFB107A DEFB107B DEFB108 DEFB108B DEFB11 DEFB110 DEFB111 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB12 DEFB120 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB13 DEFB130 DEFB130A DEFB130B DEFB131 DEFB131A DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB14 DEFB15 DEFB16 DEFB18 DEFB19 DEFB2 DEFB20 DEFB21 DEFB23 DEFB24 DEFB25 DEFB26 DEFB27 DEFB28 DEFB29 DEFB3 DEFB30 DEFB31 DEFB32 DEFB4 DEFB4A DEFB4B DEFB5 DEFB6 DEFB7 DEFB8 ESC42 HBD1 MRS
Degradation of AXIN	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Axin-1 Axin-2 E3 ubiquitin-protein ligase RNF146 E3 ubiquitin-protein ligase SMURF2 Poly [ADP-ribose] polymerase tankyrase-1 Poly [ADP-ribose] polymerase tankyrase-2 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O15169 O43242 O75832 O95271 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 Q06323 Q13200 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q99436 Q99460 Q9H2K2 Q9HAU4 Q9NTX7 Q9UL46 Q9UNM6 Q9Y2T1	AXIN AXIN1 AXIN2 C7orf76 DSS1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU PARP5A PARP5B PARPL PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RING10 RING12 RNF146 RPS27A SEM1 SHFDG1 SHFM1 SMURF2 SUG1 SUG2 TANK2 TBP1 TBP7 TIN1 TINF1 TNKL TNKS TNKS1 TNKS2 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Degradation of DVL	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-3 Dapper homolog 1 E3 ubiquitin-protein ligase HECW1 E3 ubiquitin-protein ligase RBX1 Kelch-like protein 12 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14640 O14641 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 Q06323 Q13200 Q13618 Q14997 Q15008 Q16401 Q53G59 Q76N89 Q8TAA3 Q92530 Q92997 Q99436 Q99460 Q9NYF0 Q9UL46 Q9UNM6	C3IP1 C7orf76 CUL3 DACT1 DPR1 DSS1 DVL1 DVL2 DVL3 HC2 HC3 HC8 HC9 HECW1 HNG3 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 KIAA0208 KIAA0322 KIAA0617 KLHL12 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NEDL1 NU PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Degradation of GABA	4-aminobutyrate aminotransferase, mitochondrial Succinate-semialdehyde dehydrogenase, mitochondrial	P51649 P80404	ABAT ALDH5A1 GABAT SSADH
Degradation of GLI1 by the proteasome	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RBX1 F-box/WD repeat-containing protein 1A Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein numb homolog S-phase kinase-associated protein 1 Suppressor of fused homolog Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein GLI1 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P08151 P0CG47 P0CG48 P17612 P17980 P20618 P22612 P22694 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P49757 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P63208 Q06323 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q96J02 Q99436 Q99460 Q9UL46 Q9UMX1 Q9UNM6 Q9Y297	BTRC BTRCP C14orf41 C7orf76 CUL1 DSS1 EMC19 FBW1A FBXW1A GLI GLI1 HC2 HC3 HC8 HC9 HSPC IFI5111 ITCH KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU NUMB OCP2 PFAAP4 PKACA POH1 PRKACA PRKACB PRKACG PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUFU SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Degradation of GLI2 by the proteasome	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Casein kinase I isoform alpha Cullin-1 E3 ubiquitin-protein ligase RBX1 F-box/WD repeat-containing protein 1A Glycogen synthase kinase-3 beta Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Suppressor of fused homolog Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein GLI2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P10070 P17612 P17980 P20618 P22612 P22694 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P48729 P49720 P49721 P49841 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P63208 Q06323 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q99436 Q99460 Q9UL46 Q9UMX1 Q9UNM6 Q9Y297	BTRC BTRCP C7orf76 CSNK1A1 CUL1 DSS1 EMC19 FBW1A FBXW1A GLI2 GSK3B HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 PKACA POH1 PRKACA PRKACB PRKACG PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUFU SUG1 SUG2 TBP1 TBP7 TCEB1L THP TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Degradation of beta-catenin by the destruction complex	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Cullin-1 E3 ubiquitin-protein ligase RBX1 F-box/WD repeat-containing protein 1A Glycogen synthase kinase-3 beta Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Ubiquitin thioesterase ZRANB1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O15169 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25054 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P30153 P30154 P35222 P35998 P40306 P43686 P48556 P48729 P49720 P49721 P49841 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62714 P62877 P62979 P62987 P63208 P67775 Q06323 Q13200 Q13362 Q13616 Q14738 Q14997 Q15008 Q15172 Q15173 Q16401 Q16537 Q5JTC6 Q8TAA3 Q92530 Q99436 Q99460 Q9UGI0 Q9UL46 Q9UNM6 Q9Y297	AMER1 APC AXIN AXIN1 BTRC BTRCP C7orf76 CSNK1A1 CTNNB CTNNB1 CUL1 DP2.5 DSS1 EMC19 FAM123B FBW1A FBXW1A GSK3B HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0044 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 POH1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TRABID TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WTX X Y Y2 Z ZRANB1
