GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1451 - 1475** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	Amino acid transporter heavy chain SLC3A2 Y+L amino acid transporter 1	P08195 Q9UM01	MDU1 SLC3A2 SLC7A7	Homo sapiens (human)
SMAC, XIAP-regulated apoptotic response	Caspase-3 Caspase-7 Diablo IAP-binding mitochondrial protein E3 ubiquitin-protein ligase XIAP	P42574 P55210 P98170 Q9NR28	API3 BIRC4 CASP3 CASP7 CPP32 DIABLO IAP3 MCH3 SMAC XIAP	Homo sapiens (human)
TP53 Regulates Metabolic Genes	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Cellular tumor antigen p53 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX18, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c DNA damage-inducible transcript 4 protein Fructose-2,6-bisphosphatase TIGAR GTP-binding protein Rheb Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Glutathione peroxidase 2 Hamartin Helicase MOV-10 Leucine-rich PPR motif-containing protein, mitochondrial Neutral amino acid transporter 9 Peroxiredoxin-1 Peroxiredoxin-2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribonucleoside-diphosphate reductase subunit M2 B Serine/threonine-protein kinase mTOR Sestrin-2 Sestrin-3 Surfeit locus protein 1 Target of rapamycin complex subunit LST8 Thioredoxin reductase 1, cytoplasmic Thioredoxin Translational activator of cytochrome c oxidase 1 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tuberin Tumor protein 63	O00483 O14548 O43504 O43741 O43819 O75880 O94925 P00395 P00403 P00414 P04637 P06744 P09669 P10176 P10599 P10606 P11413 P12074 P13073 P14854 P15954 P18283 P20674 P24311 P27348 P31749 P31751 P31946 P31947 P32119 P42345 P42704 P49815 P54619 P54646 P58004 P58005 P60484 P61981 P62258 P63104 P99999 Q04917 Q06830 Q0VGL1 Q13131 Q15382 Q15526 Q16881 Q49B96 Q5RI15 Q5VZM2 Q6IAA8 Q7L523 Q7LG56 Q8N122 Q8N8Q8 Q8NBW4 Q8NDV7 Q92574 Q96I36 Q9BSH4 Q9BVC4 Q9H3D4 Q9H9G7 Q9HB90 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NQ88 Q9NQL2 Q9NX09 Q9P0S2 Q9UGI9 Q9UGJ0 Q9UHA4 Q9UI32 Q9UKV8 Q9UL18 Q9UPQ9 Q9Y243 Q9Y2Q5 Q9Y478 Q9Y6N1	AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AKT3 AMPK AMPK1 AMPK2 AMPKG3 C11orf59 C12orf5 C12orf62 C14orf112 C7orf59 CAGH26 CCDC44 COI COII COIII COX11 COX14 COX16 COX18 COX19 COX2 COX20 COX4 COX4I1 COX5A COX5B COX6A1 COX6AL COX6B COX6B1 COX6C COX7A2L COX7AR COX7B COX7C COX7RP COX8 COX8A COX8L COXI COXII COXIII CYC CYCS DDIT4 EIF2C1 EIF2C2 EIF2C3 EIF2C4 FAM36A FRAP FRAP1 FRAP2 G6PD GA GBL GLS GLS1 GLS2 GPI GPX2 GRIM12 HBXIP HME1 Hi95 KDRF KET KIAA0243 KIAA0838 KIAA1093 KIAA1303 KIAA1460 KIAA1567 KIAA1582 KIAA1631 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LRP130 LRPPRC LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MMAC1 MOV10 MT-CO1 MT-CO2 MT-CO3 MTCO1 MTCO2 MTCO3 MTOR NDUFA4 NKEFB OXA1L2 P53 P53R2 P63 P73H P73L PAGA PAGB PDRO PKB PKBG PRDX1 PRDX2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTEN RAC RAFT1 RAPT1 RAPTOR REDD1 RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD RRM2B RTP801 SCO1 SCO2 SCOD1 SESN2 SESN3 SEST2 SEST3 SFN SLC38A9 SURF-1 SURF1 TACO1 TDPX1 TDPX2 TEP1 TIGAR TNRC6 TNRC6A TNRC6B TNRC6C TP53 TP63 TP73L TRDX TRX TRX1 TSC TSC1 TSC2 TSC4 TXN TXNRD1 URLC11 XIP YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
