GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **376 - 400** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲
Activated NOTCH1 Transmits Signal to the Nucleus	Beta-arrestin-1 Beta-arrestin-2 Contactin-1 Delta and Notch-like epidermal growth factor-related receptor Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 E3 ubiquitin-protein ligase DTX1 E3 ubiquitin-protein ligase DTX4 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 1 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Probable E3 ubiquitin-protein ligase DTX2 Protein delta homolog 1 Protein jagged-1 Protein jagged-2 Protein numb homolog Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O76050 P0CG47 P0CG48 P32121 P46531 P49407 P49757 P49768 P49810 P62979 P62987 P78504 P78536 P80370 Q12860 Q86UW9 Q86Y01 Q86YT6 Q8NFT8 Q8WW43 Q92542 Q96AX9 Q96BI3 Q96J02 Q9NR61 Q9NZ42 Q9Y219 Q9Y2E6	AD3 AD4 ADAM10 ADAM17 APH1A APH1B ARB2 ARR1 ARR2 ARRB1 ARRB2 BET C14orf41 CNTN1 CSVP DIP1 DLK DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 ITCH JAG1 JAG2 JAGL1 KIAA0253 KIAA0937 KIAA1323 KIAA1528 KUZ MADM MIB1 MIB2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH1 NUMB PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF155 RNF58 RNF67 RPS27A SKD STM2 TACE TAN1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2
Constitutive Signaling by NOTCH1 PEST Domain Mutants	CREB-binding protein Cullin-1 Cyclin-C Cyclin-dependent kinase 8 Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B E3 ubiquitin-protein ligase RBX1 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Histone deacetylase 11 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 4 Histone deacetylase 5 Histone deacetylase 6 Histone deacetylase 7 Histone deacetylase 8 Histone deacetylase 9 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Myc proto-oncogene protein Neurogenic locus notch homolog protein 1 Nicastrin Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Polyamine deacetylase HDAC10 Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Protein jagged-1 Protein jagged-2 Recombining binding protein suppressor of hairless S-phase kinase-associated protein 1 SNW domain-containing protein 1 Transcription factor HES-1 Transcription factor HES-5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O15379 O60907 O75376 O76050 P01106 P0CG47 P0CG48 P24863 P46531 P49336 P49768 P49810 P56524 P62877 P62979 P62987 P63208 P78504 P78536 Q06330 Q09472 Q13495 Q13547 Q13573 Q13616 Q14469 Q5TA89 Q86YT6 Q8IZL2 Q8WUI4 Q8WW43 Q92542 Q92585 Q92769 Q92793 Q92830 Q92831 Q969S8 Q96AX9 Q96BI3 Q96DB2 Q96JK9 Q9BY41 Q9BZK7 Q9NQ87 Q9NR61 Q9NZ42 Q9UBN7 Q9UBP5 Q9UKV0 Q9UQL6 Q9Y219 Q9Y5J3 Q9Y618	AD3 AD4 ADAM10 ADAM17 APH1A APH1B BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BHLHE39 CBP CCNC CDK8 CG1 CHF1 CHF2 CREBBP CSVP CTG26 CUL1 CXorf6 DIP1 DLL1 DLL4 EMC19 EP300 GCN5 GCN5L2 GRL HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC7A HDAC7B HDAC8 HDAC9 HDACL1 HDRP HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 IRA1 JAG1 JAG2 JAGL1 KAT2A KAT2B KIAA0200 KIAA0253 KIAA0288 KIAA0600 KIAA0744 KIAA0901 KIAA1047 KIAA1323 KIAA1816 KIAA1819 KUZ MADM MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MITR MYC NCOR1 NCOR2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH1 OCP2 P300 PCAF PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RBPJ RBPJK RBPSUH RBX1 RNF67 RNF75 ROC1 RPD3L1 RPS27A SKD SKIIP SKIP SKP1 SKP1A SNW1 STM2 TACE TAN1 TBL1 TBL1X TBL1XR1 TBLR1 TCEB1L UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	CREB-binding protein Cullin-1 Cyclin-C Cyclin-dependent kinase 8 Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B E3 ubiquitin-protein ligase RBX1 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Histone deacetylase 11 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 4 Histone deacetylase 5 Histone deacetylase 6 Histone deacetylase 7 Histone deacetylase 8 Histone deacetylase 9 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Myc proto-oncogene protein Neurogenic locus notch homolog protein 1 Nicastrin Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Polyamine deacetylase HDAC10 Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Protein jagged-1 Protein jagged-2 Recombining binding protein suppressor of hairless S-phase kinase-associated protein 1 SNW domain-containing protein 1 Transcription factor HES-1 Transcription factor HES-5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O15379 O60907 O75376 O76050 P01106 P0CG47 P0CG48 P24863 P46531 P49336 P49768 P49810 P56524 P62877 P62979 P62987 P63208 P78504 P78536 Q06330 Q09472 Q13495 Q13547 Q13573 Q13616 Q14469 Q5TA89 Q86YT6 Q8IZL2 Q8WUI4 Q8WW43 Q92542 Q92585 Q92769 Q92793 Q92830 Q92831 Q969S8 Q96AX9 Q96BI3 Q96DB2 Q96JK9 Q9BY41 Q9BZK7 Q9NQ87 Q9NR61 Q9NZ42 Q9UBN7 Q9UBP5 Q9UKV0 Q9UQL6 Q9Y219 Q9Y5J3 Q9Y618	AD3 AD4 ADAM10 ADAM17 APH1A APH1B BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BHLHE39 CBP CCNC CDK8 CG1 CHF1 CHF2 CREBBP CSVP CTG26 CUL1 CXorf6 DIP1 DLL1 DLL4 EMC19 EP300 GCN5 GCN5L2 GRL HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC7A HDAC7B HDAC8 HDAC9 HDACL1 HDRP HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 IRA1 JAG1 JAG2 JAGL1 KAT2A KAT2B KIAA0200 KIAA0253 KIAA0288 KIAA0600 KIAA0744 KIAA0901 KIAA1047 KIAA1323 KIAA1816 KIAA1819 KUZ MADM MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MITR MYC NCOR1 NCOR2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH1 OCP2 P300 PCAF PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RBPJ RBPJK RBPSUH RBX1 RNF67 RNF75 ROC1 RPD3L1 RPS27A SKD SKIIP SKIP SKP1 SKP1A SNW1 STM2 TACE TAN1 TBL1 TBL1X TBL1XR1 TBLR1 TCEB1L UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2
EPH-ephrin mediated repulsion of cells	72 kDa type IV collagenase AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Disintegrin and metalloproteinase domain-containing protein 10 Dynamin-1 Ephrin type-A receptor 10 Ephrin type-A receptor 1 Ephrin type-A receptor 2 Ephrin type-A receptor 3 Ephrin type-A receptor 4 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-A receptor 8 Ephrin type-B receptor 1 Ephrin type-B receptor 2 Ephrin type-B receptor 3 Ephrin type-B receptor 4 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A4 Ephrin-A5 Ephrin-B1 Ephrin-B2 Ephrin-B3 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Matrix