GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source Last Updated
Reactome March 20, 2024
ECODAB April 1, 2019
Displaying entries 376 - 400 of 1070 in total
Pathway Name Protein Name UniProt ID Gene Symbol ▲ Organism GlyTouCan ID
CTLA4 inhibitory signaling
  • Akt1
  • Akt2
  • Akt3
  • Cd80
  • Cd86
  • Ctla4
  • Fyn
  • LOC100909468
  • Lck
  • Lyn
  • Ppp2ca
  • Ppp2cb
  • Ppp2r1a
  • Ppp2r1b
  • Ppp2r5a
  • Ppp2r5b
  • Ppp2r5c
  • Ppp2r5d
  • Ppp2r5e
  • Ptpn11
  • Src
  • Yes1
Rattus norvegicus (Norway rat)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • Akt1
  • Akt2
  • Akt3
  • Cdkn1b
  • Creb-1
  • Creb1
  • Crm1
  • Erk2
  • Foxo3
  • Kis
  • Kist
  • Mapk
  • Mapk1
  • Prkm1
  • Uhmk1
  • Xpo1
  • p27Kip1
Rattus norvegicus (Norway rat)
AKT phosphorylates targets in the nucleus
  • Akt1
  • Akt2
  • Akt3
  • Creb-1
  • Creb1
  • Foxo1
  • Foxo1a
  • Foxo3
  • Foxo4
  • Foxo6
  • Hmr
  • Ngfib
  • Nr4a1
  • Rps6kb2
Rattus norvegicus (Norway rat)
Downregulation of ERBB2:ERBB3 signaling
  • Akt1
  • Akt2
  • Akt3
  • Erbb2
  • Erbb3
  • LOC100360645
  • Ndf
  • Neu
  • Nrg1
  • Nrg2
  • Ntak
  • Rnf41
  • Rps27a
  • Uba80
  • Ubb
  • Ubbl1
  • Ubc
  • Ubcep1
  • Ubcl1
  • Usp8
Rattus norvegicus (Norway rat)
Regulation of localization of FOXO transcription factors
  • Akt1
  • Akt2
  • Akt3
  • Foxo1
  • Foxo1a
  • Foxo3
  • Foxo4
  • Foxo6
  • Msfs1
  • Sfn
  • Ywhab
  • Ywhag
  • Ywhaq
  • Ywhaz
Rattus norvegicus (Norway rat)
AKT-mediated inactivation of FOXO1A
  • Akt1
  • Akt2
  • Akt3
  • Foxo1
  • Foxo1a
Rattus norvegicus (Norway rat)
Negative regulation of the PI3K/AKT network
  • Akt1
  • Akt2
  • Akt3
  • Nipk
  • Phlpp
  • Phlpp1
  • Plekhe1
  • Pten
  • Scop
  • Them4
  • Trib3
Rattus norvegicus (Norway rat)
Deactivation of the beta-catenin transactivating complex
  • Akt1
  • Akt2
  • Apc
  • Api3
  • Bars
  • Birc4
  • Btrc
  • Catnb
  • Cby
  • Cby1
  • Chd8
  • Crm1
  • Ctbp1
  • Ctbp3
  • Ctnnb1
  • Ctnnbip1
  • Esp2
  • Esp3
  • Grg4
  • Hdac1
  • LOC100360645
  • Lef1
  • Msfs1
  • Pgea1
  • Rps27a
  • Sox-6
  • Sox13
  • Sox17
  • Sox2
  • Sox3
  • Sox4
  • Sox6
  • Sox7
  • Sox9
  • Tcf7
  • Tcf7l1
  • Tcf7l2
  • Tle1
  • Tle2
  • Tle3
  • Tle4
  • Uba80
  • Ubb
  • Ubbl1
  • Ubc
  • Ubcep1
  • Ubcl1
  • Xiap
  • Xpo1
  • Ywhaz
Rattus norvegicus (Norway rat)
Integrin signaling
  • Akt1
  • Apbb1ip
  • Cgef2
  • Csk
  • Epac
  • Epac1
  • Epac2
  • Fak
  • Fak1
  • Fga
  • Fgb
  • Fgg
  • Fn1
  • Itga2b
  • Itgb3
  • Krev1
  • Pdk1
  • Pdpk1
  • Ptk2
  • Ptpn1
  • Rap1a
  • Rap1b
  • Rapgef3
  • Rapgef4
  • Rasgrp
  • Rasgrp1
  • Rasgrp2
  • Shc1
  • Src
  • Syk
  • Tln1
Rattus norvegicus (Norway rat)
eNOS activation
  • Akt1
  • Apt1
  • CaMIII
  • Calm3
  • Cam3
  • Camc
  • Cav
  • Cav1
  • Cygb
  • Ddah
  • Ddah1
  • Hsp86
  • Hsp90aa1
  • Hspca
  • Lypla1
  • Nos3
  • Spr
  • Stap
Rattus norvegicus (Norway rat)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • Akt1
  • Arap1
  • Cbl
  • Dok1
  • LOC100360645
  • Ptk6
  • Rps27a
  • Uba80
  • Ubb
  • Ubbl1
  • Ubc
  • Ubcep1
  • Ubcl1
Rattus norvegicus (Norway rat)
Extra-nuclear estrogen signaling
  • Akt1
  • Areg
  • Btc
  • CaMIII
  • Calm3
  • Cam3
  • Camc
  • Cav
  • Cav1
  • Cav2
  • Dtr
  • Egf
  • Egfr
  • Erbeta
  • Ereg
  • Esr
  • Esr1
  • Esr2
  • Estr