HATs acetylate histones	Actin, cytoplasmic 1 Actin-like protein 6A Ataxin-7-like protein 3 Ataxin-7 Bromodomain and PHD finger-containing protein 3 Bromodomain-containing protein 1 Bromodomain-containing protein 8 CREB-binding protein Chromatin modification-related protein MEAF6 Circadian locomoter output cycles protein kaput Cyclic AMP-dependent transcription factor ATF-2 Cysteine-rich protein 2-binding protein DNA methyltransferase 1-associated protein 1 E1A-binding protein p400 E3 ubiquitin-protein ligase Jade-2 E3 ubiquitin-protein ligase MSL2 Elongator complex protein 1 Elongator complex protein 2 Elongator complex protein 3 Elongator complex protein 4 Elongator complex protein 5 Elongator complex protein 6 Enhancer of polycomb homolog 1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 2-F Histone H2B type 3-B Histone H3.1 Histone H3.2 Histone H4 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase KAT5 Histone acetyltransferase KAT6A Histone acetyltransferase KAT6B Histone acetyltransferase KAT7 Histone acetyltransferase KAT8 Histone acetyltransferase p300 Histone acetyltransferase type B catalytic subunit Histone deacetylase complex subunit SAP130 Histone-binding protein RBBP7 Host cell factor 1 Inhibitor of growth protein 3 Inhibitor of growth protein 4 Inhibitor of growth protein 5 KAT8 regulatory NSL complex subunit 1 KAT8 regulatory NSL complex subunit 2 KAT8 regulatory NSL complex subunit 3 MAP3K12-binding inhibitory protein 1 MRG/MORF4L-binding protein MSL complex subunit 3 Male-specific lethal 1 homolog Microspherule protein 1 Mortality factor 4-like protein 1 Mortality factor 4-like protein 2 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 PHD finger protein 20 Paired box protein Pax-3 Peregrin Protein Dr1 Protein Jade-1 Protein Jade-3 RuvB-like 1 RuvB-like 2 SAGA-associated factor 29 STAGA complex 65 subunit gamma TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L Transcription and mRNA export factor ENY2 Transcription factor SPT20 homolog Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 9 Transcription initiation protein SPT3 homolog Transcriptional adapter 1 Transcriptional adapter 2-alpha Transcriptional adapter 2-beta Transcriptional adapter 3 Transformation/transcription domain-associated protein UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Ubiquitin carboxyl-terminal hydrolase 22 Vacuolar protein sorting-associated protein 72 homolog WD repeat-containing protein 5 YEATS domain-containing protein 2 YEATS domain-containing protein 4 ZZ-type zinc finger-containing protein 3	O14929 O15265 O15294 O15516 O60814 O75478 O75486 O75528 O75529 O94864 O95163 O95251 O95619 O95696 O96019 P04908 P06899 P0C0S8 P15336 P20671 P23527 P23760 P33778 P51610 P55201 P58876 P60709 P61964 P62805 P62807 P68431 Q01658 Q09472 Q0PNE2 Q12962 Q14CW9 Q15014 Q15596 Q15788 Q15906 Q16514 Q16576 Q16594 Q16777 Q16778 Q5QNW6 Q68DK7 Q6FI13 Q6IA86 Q6IE81 Q71DI3 Q7L7L0 Q7Z3B3 Q86TJ2 Q8IUE6 Q8IYH5 Q8N257 Q8N5Y2 Q8NEM7 Q8TE02 Q8WYB5 Q8WYH8 Q92613 Q92793 Q92794 Q92830 Q92831 Q92993 Q93077 Q93079 Q96A08 Q96BN2 Q96EB1 Q96ES7 Q96EZ8 Q96KK5 Q96L91 Q96QV6 Q99877 Q99878 Q99879 Q99880 Q9BVI0 Q9H0E3 Q9H0E9 Q9H2F5 Q9H7Z6 Q9H8E8 Q9H9L4 Q9H9T3 Q9HAF1 Q9HCI7 Q9NPA8 Q9NPF5 Q9NQC1 Q9NS73 Q9NV56 Q9NXR8 Q9P2N6 Q9UBU8 Q9ULD4 Q9ULM3 Q9UNL4 Q9UPT9 Q9Y230 Q9Y265 Q9Y4A5 Q9Y6J9	ACTB ACTL6A ADA2B ADA3 ATF2 ATP1 ATXN7 ATXN7L3 BAF53 BAF53A BHLHE74 BHLHE75 BHLHE8 BIG3 BR140 BRD1 BRD8 BRL BRPF1 BRPF2 BRPF3 C11orf19 