GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **476 - 500** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism
Nef mediated downregulation of MHC class I complex cell surface expression	AP-1 complex subunit beta-1 AP-1 complex subunit gamma-1 AP-1 complex subunit mu-1 AP-1 complex subunit mu-2 AP-1 complex subunit sigma-1A AP-1 complex subunit sigma-2 AP-1 complex subunit sigma-3 Beta-2-microglobulin HLA class I histocompatibility antigen, A alpha chain Phosphofurin acidic cluster sorting protein 1 Protein Nef	O43747 P04439 P04601 P56377 P61769 P61966 Q10567 Q6VY07 Q96PC3 Q9BXS5 Q9Y6Q5	ADTB1 ADTG AP19 AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 B2M BAM22 CLAPB2 CLAPG1 CLAPS1 CLTNM HLA-A HLAA KIAA1175 PACS1 nef	Homo sapiens (human)
Signaling by BRAF and RAF1 fusions	14-3-3 protein beta/alpha A-kinase anchor protein 9 AP-3 complex subunit beta-1 Acylglycerol kinase, mitochondrial Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Angiogenic factor with G patch and FHA domains 1 Bcl-2-like protein 11 Beta-arrestin-1 Beta-arrestin-2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Epithelial splicing regulatory protein 1 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas H(+)/Cl(-) exchange transporter 6 Integrin alpha-IIb Integrin beta-3 KH domain-containing RNA-binding protein QKI Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 Lysine-specific demethylase 7A MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myosin phosphatase Rho-interacting protein Phosphatidylethanolamine-binding protein 1 Prelamin-A/C Protein FAM114A2 Protein FAM131B Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase RNA-binding protein FXR1 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Staphylococcal nuclease domain-containing protein 1 Talin-1 Terminal nucleotidyltransferase 4A Trafficking kinesin-binding protein 1 Transcription intermediary factor 1-alpha Type-1 angiotensin II receptor-associated protein Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 UPF0606 protein KIAA1549 Ubiquitin-like modifier-activating enzyme ATG7 Vinculin Zinc finger CCCH-type antiviral protein 1 von Willebrand factor	O00203 O15164 O43252 O43521 O60674 O95352 P01111 P01112 P02545 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P51114 P51797 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q53H12 Q5XG87 Q6NXG1 Q6RW13 Q6VAB6 Q6WCQ1 Q6ZMT4 Q7KZF4 Q7Z2W4 Q7Z5R6 Q86XD5 Q8IVT5 Q8N302 Q8WXI2 Q969H4 Q96PU8 Q99996 Q9HCM3 Q9NRY5 Q9UPV9 Q9UQM7 Q9Y490	ADTB3A AGGF1 AGK AGTRAP AKAP350 AKAP450 AKAP9 AP3B1 APBB1IP APG7L ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 ATG7 ATPSK1 ATRAP BCL2L11 BIM BRAF BRAF1 C5orf3 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CLCN6 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 ESRP1 F8VWF FAM114A2 FAM131B FGA FGB FGG FN FN1 FXR1 GP2B GP3A GPATC7 GPATCH7 HKQ HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 JHDM1D KDM7 KDM7A KIAA0046 KIAA0051 KIAA0773 KIAA0803 KIAA0864 KIAA0902 KIAA0968 KIAA1027 KIAA1042 KIAA1549 KIAA1718 KREV1 KSR KSR1 KSR2 LMN1 LMNA MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MPRIP MRIP MULK NRAS OIP106 PAPD7 PAPSS PAPSS1 PBP PEBP PEBP1 PKS PKS2 POLS PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 QKI RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RBM35A RHOIP3 RIAM RNF82 SND1 SRC SRC1 TDRD11 TENT4A TIF1 TIF1A TLN TLN1 TRAK1 TRF4 TRIM24 VCL VG5Q VWF YWHAB ZC3HAV1 ZC3HDC2	Homo sapiens (human)