metalloproteinase-9 Nicastrin Presenilin-1 Presenilin-2 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor TIAM1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O14672 O15197 O43921 O94973 O95782 P06241 P07947 P07948 P08253 P09496 P09497 P14780 P20827 P21709 P29317 P29320 P29322 P29323 P49768 P49810 P52735 P52797 P52798 P52799 P52803 P53675 P53680 P54753 P54756 P54760 P54762 P54764 P63000 P63010 P98172 Q00610 Q05193 Q13009 Q15375 Q15768 Q5JZY3 Q8WW43 Q92542 Q96BI3 Q96CW1 Q9NZ42 Q9UF33 Q9UKW4	AD3 AD4 ADAM10 ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B BSK CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLG4A CLG4B CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD DNM DNM1 DRT ECK EEK EFL2 EFL3 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EHK1 EHK2 EHK3 ELK EPH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPHT EPHT1 EPHT2 EPHT3 EPLG1 EPLG2 EPLG3 EPLG4 EPLG5 EPLG6 EPLG7 EPLG8 EPTH3 ERK ETK ETK1 ETK2 FYN HEK HEK11 HEK12 HEK2 HEK3 HEK5 HEK6 HEK7 HEK8 HIP9 HTK HTKL HYPJ JTK8 KIAA0034 KIAA0109 KIAA0253 KIAA0899 KIAA1459 KUZ LERK1 LERK2 LERK3 LERK4 LERK5 LERK6 LERK7 LERK8 LYN MADM MMP2 MMP9 MYK1 NCSTN NET PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RAC1 SEK STM2 TC25 TIAM1 TNFAIP4 TYRO1 TYRO11 TYRO4 TYRO5 TYRO6 VAV2 VAV3 YES YES1
NOTCH2 Activation and Transmission of Signal to the Nucleus	Contactin-1 Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Midkine Neurogenic locus notch homolog protein 2 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Protein jagged-1 Protein jagged-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O76050 P0CG47 P0CG48 P21741 P49768 P49810 P62979 P62987 P78504 Q04721 Q12860 Q86YT6 Q8WW43 Q92542 Q96AX9 Q96BI3 Q9NR61 Q9NZ42 Q9Y219	AD3 AD4 ADAM10 APH1A APH1B CNTN1 DIP1 DLL1 DLL4 JAG1 JAG2 JAGL1 KIAA0253 KIAA1323 KUZ MADM MDK MIB1 MIB2 MK1 NCSTN NEGF2 NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH2 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF67 RPS27A SKD STM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2
NOTCH3 Activation and Transmission of Signal to the Nucleus	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Epidermal growth factor receptor Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Neurogenic locus notch homolog protein 3 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Pro-epidermal growth factor Protein jagged-1 Protein jagged-2 Transforming acidic coiled-coil-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00308 O00548 O14672 O76050 P00533 P01133 P0CG47 P0CG48 P49768 P49810 P62979 P62987 P78504 Q86YT6 Q8WW43 Q92542 Q96AX9 Q96BI3 Q9NR61 Q9NZ42 Q9UM47 Q9Y219 Q9Y6A5	AD3 AD4 ADAM10 APH1A APH1B DIP1 DLL1 DLL4 EGF EGFR ERBB ERBB1 ERIC1 HER1 JAG1 JAG2 JAGL1 KIAA0253 KIAA1323 KUZ MADM MIB1 MIB2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH3 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF67 RPS27A SKD STM2 TACC3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WWP2 ZZANK1 ZZANK2
