C6 deamination of adenosine
|
|
|
- ADAR
- ADAR1
- ADAR2
- ADARB1
- DRADA2
- DSRAD
- G1P1
- IFI4
- RED1
|
Homo sapiens (human)
|
|
Thyroxine biosynthesis
|
|
|
- C6orf71
- CGA
- DEHAL1
- DUOX
- DUOX1
- DUOX2
- IYD
- LNOX1
- LNOX2
- NIS
- SLC5A5
- THOX1
- THOX2
- TPO
- TSHB
|
Homo sapiens (human)
|
|
Negative feedback regulation of MAPK pathway
|
|
|
- BRAF
- BRAF1
- ERK1
- ERK2
- MAP2K1
- MAP2K2
- MAPK1
- MAPK3
- MEK1
- MEK2
- MKK2
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
- RAF
- RAF1
- RAFB1
|
Homo sapiens (human)
|
|
Signaling by MAP2K mutants
|
|
|
- ERK1
- ERK2
- MAP2K1
- MAP2K2
- MAPK1
- MAPK3
- MEK1
- MEK2
- MKK2
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
|
Homo sapiens (human)
|
|
MAPK1 (ERK2) activation
|
|
|
- ERK2
- IFNB2
- IL6
- IL6R
- JAK1
- JAK1A
- JAK1B
- JAK2
- MAP2K2
- MAPK1
- MEK2
- MKK2
- PRKM1
- PRKM2
- PRKMK2
- PTP2C
- PTPN11
- SHPTP2
- TYK2
|
Homo sapiens (human)
|
|
activated TAK1 mediates p38 MAPK activation
|
|
|
- BLU
- CARD15
- CARD4
- CARDIAK
- CROC1
- CSBP
- CSBP1
- CSBP2
- CSPB1
- FIP3
- IKBKG
- IRAK
- IRAK1
- IRAK2
- KIAA0733
- MAP2K3
- MAP2K6
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MAPK11
- MAPK14
- MAPKAPK2
- MAPKAPK3
- MEK3
- MEK6
- MKK3
- MKK6
- MXI2
- NEMO
- NOD1
- NOD2
- PRKM11
- PRKMK3
- PRKMK6
- RICK
- RIP2
- RIPK2
- RNF85
- SAPK2
- SAPK2A
- SAPK2B
- SKK2
- SKK3
- TAB1
- TAB2
- TAB3
- TAK1
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
Homo sapiens (human)
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
|
|
- BLU
- CARD15
- CARD4
- CARDIAK
- CROC1
- FIP3
- IKBKG
- IRAK
- IRAK1
- IRAK2
- JNK1
- JNK2
- JNK3
- JNK3A
- JNKK1
- JNKK2
- KIAA0733
- MAP2K4
- MAP2K7
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MAPK10
- MAPK8
- MAPK9
- MEK4
- MEK7
- MKK4
- MKK7
- NEMO
- NOD1
- NOD2
- PRKM10
- PRKM8
- PRKM9
- PRKMK4
- PRKMK7
- RICK
- RIP2
- RIPK2
- RNF85
- SAPK1
- SAPK1A
- SAPK1B
- SAPK1C
- SEK1
- SERK1
- SKK1
- SKK4
- TAB1
- TAB2
- TAB3
- TAK1
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
Homo sapiens (human)
|
|
Signalling to ERK5
|
|
|
- BMK1
- ERK5
- MAP2K5
- MAPK7
- MEK5
- MKK5
- PRKM7
- PRKMK5
|
Homo sapiens (human)
|
|
Signaling by MAPK mutants
|
|
|
- C11orf81
- DUSP10
- DUSP16
- DUSP6
- DUSP7
- DUSP8
- DUSP9
- ERK2
- KIAA1700
- MAPK1
- MKP3
- MKP4
- MKP5
- MKP7
- PRKM1
- PRKM2
- PYST1
- PYST2
- VH5
|
Homo sapiens (human)
|
|
Suppression of autophagy
|
|
|
- DUSP16
- KIAA1700
- MKP7
- RAB7
- RAB7A
- eis
- sapM
|
Homo sapiens (human)
|
|
ERKs are inactivated
|
|
|
- BMK1
- DUSP3
- DUSP4
- DUSP6
- DUSP7
- ERK1
- ERK2
- ERK5
- MAPK1
- MAPK3
- MAPK7
- MKP2
- MKP3
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5D
- PRKM1
- PRKM2
- PRKM3
- PRKM7
- PYST1
- PYST2
- VH2
- VHR
- VRK3
|
Homo sapiens (human)
|
|
Regulation of Apoptosis
|
|
|
|
Homo sapiens (human)
|
|
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
|
|
|
|
Homo sapiens (human)
|
|
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
|
|
|
|
Homo sapiens (human)
|
|
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
|
|
|
|
Homo sapiens (human)
|
|
Regulation of IFNG signaling
|
|
|
- CIS3
- DDXBP1
- HCP