Endogenous sterols	24-hydroxycholesterol 7-alpha-hydroxylase Adrenodoxin, mitochondrial Aromatase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Bile acid receptor Cholesterol 24-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B2, mitochondrial Cytochrome P450 1B1 Cytochrome P450 4V2 Cytochrome P450 7A1 Cytochrome P450 7B1 Ferredoxin-2, mitochondrial Lanosterol 14-alpha demethylase NADPH Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Pro-opiomelanocortin Retinoic acid receptor RXR-alpha Steroid 21-hydroxylase Sterol 26-hydroxylase, mitochondrial	A9YTQ3 O75881 P01189 P05108 P08686 P10109 P11511 P15538 P19099 P19793 P22570 P22680 P27540 P35869 Q02318 Q15596 Q15788 Q16678 Q16850 Q6P4F2 Q6ZWL3 Q96RI1 Q9HBZ2 Q9NYL5 Q9Y6A2	ADX ADXR AHR AHRR ARNT ARNT2 ARO1 BAR BHLHE1 BHLHE2 BHLHE74 BHLHE75 BHLHE76 BHLHE77 CYAR CYP11A CYP11A1 CYP11B1 CYP11B2 CYP19 CYP19A1 CYP1B1 CYP21 CYP21A2 CYP21B CYP27 CYP27A1 CYP39A1 CYP46 CYP46A1 CYP4V2 CYP51 CYP51A1 CYP7 CYP7A1 CYP7B1 FDX1 FDX1L FDX2 FDXR FXR HRR1 KIAA0307 KIAA1234 NCOA1 NCOA2 NR1H4 NR2B1 POMC RIP14 RXRA S11BH SRC1 SRC2 TIF2	Homo sapiens (human)
Pregnenolone biosynthesis	Adrenodoxin, mitochondrial Aldo-keto reductase family 1 member B1 Cholesterol side-chain cleavage enzyme, mitochondrial Ferredoxin-2, mitochondrial NADPH Peripheral-type benzodiazepine receptor-associated protein 1 STARD3 N-terminal-like protein StAR-related lipid transfer protein 3 StAR-related lipid transfer protein 4 StAR-related lipid transfer protein 6 Steroidogenic acute regulatory protein, mitochondrial Translocator protein	O95153 O95772 P05108 P10109 P15121 P22570 P30536 P49675 P59095 Q14849 Q6P4F2 Q96DR4	ADX ADXR AKR1B1 ALDR1 ALR2 BZRAP1 BZRP CAB1 CYP11A CYP11A1 FDX1 FDX1L FDX2 FDXR KIAA0612 MBR MENTHO MLN64 RBP1 RIMBP1 STAR STARD1 STARD3 STARD3NL STARD4 STARD6 TSPO TSPOAP1	Homo sapiens (human)
Defective CYP11A1 causes AICSR	Adrenodoxin, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Ferredoxin-2, mitochondrial NADPH	P05108 P10109 P22570 Q6P4F2	ADX ADXR CYP11A CYP11A1 FDX1 FDX1L FDX2 FDXR	Homo sapiens (human)
Electron transport from NADPH to Ferredoxin	Adrenodoxin, mitochondrial Ferredoxin-2, mitochondrial NADPH	P10109 P22570 Q6P4F2	ADX ADXR FDX1 FDX1L FDX2 FDXR	Homo sapiens (human)
Protein lipoylation	Acyl carrier protein, mitochondrial Adrenodoxin, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Glycine cleavage system H protein, mitochondrial Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Lipoyl amidotransferase LIPT1, mitochondrial Lipoyl synthase, mitochondrial NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Octanoyl-[acyl-carrier-protein]	A6NK58 O14561 O43766 P10109 P10515 P11182 P23434 P36957 Q9UMS0 Q9Y234	ADX BCATE2 BCKDHE2 DBT DLAT DLST DLTA DLTS FDX1 GCSH HIRIP5 LAS LIAS LIPT1 LIPT2 NDUFAB1 NFU1	Homo sapiens (human)
Mitochondrial iron-sulfur cluster biogenesis	Adrenodoxin, mitochondrial Ferredoxin-2, mitochondrial Frataxin, mitochondrial Glutaredoxin-related protein 5, mitochondrial Iron-sulfur cluster assembly 1 homolog, mitochondrial Iron-sulfur cluster assembly 2 homolog, mitochondrial Iron-sulfur cluster co-chaperone protein HscB LYR motif-containing protein 4 Mitoferrin-1 Mitoferrin-2	P10109 Q16595 Q6P4F2 Q86SX6 Q86U28 Q8IWL3 Q96A46 Q9BUE6 Q9HD34 Q9NYZ2	ADX C14orf87 C6orf149 DNAJC20 FDX1 FDX1L FDX2 FRDA FXN GLRX5 HBLD1 HBLD2 HSC20 HSCB ISCA1 ISCA2 ISD11 LYRM4 MFRN MFRN2 MSCP SLC25A28 SLC25A37 X25	Homo sapiens (human)
