GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **876 - 900** of **1070** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
A tetrasaccharide linker sequence is required for GAG synthesis	Agrin Beta-1,4-galactosyltransferase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 Glypican 4 Glypican 5 Glypican 6 Glypican-1 Glypican-2 Glypican-3 Hexosyltransferase Neurocan core protein Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Versican core protein (Fragments) Xylosyltransferase 1 (Fragment) Xylosyltransferase 2	A0A0G2K4C0 A0A8I6A609 A0A8I6ACQ6 D3ZQC1 O35789 P13265 P25304 P26260 P33671 P34900 P34901 P35053 P47853 P51653 P55067 P55068 Q00657 Q01129 Q642B0 Q9EPI0 Q9EPI1 Q9ERB4 Q9ERQ6 Q9Z137	Agrin Agrn B3galt6 B3gat1 B3gat2 B4galt7 Bcan Behab Bgn Caleb Cspg2 Cspg3 Cspg4 Cspg5 Dcn Glcats Gpc1 Gpc2 Gpc3 Gpc4 Gpc5 Gpc6 Hspg1 Ncan Ng2 Ngc Sdc1 Sdc2 Sdc3 Sdc4 Synd1 Synd2 Synd3 Synd4 Vcan Xylt1 Xylt2	Rattus norvegicus (Norway rat)
GABA B receptor activation	Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2	O88871 Q9Z0U4	Gabbr1 Gabbr2 Gpr51	Rattus norvegicus (Norway rat)
MAPK6/MAPK4 signaling	26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cdc42 effector protein 2 Cell division control protein 42 homolog Cell division cycle 14A Cell division cycle 14B Cyclin-dependent kinase 1 DnaJ heat shock protein family (Hsp40) member B1 ETS variant transcription factor 4 Exportin-1 Forkhead box O3 Forkhead box protein O1 G1/S-specific cyclin-D3 Heat shock protein beta-1 Kalirin MAPK activated protein kinase 5 Mitogen-activated protein kinase 4 (Fragment) Mitogen-activated protein kinase 6 Nuclear receptor coactivator 3 (Fragment) Polyubiquitin-B Polyubiquitin-C Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha type Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Proteasome subunit beta Ras-related C3 botulinum toxin substrate 1 Septin-7 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta	A0A0G2JSL0 A0A0G2JX95 A0A0G2KAX0 A0A8I5ZM79 A0A8I5ZNE7 A0A8I5ZZU6 A0A8I6A5Y3 A0A8I6B415 B0BN93 D3ZBQ1 D3ZUU5 F1LMQ3 F1LMZ8 F1LN87 F1M6I7 F7FGV7 G3V6W6 G3V7R4 G3V8G2 O88761 P0CG51 P17220 P18420 P18421 P18422 P21670 P27704 P27791 P28064 P28073 P28075 P28077 P34064 P34067 P35465 P39951 P40112 P40307 P42930 P48004 P48961 P60901 P62193 P62198 P62982 P68182 P97924 Q4FZT9 Q4KM35 Q4V8E2 Q5PQP4 Q5XIC6 Q5XIU5 Q62829 Q63347 Q63429 Q63454 Q63569 Q63570 Q63797 Q63798 Q64303 Q6RUV5 Q80U96 Q8CFN2 Q9EPU2 Q9JHW0 Q9WTV5 Q9WVC0 Q9Z2X3	Aib1 Borg1 Ccnd3 Cdc10 Cdc14a Cdc14b Cdc2 Cdc2a Cdc42 Cdc42ep2 Cdk1 Cdkn1 Cep2 Crm1 Dnajb1 Duo Erk3 Etv4 Foxo1 Foxo1a Foxo3 Hapip Hsp27 Hspb1 Kalrn LOC100360645 LOC100360846 LOC100365869 Lmp10 Lmp2 Mapk4 Mapk6 Mapkapk5 Mecl1 Mss1 Ncoa3 Pak1 Pak2 Pak3 Pkacb Prkaca Prkacb Prkm4 Prkm6 Psma1 Psma2 Psma3 Psma4 Psma5 Psma6 Psma7 Psma8 Psmb1 Psmb10 Psmb2 Psmb3 Psmb4 Psmb5 Psmb6 Psmb6l Psmb6l1 Psmb7 Psmb8 Psmb9 Psmc1 Psmc2 Psmc3 Psmc4 Psmc5 Psmc6 Psmd1 Psmd10 Psmd11 Psmd12 Psmd13 Psmd14 Psmd2 Psmd3 Psmd5 Psmd6 Psmd7 Psmd8 Psmd9 Psme1 Psme2 Psme4 Psmf1 Rac Rac1 Ring12 Rps27a Sept7 Septin7 Sug1 Tbp1 Tbp7 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Xpo1	Rattus norvegicus (Norway rat)