C12orf41 C13orf19 C17orf81 C1orf149 C20orf104 C20orf20 C3orf75 CAGH32 CBP CCDC101 CENP-28 CENP-36 CLOCK CREB2 CREBBP CREBP1 CSRP2BP DERP6 DMAP1 DR1 EAF6 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 FAM48A GAS41 GCN5 GCN5L2 GLEA2 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFT H2BU1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HAT1 HBO1 HBOa HCA58 HCF1 HCFC1 HFC1 HIRIP1 HIRIP2 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2A HIST3H2BB HIST4H4 HTATIP HUP2 IKAP IKBKAP ING3 ING4 ING5 INO80H INO80J INO80K INO80Q JADE1 JADE2 JADE3 KANSL1 KANSL2 KANSL3 KAT1 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KIAA0026 KIAA0215 KIAA0239 KIAA0334 KIAA0383 KIAA0764 KIAA1063 KIAA1197 KIAA1267 KIAA1286 KIAA1310 KIAA1425 KIAA1498 KIAA1585 KIAA1807 KIAA1818 MBIP MCRS1 MEAF6 MOF MORF MORF4L1 MORF4L2 MOZ MOZ2 MRG15 MRGBP MRGX MSL1 MSL1L1 MSL1V1 MSL2 MSL2L1 MSL3 MSL3L1 MSP58 MYST1 MYST2 MYST3 MYST4 NCOA1 NCOA2 NMP238 NSL1 NSL2 NSL3 NZF OGT P300 PAF400 PAF65A PAF65B PAX3 PAXNEB PCAF PHF15 PHF16 PHF17 PHF20 PRTD RBAP46 RBBP7 RNF184 RUNXBP2 RUVBL1 RUVBL2 SAP130 SCA7 SGF29 SI1 SMAP SMAP2 SPT3 SRC1 SRC2 STATIP1 SUPT20H SUPT3H SUPT7L TADA1 TADA1L TADA2A TADA2B TADA2L TADA3 TADA3L TAF10 TAF12 TAF15 TAF2A TAF2G TAF2H TAF2J TAF5L TAF6L TAF9 TAFII20 TAFII30 TAFII31 TCFL1 TIF2 TIP48 TIP49 TIP49A TIP49B TIP60 TMEM103 TNRC12 TRRAP TSH2B TZP USP22 USP3L VPS72 WDR5 YEATS2 YEATS4 YL1 ZNF220 ZZZ3	Homo sapiens (human)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Peptidyl-prolyl cis-trans isomerase D Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP5 Prostaglandin E synthase 3 Serine/threonine-protein phosphatase 5	P03372 P07900 P08238 P27361 P28482 P53041 Q02790 Q08752 Q13451 Q15185 Q92731	AIG6 CYP40 CYPD ERK1 ERK2 ESR ESR1 ESR2 ESTRB FKBP4 FKBP5 FKBP51 FKBP52 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB MAPK1 MAPK3 NR3A1 NR3A2 P23 PPID PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTGES3 TEBP	Homo sapiens (human)
Abortive elongation of HIV-1 transcript in the absence of Tat	DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 RNA polymerase II subunit A C-terminal domain phosphatase Transcription elongation factor SPT4 Transcription elongation factor SPT5	O00267 O15514 P13984 P18615 P19387 P19388 P24928 P30876 P35269 P36954 P52298 P52434 P52435 P53803 P61218 P62487 P62875 P63272 Q09161 Q8IXH7 Q8WX92 Q9H3P2 Q9Y5B0	CBP20 CBP80 COBRA1 CTDP1 FCP1 GTF2F1 GTF2F2 KIAA1182 NCBP NCBP1 NCBP2 NELFA NELFB NELFCD NELFD NELFE POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RD RDBP RPB7 SPT4H SPT5 SPT5H SUPT4H SUPT4H1 SUPT5H TH1 TH1L WHSC2	Homo sapiens (human)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	Acetylcholine receptor subunit delta Acetylcholine receptor subunit epsilon Acetylcholine receptor subunit gamma Neuronal acetylcholine receptor subunit alpha-3 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-4	P07510 P17787 P30926 P32297 P43681 Q04844 Q07001	ACHRD ACHRE ACHRG CHRNA3 CHRNA4 CHRNB2 CHRNB4 CHRND CHRNE CHRNG NACHRA3 NACRA4	Homo sapiens (human)
MGMT-mediated DNA damage reversal	Methylated-DNA--protein-cysteine methyltransferase	P16455	MGMT	Homo sapiens (human)