- IFNG
- IFNGR1
- IFNGR2
- IFNGT1
- JAK1
- JAK1A
- JAK1B
- JAK2
- PIAS1
- PTP1B
- PTP1C
- PTP2C
- PTPN1
- PTPN11
- PTPN6
- SHPTP2
- SMT3C
- SMT3H3
- SOCS1
- SOCS3
- SSI1
- SSI3
- SUMO1
- TIP3
- UBL1
|
Homo sapiens (human)
|
|
SUMOylation of immune response proteins
|
|
|
- EIF2AK2
- FIP3
- IKBA
- IKBKE
- IKBKG
- IKKE
- IKKI
- KIAA0151
- LUN
- LYT10
- MAD3
- NEMO
- NFKB2
- NFKB3
- NFKBI
- NFKBIA
- PIAS3
- PIAS4
- PIASG
- PKR
- PRKR
- RELA
- SMT3A
- SMT3C
- SMT3H1
- SMT3H3
- SUMO1
- SUMO3
- TOPORS
- TP53BPL
- UBC9
- UBCE9
- UBE2I
- UBL1
|
Homo sapiens (human)
|
|
Downregulation of SMAD2/3:SMAD4 transcriptional activity
|
|
|
- ADPRT
- ATP1B4
- CTG26
- DFFRX
- DPC4
- ERK1
- ERK2
- FAM
- HDAC1
- KIAA0439
- KIAA1047
- KIAA1113
- MADH2
- MADH3
- MADH4
- MADH7
- MADH8
- MADR2
- MAPK1
- MAPK3
- NCOR1
- NCOR2
- NEDD4L
- NEDL3
- PARP1
- PPM1A
- PPOL
- PPPM1A
- PRKM1
- PRKM2
- PRKM3
- RFG7
- RNF111
- RPD3L1
- RPS27A
- SFT
- SKI
- SKIIP
- SKIL
- SKIP
- SMAD2
- SMAD3
- SMAD4
- SMAD7
- SMURF2
- SNO
- SNW1
- TAZ
- TGIF
- TGIF1
- TGIF2
- TIF1G
- TRIM33
- UBA52
- UBA80
- UBB
- UBC
- UBC5A
- UBC5C
- UBCEP1
- UBCEP2
- UBCH5
- UBCH5A
- UBCH5C
- UBE2D1
- UBE2D3
- USP9
- USP9X
- WWTR1
|
Homo sapiens (human)
|
|
Negative regulation of MET activity
|
|
|
- AF1P
- CBL
- CBL2
- CIN85
- CNSA1
- CNSA2
- CNSA3
- DEP1
- EPS15
- HBP
- HGF
- HGS
- HPTA
- HRS
- KIAA0055
- LIG1
- LRIG1
- MET
- PTP1B
- PTPN1
- PTPN2
- PTPRJ
- PTPT
- RNF55
- RPS27A
- SH3D2A
- SH3D2B
- SH3D2C
- SH3GL1
- SH3GL2
- SH3GL3
- SH3KBP1
- STAM
- STAM1
- STAM2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBPY
- USP8
|
Homo sapiens (human)
|
|
InlB-mediated entry of Listeria monocytogenes into host cell
|
|
|
- AF1P
- CBL
- CBL2
- CIN85
- CNSA1
- CNSA2
- CNSA3
- EPS15
- HBP
- HGS
- HRS
- MET
- RNF55
- RPS27A
- SH3D2A
- SH3D2B
- SH3D2C
- SH3GL1
- SH3GL2
- SH3GL3
- SH3KBP1
- STAM
- STAM1
- STAM2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- inlB
|
Homo sapiens (human)
|
|
Negative regulation of FGFR2 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
Negative regulation of FGFR3 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HSTF1
- HYPF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
Negative regulation of FLT3
|
|
|
- ABL2
- ABLL
- ARG
- C20orf156
- CBL
- CBL2
- CD135
- CIS2
- CIS4
- CSK
- DEP1
- FLK2
- FLT3
- FLT3LG
- LNK
- PTPRJ
- RNF55
- RPS27A
- SH2B3
- SLA
- SLA2
- SLAP
- SLAP1
- SLAP2
- SOCS2
- SOCS4
- SOCS6
- SSI2
- STATI2
- STK1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
FLT3 signaling by CBL mutants
|
|
|
- CBL
- CBL2
- CD135
- FLK2
- FLT3
- FLT3LG
- RNF55
- RPS27A
- STK1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
TGF-beta receptor signaling activates SMADs
|
|
|
- ALK5
- C14orf141
- CBL
- CBL2
- DPC4
- FKBP1
- FKBP12
- FKBP1A
- FNRB
- FUR
- FURIN
- GP3A
- ITGA8
- ITGAV
- ITGB1
- ITGB3
- ITGB5
- ITGB6
- ITGB8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MADH2
- MADH3
- MADH4
- MADR2
- MDF2
- MSK12
- MSK8
- NEDD8
- PACE
- PCSK3
- RNF55
- SKR4
- SMAD2
- SMAD3
- SMAD4
- TGFB
- TGFB1
- TGFB2
- TGFB3
- TGFBR1
- TGFBR2
- TGFBR3
- UBC12
- UBE2M
- VNRA
- VTNR
|
Homo sapiens (human)
|
|