Bicarbonate transporters	Adenosylhomocysteinase 3 Anion exchange protein 2 Anion exchange protein 3 Anion exchange protein 4 Band 3 anion transport protein Electrogenic sodium bicarbonate cotransporter 1 Electrogenic sodium bicarbonate cotransporter 4 Electroneutral sodium bicarbonate exchanger 1 Sodium bicarbonate cotransporter 3 Sodium-driven chloride bicarbonate exchanger	P02730 P04920 P48751 Q2Y0W8 Q6U841 Q96HN2 Q96Q91 Q9BY07 Q9Y6M7 Q9Y6R1	AE1 AE2 AE3 AE4 AHCYL2 BT DI EPB3 EPB3L1 HKB3 KIAA0739 KIAA0828 MPB3L NBC NBC1 NBC2 NBC2B NBC3 NBC4 NBCE1 NBCN2 NBCn1 NCBE NDCBE1 SBC2 SBC5 SLC4A1 SLC4A10 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A6 SLC4A7 SLC4A8 SLC4A9	Homo sapiens (human)
Erythrocytes take up carbon dioxide and release oxygen	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Cytochrome b5 reductase 4 Hemoglobin subunit alpha Hemoglobin subunit beta NADH-cytochrome b5 reductase 1 NADH-cytochrome b5 reductase 2 NADH-cytochrome b5 reductase-like	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094 Q6BCY4 Q6IPT4 Q7L1T6 Q9UHQ9	AE1 AQP1 CA1 CA2 CA4 CHIP28 CYB5R1 CYB5R2 CYB5R4 CYB5RL DI EPB3 HBA1 HBA2 HBB NCB5OR NQO3A2 RH50 RHAG SLC4A1	Homo sapiens (human)
Erythrocytes take up oxygen and release carbon dioxide	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Hemoglobin subunit alpha Hemoglobin subunit beta	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094	AE1 AQP1 CA1 CA2 CA4 CHIP28 DI EPB3 HBA1 HBA2 HBB RH50 RHAG SLC4A1	Homo sapiens (human)
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Band 3 anion transport protein	P02730	AE1 DI EPB3 SLC4A1	Homo sapiens (human)
PRC2 methylates histones and DNA	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Metal-response element-binding transcription factor 2 PHD finger protein 19 PHD finger protein 1 Polycomb protein EED Polycomb protein SUZ12 Protein Jumonji Zinc finger protein AEBP2	O43189 O60814 O75530 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q09028 Q15022 Q15910 Q16576 Q16777 Q16778 Q5T6S3 Q6FI13 Q6ZN18 Q71DI3 Q71UI9 Q8N257 Q92833 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9Y483 Q9Y6K1	AEBP2 AIM CHET9 CXXC9 DNMT DNMT1 DNMT3A DNMT3B EED EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JARID2 JJAZ1 JMJ KIAA0160 KMT6 MTF2 PCL1 PCL2 PCL3 PHF1 PHF19 RBAP46 RBAP48 RBBP4 RBBP7 SUZ12 TSH2B	Homo sapiens (human)
PKMTs methylate histone lysines	Actin-histidine N-methyltransferase Activating transcription factor 7-interacting protein 1 Histone H3.1 Histone H3.2 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase ASH1L Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase KMT5B Histone-lysine N-methyltransferase KMT5C Histone-lysine N-methyltransferase MECOM Histone-lysine N-methyltransferase NSD2 Histone-lysine N-methyltransferase NSD3 Histone-lysine N-methyltransferase PRDM16 Histone-lysine N-methyltransferase PRDM9 Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Histone-lysine N-methyltransferase SETD2 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB1 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase SMYD3 Histone-lysine N-methyltransferase SUV39H1 Histone-lysine N-methyltransferase SUV39H2 Histone-lysine N-methyltransferase, H3 lysine-36 specific Histone-lysine