Synthesis of glycosylphosphatidylinositol (GPI)	Dolichol phosphate-mannose biosynthesis regulatory protein Dolichol phosphate-mannose biosynthesis regulatory protein GPI ethanolamine phosphate transferase 1 GPI ethanolamine phosphate transferase 2 GPI mannosyltransferase 1 GPI mannosyltransferase 2 Mannosyltransferase N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Phosphatidylinositol glycan anchor biosynthesis, class F Phosphatidylinositol glycan anchor biosynthesis, class H Phosphatidylinositol glycan anchor biosynthesis, class P Phosphatidylinositol glycan anchor biosynthesis, class Q Phosphatidylinositol-glycan biosynthesis class W protein Phosphatidylinositol-glycan biosynthesis class X protein phosphatidylinositol N-acetylglucosaminyltransferase	A0A0G2K579 A0A8I5ZK79 A0A8I6A044 A0A8I6AHS9 D3ZYY8 D4AAY7 E9PTA5 M0R9J2 O35790 Q5KR61 Q5PQQ4 Q60GF7 Q642B8 Q7TSN4 Q9EQY6 Q9Z325	Dpm2 Piga Pigb Pigc Pigf Pigg Pigh Pigl Pigm Pign Pigp Pigq Pigv Pigw Pigx	Rattus norvegicus (Norway rat)
Biotin transport and metabolism	Acetyl-CoA carboxylase 1 Biotinidase Holocarboxylase synthetase Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial PDZ domain-containing protein 11 Propionyl-CoA carboxylase alpha chain, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate carboxylase, mitochondrial Sodium-dependent multivitamin transporter acetyl-CoA carboxylase	A0A0G2K1F2 A0A8I6A968 A0A8I6A9Z8 O70247 P07633 P11497 P14882 P52873 Q5FVF9 Q5I0C3 Q5XIT9	Acac Acaca Acacb Btd Hlcs Mcca Mccc1 Mccc2 Pc Pcca Pccb Pdzd11 Slc5a6 Smvt	Rattus norvegicus (Norway rat)
Miscellaneous transport and binding events	Alpha-adducin Beta-adducin Cystinosin, lysosomal cystine transporter Dematin actin binding protein Gamma-adducin Leucine rich repeat containing 8 VRAC subunit B Lysosomal amino acid transporter 1 homolog Magnesium transporter MRS2 homolog, mitochondrial Magnesium transporter protein 1 Mineralization regulator ANKH NIPA magnesium transporter 1 NIPA magnesium transporter 2 NIPA-like domain containing 1 NIPA-like domain containing 2 NIPA-like domain containing 3 NIPA-like domain containing 4 Prolactin-inducible protein homolog Tumor suppressor candidate 3 Volume-regulated anion channel subunit LRRC8A Volume-regulated anion channel subunit LRRC8C Volume-regulated anion channel subunit LRRC8D Volume-regulated anion channel subunit LRRC8E Zinc-alpha-2-glycoprotein	A0A0G2K4T6 A0A8I5ZXT2 A0A8I6GMM8 B0BMY1 D3ZA72 D3ZG79 D3ZKE2 D3ZUV1 D4A758 F1M5J3 O35777 O70417 P58366 Q05764 Q3KRC6 Q498T9 Q4V8I7 Q5U308 Q62847 Q63028 Q63678 Q6AY49 Q9ET09	Add1 Add2 Add3 Ank Ankh Azgp1 Ctns Dmtn Iag2 Lrrc5 Lrrc8 Lrrc8a Lrrc8b Lrrc8c Lrrc8d Lrrc8e Magt1 Mrs2 Mrs2l Nipa1 Nipa2 Nipal1 Nipal2 Nipal3 Nipal4 Pip Pqlc2 Rpt Slc66a1 Tusc3	Rattus norvegicus (Norway rat)