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin Focal adhesion kinase 1 Integrin alpha-IIb Integrin beta-3 Proto-oncogene tyrosine-protein kinase Src RAC-alpha serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Ras-related protein Rap-1A Ras-related protein Rap-1b SHC-transforming protein 1 Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 1 von Willebrand factor	O15530 O95267 O95398 P02671 P02675 P02679 P02751 P04275 P05106 P08514 P12931 P18031 P29353 P31749 P41240 P43405 P61224 P62834 Q05397 Q7LDG7 Q7Z5R6 Q8WZA2 Q9Y490	AKT1 APBB1IP CDC25L CGEF1 CGEF2 CSK EPAC EPAC1 EPAC2 F8VWF FAK FAK1 FGA FGB FGG FN FN1 GP2B GP3A ITGA2B ITGAB ITGB3 KIAA1027 KREV1 MCG7 PDK1 PDPK1 PKB PREL1 PTK2 PTP1B PTPN1 RAC RAP1A RAP1B RAPGEF3 RAPGEF4 RARP1 RASGRP RASGRP1 RASGRP2 RIAM SHC SHC1 SHCA SRC SRC1 SYK TLN TLN1 VWF	Homo sapiens (human)
MTOR signalling	14-3-3 protein beta/alpha GTP-binding protein Rheb Neutral amino acid transporter 9 Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O43504 P31749 P31946 P42345 Q0VGL1 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1 AKT1S1 C11orf59 C7orf59 FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PKB PRAS40 RAC RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 URLC11 XIP YWHAB	Homo sapiens (human)
Signaling by CSF3 (G-CSF)	GRB2-associated-binding protein 2 GTPase KRas Granulocyte colony-stimulating factor receptor Granulocyte colony-stimulating factor Growth factor receptor-bound protein 2 Non-receptor tyrosine-protein kinase TYK2 SHC-transforming protein 1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase HCK Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 11	O14543 O15524 O60674 P01116 P07948 P08631 P09919 P23458 P29353 P29597 P40763 P42224 P42229 P43405 P51692 P62993 Q06124 Q99062 Q9UQC2	APRF ASH C17orf33 CIS3 CSF3 CSF3R GAB2 GCSF GCSFR GRB2 HCK JAK1 JAK1A JAK1B JAK2 JTK8 KIAA0571 KRAS KRAS2 LYN PTP2C PTPN11 RASK2 SHC SHC1 SHCA SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B SYK TIP3 TYK2	Homo sapiens (human)
NOTCH4 Intracellular Domain Regulates Transcription	Actin, aortic smooth muscle CREB-binding protein Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Mothers against decapentaplegic homolog 3 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 4 Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Transcription factor HES-1 Transcription factor HES-5 Vascular endothelial growth factor receptor 3	P35916 P46531 P62736 P84022 Q04721 Q06330 Q09472 Q13495 Q13573 Q14469 Q5TA89 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q99466 Q9UBP5 Q9Y5J3	ACTA2 ACTSA ACTVS BHLHB31 BHLHB32 BHLHB38 BHLHB39 CBP CG1 CHF1 CHF2 CREBBP CXorf6 EP300 FLT4 GCN5 GCN5L2 GRL HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HL HRT1 HRT2 HRY IGKJRB IGKJRB1 INT3 KAT2A KAT2B KIAA0200 KIAA1816 KIAA1819 MADH3 MAML1 MAML2 MAML3 MAMLD1 NOTCH1 NOTCH2 NOTCH4 P300 PCAF RBPJ RBPJK RBPSUH SKIIP SKIP SMAD3 SNW1 TAN1 VEGFR3	Homo sapiens (human)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIE subunit 1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 TATA-binding protein-associated factor 2N TATA-box-binding protein Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B	O00268 O15514 P13984 P18074 P19387 P19388 P19447 P20226 P21675 P24928 P29083 P29084 P30876 P32780 P35269 P36954 P49848 P50613 P51946 P51948 P52434 P52435 P52655 P52657 P53803 P61218 P62487 P62875 Q00403 Q12962 Q13888 Q13889 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q5H9L4 Q5VWG9 Q6P1X5 Q6ZYL4 Q8IZX4 Q92750 Q92759 Q92804 Q9HBM6	BA2R BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CCG1 CCGS CCNH CDK7 CDKN7 CIF150 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2D1 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MAT1 MNAT1 MO15 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RBP56 RNF66 RPB7 STK1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TBP TF2A1 TF2A2 TF2B TF2D TF2E1 TF2E2 TFIIB TFIID TTDA XPB XPBC XPD XPDC	Homo sapiens (human)