N-methyltransferase, H3 lysine-79 specific N-lysine methyltransferase KMT5A N-lysine methyltransferase SETD6 N-lysine methyltransferase SMYD2 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Polycomb protein EED Polycomb protein SUZ12 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Transcription factor p65 WD repeat-containing protein 5 Zinc finger protein AEBP2	O14686 O15047 O43463 O75530 O96028 P19838 P61964 P62805 P68431 Q00653 Q03112 Q03164 Q04206 Q09028 Q15022 Q15047 Q15291 Q15910 Q16576 Q4FZB7 Q6VMQ6 Q6ZN18 Q71DI3 Q86TU7 Q86Y97 Q8NEZ4 Q8TBK2 Q8TEK3 Q8WTS6 Q96KQ7 Q96L73 Q96T68 Q9BYW2 Q9BZ95 Q9C005 Q9H5I1 Q9H7B4 Q9H9B1 Q9HAZ2 Q9NQR1 Q9NQV7 Q9NR48 Q9NRG4 Q9UBL3 Q9UMN6 Q9UPS6	AEBP2 ALL1 ALR ARA267 ASH1L ASH2L ASH2L1 ATF7IP BAT8 BIG3 C13orf4 C14orf154 C6orf30 CHET9 CLLD8 CXXC7 DOT1L DPY30 EED EHMT1 EHMT2 ESET EUHMTASE1 EVI1 EZH2 G9A GLP H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HIF1 HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST4H4 HRX HRX2 HTRX HYPB JJAZ1 KIAA0067 KIAA0160 KIAA0304 KIAA0339 KIAA1076 KIAA1090 KIAA1420 KIAA1506 KIAA1675 KIAA1717 KIAA1732 KIAA1814 KIAA1876 KMT1A KMT1B KMT1C KMT1D KMT1E KMT1F KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G KMT2H KMT3A KMT3B KMT3C KMT4 KMT5A KMT5B KMT5C KMT6 KMT7 LYT10 MCAF MCAF1 MDS1 MECOM MEL1 MLL MLL1 MLL2 MLL3 MLL4 MMSET NFKB1 NFKB2 NFKB3 NG36 NSD1 NSD2 NSD3 PFM13 PFM6 PRDM16 PRDM3 PRDM9 PRSET7 RBAP46 RBAP48 RBBP4 RBBP5 RBBP7 RBQ3 RELA SET07 SET1 SET1A SET1B SET2 SET7 SET8 SET9 SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETD8 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H SUV39H1 SUV39H2 SUV420H1 SUV420H2 SUZ12 TRX1 TRX2 TRX5 WBP7 WDR5 WHSC1 WHSC1L1 ZMYND1 ZNFN3A1	Homo sapiens (human)
Repression of WNT target genes	C-terminal-binding protein 1 C-terminal-binding protein 2 Histone deacetylase 1 Lymphoid enhancer-binding factor 1 TLE family member 5 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 3 Transducin-like enhancer protein 4	P36402 P56545 Q04724 Q04725 Q04726 Q04727 Q08117 Q13363 Q13547 Q9HCS4 Q9NQB0 Q9UJU2	AES CTBP CTBP1 CTBP2 GRG GRG4 GRG5 HDAC1 KIAA1261 KIAA1547 LEF1 RPD3L1 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 TLE5	Homo sapiens (human)
EGFR downregulation	Amphiregulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor-type tyrosine-protein phosphatase kappa Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14944 O14964 O43597 O43609 O75886 P00533 P01133 P01135 P0CG47 P0CG48 P15514 P22681 P26045 P35070 P42566 P60953 P62979 P62987 Q05209 Q14155 Q15262 Q6UW88 Q92783 Q96B97 Q99075 Q99961 Q99962 Q99963 Q9UBC2 Q9Y6I3	AF1P AREG AREGB ARHGEF7 BTC CBL CBL2 CDC42 CIN85 CNSA1 CNSA2 CNSA3 COOL1 DTR DTS EGF EGFR EPGN EPN1 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG HBEGF HBP HEGFL HER1 HGS HRS KIAA0142 P85SPR PAK3BP PIXB PTPH1 PTPK PTPN12 PTPN3 PTPRK RNF55 RPS27A SDGF SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SPRY1 SPRY2 STAM STAM1 STAM2 TGFA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine-rich repeats and immunoglobulin-like domains protein 1 Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein phosphatase eta SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P14210 P17706 P18031 P22681 P40818 P42566 P62979 P62987 Q12913 Q92783 Q96B97 Q96JA1 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 DEP1 EPS15 HBP HGF HGS HPTA HRS KIAA0055 LIG1 LRIG1 MET PTP1B PTPN1 PTPN2 PTPRJ PTPT RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