NOTCH4 Activation and Transmission of Signal to the Nucleus	14-3-3 protein zeta/delta Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 4 Nicastrin Presenilin-1 Presenilin-2 Protein jagged-1	O14672 P49768 P49810 P63104 P78504 Q8WW43 Q92542 Q96BI3 Q99466 Q9NR61 Q9NZ42	AD3 AD4 ADAM10 APH1A APH1B DLL4 INT3 JAG1 JAGL1 KIAA0253 KUZ MADM NCSTN NOTCH4 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 STM2 YWHAZ
Nuclear signaling by ERBB4	Apolipoprotein E Arf-GAP with dual PH domain-containing protein 1 Beta-casein Disintegrin and metalloproteinase domain-containing protein 17 Estrogen receptor Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Glial fibrillary acidic protein Max dimerization protein 4 Nicastrin Nuclear receptor corepressor 1 Presenilin-1 Presenilin-2 Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Progesterone receptor Proheparin-binding EGF-like growth factor Protein S100-B Proto-oncogene tyrosine-protein kinase Src SPARC Signal transducer and activator of transcription 5A Stathmin Stromal cell-derived factor 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Transcriptional coactivator YAP1 WW domain-containing oxidoreductase	O14511 O14944 O75376 O75689 P02649 P03372 P04271 P05814 P06401 P09486 P12931 P14136 P16949 P35070 P42229 P46937 P48061 P49768 P49810 P56975 P78536 Q02297 Q14582 Q8WW43 Q8WWG1 Q92542 Q96BI3 Q99075 Q9NYJ8 Q9NZ42 Q9NZC7	AD3 AD4 ADAM17 ADAP1 APH1A APH1B APOE BHLHC12 BTC C1orf215 CASB CENTA1 CSN2 CSVP CXCL12 DTR DTS EREG ESR ESR1 FOR GFAP GGF HBEGF HEGFL HGL HRGA KIAA0253 KIAA0733 KIAA1047 LAP18 MAD4 MAP3K7IP2 MXD4 NCOR1 NCSTN NDF NR3A1 NR3C3 NRG1 NRG2 NRG3 NRG4 NTAK ON OP18 PEN2 PGR PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 S100B SDF1 SDF1A SDF1B SDR41C1 SMDF SPARC SRC SRC1 STAT5 STAT5A STM2 STMN1 TAB2 TACE WOX1 WWOX YAP1 YAP65
Regulated proteolysis of p75NTR	Disintegrin and metalloproteinase domain-containing protein 17 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Nicastrin Nuclear factor NF-kappa-B p105 subunit Presenilin-1 Presenilin-2 TNF receptor-associated factor 6 Transcription factor p65 Tumor necrosis factor receptor superfamily member 16	P08138 P19838 P49768 P49810 P78536 Q04206 Q8WW43 Q92542 Q96BI3 Q9NZ42 Q9Y4K3	AD3 AD4 ADAM17 APH1A APH1B CSVP KIAA0253 NCSTN NFKB1 NFKB3 NGFR PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RELA RNF85 STM2 TACE TNFRSF16 TRAF6
NRIF signals cell death from the nucleus	Beta-nerve growth factor Centromere protein R Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Mitogen-activated protein kinase 8 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Sequestosome-1 TNF receptor-associated factor 6 Tumor necrosis factor receptor superfamily member 16 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01138 P08138 P0CG47 P0CG48 P45983 P49768 P49810 P62979 P62987 Q13352 Q13501 Q8WW43 Q92542 Q96BI3 Q9NZ42 Q9Y4K3	AD3 AD4 APH1A APH1B CENPR ITGB3BP JNK1 KIAA0253 MAPK8 NCSTN NGF NGFB NGFR NRIF3 ORCA OSIL PEN2 PRKM8 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF85 RPS27A SAPK1 SAPK1C SQSTM1 STM2 TNFRSF16 TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Noncanonical activation of NOTCH3	Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 3 Nicastrin Presenilin-1 Presenilin-2 Y-box-binding protein 1	P49768 P49810 P67809 Q8WW43 Q92542 Q96BI3 Q9NZ42 Q9UM47	AD3 AD4 APH1A APH1B KIAA0253 NCSTN NOTCH3 NSEP1 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 STM2 YB1 YBX1
