Interleukin-6 signaling
|
|
|
- APRF
- CBL
- CBL2
- CIS3
- IFNB2
- IL6
- IL6R
- IL6ST
- JAK1
- JAK1A
- JAK1B
- JAK2
- PTP2C
- PTPN11
- RNF55
- SHPTP2
- SOCS3
- SSI3
- STAT1
- STAT3
- TYK2
|
|
Spry regulation of FGF signaling
|
|
|
- BRAF
- BRAF1
- CBL
- CBL2
- ERK1
- ERK2
- MAPK1
- MAPK3
- MKNK1
- MNK1
- PPP2CA
- PPP2CB
- PPP2R1A
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RAFB1
- RNF55
- RPS27A
- SHPTP2
- SPRY2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Regulation of KIT signaling
|
|
|
- APS
- CBL
- CBL2
- CIS4
- FYN
- HCP
- JTK8
- KIT
- LCK
- LNK
- LYN
- PKCA
- PRKACA
- PRKCA
- PTP1C
- PTPN6
- RNF55
- SCFR
- SH2B2
- SH2B3
- SOCS1
- SOCS4
- SOCS6
- SOS1
- SSI1
- TIP3
- YES
- YES1
|
|
Regulation of innate immune responses to cytosolic DNA
|
|
|
- ABS
- C20orf183
- DDX41
- DLM1
- DTX4
- ERIS
- HT2A
- IRF3
- KIAA0937
- MITA
- NAK
- NALP4
- NLRP4
- PAN2
- PYPAF4
- RNF109
- RNF155
- RNF81
- RNH2
- RO52
- RPS27A
- SSA1
- STING
- STING1
- TBK1
- TMEM173
- TRIM21
- TRIM32
- TRIM56
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- ZBP1
|
|
IRF3 mediated activation of type 1 IFN
|
|
|
- C20orf183
- DLM1
- DTX4
- IRF3
- KIAA0937
- NAK
- NALP4
- NLRP4
- PAN2
- PYPAF4
- RNF155
- RNH2
- TBK1
- ZBP1
|
|
Downregulation of ERBB4 signaling
|
|
|
- ITCH
- KIAA0093
- NEDD4
- NEDD4-1
- RPF1
- RPS27A
- SRC
- SRC1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WWP1
|
|
LXRs regulate gene expression to limit cholesterol uptake
|
|
|
- BZF1
- IDOL
- LXRA
- LXRB
- MYLIP
- NER
- NR1H2
- NR1H3
- NR2B1
- NR2B2
- RXRA
- RXRB
- UNR
|
|
Regulation of PTEN localization
|
|
|
- API3
- BIRC4
- HAUSP
- IAP3
- KIAA0093
- MMAC1
- MYL
- NEDD4
- NEDD4-1
- PML
- PP8675
- PTEN
- RNF71
- RPF1
- RPS27A
- TEP1
- TRIM19
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- USP7
- XIAP
|
|
Myoclonic epilepsy of Lafora
|
|
|
- EPM2A
- EPM2B
- GYG
- GYG1
- GYS
- GYS1
- NHLRC1
- PPP1R3C
- PPP1R5
- RPS27A
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Downregulation of ERBB2:ERBB3 signaling
|
|
|
- AKT1
- AKT2
- AKT3
- ERBB2
- FLRF
- GGF
- HER2
- HGL
- HRGA
- KIAA0055
- MLN19
- NDF
- NEU
- NGL
- NRDP1
- NRG1
- NRG2
- NTAK
- PKB
- PKBG
- RAC
- RNF41
- RPS27A
- SMDF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBPY
- USP8
|
|
Regulation of FZD by ubiquitination
|
|
|
- C20orf182
- C2orf31
- FZD4
- FZD5
- FZD6
- FZD8
- GPR48
- GPR49
- GPR67
- KIAA0055
- KIAA1133
- LGR4
- LGR5
- LGR6
- LR3
- LRP5
- LRP6
- LRP7
- PWTSR
- RNF203
- RNF43
- RPS27A
- RSPO1
- RSPO2
- RSPO3
- RSPO4
- THSD2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBPY
- USP8
- WNT3A
- ZNRF3
|
|
Signaling by RNF43 mutants
|
|
|
- C2orf31
- FZD4
- FZD5
- FZD6
- FZD8
- LR3
- LRP5
- LRP6
- LRP7
- RNF43
- WNT3A
|
|
IRAK1 recruits IKK complex
|
|
|
- BLU
- CHUK
- CROC1
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- IRAK
- IRAK1
- NEMO
- PELI1
- PELI2
- PELI3
- PRISM
- RNF85
- TCF16
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
|
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
|
|
|
- BLU
- CHUK
- CROC1
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- IRAK
- IRAK1
- NEMO
- PELI1
- PELI2
- PELI3
- PRISM
- RNF85
- TCF16
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
|
Inhibition of membrane repair
|
|
|
|
|
ERK/MAPK targets
|
|
|