InlB-mediated entry of Listeria monocytogenes into host cell	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Internalin B Internalin B Polyubiquitin-B Polyubiquitin-C SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P0DQD2 P0DQD3 P22681 P42566 P62979 P62987 Q92783 Q96B97 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 EPS15 HBP HGS HRS MET RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 inlB	Homo sapiens (human)
RNA Polymerase II Pre-transcription Events	AF4/FMR2 family member 4 CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELL-associated factor 1 ELL-associated factor 2 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIE subunit 1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Parafibromin Protein AF-9 Protein ENL Protein IWS1 homolog RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Superkiller complex protein 8 TATA-binding protein-associated factor 2N TATA-box-binding protein Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription elongation factor SPT6 Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B	O00267 O00268 O15514 O60563 O60583 O75909 P13984 P18074 P18615 P19387 P19388 P19447 P20226 P21675 P23193 P24928 P29083 P29084 P30876 P32780 P35269 P36954 P42568 P49848 P50613 P50750 P51946 P51948 P52298 P52434 P52435 P52655 P52657 P53803 P55199 P61218 P62487 P62875 P63272 Q00403 Q03111 Q08945 Q09161 Q12962 Q13888 Q13889 Q14241 Q15369 Q15370 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q5H9L4 Q5VWG9 Q6P1J9 Q6P1X5 Q6PD62 Q6ZYL4 Q7KZ85 Q8IXH7 Q8IYF1 Q8IZX4 Q8N7H5 Q8WVC0 Q8WX92 Q92541 Q92750 Q92759 Q92804 Q96CJ1 Q96JC9 Q96ST2 Q9GZS3 Q9H3P2 Q9HBM6 Q9UHB7 Q9Y5B0 Q9Y5B9	AF5Q31 AF9 AFF4 BA2R BTF2 BTF2P44 C19orf17 C1orf28 C6orf175 CAK CAK1 CAP35 CBP20 CBP80 CCG1 CCGS CCNH CCNK CCNT1 CCNT2 CDC2L4 CDC73 CDK7 CDK9 CDKN7 CIF150 COBRA1 CPR4 CTDP1 CTR9 EAF1 EAF2 ELL ELOA ELOA2 ELOB ELOC ENL ERCC2 ERCC3 FACT140 FACT80 FACTP140 FCP1 GTF2A1 GTF2A2 GTF2B GTF2D1 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HRPT2 IWS1 IWS1L KIAA0155 KIAA0162 KIAA0252 KIAA1182 LEO1 LTG19 MAT1 MCEF MLLT1 MLLT3 MNAT1 MO15 NCBP NCBP1 NCBP2 NELFA NELFB NELFCD NELFD NELFE PAF1 PD2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RBP56 RD RDBP RDL RNF66 RPB7 RTF1 SH2BP1 SKIC8 SPT4H SPT5 SPT5H SPT6H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H SUPT6H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TAK TBP TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TF2A1 TF2A2 TF2B TF2D TF2E1 TF2E2 TFIIB TFIID TFIIS TH1 TH1L TRAITS TTDA WDR61 WHSC2 XPB XPBC XPD XPDC YEATS1 YEATS3	Homo sapiens (human)
Formation of RNA Pol II elongation complex	AF4/FMR2 family member 4 CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELL-associated factor 1 ELL-associated factor 2 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Parafibromin Protein AF-9 Protein ENL Protein IWS1 homolog RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Superkiller complex protein 8 Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription elongation factor SPT6	O00267 O15514 O60563 O60583 O75909 P13984 P18074 P18615 P19387 P19388 P19447 P23193 P24928 P30876 P32780 P35269 P36954 P42568 P50613 P50750 P51946 P51948 P52298 P52434 P52435 P53803 P55199 P61218 P62487 P62875 P63272 Q03111 Q08945 Q09161 Q13888 Q13889 Q14241 Q15369 Q15370 Q6P1J9 