Transcriptional regulation of testis differentiation	Desert hedgehog protein Doublesex- and mab-3-related transcription factor 1 Fibroblast growth factor 9 Muellerian-inhibiting factor Prostaglandin-H2 D-isomerase Sex-determining region Y protein Steroidogenic factor 1 Transcription factor GATA-4 Transcription factor SOX-9 Wilms tumor protein Zinc finger protein ZFPM2	O43323 P03971 P19544 P31371 P41222 P43694 P48436 Q05066 Q13285 Q8WW38 Q9Y5R6	AD4BP AMH DHH DMRT1 DMT1 FGF9 FOG2 FTZF1 GATA4 MIF NR5A1 PDS PTGDS SF1 SOX9 SRY TDF WT1 ZFPM2 ZNF89B
Transcriptional regulation of pluripotent stem cells	Endothelial PAS domain-containing protein 1 Homeobox protein NANOG Hypoxia-inducible factor 3-alpha Krueppel-like factor 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 4 POU domain, class 5, transcription factor 1 PR domain zinc finger protein 14 Pre-B-cell leukemia transcription factor 1 Protein lin-28 homolog A Sal-like protein 4 Signal transducer and activator of transcription 3 Steroidogenic factor 1 Transcription factor SOX-2 Zinc finger and SCAN domain-containing protein 10 Zinc finger protein ZIC 3	O43474 O60481 P40424 P40763 P48431 Q01860 Q13285 Q13485 Q15796 Q96SZ4 Q99814 Q9GZV8 Q9H9S0 Q9H9Z2 Q9UJQ4 Q9Y2N7	AD4BP APRF BHLHE17 BHLHE73 CSDD1 DPC4 EPAS1 EZF FTZF1 GKLF HIF2A HIF3A KLF4 LIN28 LIN28A MADH2 MADH4 MADR2 MOP2 MOP7 NANOG NR5A1 OCT3 OCT4 OTF3 PASD2 PASD7 PBX1 POU5F1 PRDM14 PRL SALL4 SF1 SMAD2 SMAD4 SOX2 STAT3 ZCCHC1 ZIC3 ZNF203 ZNF206 ZNF797 ZSCAN10
Nuclear Receptor transcription pathway	Androgen receptor COUP transcription factor 1 Estrogen receptor beta Estrogen receptor Estrogen-related receptor gamma Hepatocyte nuclear factor 4-alpha Hepatocyte nuclear factor 4-gamma Mediator of RNA polymerase II transcription subunit 1 Nuclear receptor 2C2-associated protein Nuclear receptor ROR-alpha Nuclear receptor ROR-beta Nuclear receptor ROR-gamma Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Nuclear receptor subfamily 0 group B member 2 Nuclear receptor subfamily 1 group D member 1 Nuclear receptor subfamily 1 group D member 2 Nuclear receptor subfamily 2 group C member 1 Nuclear receptor subfamily 2 group C member 2 Nuclear receptor subfamily 2 group E member 1 Nuclear receptor subfamily 2 group F member 6 Nuclear receptor subfamily 4 group A member 2 Nuclear receptor subfamily 4immunitygroup A member 1 Nuclear receptor-binding protein Oxysterols receptor LXR-beta Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor delta Peroxisome proliferator-activated receptor gamma Progesterone receptor Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma Steroid hormone receptor ERR1 Steroid hormone receptor ERR2 Steroidogenic factor 1 Thyroid hormone receptor alpha Thyroid hormone receptor beta Vitamin D3 receptor	O75376 O95718 P03372 P06401 P10275 P10276 P10588 P10589 P10826 P10827 P10828 P11473 P11474 P13056 P13631 P19793 P20393 P22736 P28702 P35398 P37231 P41235 P43354 P48443 P49116 P51449 P55055 P62508 Q03181 Q07869 Q13285 