Vasopressin regulates renal water homeostasis via Aquaporins	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Rab11 family-interacting protein 2 Ras-related protein Rab-11A Unconventional myosin-Vb Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O14610 O14775 O43306 O60262 O60266 O60503 O95622 P01185 P10644 P13861 P16520 P17612 P22612 P22694 P29972 P30518 P31321 P31323 P40145 P41181 P50150 P50151 P51828 P55087 P59768 P61952 P62491 P62873 P62879 P63092 P63211 P63215 P63218 Q08462 Q08828 Q5JWF2 Q7L804 Q8NFM4 Q92482 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08 Q9ULV0	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADHR AQP1 AQP2 AQP3 AQP4 ARVP AVP AVPR2 CHIP28 DIR DIR3 GNAS GNAS1 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GSP KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA0941 KIAA1060 KIAA1119 MYO5B PKACA PKR1 PKR2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B RAB11 RAB11A RAB11FIP2 TSE1 V2R VP	Homo sapiens (human)
Defective VWF cleavage by ADAMTS13 variant	A disintegrin and metalloproteinase with thrombospondin motifs 13 von Willebrand factor	P04275 Q76LX8	ADAMTS13 C9orf8 F8VWF VWF	Homo sapiens (human)
Defective pro-SFTPB causes SMDP1 and RDS	Pulmonary surfactant-associated protein B	P07988	SFTP3 SFTPB	Homo sapiens (human)
Maturation of protein 3a	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 Beta-galactoside alpha-2,6-sialyltransferase 1 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 ORF3a protein Polypeptide N-acetylgalactosaminyltransferase 1	P15907 P59632 Q10472 Q11201 Q11203 Q11206 Q16842 Q8NDV1 Q9H4F1 Q9UJ37	3a CGS23 GALNT1 NANTA3 SIAT1 SIAT3C SIAT4 SIAT4A SIAT4B SIAT4C SIAT6 SIAT7B SIAT7C SIAT7D SIATL1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 STHM STZ	Homo sapiens (human)
Synthesis of PS	Phosphatidylserine synthase 1 Phosphatidylserine synthase 2	P48651 Q9BVG9	KIAA0024 PSS2 PSSA PTDSS1 PTDSS2	Homo sapiens (human)
Synthesis of PIPs at the ER membrane	Myotubularin-related protein 2 Myotubularin-related protein 5 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol-3-phosphatase SAC1	O95248 P42356 Q13614 Q8TCG2 Q9NTJ5	KIAA0851 KIAA1073 MTMR2 MTMR5 PI4K2B PI4KA PIK4 PIK4CA SAC1 SACM1L SBF1	Homo sapiens (human)
NS1 Mediated Effects on Host Pathways	Aladin E3 SUMO-protein ligase RanBP2 Importin subunit alpha-1 Importin subunit alpha-3 Importin subunit alpha-4 Importin subunit alpha-5 Importin subunit alpha-6 Importin subunit alpha-8 Importin subunit beta-1 Non-structural protein 1 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Protein SEC13 homolog Ubiquitin-like protein ISG15 mRNA export factor RAE1	A8CG34 A9QM74 O00505 O00629 O15131 O15504 O75694 P03496 P05161 P12270 P35658 P37198 P49790 P49792 P52292 P52294 P55735 P57740 P78406 Q12769 Q14974 Q5SRE5 Q7Z3B4 Q8N1F7 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q96HA1 Q99567 Q9BTX1 Q9BW27 Q9NRG9 Q9UKX7	AAAS ADRACALA C7orf14 CAIN CAN CG1 D3S1231E G1P2 ISG15 KIAA0023 KIAA0095 KIAA0169 KIAA0197 KIAA0225 KIAA0618 KIAA0791 KIAA0906 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA7 KPNB1 MP44 MRNP41 NDC1 NPAP60L NS NTF97 NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 PCNT1 POM121 POM121A POM121C QIP1 QIP2 RAE1 RANBP2 RCH1 RCH2 SEC13 SEC13A SEC13L1 SEC13R SRP1 TMEM48 TPR UCRP	Homo sapiens (human)