Q6PD62 Q6ZYL4 Q7KZ85 Q8IXH7 Q8IYF1 Q8N7H5 Q8WVC0 Q8WX92 Q92541 Q92759 Q96CJ1 Q96JC9 Q96ST2 Q9GZS3 Q9H3P2 Q9UHB7 Q9Y5B0 Q9Y5B9	AF5Q31 AF9 AFF4 BTF2 BTF2P44 C19orf17 C1orf28 C6orf175 CAK CAK1 CAP35 CBP20 CBP80 CCNH CCNK CCNT1 CCNT2 CDC2L4 CDC73 CDK7 CDK9 CDKN7 COBRA1 CPR4 CTDP1 CTR9 EAF1 EAF2 ELL ELOA ELOA2 ELOB ELOC ENL ERCC2 ERCC3 FACT140 FACT80 FACTP140 FCP1 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HRPT2 IWS1 IWS1L KIAA0155 KIAA0162 KIAA0252 KIAA1182 LEO1 LTG19 MAT1 MCEF MLLT1 MLLT3 MNAT1 MO15 NCBP NCBP1 NCBP2 NELFA NELFB NELFCD NELFD NELFE PAF1 PD2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RD RDBP RDL RNF66 RPB7 RTF1 SH2BP1 SKIC8 SPT4H SPT5 SPT5H SPT6H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H SUPT6H TAK TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TFIIS TH1 TH1L TRAITS TTDA WDR61 WHSC2 XPB XPBC XPD XPDC YEATS1 YEATS3	Homo sapiens (human)
RNA Polymerase II Transcription Elongation	AF4/FMR2 family member 4 CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELL-associated factor 1 ELL-associated factor 2 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Parafibromin Protein AF-9 Protein ENL Protein IWS1 homolog RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Superkiller complex protein 8 Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription elongation factor SPT6	O00267 O15514 O60563 O60583 O75909 P13984 P18074 P18615 P19387 P19388 P19447 P23193 P24928 P30876 P32780 P35269 P36954 P42568 P50613 P50750 P51946 P51948 P52434 P52435 P53803 P55199 P61218 P62487 P62875 P63272 Q03111 Q08945 Q13888 Q13889 Q14241 Q15369 Q15370 Q6P1J9 Q6PD62 Q6ZYL4 Q7KZ85 Q8IXH7 Q8IYF1 Q8N7H5 Q8WVC0 Q8WX92 Q92541 Q92759 Q96CJ1 Q96JC9 Q96ST2 Q9GZS3 Q9H3P2 Q9UHB7 Q9Y5B0 Q9Y5B9	AF5Q31 AF9 AFF4 BTF2 BTF2P44 C19orf17 C1orf28 C6orf175 CAK CAK1 CAP35 CCNH CCNK CCNT1 CCNT2 CDC2L4 CDC73 CDK7 CDK9 CDKN7 COBRA1 CPR4 CTDP1 CTR9 EAF1 EAF2 ELL ELOA ELOA2 ELOB ELOC ENL ERCC2 ERCC3 FACT140 FACT80 FACTP140 FCP1 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HRPT2 IWS1 IWS1L KIAA0155 KIAA0162 KIAA0252 KIAA1182 LEO1 LTG19 MAT1 MCEF MLLT1 MLLT3 MNAT1 MO15 NELFA NELFB NELFCD NELFD NELFE PAF1 PD2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RD RDBP RDL RNF66 RPB7 RTF1 SH2BP1 SKIC8 SPT4H SPT5 SPT5H SPT6H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H SUPT6H TAK TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TFIIS TH1 TH1L TRAITS TTDA WDR61 WHSC2 XPB XPBC XPD XPDC YEATS1 YEATS3	Homo sapiens (human)
Regulation of RAS by GAPs	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-3 Disabled homolog 2-interacting protein E3 ubiquitin-protein ligase RBX1 GTPase HRas GTPase NRas Kelch repeat and BTB domain-containing protein 7 Neurofibromin Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 RAS protein activator like-3 Ras GTPase-activating protein 1 Ras GTPase-activating protein 2 Ras GTPase-activating protein 3 Ras GTPase-activating protein 4 Ras GTPase-activating protein nGAP Ras/Rap GTPase-activating protein SynGAP RasGAP-activating-like protein 1 Sprouty-related, EVH1 domain-containing protein 1 Sprouty-related, EVH1 domain-containing protein 2 Sprouty-related, EVH1 domain-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O43374 O75832 O95294 P01111 P01112 P0CG47 P0CG48 P17980 P20618 P20936 P21359 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 Q06323 Q13200 Q13618 Q14644 