Q14541 Q14995 Q15466 Q15648 Q86WQ0 Q92731 Q92753 Q9UHY1 Q9Y466 Q9Y618	AD4BP AR ARC205 BCON3 CRSP1 CRSP200 CTG26 DHTR DRIP205 DRIP230 EAR1 EAR2 EAR3 EAR7 ERBA1 ERBA2 ERBAL2 ERBAL3 ERR1 ERR3 ERRB2 ERRG2 ESR ESR1 ESR2 ESRL1 ESRL2 ESRRA ESRRB ESRRG ESTRB FTZF1 GFRP1 HAP HMR HNF4 HNF4A HNF4G HREV KIAA0832 KIAA1047 LXRB MED1 NAK1 NCOR1 NCOR2 NER NOT NR0B2 NR1A1 NR1A2 NR1B1 NR1B2 NR1B3 NR1C1 NR1C2 NR1C3 NR1D1 NR1D2 NR1F1 NR1F2 NR1F3 NR1H2 NR1I1 NR2A1 NR2A2 NR2B1 NR2B2 NR2B3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2F1 NR2F6 NR3A1 NR3A2 NR3B1 NR3B2 NR3B3 NR3C3 NR3C4 NR4A1 NR4A2 NR5A1 NRBP NRBP1 NURR1 PBP PGR PPAR PPARA PPARB PPARBP PPARD PPARG PPARGBP RARA RARB RARG RB18A RORA RORB RORC RORG RXRA RXRB RXRG RZRA RZRB RZRG SF1 SHP TAK1 TCF14 TFCOUP1 THR1 THRA THRA1 THRA2 THRAL THRB TINUR TLX TR2 TR4 TRA16 TRAP220 TRIP2 UNR VDR
SUMOylation of intracellular receptors	Androgen receptor E3 SUMO-protein ligase PIAS1 E3 SUMO-protein ligase PIAS3 E3 SUMO-protein ligase PIAS4 Estrogen receptor Glucocorticoid receptor Histone deacetylase 4 Mineralocorticoid receptor Nuclear receptor ROR-alpha Nuclear receptor subfamily 2 group C member 1 Nuclear receptor subfamily 4 group A member 2 Oxysterols receptor LXR-beta Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma Progesterone receptor Retinoic acid receptor RXR-alpha Retinoic acid receptor alpha SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3 Steroidogenic factor 1 Thyroid hormone receptor beta Vitamin D3 receptor	O75925 P03372 P04150 P06401 P08235 P10275 P10276 P10828 P11473 P13056 P19793 P35398 P37231 P43354 P55055 P55854 P56524 P61956 P63165 P63279 Q07869 Q13285 Q8N2W9 Q9Y6X2	AD4BP AR DDXBP1 DHTR ERBA2 ESR ESR1 FTZF1 GRL HDAC4 KIAA0288 LXRB MCR MLR NER NOT NR1A2 NR1B1 NR1C1 NR1C3 NR1F1 NR1H2 NR1I1 NR2B1 NR2C1 NR3A1 NR3C1 NR3C2 NR3C3 NR3C4 NR4A2 NR5A1 NURR1 PGR PIAS1 PIAS3 PIAS4 PIASG PPAR PPARA PPARG RARA RORA RXRA RZRA SF1 SMT3A SMT3B SMT3C SMT3H1 SMT3H2 SMT3H3 SUMO1 SUMO2 SUMO3 THR1 THRB TINUR TR2 UBC9 UBCE9 UBE2I UBL1 UNR VDR
Purine salvage	AMP deaminase 1 AMP deaminase 2 AMP deaminase 3 Adenine phosphoribosyltransferase Adenosine deaminase-like protein Adenosine deaminase Adenosine kinase Deoxycytidine kinase Deoxyguanosine kinase, mitochondrial GMP reductase 1 GMP reductase 2 Hypoxanthine-guanine phosphoribosyltransferase Purine nucleoside phosphorylase	P00491 P00492 P00813 P07741 P23109 P27707 P36959 P55263 Q01432 Q01433 Q16854 Q6DHV7 Q9P2T1	ADA ADA1 ADAL ADAL1 ADK AMPD1 AMPD2 AMPD3 APRT DCK DGK DGUOK GMPR GMPR1 GMPR2 HPRT HPRT1 NP PNP
Ribavirin ADME	Adenosine deaminase Adenosine kinase Cytosolic purine 5'-nucleotidase Equilibrative nucleoside transporter 1 Equilibrative nucleoside transporter 3 Inosine triphosphate pyrophosphatase Nucleoside diphosphate kinase A Nucleoside diphosphate kinase B Purine nucleoside phosphorylase Sodium/nucleoside cotransporter 2 Solute carrier family 28 member 3	O43868 P00491 P00813 P15531 P22392 P49902 P55263 Q99808 Q9BY32 Q9BZD2 Q9HAS3	ADA ADA1 ADK C20orf37 CNT2 CNT3 ENT1 ENT3 ITPA NDPKA NM23 NM23B NME1 NME2 NP NT5B NT5C2 NT5CP PNP PNT5 SLC28A2 SLC28A3 SLC29A1 SLC29A3