Acyl chain remodelling of PS	Cytosolic phospholipase A2 Group 10 secretory phospholipase A2 Lysophosphatidylcholine acyltransferase 4 Lysophospholipid acyltransferase 5 Membrane bound O-acyltransferase domain containing 1 Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Phospholipase A and acyltransferase 3 Phospholipase A1 member A Phospholipase A2 group V Phospholipase A2, group XIIA Phospholipase A2, membrane associated Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Secretory phospholipase A2 receptor	A0A0G2JXN8 A0A8I5ZU98 B0K018 D3Z9B7 D3ZLB5 D3ZQH6 D3ZR52 D4A1I6 F1LPY6 F1LV18 F1LWM8 F1M495 F7F420 P04055 P14423 P50393 P51433 P53817 P97535 Q5FVN0 Q9QZT3	Cpla2 Grcc3f H-rev107 Hrasls3 Hrev107 Lpcat3 Lpcat4 Mboat1 Mboat5 Oact5 Osbpl10 Osbpl5 Osbpl8 Pla1a Pla2g10 Pla2g12a Pla2g16 Pla2g1b Pla2g2a Pla2g2d Pla2g2f Pla2g4 Pla2g4a Pla2g4b Pla2g4d Pla2g4e Pla2g4f Pla2g5 Pla2r1 Plaat3 Pspla1 Rlp-3	Rattus norvegicus (Norway rat)
Cyclin E associated events during G1/S transition	CDK-activating kinase assembly factor MAT1 Cdk5 and Abl enzyme substrate 1 Cyclin E2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 (Fragment) Cyclin-dependent kinase inhibitor 1A Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-E1 M-phase inducer phosphatase 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Wee1-like protein kinase	A0A8I5ZZ18 A0A8I6AIM6 D3ZQ41 F7EX11 O08769 P33568 P39949 P47196 P47197 P48965 P51952 Q63484 Q63699 Q63802 Q9R1A0	Akt1 Akt2 Akt3 Cables1 Cak Cak1 Ccne Ccne1 Ccne2 Ccnh Cdc25a Cdk2 Cdk7 Cdkn1a Cdkn1b Cdkn2 Mnat1 Mo15 Rb-1 Rb1 Wee1 p27Kip1	Rattus norvegicus (Norway rat)
Interferon gamma signaling	Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Protein kinase C delta type Signal transducer and activator of transcription 4 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 6 Y-box-binding protein 1	A0A0G2JX93 A0A8I6AM23 D4A109 F7FHZ1 O88583 P01581 P08413 P09215 P11275 P11730 P15791 P21708 P62961 P63086 P81718 Q62689 Q9QX78	Camk2a Camk2b Camk2d Camk2g Cish3 Erk1 Erk2 Ifng Ifngr1 Ifngr2 Jak1 Jak2 Mapk Mapk1 Mapk3 Pkcd Prkcd Prkm1 Prkm3 Ptph6 Ptpn6 Socs1 Socs3 Stat1 Stat4 Yb1 Ybx1	Rattus norvegicus (Norway rat)
ADP signalling through P2Y purinoceptor 12	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(t) subunit alpha-3 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma P2Y purinoceptor 12	A0A8I6AF64 A0A8I6GAY3 A0A8I6GLD4 D4AAI1 F2Z3T8 G3V8K2 O35353 P04897 P08753 P10824 P29348 P43425 P52287 P54311 P54313 P61954 P62882 P63077 P63219 Q9EPX4	Gnai-1 Gnai-2 Gnai-3 Gnai1 Gnai2 Gnai3 Gnat-3 Gnat3 Gnb1 Gnb2 Gnb3 Gnb4 Gnb5 Gng10-ps1 Gng11 Gng12 Gng3 Gng4 Gng5 Gng5-ps4 Gng7 Gng8 Gng9 Gngt1 Gngt11 Gngt5 Gngt7 Gngt9 P2ry12 P2y12	Rattus norvegicus (Norway rat)
Deadenylation of mRNA	Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic initiation factor 4A-III Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4E PAN2-PAN3 deadenylation complex catalytic subunit Pan2 PAN2-PAN3 deadenylation complex subunit PAN3 Poly(A) binding protein interacting protein 1 Polyadenylate-binding protein 1	A0A0G2JVP5 D4ADM2 F7F7A6 M0RD03 P63074 Q3B8Q2 Q5RKI1 Q6IE70 Q9EPH8	Ddx48 Eif4a1 Eif4a2 Eif4a3 Eif4e Eif4g1 PAN3 Pabp1 Pabpc1 Paip1 Pan2 Pan3 Usp52	Rattus norvegicus (Norway rat)