  • Fak
  • Fak1
  • Gnai-1
  • Gnai-2
  • Gnai-3
  • Gnai1
  • Gnai2
  • Gnai3
  • Gnat-3
  • Gnat3
  • Hbegf
  • Hegfl
  • Hrmt1l2
  • Hsp86
  • Hsp90aa1
  • Hspca
  • Igf1r
  • Mmp-7
  • Mmp2
  • Mmp3
  • Mmp7
  • Mmp9
  • Nos3
  • Nr3a1
  • Nr3a2
  • Pik3ca
  • Pik3r1
  • Pik3r2
  • Pik3r3
  • Prmt1
  • Ptk2
  • S1pr3
  • Sdgf
  • Serz
  • Shc1
  • Sphk1
  • Src
  • Strn
  • Tgfa
  • Zdhhc7
Rattus norvegicus (Norway rat)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Akt1
  • Brf1
  • Cmg1
  • Dcp1a
  • Dcp2
  • Dis3
  • Exosc1
  • Exosc2
  • Exosc3
  • Exosc4
  • Exosc5
  • Exosc6
  • Exosc7
  • Exosc8
  • Exosc9
  • LOC103690064
  • LOC679140
  • Mapkapk2
  • Tis11b
  • Xrn1
  • Ywhab
  • Zfp36l1
Rattus norvegicus (Norway rat)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • Akt1
  • CaMIII
  • Calm3
  • Cam3
  • Camc
  • Gch
  • Gch1
  • Gchfr
  • Gfrp
  • Hsp86
  • Hsp90aa1
  • Hspca
  • Nos3
  • Prkg2
  • Pts
  • Spr
Rattus norvegicus (Norway rat)
KSRP (KHSRP) binds and destabilizes mRNA
  • Akt1
  • Dcp2
  • Dis3
  • Exosc1
  • Exosc2
  • Exosc3
  • Exosc4
  • Exosc5
  • Exosc6
  • Exosc7
  • Exosc8
  • Exosc9
  • Fubp2
  • Khsrp
  • LOC103690064
  • LOC679140
  • Msfs1
  • Parn
  • Ywhaz
Rattus norvegicus (Norway rat)
Negative regulation of NOTCH4 signaling
  • Akt1
Rattus norvegicus (Norway rat)
HSF1-dependent transactivation
  • Akt1s1
  • Camk2a
  • Camk2b
  • Camk2d
  • Camk2g
  • Cryab
  • Cryac
  • Dnajb1
  • Frap1
  • Gbl
  • Hsbp1
  • Hsc70
  • Hsc73
  • Hsf1
  • Hsp22
  • Hsp70-1
  • Hsp70-2
  • Hsp70-3
  • Hsp84
  • Hsp86
  • Hsp90aa1
  • Hsp90ab1
  • Hspa1
  • Hspa1a
  • Hspa1b
  • Hspa1l
  • Hspa2
  • Hspa8
  • Hspb8
  • Hspc3
  • Hspca
  • Hspcb
  • Lst8
  • Mlst8
  • Mtor
  • Raft1
  • Rptor
Rattus norvegicus (Norway rat)
mTORC1-mediated signalling
  • Akt1s1
  • ENSRNOG00000066475
  • Eef2k
  • Eif4e
  • Eif4ebp1
  • Eif4g1
  • Fkbp1
  • Fkbp1a
  • Frap1
  • Gbl
  • Lamtor1
  • Lamtor3
  • Lamtor4
  • Lamtor5
  • Lst8
  • Map2k1ip1
  • Mlst8
  • Mtor
  • Raft1
  • Rheb
  • Rps6
  • Rps6kb1
  • Rptor
  • RragB
  • Rraga
  • Rragc
  • Rragc_predicted
  • Rragd
  • Slc38a9
  • Ywhab
Rattus norvegicus (Norway rat)
Activation of PKB
  • Akt2
  • Nipk
  • Pdk1
  • Pdpk1
  • Them4
  • Trib3
Rattus norvegicus (Norway rat)
Inhibition of TSC complex formation by PKB
  • Akt2
  • Tsc1
  • Tsc2
Rattus norvegicus (Norway rat)
Choline catabolism
  • Ald7a1
  • Aldh7a1
  • Bhmt
  • Cd92
  • Cdw92
  • Chdh
  • Ctl1
  • Dmgdh
  • Sardh
  • Slc44a1
Rattus norvegicus (Norway rat)
Fructose catabolism
  • Aldh
  • Aldh1a1
  • Aldob
  • Dak
  • Glyctk
  • Khk
  • Tkfc
Rattus norvegicus (Norway rat)
Glutamate and glutamine metabolism
  • Aldh18a1
  • Ccbl1
  • Ga
  • Glns
  • Gls
  • Gls2
  • Glud
  • Glud1
  • Glul
  • Got2
  • Kat
  • Kyat1
  • Maat
  • Oat
  • Pycr1
  • Pycr2
  • Pycr3
  • Pycrl
  • Rimkla
  • Rimklb
Rattus norvegicus (Norway rat)
Metabolism of folate and pterines
  • Aldh1l1
  • Aldh1l2
  • Dhfr
  • Folr2
  • Fpgs
  • Fthfd
  • Hcp1
  • Mthfd
  • Mthfd1
  • Mthfd1l
  • Mthfd2
  • Mthfd2l
  • Mthfr
  • Mthfs
  • Pcft
  • Shmt1
  • Shmt2
  • Slc19a1
  • Slc25a32
  • Slc46a1
Rattus norvegicus (Norway rat)
Metabolism of serotonin
  • Aldh2
  • Maoa
Rattus norvegicus (Norway rat)

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024