Defective ADA disrupts (deoxy)adenosine deamination	Adenosine deaminase	P00813	ADA ADA1
Formation of WDR5-containing histone-modifying complexes	A-kinase anchor protein 8-like Biorientation of chromosomes in cell division protein 1-like 1 Biorientation of chromosomes in cell division protein 1 CXXC-type zinc finger protein 1 Cysteine-rich protein 2-binding protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase KAT8 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Host cell factor 1 Host cell factor 2 KAT8 regulatory NSL complex subunit 1 KAT8 regulatory NSL complex subunit 2 KAT8 regulatory NSL complex subunit 3 Lysine-specific demethylase 6A MAP3K12-binding inhibitory protein 1 Menin Microspherule protein 1 Nuclear receptor coactivator 6 PAX-interacting protein 1 PAXIP1-associated glutamate-rich protein 1 PC4 and SFRS1-interacting protein PHD finger protein 20-like protein 1 PHD finger protein 20 Protein Dr1 Protein dpy-30 homolog Retinoblastoma-binding protein 5 SAGA-associated factor 29 Set1/Ash2 histone methyltransferase complex subunit ASH2 Threonine aspartase 1 Transcriptional adapter 2-alpha Transcriptional adapter 3 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit WD repeat-containing protein 5 WD repeat-containing protein 82 YEATS domain-containing protein 2 ZZ-type zinc finger-containing protein 3	A8MW92 O00255 O14686 O15047 O15294 O15550 O75475 O75478 O75528 P51610 P61964 Q01658 Q03164 Q14686 Q15291 Q6UXN9 Q6ZW49 Q7Z3B3 Q8IYH5 Q8NEZ4 Q8NFC6 Q92830 Q92831 Q96ES7 Q96EZ8 Q96IK1 Q9BTK6 Q9BVI0 Q9C005 Q9H6P5 Q9H7Z6 Q9H8E8 Q9H9L4 Q9NS73 Q9P0U4 Q9P2N6 Q9UBL3 Q9ULM3 Q9ULX6 Q9UMN6 Q9UPS6 Q9Y5Z7	ADA3 AIB3 AKAP8L ALL1 ALR ASH2L ASH2L1 BIG3 BOD1 BOD1L BOD1L1 C12orf41 C16orf53 C20orf104 C20orf13 CCDC101 CENP-36 CFP1 CGBP CSRP2BP CXXC1 CXXC7 DFS70 DPY30 DR1 FAM44A FAM44B GCN5 GCN5L2 GLEA2 HALR HCA58 HCF1 HCFC1 HCFC2 HFC1 HRX HRX2 HTRX INO80Q KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT8 KDM6A KIAA0181 KIAA0304 KIAA0339 KIAA1076 KIAA1197 KIAA1267 KIAA1310 KIAA1327 KIAA1506 KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G LEDGF MBIP MCRS1 MEN1 MLL MLL1 MLL2 MLL3 MLL4 MOF MSL1V1 MSP58 MYST1 NAKAP NAKAP95 NCOA6 NSL1 NSL2 NSL3 NZF OGT PA1 PAGR1 PAXIP1 PAXIP1L PCAF PCCX1 PHF18 PHF20 PHF20L1 PRTD PSIP1 PSIP2 PTIP RAP250 RBBP5 RBQ3 SCG2 SET1 SET1A SET1B SETD1A SETD1B SGF29 SI1 SWD2 TADA2A TADA2L TADA3 TADA3L TASP1 TMEM113 TRBP TRX1 TRX2 TZP UTX WBP7 WDR5 WDR82 WDR82A YEATS2 ZZZ3
Abacavir metabolism	Adenosine deaminase-like protein Alcohol dehydrogenase 1A Cytosolic purine 5'-nucleotidase Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	P07327 P35558 P49902 Q6DHV7	ADAL ADAL1 ADH1 ADH1A NT5B NT5C2 NT5CP PCK1 PEPCK1 PNT5
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Cathepsin K Collagen alpha-1(IX) chain Collagen alpha-1(XII) chain Collagen alpha-1(XIII) chain Collagen alpha-1(XIV) chain Collagen alpha-1(XIX) chain Collagen alpha-1(XV) chain Collagen alpha-1(XVI) chain Collagen alpha-1(XVII) chain Collagen alpha-1(XVIII) chain Collagen alpha-1(XXIII) chain Collagen alpha-1(XXV) chain Collagen alpha-1(XXVI) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Collagenase 3 