Metabolism of folate and pterines	10-formyltetrahydrofolate dehydrogenase 5-formyltetrahydrofolate cyclo-ligase Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic Cytosolic 10-formyltetrahydrofolate dehydrogenase Dihydrofolate reductase Folate receptor beta Folylpolyglutamate synthase Methylenetetrahydrofolate reductase Proton-coupled folate transporter Reduced folate transporter Serine hydroxymethyltransferase Serine hydroxymethyltransferase Solute carrier family 25 member 32 formate--tetrahydrofolate ligase methenyltetrahydrofolate cyclohydrolase	A0A8I5Y115 A0A8I5ZRH3 A0A8I6A4C5 A0A8I6AG23 A0A8I6GID3 B2GUZ3 D3ZUA0 D4A4S5 M0R401 P27653 P28037 Q5EBA8 Q5U3Z7 Q62866 Q6TXG7 Q920D2	Aldh1l1 Aldh1l2 Dhfr Folr2 Fpgs Fthfd Hcp1 Mthfd Mthfd1 Mthfd1l Mthfd2 Mthfd2l Mthfr Mthfs Pcft Shmt1 Shmt2 Slc19a1 Slc25a32 Slc46a1	Rattus norvegicus (Norway rat)
Formation of ATP by chemiosmotic coupling	ATP synthase F(0) complex subunit B1, mitochondrial ATP synthase F(0) complex subunit C1, mitochondrial ATP synthase F(0) complex subunit C2, mitochondrial ATP synthase F(0) complex subunit C3, mitochondrial ATP synthase protein 8 ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit delta, mitochondrial ATP synthase subunit e, mitochondrial ATP synthase subunit epsilon, mitochondrial ATP synthase subunit f, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase subunit s, mitochondrial ATP synthase-coupling factor 6, mitochondrial	D3ZAF6 P05504 P10719 P11608 P15999 P19511 P21571 P29418 P29419 P31399 P35434 P35435 Q06645 Q06646 Q06647 Q5XIM4 Q6PDU7 Q71S46	Atp5a1 Atp5b Atp5c Atp5c1 Atp5d Atp5e Atp5f Atp5f1 Atp5f1a Atp5f1b Atp5f1c Atp5f1d Atp5f1e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5i Atp5j Atp5j2 Atp5jd Atp5l Atp5mc1 Atp5mc2 Atp5mc3 Atp5me Atp5mf Atp5mg Atp5o Atp5pb Atp5pd Atp5pf Atp5po Atp5s Atp6 Atp8 Atpase6 Atpase8 Dmac2l Mt-atp6 Mt-atp8 Mtatp6 Mtatp8	Rattus norvegicus (Norway rat)
NRIF signals cell death from the nucleus	Beta-nerve growth factor Centromere protein R Gamma-secretase subunit APH-1 Gamma-secretase subunit PEN-2 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Sequestosome-1 TNF receptor-associated factor 6 Tumor necrosis factor receptor superfamily member 16 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein	A0A8I6A5Y3 B5DF45 F7EYZ3 O08623 O88777 P07174 P0CG51 P25427 P62982 P97887 Q5U1Z7 Q63429 Q6QI68 Q8CGU6	Aph1a Cenpr Itgb3bp LOC100360645 Ncstn Ngf Ngfb Ngfr Nrif3 Ps2 Psen1 Psen2 Psenen Psnl1 Psnl2 Rps27a Sqstm1 Tnfrsf16 Traf6 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Zip	Rattus norvegicus (Norway rat)
Triglyceride catabolism	Fatty acid-binding protein 12 Fatty acid-binding protein 5 Fatty acid-binding protein 9 Fatty acid-binding protein, adipocyte Fatty acid-binding protein, brain Fatty acid-binding protein, heart Fatty acid-binding protein, intestinal Fatty acid-binding protein, liver Gastrotropin Glycerol-3-phosphate dehydrogenase, mitochondrial Patatin like phospholipase domain containing 4 Patatin-like phospholipase domain containing 5	B7SUM8 D3ZXU1 D4A227 P02692 P02693 P07483 P35571 P55051 P55053 P55054 P70623 P80020	Blbp FABP12 Fabp1 Fabp2 Fabp3 Fabp4 Fabp5 Fabp6 Fabp7 Fabp9 Fabpi Gpd2 Ilbp Illbp Perf15 Pnpla4 Pnpla5 RGD1562200	Rattus norvegicus (Norway rat)
