GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1476 - 1500** of **2090** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol
C6 deamination of adenosine	Double-stranded RNA-specific adenosine deaminase Double-stranded RNA-specific editase 1	P55265 P78563	ADAR ADAR1 ADAR2 ADARB1 DRADA2 DSRAD G1P1 IFI4 RED1
Thyroxine biosynthesis	Dual oxidase 1 Dual oxidase 2 Glycoprotein hormones alpha chain Iodotyrosine deiodinase 1 Sodium/iodide cotransporter Thyroid peroxidase Thyrotropin subunit beta	P01215 P01222 P07202 Q6PHW0 Q92911 Q9NRD8 Q9NRD9	C6orf71 CGA DEHAL1 DUOX DUOX1 DUOX2 IYD LNOX1 LNOX2 NIS SLC5A5 THOX1 THOX2 TPO TSHB
Negative feedback regulation of MAPK pathway	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase B-raf	P04049 P15056 P27361 P28482 P36507 Q02750	BRAF BRAF1 ERK1 ERK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1
Signaling by MAP2K mutants	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P36507 Q02750	ERK1 ERK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2
MAPK1 (ERK2) activation	Dual specificity mitogen-activated protein kinase kinase 2 Interleukin-6 receptor subunit alpha Interleukin-6 Mitogen-activated protein kinase 1 Non-receptor tyrosine-protein kinase TYK2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O60674 P05231 P08887 P23458 P28482 P29597 P36507 Q06124	ERK2 IFNB2 IL6 IL6R JAK1 JAK1A JAK1B JAK2 MAP2K2 MAPK1 MEK2 MKK2 PRKM1 PRKM2 PRKMK2 PTP2C PTPN11 SHPTP2 TYK2
activated TAK1 mediates p38 MAPK activation	Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 6 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O43187 O43318 O43353 P46734 P49137 P51617 P52564 P61088 Q13404 Q15750 Q15759 Q16539 Q16644 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 CSBP CSBP1 CSBP2 CSPB1 FIP3 IKBKG IRAK IRAK1 IRAK2 KIAA0733 MAP2K3 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 MEK3 MEK6 MKK3 MKK6 MXI2 NEMO NOD1 NOD2 PRKM11 PRKMK3 PRKMK6 RICK RIP2 RIPK2 RNF85 SAPK2 SAPK2A SAPK2B SKK2 SKK3 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14733 O43187 O43318 O43353 P45983 P45984 P45985 P51617 P53779 P61088 Q13404 Q15750 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 FIP3 IKBKG IRAK IRAK1 IRAK2 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 KIAA0733 MAP2K4 MAP2K7 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK10 MAPK8 MAPK9 MEK4 MEK7 MKK4 MKK7 NEMO NOD1 NOD2 PRKM10 PRKM8 PRKM9 PRKMK4 PRKMK7 RICK RIP2 RIPK2 RNF85 SAPK1 SAPK1A SAPK1B SAPK1C SEK1 SERK1 SKK1 SKK4 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1
Signalling to ERK5	Dual specificity mitogen-activated protein kinase kinase 5 Mitogen-activated protein kinase 7	Q13163 Q13164	BMK1 ERK5 MAP2K5 MAPK7 MEK5 MKK5 PRKM7 PRKMK5
Signaling by MAPK mutants	Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 Mitogen-activated protein kinase 1	P28482 Q13202 Q16828 Q16829 Q99956 Q9BY84 Q9Y6W6	C11orf81 DUSP10 DUSP16 DUSP6 DUSP7 DUSP8 DUSP9 ERK2 KIAA1700 MAPK1 MKP3 MKP4 MKP5 MKP7 PRKM1 PRKM2 PYST1 PYST2 VH5
Suppression of autophagy	Dual specificity protein phosphatase 16 N-acetyltransferase Eis Phosphatidylinositol-3-phosphatase Ras-related protein Rab-7a	O53361 P51149 P9WFK7 Q9BY84	DUSP16 KIAA1700 MKP7 RAB7 RAB7A eis sapM