FGFR3c ligand binding and activation	Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 Polypeptide N-acetylgalactosaminyltransferase 3	O43320 O76093 P05230 P08620 P09038 P31371 Q14435 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB GALNT3 HST HSTF1 HYPF KS3	Homo sapiens (human)
RA biosynthesis pathway	2-aminomuconic semialdehyde dehydrogenase Alcohol dehydrogenase 1A Alcohol dehydrogenase 1C Aldehyde dehydrogenase 1A1 Aldo-keto reductase family 1 member C3 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Cellular retinoic acid-binding protein 1 Cytochrome P450 26A1 Cytochrome P450 26B1 Cytochrome P450 26C1 Dehydrogenase/reductase SDR family member 4 Dehydrogenase/reductase SDR family member 9 Epidermal retinol dehydrogenase 2 Retinal dehydrogenase 2 Retinaldehyde dehydrogenase 3 Retinol dehydrogenase 10 Retinol dehydrogenase 11 Retinol dehydrogenase 13 Retinol dehydrogenase 14 Retinol dehydrogenase 16 Retinol dehydrogenase 5 Short-chain dehydrogenase/reductase 3	O43174 O75452 O75911 O94788 P00326 P00352 P07327 P08319 P29762 P42330 P47895 Q6V0L0 Q8IZV5 Q8N3Y7 Q8NBN7 Q8TC12 Q92781 Q9BPW9 Q9BTZ2 Q9H2A2 Q9HBH5 Q9NR63	ADH1 ADH1A ADH1C ADH2 ADH3 ADH4 AKR1C3 ALDC ALDH1 ALDH12 ALDH1A1 ALDH1A2 ALDH1A3 ALDH6 ALDH8A1 ARSDR1 CRABP1 CYP26 CYP26A1 CYP26A2 CYP26B1 CYP26C1 DDH1 DHRS3 DHRS4 DHRS9 HSD17B5 HSD17B9 KIAA0119 P450RAI1 P450RAI2 PAN2 PGFS PSDR1 PUMB1 RALDH2 RBP5 RDH1 RDH10 RDH11 RDH13 RDH14 RDH15 RDH16 RDH17 RDH5 RDHE2 RODH4 SDR16C1 SDR16C4 SDR16C5 SDR25C2 SDR7C1 SDR7C3 SDR7C4 SDR9C4 SDR9C5 SDR9C8	Homo sapiens (human)
Regulation of BACH1 activity	Cullin-1 E3 ubiquitin-protein ligase RBX1 F-box/LRR-repeat protein 17 Polyubiquitin-B Polyubiquitin-C S-phase kinase-associated protein 1 S-phase kinase-associated protein 2 Transcription factor MafK Transcription regulator protein BACH1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14867 O60675 P0CG47 P0CG48 P62877 P62979 P62987 P63208 Q13309 Q13616 Q9UF56	BACH1 CUL1 EMC19 FBL17 FBX13 FBXL1 FBXL17 FBXO13 MAFK OCP2 RBX1 RNF75 ROC1 RPS27A SKP1 SKP1A SKP2 TCEB1L UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Zinc efflux and compartmentalization by the SLC30 family	Probable proton-coupled zinc antiporter SLC30A3 Proton-coupled zinc antiporter SLC30A1 Proton-coupled zinc antiporter SLC30A2 Proton-coupled zinc antiporter SLC30A5 Proton-coupled zinc antiporter SLC30A8	Q8IWU4 Q8TAD4 Q99726 Q9BRI3 Q9Y6M5	SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A8 ZNT1 ZNT2 ZNT3 ZNT5 ZNT8 ZNTL1 ZTL1	Homo sapiens (human)
TLR3-mediated TICAM1-dependent programmed cell death	Caspase-8 FAS-associated death domain protein Receptor-interacting serine/threonine-protein kinase 1 Receptor-interacting serine/threonine-protein kinase 3 TIR domain-containing adapter molecule 1 Toll-like receptor 3	O15455 Q13158 Q13546 Q14790 Q8IUC6 Q9Y572	CASP8 FADD MCH5 MORT1 PRVTIRB RIP RIP1 RIP3 RIPK1 RIPK3 TICAM1 TLR3 TRIF	Homo sapiens (human)

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