Reelin signalling pathway	Disabled homolog 1 Reelin SH3 domain-containing kinase-binding protein 1 Tyrosine-protein kinase Fyn Very low-density lipoprotein receptor	P58751 P98166 Q62844 Q8CJH2 Q925Q9	Dab1 Fyn Reln Ruk Seta Sh3kbp1 Vldlr	Rattus norvegicus (Norway rat)
G alpha (z) signalling events	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Alpha-2A adrenergic receptor Alpha-2B adrenergic receptor Alpha-2C adrenergic receptor Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(z) subunit alpha Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Regulator of G-protein signaling 16 Regulator of G-protein signaling 17 Regulator of G-protein signaling 20 adenylate cyclase	A0A8I5ZV65 A0A8I6AF64 A0A8I6GAY3 A0A8I6GBE3 A0A8I6GLD4 D4A3N4 D4AAI1 F1LQT1 F2Z3T8 G3V8K2 M0R5U4 O35353 P19328 P19627 P21932 P22086 P22909 P26769 P26770 P40146 P43425 P52287 P54311 P54313 P56700 P61954 P62882 P63077 P63219 Q03343 Q04400	Adcy1 Adcy2 Adcy3 Adcy4 Adcy5 Adcy6 Adcy7 Adcy8 Adcy9 Adra2a Adra2b Adra2c Gnaz Gnb1 Gnb2 Gnb3 Gnb4 Gnb5 Gng10-ps1 Gng11 Gng12 Gng3 Gng4 Gng5 Gng5-ps4 Gng7 Gng8 Gng9 Gngt1 Gngt11 Gngt5 Gngt7 Gngt9 Rgs16 Rgs17 Rgs20 Rgsr	Rattus norvegicus (Norway rat)
VEGFR2 mediated cell proliferation	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 3-phosphoinositide-dependent protein kinase 1 GTPase HRas GTPase KRas GTPase NRas Protein kinase C alpha type Protein kinase C beta type Protein kinase C delta type Protein kinase C zeta type Proto-oncogene tyrosine-protein kinase Src Ras GTPase-activating protein 1 Sphingosine kinase 1 Vascular endothelial growth factor A Vascular endothelial growth factor receptor 2	O08775 O55173 P05696 P08644 P09215 P09217 P10686 P16612 P20171 P50904 P68403 Q04970 Q91V26 Q9WUD9	Flk1 Hras Hras1 Kdr Kras Kras2 Nras Pdk1 Pdpk1 Pkca Pkcb Pkcd Pkcz Plcg1 Prkca Prkcb Prkcb1 Prkcd Prkcz Rasa Rasa1 Sphk1 Src Vegf Vegfa	Rattus norvegicus (Norway rat)
Cargo recognition for clathrin-mediated endocytosis	AP-2 complex subunit alpha-2 AP-2 complex subunit alpha AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma AP2-associated protein kinase 1 Adaptin ear-binding coat-associated protein 1 Adaptin ear-binding coat-associated protein 2 Amphiregulin Apolipoprotein B-100 Arf-GAP domain and FG repeat-containing protein 1 Beta-2 adrenergic receptor Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Betacellulin COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 6 COP9 signalosome complex subunit 8 COP9 signalosome subunit 5 COP9 signalosome subunit 7A COP9 signalosome subunit 7B Cation-dependent mannose-6-phosphate receptor Clathrin coat assembly protein AP180 Clathrin heavy chain 1 Clathrin light chain A Clathrin light chain B Cystic fibrosis transmembrane conductance