ERKs are inactivated	Dual specificity protein phosphatase 3 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Serine/threonine-protein kinase VRK3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	P27361 P28482 P30153 P30154 P51452 P62714 P67775 Q13115 Q13164 Q14738 Q16828 Q16829 Q8IV63	BMK1 DUSP3 DUSP4 DUSP6 DUSP7 ERK1 ERK2 ERK5 MAPK1 MAPK3 MAPK7 MKP2 MKP3 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKM1 PRKM2 PRKM3 PRKM7 PYST1 PYST2 VH2 VHR VRK3
Regulation of Apoptosis	Dynamin-like GTPase OPA1, mitochondrial Metalloendopeptidase OMA1, mitochondrial	O60313 Q96E52	KIAA0567 MPRP1 OMA1 OPA1
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	Dystroglycan 1 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	Q14118 Q8WZA1	DAG1 MGAT1.2 POMGNT1
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	Dystroglycan 1 Protein O-mannosyl-transferase 1 Protein O-mannosyl-transferase 2	Q14118 Q9UKY4 Q9Y6A1	DAG1 POMT1 POMT2
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	Dystroglycan 1 Protein O-mannosyl-transferase 1 Protein O-mannosyl-transferase 2	Q14118 Q9UKY4 Q9Y6A1	DAG1 POMT1 POMT2
Regulation of IFNG signaling	E3 SUMO-protein ligase PIAS1 Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Small ubiquitin-related modifier 1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6	O14543 O15524 O60674 O75925 P01579 P15260 P18031 P23458 P29350 P38484 P63165 Q06124	CIS3 DDXBP1 HCP IFNG IFNGR1 IFNGR2 IFNGT1 JAK1 JAK1A JAK1B JAK2 PIAS1 PTP1B PTP1C PTP2C PTPN1 PTPN11 PTPN6 SHPTP2 SMT3C SMT3H3 SOCS1 SOCS3 SSI1 SSI3 SUMO1 TIP3 UBL1
SUMOylation of immune response proteins	E3 SUMO-protein ligase PIAS3 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase Topors Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon-induced, double-stranded RNA-activated protein kinase NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p100 subunit SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 3 Transcription factor p65	P19525 P25963 P55854 P63165 P63279 Q00653 Q04206 Q14164 Q8N2W9 Q9NS56 Q9Y6K9 Q9Y6X2	EIF2AK2 FIP3 IKBA IKBKE IKBKG IKKE IKKI KIAA0151 LUN LYT10 MAD3 NEMO NFKB2 NFKB3 NFKBI NFKBIA PIAS3 PIAS4 PIASG PKR PRKR RELA SMT3A SMT3C SMT3H1 SMT3H3 SUMO1 SUMO3 TOPORS TP53BPL UBC9 UBCE9 UBE2I UBL1
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase Arkadia E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 7 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing transcription regulator protein 1	O15105 O75376 P09874 P0CG47 P0CG48 P12755 P12757 P27361 P28482 P35813 P51668 P61077 P62979 P62987 P84022 Q13485 Q13547 Q13573 Q15583 Q15796 Q6ZNA4 Q93008 Q96PU5 Q9GZN2 Q9GZV5 Q9HAU4 Q9UN42 Q9UPN9 Q9Y618	ADPRT ATP1B4 CTG26 DFFRX DPC4 ERK1 ERK2 FAM HDAC1 KIAA0439 KIAA1047 KIAA1113 MADH2 MADH3 MADH4 MADH7 MADH8 MADR2 MAPK1 MAPK3 NCOR1 NCOR2 NEDD4L NEDL3 PARP1 PPM1A PPOL PPPM1A PRKM1 PRKM2 PRKM3 RFG7 RNF111 RPD3L1 RPS27A SFT SKI SKIIP SKIL SKIP SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNO SNW1 TAZ TGIF TGIF1 TGIF2 TIF1G TRIM33 UBA52 UBA80 UBB UBC UBC5A UBC5C UBCEP1 UBCEP2 UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 USP9 USP9X WWTR1
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine-rich repeats and immunoglobulin-like domains protein 1 Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein phosphatase eta SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P14210 P17706 P18031 P22681 P40818 P42566 P62979 P62987 Q12913 Q92783 Q96B97 Q96JA1 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 DEP1 EPS15 HBP HGF HGS HPTA HRS KIAA0055 LIG1 LRIG1 MET PTP1B PTPN1 PTPN2 PTPRJ PTPT RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8