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 Disintegrin and metalloproteinase domain-containing protein 9 Furin Interstitial collagenase Macrophage metalloelastase Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-19 Matrix metalloproteinase-20 Matrix metalloproteinase-9 Neutrophil collagenase Neutrophil elastase Procathepsin L Stromelysin-1 Stromelysin-2 Stromelysin-3 Transmembrane protease serine 6 Trypsin-2	O14672 O60882 P03956 P07339 P07478 P07711 P07858 P08246 P08253 P08254 P09237 P09238 P09958 P14780 P20849 P22894 P24347 P39059 P39060 P39900 P43235 P45452 P50281 P51511 P78536 Q05707 Q07092 Q13443 Q14050 Q14055 Q14993 Q5TAT6 Q86Y22 Q8IU80 Q8IUZ5 Q96A83 Q99542 Q99715 Q9BXS0 Q9UMD9	ADAM10 ADAM17 ADAM9 AGXT2L2 BP180 BPAG2 CLG CLG1 CLG4A CLG4B COL12A1 COL12A1L COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL23A1 COL25A1 COL26A1 COL9A1 COL9A2 COL9A3 CPSB CPSD CSVP CTSB CTSD CTSK CTSL CTSL1 CTSO CTSO2 ELA2 ELANE EMID2 EMU2 FUR FURIN HME KIAA0021 KUZ MADM MCMP MDC9 MLTNG MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP18 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 MPSL1 PACE PCSK3 PHYKPL PRSS2 PUMP1 RASI STMY1 STMY2 STMY3 TACE TMPRSS6 TRY2 TRYP2 UND
Constitutive Signaling by NOTCH1 HD Domain Mutants	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Neurogenic locus notch homolog protein 1 Polyubiquitin-B Polyubiquitin-C Protein jagged-1 Protein jagged-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O76050 P0CG47 P0CG48 P46531 P62979 P62987 P78504 P78536 Q86YT6 Q96AX9 Q9NR61 Q9Y219	ADAM10 ADAM17 CSVP DIP1 DLL1 DLL4 JAG1 JAG2 JAGL1 KIAA1323 KUZ MADM MIB1 MIB2 NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH1 RNF67 RPS27A SKD TACE TAN1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 Neurogenic locus notch homolog protein 1 Protein jagged-1 Protein jagged-2	O00548 O14672 P46531 P78504 P78536 Q9NR61 Q9Y219	ADAM10 ADAM17 CSVP DLL1 DLL4 JAG1 JAG2 JAGL1 KUZ MADM NOTCH1 TACE TAN1
LGI-ADAM interactions	Disintegrin and metalloproteinase domain-containing protein 11 Disintegrin and metalloproteinase domain-containing protein 22 Disintegrin and metalloproteinase domain-containing protein 23 Disks large homolog 4 Leucine-rich glioma-inactivated protein 1 Leucine-rich repeat LGI family member 2 Leucine-rich repeat LGI family member 3 Leucine-rich repeat LGI family member 4 Syntaxin-1A Syntaxin-1B Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-3 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-8 subunit	O60359 O75077 O75078 O95970 P61266 P78352 Q16623 Q8N0V4 Q8N135 Q8N145 Q8WXS5 Q9P0K1 Q9UBN1 Q9Y698	ADAM11 ADAM22 ADAM23 CACNG2 CACNG3 CACNG4 CACNG6 CACNG8 DLG4 EPT KIAA1916 LGI1 LGI2 LGI3 LGI4 LGIL2 LGIL3 LGIL4 MDC MDC2 MDC3 PSD95 STX1 STX1A STX1B STX1B1 STX1B2
Invadopodia formation	Disintegrin and metalloproteinase domain-containing protein 12 Disintegrin and metalloproteinase domain-containing protein 15 Disintegrin and metalloproteinase domain-containing protein 19 SH3 and PX domain-containing protein 2A	O43184 Q13444 Q5TCZ1 Q9H013	ADAM12 ADAM15 ADAM19 FISH KIAA0418 MDC15 MLTN MLTNB SH3MD1 SH3PXD2A TKS5

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