regulator Disabled homolog 2 Dishevelled segment polarity protein 2 Dyslexia-associated protein KIAA0319 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor pathway substrate 15-like 1 Epidermal growth factor receptor pathway substrate 15 Epsin-1 Epsin-2 F-BAR domain only protein 2 FCH and mu domain containing endocytic adaptor 1 Frizzled-4 G protein-coupled receptor kinase 3 Growth factor receptor-bound protein 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Insulin-like growth factor 2 receptor Interleukin-7 receptor subunit alpha Intersectin 2 Intersectin-1 Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Low-density lipoprotein receptor Lysosome membrane protein 2 Muscarinic acetylcholine receptor M2 NEDD8 Phosphatidylinositol-binding clathrin assembly protein Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Proepiregulin Proheparin-binding EGF-like growth factor Protein Wnt-5a Protransforming growth factor alpha RALBP1 associated Eps domain containing 1 RALBP1 associated Eps domain containing 2 Receptor protein-tyrosine kinase SH3 domain-containing kinase-binding protein 1 Serotransferrin Signal transducing adapter molecule 2 Signal transducing adaptor molecule Solute carrier family 2, facilitated glucose transporter member 8 Stonin-1 Stonin-2 Substance-P receptor Synaptotagmin-11 Synaptotagmin-1 Synaptotagmin-2 Synaptotagmin-8 Synaptotagmin-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Torsin-1A Trans-Golgi network integral membrane protein TGN38 Transferrin receptor protein 1 Type-1 angiotensin II receptor A Ubiquilin 2 Ubiquilin-1 Ubiquitin B-like Ubiquitin-ribosomal protein eS31 fusion protein Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 Vesicular acetylcholine transporter	A0A096MJ99 A0A8I5YBR2 A0A8I5YC99 A0A8I6A4J2 A0A8I6A5Y3 A0A8I6A726 A0A8I6A8K6 A0A8I6A974 A0A8I6AED1 A0A8I6AQ55 A0A8I6G3R2 A0A8I6GJC5 B5DF55 D3ZAR1 D3ZB71 D3ZIM5 D3ZU52 D3ZYR1 D4A3X8 D4AA63 D4AB66 F1MAA2 F7EUU4 G3V6K6 G3V824 O08835 O35179 O35180 O35964 O55012 O88339 O88797 P01134 P01186 P05540 P07522 P08081 P08082 P0C1X8 P0CG51 P0CI71 P10608 P10980 P11442 P12346 P14600 P18484 P19377 P19814 P21707 P24338 P25095 P26817 P26819 P27615 P29066 P29067 P29101 P34158 P35952 P61203 P62744 P62944 P62982 P62994 P63025 P63045 P69682 P84092 P97834 P98158 Q00788 Q05140 Q06175 Q4KLH5 Q5XHY7 Q62666 Q63429 Q64159 Q68FS2 Q68FW9 Q68G38 Q6AY20 Q6P4Z9 Q6P756 Q71UE8 Q7TMA5 Q925B4 Q925C0 Q925Q9 Q99376 Q9JHW5 Q9JJ50 Q9JJP9 Q9JJZ1 Q9QXQ7 Q9QZH0 Q9WUF4 Q9WVE9 Q9Z0L5 Q9Z1Z3	Aak1 Abcc7 Adrb2 Adrb2r Adrbk1 Adrbk2 Adtab Agfg1 Agfg1-ps1 Agtr1 Agtr1a Ap17 Ap2a1 Ap2a2 Ap2b1 Ap2m1 Ap2s1 Apob Areg Arh Arrb1 Arrb2 Ash At1a Avp Avpr2 Btc Calm Cbl Cd36l2 Cd3d Cd3g Cd4 Cftr Chrm-2 Chrm2 Clapb1 Claps2 Clta Cltb Cltc Cops1 Cops2 Cops3 Cops4 Cops5 Cops6 Cops7a Cops7b Cops8 Csn1 Csn2 Csn3 Csn4 Csn8 Da41 Dab2 Doc2 Dtr Dvl2 Dyt1 Egf Egfr Ehsh1 Epn1 Epn2 Eps15 Eps15l1 Ereg Fcho1 Fcho2 Fzd4 Glut8 Glutx1 Gps1 Grb2 Grk2 Grk3 Hbegf Hegfl Hgs Hrb Hrs Hrs2 Igf2r Il7r Itsn Itsn1 Itsn2 LOC100360645 LOC100361515 Ldlr Ldlrap1 Limpii Lrp2 M6pr Necap1 Necap2 Nedd8 Picalm Plic1 Reps1 Reps2 Rip Rps27a Ruk Scarb2 Sdgf Seta Sh3d2a Sh3d2c1 Sh3gl1 Sh3gl2 Sh3gl3 Sh3kbp1 Sh3p13 Sh3p4 Sh3p8 Slc18a3 Slc2a8 Snap91 Stam Stam2 Ston1 Ston2 Syb2 Syb3 Sybl1 Syt1 Syt11 Syt2 Syt5 Syt8 Syt9 T3d Tac1r Tacr1 Tf Tfrc Tgfa Tor1a Trfr Trip15 Ttgn1 Uba80 Ubb Ubbl1 Ubc Ubcep1 Ubcl1 Ubqln1 Ubqln2 Vacht Vamp2 Vamp3 Vamp4 Vamp7 Vamp8 Vat Wnt-5a Wnt5a	Rattus norvegicus (Norway rat)