- BMK1
- CSBP
- CSBP1
- CSBP2
- CSPB1
- ELK1
- ERK1
- ERK2
- ERK5
- ISPK1
- MAPK1
- MAPK11
- MAPK14
- MAPK3
- MAPK7
- MAPKAPK1A
- MAPKAPK1B
- MAPKAPK1C
- MEF2
- MEF2A
- MEF2C
- MSK1
- MXI2
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5D
- PRKM1
- PRKM11
- PRKM2
- PRKM3
- PRKM7
- RPS6KA1
- RPS6KA2
- RPS6KA3
- RPS6KA5
- RSK1
- RSK2
- RSK3
- SAPK2
- SAPK2A
- SAPK2B
|
|
Toll Like Receptor 9 (TLR9) Cascade
|
|
|
- EEA1
- PIK3C3
- PIK3R4
- RBSN
- TLR9
- VPS15
- VPS34
- ZFYVE2
- ZFYVE20
|
|
Phosphate bond hydrolysis by NTPDase proteins
|
|
|
- CD39
- CD39L1
- CD39L2
- CD39L3
- CD39L4
- ENTPD1
- ENTPD2
- ENTPD3
- ENTPD4
- ENTPD5
- ENTPD6
- ENTPD7
- ENTPD8
- IL6ST2
- KIAA0392
- LALP1
- LALP70
- LYSAL1
- PCPH
|
|
Vitamin B2 (riboflavin) metabolism
|
|
|
- ACP5
- C20orf54
- ENPP1
- FLAD1
- GPR172A
- GPR172B
- M6S1
- NPPS
- PAR1
- PAR2
- PC1
- PDNP1
- RFK
- RFT1
- RFT2
- RFT3
- RFVT3
- SLC52A1
- SLC52A2
- SLC52A3
|
|
Elastic fibre formation
|
|
|
- DANCE
- ELN
- FBLN5
- FBN
- FBN1
- FBN2
- FBN3
- FNRA
- FNRB
- FUR
- FURIN
- GP3A
- ITGA5
- ITGAV
- ITGB1
- ITGB3
- ITGB6
- KIAA1776
- LOX
- LOXC
- LOXL
- LOXL1
- LOXL2
- LOXL3
- LOXL4
- MAGP1
- MAGP2
- MDF2
- MFAP2
- MFAP5
- MSK12
- MSK8
- PACE
- PCSK3
- VNRA
- VTNR
|
|
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
|
|
|
|
|
Eukaryotic Translation Elongation
|
|
|
- EEF1A
- EEF1A1
- EEF1A1P5
- EEF1A2
- EEF1AL
- EEF1AL3
- EEF1B
- EEF1B2
- EEF1D
- EEF1G
- EF1A
- EF1B
- EF1D
- EF1G
- LENG7
- STN
|
|
Peptide chain elongation
|
|
|
- BBC1
- CCG2
- D11S2243E
- D6S218E
- DXS648E
- EC45
- EEF1A
- EEF1A1
- EEF2
- EF1A
- EF2
- FAU
- FTE1
- LAMBR
- LAMR1
- LENG7
- MFTL
- MPS1
- NEDD6
- QM
- RIG
- RPL1
- RPL10
- RPL10A
- RPL10L
- RPL11
- RPL12
- RPL13
- RPL13A
- RPL14
- RPL15
- RPL17
- RPL18
- RPL18A
- RPL19
- RPL21
- RPL22
- RPL22L1
- RPL23
- RPL23A
- RPL24
- RPL26
- RPL26L1
- RPL26P1
- RPL27
- RPL27A
- RPL28
- RPL29
- RPL3
- RPL30
- RPL31
- RPL32
- RPL34
- RPL35
- RPL35A
- RPL36
- RPL36A
- RPL36AL
- RPL37
- RPL37A
- RPL38
- RPL39
- RPL39L
- RPL39L1
- RPL3L
- RPL4
- RPL41
- RPL44
- RPL5
- RPL6
- RPL7
- RPL7A
- RPL8
- RPL9
- RPL9P7
- RPL9P8
- RPL9P9
- RPLP0
- RPLP1
- RPLP2
- RPP2
- RPS10
- RPS11
- RPS12
- RPS13
- RPS14
- RPS15
- RPS15A
- RPS16
- RPS17
- RPS17L
- RPS18
- RPS19
- RPS2
- RPS20
- RPS21
- RPS23
- RPS24
- RPS25
- RPS26
- RPS27
- RPS27A
- RPS27L
- RPS28
- RPS29
- RPS3
- RPS3A
- RPS4
- RPS4X
- RPS4Y
- RPS4Y1
- RPS4Y2
- RPS4Y2P
- RPS5
- RPS6
- RPS7
- RPS8
- RPS9
- RPSA
- RRP1
- SCAR
- SURF-3
- SURF3
- TXREB1
- UBA52
- UBA80
- UBCEP1
- UBCEP2
|
|
SARS-CoV-1 modulates host translation machinery
|
|
|
- 1a
- CCG2
- D6S218E
- EEF1A
- EEF1A1
- EF1A
- FAU
- FTE1
- HNRNPA1
- HNRPA1
- LAMBR
- LAMR1
- LENG7
- MFTL
- MPS1
- N
- RIG
- RPS10
- RPS11
- RPS12
- RPS13
- RPS14
- RPS15
- RPS15A
- RPS16
- RPS17
- RPS17L
- RPS18
- RPS19
- RPS2
- RPS20
- RPS21
- RPS23
- RPS24
- RPS25
- RPS26
- RPS27
- RPS27A
- RPS27L
- RPS28
- RPS29
- RPS3
- RPS3A
- RPS4
- RPS4X
- RPS4Y
- RPS4Y1
- RPS4Y2
- RPS4Y2P
- RPS5
- RPS6
- RPS7
- RPS8
- RPS9
- RPSA
- SCAR
- UBA80
- UBCEP1
- rep
|
|
SARS-CoV-2 modulates autophagy
|
|
|
- 3a
- 7a
- KIAA0770
- KIAA1475
- M
- MAP1ALC3
- MAP1LC3B
- RNF108
- TLP
- TUFM
- UVRAG
- VAM6
- VPS11
- VPS16
- VPS18
- VPS33A
- VPS33B
- VPS39
- VPS41
- VPS45
- VPS45A
- VPS45B
|
|