Q14997 Q15008 Q15283 Q16401 Q2MJR0 Q5VWQ8 Q7Z698 Q7Z699 Q86YV0 Q8TAA3 Q8WVZ9 Q92530 Q96PV0 Q99436 Q99460 Q9UJF2 Q9UL46 Q9UNM6	AF9Q34 AIP1 C7orf76 CAPRI CUL3 DAB2IP DSS1 EVE-3 GAP GAP1M GAPL HC2 HC3 HC8 HC9 HRAS HRAS1 HSPC IFI5111 KBTBD7 KIAA0072 KIAA0077 KIAA0107 KIAA0538 KIAA0617 KIAA1743 KIAA1938 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NF1 NGAP NRAS NU PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RASA RASA1 RASA2 RASA3 RASA4 RASAL RASAL1 RASAL2 RASAL3 RASGAP RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SPRED1 SPRED2 SPRED3 SUG1 SUG2 SYNGAP1 TBP1 TBP7 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z	Homo sapiens (human)
Processing of SMDT1	ATP-dependent zinc metalloprotease YME1L1 Calcium uniporter protein, mitochondrial Calcium uniporter regulatory subunit MCUb, mitochondrial Calcium uptake protein 1, mitochondrial Calcium uptake protein 2, mitochondrial Calcium uptake protein 3, mitochondrial Essential MCU regulator, mitochondrial Mitochondrial inner membrane m-AAA protease component AFG3L2 Mitochondrial inner membrane m-AAA protease component paraplegin Mitochondrial-processing peptidase subunit alpha Mitochondrial-processing peptidase subunit beta Presenilin-associated rhomboid-like protein, mitochondrial Prohibitin 1 Prohibitin-2 Stomatin-like protein 2, mitochondrial m-AAA protease-interacting protein 1, mitochondrial	O75439 P35232 Q10713 Q86XE3 Q8IYU8 Q8NE86 Q8WWC4 Q96TA2 Q99623 Q9BPX6 Q9H300 Q9H4I9 Q9NWR8 Q9UJZ1 Q9UQ90 Q9Y4W6	AFG3L2 BAP C10orf42 C22orf32 C2orf47 CALC CAR CBARA1 CCDC109A CCDC109B CMAR EFHA1 EFHA2 EMRE FTSH1 INPP5E KIAA0123 MAIP1 MCU MCUB MICU1 MICU2 MICU3 MPPA MPPB PARL PGN PHB PHB1 PHB2 PMPCA PMPCB PSARL REA SLP2 SMDT1 SPG7 STOML2 YME1L YME1L1	Homo sapiens (human)
Constitutive Signaling by AKT1 E17K in Cancer	3-phosphoinositide-dependent protein kinase 1 Bcl2-associated agonist of cell death Caspase-9 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Forkhead box protein O6 Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Nuclear receptor subfamily 4immunitygroup A member 1 Proline-rich AKT1 substrate 1 Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ribosomal protein S6 kinase beta-2 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tuberin	A8MYZ6 O15111 O15530 O43524 P22736 P31749 P31751 P38936 P42345 P46527 P49815 P49840 P49841 P55211 P85299 P98177 Q00987 Q12778 Q6R327 Q92934 Q96B36 Q9BPZ7 Q9BVC4 Q9UBS0 Q9Y243	AFX AFX1 AKT1 AKT1S1 AKT2 AKT3 BAD BBC6 BCL2L8 CAP20 CASP9 CDKN1 CDKN1A CDKN1B CHUK CIP1 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 FOXO6 FRAP FRAP1 FRAP2 GBL GFRP1 GSK3A GSK3B HMR IKKA KIAA1999 KIP1 LST8 MAPKAP1 MCH6 MDA6 MDM2 MIP1 MLLT7 MLST8 MTOR NAK1 NR4A1 PDK1 PDPK1 PIC1 PKB PKBG PRAS40 PROTOR1 PRR5 RAC RAFT1 RAPT1 RICTOR RPS6KB2 SDI1 SIN1 STK14B TCF16 TSC2 TSC4 WAF1 p27	Homo sapiens (human)
AKT phosphorylates targets in the nucleus	Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Forkhead box protein O6 Nuclear receptor subfamily 4immunitygroup A member 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ribosomal protein S6 kinase beta-2	A8MYZ6 O43524 P22736 P31749 P31751 P98177 Q12778 Q9UBS0 Q9Y243	AFX AFX1 AKT1 AKT2 AKT3 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 FOXO6 GFRP1 HMR MLLT7 NAK1 NR4A1 PKB PKBG RAC RPS6KB2 STK14B	Homo sapiens (human)

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