Ca activated K+ channels	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel subunit beta-2 Calcium-activated potassium channel subunit beta-3 Calcium-activated potassium channel subunit beta-4 Intermediate conductance calcium-activated potassium channel protein 4 Small conductance calcium-activated potassium channel protein 1 Small conductance calcium-activated potassium channel protein 2 Small conductance calcium-activated potassium channel protein 3	A7VL23 P70604 P70605 P70606 P97678 Q62976 Q811Q0 Q9ESK8 Q9QYW1	Ik1 Kcnma Kcnma1 Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn1 Kcnn2 Kcnn3 Kcnn4 Sk1 Sk4 Smik	Rattus norvegicus (Norway rat)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Aldehyde dehydrogenase family 3 member A2 Amyloid-beta precursor protein Cytochrome b5 E2 ubiquitin-conjugating enzyme Emerin Heme oxygenase 1 Major prion protein Protein transport protein Sec61 subunit beta Protein transport protein Sec61 subunit gamma Small glutamine-rich tetratricopeptide repeat-containing protein alpha Stress-associated endoplasmic reticulum protein 1 Syntaxin-1A Syntaxin-5 Vesicle-associated membrane protein 2 Vesicle-associated membrane protein-associated protein A	A0A0G2K8C5 A0A8J8XD56 B2RZD1 O70593 P00173 P06762 P08592 P13852 P30839 P32851 P63045 Q08851 Q63190 Q9R2C1 Q9Z270	A4 AD1 Aldh3a2 Aldh4 App Cyb5 Cyb5a Emd Hmox1 Prn Prnp Prp Ramp4 Sap Sec61b Sec61g Serp1 Sgt Sgt1 Sgta Stg Stx1a Stx5 Stx5a Syb2 Ube2j2 Vamp2 Vap33 Vapa	Rattus norvegicus (Norway rat)
VEGF ligand-receptor interactions	Placenta growth factor Vascular endothelial growth factor A Vascular endothelial growth factor B Vascular endothelial growth factor C Vascular endothelial growth factor D	O35251 O35485 O35757 P16612 Q63434	Figf Pgf Plgf Vegf Vegfa Vegfb Vegfc Vegfd Vrf	Rattus norvegicus (Norway rat)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A8I6B5D5 D4A3T0 F1LSG7 F1LSQ8 O54769 O88182 P08644 P13109 P20171 P36364 P48807 P61149 P62994 P63076 P70492 Q02195 Q04970 Q5M824 Q8R5L5 Q8R5L9 Q8VI79 Q8VI82 Q9EST9	Ash FGF22 FGF6 Fgf-1 Fgf-2 Fgf-5 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf5c Fgf5d Fgf6 Fgf7 Fgf7a Fgf7b Fgf8 Fgf9 Fgfa Fgfr2 Grb2 Hras Hras1 Kgf Kras Kras2 Nras Shc1 Sos1	Rattus norvegicus (Norway rat)