InlB-mediated entry of Listeria monocytogenes into host cell	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Internalin B Internalin B Polyubiquitin-B Polyubiquitin-C SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P0DQD2 P0DQD3 P22681 P42566 P62979 P62987 Q92783 Q96B97 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 EPS15 HBP HGS HRS MET RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 inlB
Negative regulation of FGFR2 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15520 O43320 O76093 P05230 P08620 P09038 P0CG47 P0CG48 P10767 P11487 P21781 P22681 P27361 P28482 P31371 P62979 P62987 Q06124 Q8WU20 Q9GZV9 Q9HCT0 Q9NP95	CBL CBL2 ERK1 ERK2 FGF1 FGF10 FGF16 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FRS2 HST HST2 HSTF1 HSTF2 HYPF INT2 KGF KS3 MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RNF55 RPS27A SHPTP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Negative regulation of FGFR3 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43320 O76093 P05230 P08620 P09038 P0CG47 P0CG48 P22681 P27361 P28482 P31371 P62979 P62987 Q06124 Q8WU20 Q9GZV9 Q9NP95	CBL CBL2 ERK1 ERK2 FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB FRS2 HST HSTF1 HYPF KS3 MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RNF55 RPS27A SHPTP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Negative regulation of FLT3	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase eta SH2B adapter protein 3 Src-like-adapter 2 Src-like-adapter Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 6 Tyrosine-protein kinase ABL2 Tyrosine-protein kinase CSK Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14508 O14544 P0CG47 P0CG48 P22681 P36888 P41240 P42684 P49771 P62979 P62987 Q12913 Q13239 Q9H6Q3 Q9UQQ2	ABL2 ABLL ARG C20orf156 CBL CBL2 CD135 CIS2 CIS4 CSK DEP1 FLK2 FLT3 FLT3LG LNK PTPRJ RNF55 RPS27A SH2B3 SLA SLA2 SLAP SLAP1 SLAP2 SOCS2 SOCS4 SOCS6 SSI2 STATI2 STK1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
FLT3 signaling by CBL mutants	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P22681 P36888 P49771 P62979 P62987	CBL CBL2 CD135 FLK2 FLT3 FLT3LG RNF55 RPS27A STK1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
TGF-beta receptor signaling activates SMADs	E3 ubiquitin-protein ligase CBL Furin Integrin alpha-8 Integrin alpha-V Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin beta-8 Latent-transforming growth factor beta-binding protein 1 Latent-transforming growth factor beta-binding protein 2 Latent-transforming growth factor beta-binding protein 3 Latent-transforming growth factor beta-binding protein 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 NEDD8-conjugating enzyme Ubc12 NEDD8 Peptidyl-prolyl cis-trans isomerase FKBP1A TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta receptor type 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein	P01137 P05106 P05556 P06756 P09958 P10600 P18084 P18564 P22681 P26012 P36897 P37173 P53708 P61081 P61812 P62942 P84022 Q03167 Q13485 Q14766 Q14767 Q15796 Q15843 Q8N2S1 Q9NS15	ALK5 C14orf141 CBL CBL2 DPC4 FKBP1 FKBP12 FKBP1A FNRB FUR FURIN GP3A ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP2 LTBP3 LTBP4 MADH2 MADH3 MADH4 MADR2 MDF2 MSK12 MSK8 NEDD8 PACE PCSK3 RNF55 SKR4 SMAD2 SMAD3 SMAD4 TGFB TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 UBC12 UBE2M VNRA VTNR

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