Degradation of cysteine and homocysteine	2-aminoethanethiol dioxygenase 3-mercaptopyruvate sulfurtransferase Acidic amino acid decarboxylase GADL1 Aspartate aminotransferase, mitochondrial Cystathionine gamma-lyase Cysteine dioxygenase type 1 Cysteine sulfinic acid decarboxylase Flavin-containing monooxygenase 1 Thioredoxin, mitochondrial Thiosulfate sulfurtransferase	P00505 P25325 P32929 Q01740 Q16762 Q16878 Q6ZQY3 Q96SZ5 Q99757 Q9Y600	ADO C10orf22 CDO1 CSAD CSD CTH FMO1 GADL1 GOT2 KYAT4 MPST TRX2 TST TST2 TXN2
Degradation of the extracellular matrix	72 kDa type IV collagenase A disintegrin and metalloproteinase with thrombospondin motifs 16 A disintegrin and metalloproteinase with thrombospondin motifs 18 A disintegrin and metalloproteinase with thrombospondin motifs 1 A disintegrin and metalloproteinase with thrombospondin motifs 4 A disintegrin and metalloproteinase with thrombospondin motifs 5 A disintegrin and metalloproteinase with thrombospondin motifs 8 A disintegrin and metalloproteinase with thrombospondin motifs 9 Aggrecan core protein Alpha-2-macroglobulin Basement membrane-specific heparan sulfate proteoglycan core protein Basigin Bone morphogenetic protein 1 Brevican core protein CD44 antigen Cadherin-1 Calpain small subunit 1 Calpain small subunit 2 Calpain-1 catalytic subunit Calpain-10 Calpain-11 Calpain-12 Calpain-13 Calpain-14 Calpain-15 Calpain-2 catalytic subunit Calpain-3 Calpain-5 Calpain-6 Calpain-7 Calpain-8 Calpain-9 Calpastatin Caspase-3 Cathepsin G Cathepsin K Cathepsin L2 Cathepsin S Collagenase 3 Decorin Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 15 Disintegrin and metalloproteinase domain-containing protein 8 Interstitial collagenase Kallikrein-7 Laminin subunit alpha-3 Laminin subunit alpha-5 Laminin subunit beta-1 Laminin subunit beta-3 Laminin subunit gamma-1 Laminin subunit gamma-2 Macrophage metalloelastase Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-19 Matrix metalloproteinase-20 Matrix metalloproteinase-9 Neutrophil collagenase Neutrophil elastase Nicastrin Nidogen-1 Opticin Osteopontin Plasminogen Presenilin-1 Procathepsin L Serine protease HTRA1 Signal peptide, CUB and EGF-like domain-containing protein 1 Signal peptide, CUB and EGF-like domain-containing protein 3 Stromelysin-1 Stromelysin-2 Stromelysin-3 Tolloid-like protein 1 Tolloid-like protein 2 Transmembrane protease serine 6	A6NHC0 A8MX76 O14672 O14815 O15230 O15484 O43897 O60882 O60911 O75173 O75808 P00747 P01023 P03956 P04632 P07384 P07585 P07711 P07942 P08246 P08253 P08254 P08311 P09237 P09238 P10451 P11047 P12830 P13497 P14543 P14780 P16070 P16112 P17655 P20807 P20810 P22894 P24347 P25774 P35613 P39900 P42574 P43235 P45452 P49768 P49862 P50281 P51511 P78325 P98160 Q13444 Q13751 Q13753 Q16787 Q6MZZ7 Q6ZSI9 Q8IU80 Q8IWY4 Q8IX30 Q8TE57 Q8TE60 Q92542 Q92743 Q96GW7 Q96L46 Q99542 Q9HC96 Q9P2N4 Q9UBM4 Q9UHI8 Q9UMQ6 Q9UNA0 Q9UP79 Q9Y6L7 Q9Y6Q1 Q9Y6W3	A2M ACAN AD3 ADAM10 ADAM15 ADAM8 ADAMTS1 ADAMTS11 ADAMTS16 ADAMTS18 ADAMTS21 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADMP2 AGC1 BCAN BEHAB BMP1 BNSP BSG CALPM CANP3 CANPL1 CANPL2 CANPL3 CANPX CAPN1 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPN15 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPNS CAPNS1 CAPNS2 CASP3 CAST CATL2 CD44 CDH1 CDHE CEGF3 CLG CLG1 CLG4A CLG4B CPAMD5 CPP32 CSPG1 CSPG7 CTSG CTSK CTSL CTSL1 CTSL2 CTSO CTSO2 CTSS CTSU CTSV DCN ELA2 ELANE HME HSPG2 HTRA HTRA1 KIAA0253 KIAA0533 KIAA0688 KIAA0932 KIAA1312 KIAA1346 KIAA1845 KIAA1907 KIAA2029 KLK7 KUZ LAMA3 LAMA5 LAMB1 LAMB2 LAMB2T LAMB3 LAMC1 LAMC2 LAMNA LAMNB1 LAMNB2 LHR MADM MDC15 MDU2 MDU3 METH1 METH2 MIC4 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP18 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 MPSL1 MS2 MSK16 NCL1 NCL2 NCL3 NCL4 NCSTN NID NID1 OPN OPT OPTC PALBH PCOLC PLG PRSS11 PRSS6 PS1 PSEN1 PSNL1 PUMP1 RASI SCCE SCUBE1 SCUBE3 SLRR1B SOLH SPP1 STMY1 STMY2 STMY3 TLL TLL1 TLL2 TMPRSS6 UVO

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