SUMOylation of DNA damage response and repair proteins	Aladin WD repeat nucleoporin Breast cancer type 1 susceptibility protein homolog Centrin 2 Chromobox 2 Chromobox 4 Chromobox 8 Cohesin subunit SA Cohesin subunit SA DNA 3'-5' helicase E3 SUMO-protein ligase NSE2 E3 SUMO-protein ligase PIAS2 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 E3 ubiquitin-protein ligase RNF168 HECT-type E3 ubiquitin transferase LOC683983 protein Mediator of DNA damage checkpoint protein 1 Melanoma-associated antigen G1-like Non-structural maintenance of chromosomes element 1 homolog Non-structural maintenance of chromosomes element 4 Nuclear envelope pore membrane protein POM 121 Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup54 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore complex protein Nup98-Nup96 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin 133 Nucleoporin 160 Nucleoporin 205 Nucleoporin 214 Nucleoporin 37 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin p58/p45 Nucleoprotein TPR PML nuclear body scaffold Poly [ADP-ribose] polymerase 1 Polyhomeotic homolog 1 Polyhomeotic homolog 2 Polyhomeotic homolog 3 Protein SEC13 homolog Protein inhibitor of activated STAT, 1 Protein inhibitor of activated STAT, 4 RAD21 cohesin complex component RAD52 homolog, DNA repair protein RAN binding protein 2 Replication protein A subunit SP100 nuclear antigen SUMO-conjugating enzyme UBC9 Scm polycomb group protein like 2 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3 Structural maintenance of chromosomes 6 Structural maintenance of chromosomes protein 1A Structural maintenance of chromosomes protein 3 Structural maintenance of chromosomes protein 5 Thymine-DNA glycosylase X-ray repair cross complementing 4 XPC complex subunit, DNA damage recognition and repair factor mRNA export factor	A0A096MK32 A0A0G2JUC9 A0A0G2K2B0 A0A0G2K397 A0A0G2K3M4 A0A0G2K4D9 A0A0G2K4T5 A0A8I5Y5Z6 A0A8I5YC36 A0A8I5YCH6 A0A8I5ZJ67 A0A8I5ZKI2 A0A8I5ZMG5 A0A8I6AC37 A0A8I6ACN6 A0A8I6ADB5 A0A8I6AHM8 A0A8I6AJT7 A0A8I6GKN6 B0BNB5 B2RYR0 B5DFF9 D3Z8B2 D3Z9K8 D3ZBL6 D3ZHV0 D3ZQW1 D3ZRL8 D3ZZL1 D4A0M3 D4A3D8 D4ACK1 F1LRC6 F1MA98 G3V9W0 M0RE14 O08587 O08658 O54952 P11654 P17955 P27008 P37199 P49791 P49793 P52590 P52591 P61959 P63281 P70581 P70582 P97690 Q3SWS8 Q499U6 Q4KLH7 Q4KLY4 Q4QQS8 Q4V8A0 Q5I0H3 Q5U2M8 Q5XFW8 Q5XIF4 Q66HC5 Q68FY1 Q6AXN4 Q6AZ28 Q6MGB6 Q7TP21 Q9Z1M9	Aaas Adprt Bam Blm Bmh Brca1 Cbx2 Cbx4 Cbx8 Cetn2 Cspg6 Gp210 Herc2 LOC102551929 LOC683983 Mageb10 Mdc1 Miz1 Mms21 Mrnp41 Ndc1 Npap60 Nsmce1 Nsmce2 Nsmce4a Nup107 Nup121 Nup133 Nup153 Nup155 Nup160 Nup188 Nup205 Nup210 Nup214 Nup35 Nup37 Nup42 Nup43 Nup50 Nup53 Nup54 Nup58 Nup62 Nup84 Nup85 Nup88 Nup93 Nup98 Nupl1 Nupl2 Parp1 Pcnt1 Phc1 Phc2 Phc3 Pias1 Pias2 Pias4 Piasx Pml Pom121 Pom210 Rad21 Rad52 Rae1 Ranbp2 Ring1 Ring1b Rnf1 Rnf168 Rnf2 Rpa1 Scml2 Sec13 Sec13l1 Smc1 Smc1a Smc1l1 Smc3 Smc3l1 Smc5 Smc6 Smt3a Smt3h2 Sp100 Stag1 Stag2 Sumo1 Sumo2 Sumo3 Tdg Tmem48 Tpr Ubce9 Ube2i Xpc Xrcc4	Rattus norvegicus (Norway rat)
Ligand-receptor interactions	Cell adhesion molecule-related/down-regulated by oncogenes Hedgehog protein Hedgehog protein Hedgehog-interacting protein Patched Sonic hedgehog protein	D3ZGL3 F1LP42 G3V7Y0 O35158 Q63673 Q6UY90	Cdo Cdon Dhh Hhip Ihh Ptch Ptch1 Shh Vhh-1	Rattus norvegicus (Norway rat)

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