GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1476 - 1500** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Beta-oxidation of very long chain fatty acids	3-ketoacyl-CoA thiolase, peroxisomal ATP-binding cassette sub-family D member 1 Acyl-coenzyme A thioesterase 6 Acyl-coenzyme A thioesterase 8 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] Peroxisomal bifunctional enzyme Peroxisomal multifunctional enzyme type 2 Peroxisomal succinyl-coenzyme A thioesterase	O14734 P09110 P33897 P51659 Q08426 Q3I5F7 Q8N9L9 Q9NUI1	ABCD1 ACAA ACAA1 ACOT4 ACOT6 ACOT8 ACTEIII ALD C14orf42 DECR2 ECHD EDH17B4 EHHADH HSD17B4 PDCR PTE1 PTE2B PTEIB PTHIO SDR17C1 SDR8C1	Homo sapiens (human)
alpha-linolenic acid (ALA) metabolism	3-ketoacyl-CoA thiolase, peroxisomal ATP-binding cassette sub-family D member 1 Acyl-CoA (8-3)-desaturase Acyl-CoA 6-desaturase Acyl-coenzyme A thioesterase 8 Long-chain-fatty-acid--CoA ligase 1 Peroxisomal multifunctional enzyme type 2 Sterol carrier protein 2 Very long chain fatty acid elongase 1 Very long chain fatty acid elongase 2 Very long chain fatty acid elongase 3 Very long chain fatty acid elongase 5	O14734 O60427 O95864 P09110 P22307 P33121 P33897 P51659 Q9BW60 Q9HB03 Q9NXB9 Q9NYP7	ABCD1 ACAA ACAA1 ACOT8 ACSL1 ACTEIII ALD CIG30 EDH17B4 ELG3 ELOVL1 ELOVL2 ELOVL3 ELOVL5 FACL1 FACL2 FADS1 FADS2 FADSD5 HSD17B4 LACS LACS1 LACS2 PTE1 PTHIO SCP2 SDR8C1 SSC1 SSC2	Homo sapiens (human)
Beta-oxidation of pristanoyl-CoA	Acyl-coenzyme A oxidase-like protein Acyl-coenzyme A thioesterase 8 Alpha-methylacyl-CoA racemase Carnitine O-acetyltransferase Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal acyl-coenzyme A oxidase 3 Peroxisomal carnitine O-octanoyltransferase Peroxisomal multifunctional enzyme type 2	O14734 O15254 P43155 P51659 Q99424 Q9NUZ1 Q9UHK6 Q9UKG9	ACOT8 ACOX2 ACOX3 ACOXL ACTEIII AMACR BRCOX CAT1 COT CRAT CROT EDH17B4 HSD17B4 PRCOX PTE1 SDR8C1	Homo sapiens (human)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Acyl-coenzyme A thioesterase 8 Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Alpha-methylacyl-CoA racemase Bile acid receptor Bile acid-CoA Bile salt export pump Cytochrome P450 7A1 Cytochrome P450 7B1 Long-chain fatty acid transport protein 2 Long-chain fatty acid transport protein 5 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal multifunctional enzyme type 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O14734 O14975 O75881 O95342 P17516 P19793 P22680 P42330 P51659 P51857 P52895 Q02318 Q04828 Q14032 Q15596 Q15788 Q16647 Q96RI1 Q99424 Q9H2F3 Q9UHK6 Q9UNU6 Q9Y2P5	ABCB11 ACOT8 ACOX2 ACSB ACSVL1 ACSVL6 ACTEIII AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR BAAT BAR BHLHE74 BHLHE75 BSEP CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 EDH17B4 FACVL1 FACVL3 FATP2 FATP5 FXR HRR1 HSD17B4 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTE1 PTGIS RIP14 RXRA SDR8C1 SLC27A2 SLC27A5 SRC1 SRC2 SRD5B1 TIF2 VLACS	Homo sapiens (human)
Uptake and function of anthrax toxins	Calmodulin-1 Calmodulin-sensitive adenylate cyclase Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 Furin Lethal factor Programmed cell death 6-interacting protein Protective antigen	O14733 P09958 P0DP23 P13423 P15917 P36507 P40136 P45985 Q02750 Q8WUM4	AIP1 ALIX CALM CALM1 CAM CAM1 FUR FURIN JNKK1 JNKK2 KIAA1375 MAP2K1 MAP2K2 MAP2K4 MAP2K7 MEK1 MEK2 MEK4 MEK7 MKK2 MKK4 MKK7 PACE PCSK3 PDCD6IP PRKMK1 PRKMK2 PRKMK4 PRKMK7 SEK1 SERK1 SKK1 SKK4 cya lef pag pagA	Homo sapiens (human)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14733 O43187 O43318 O43353 P45983 P45984 P45985 P51617 P53779 P61088 Q13404 Q15750 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 FIP3 IKBKG IRAK IRAK1 IRAK2 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 KIAA0733 MAP2K4 MAP2K7 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK10 MAPK8 MAPK9 MEK4 MEK7 MKK4 MKK7 NEMO NOD1 NOD2 PRKM10 PRKM8 PRKM9 PRKMK4 PRKMK7 RICK RIP2 RIPK2 RNF85 SAPK1 SAPK1A SAPK1B SAPK1C SEK1 SERK1 SKK1 SKK4 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Synthesis of IP2, IP, and Ins in the cytosol	Inositol monophosphatase 1 Inositol monophosphatase 2 Inositol oxygenase Inositol polyphosphate 1-phosphatase Inositol polyphosphate 4-phosphatase type II Inositol polyphosphate 5-phosphatase OCRL Inositol polyphosphate-4-phosphatase type I A Inositol polyphosphate-5-phosphatase A Inositol-3-phosphate synthase 1 Myotubularin-related protein 7 Myotubularin-related protein 9 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Synaptojanin-1 Type II inositol 1,4,5-trisphosphate 5-phosphatase	O14732 O15327 O43426 P29218 P32019 P49441 Q01968 Q14642 Q15735 Q96PE3 Q96QG7 Q9NPH2 Q9UGB7 Q9Y216	5PTASE ALDRL6 C8orf9 IMP.18P IMPA IMPA1 IMPA2 INO1 INPP1 INPP4A INPP4B INPP5A INPP5B INPP5J ISYNA1 KIAA0910 KSP32 MIOX MTMR7 MTMR8 MTMR9 OCRL OCRL1 OCRL2 PIB5PA PIPP RSOR SYNJ1	Homo sapiens (human)
Formation of apoptosome	Apoptotic protease-activating factor 1 Caspase recruitment domain-containing protein 8 Caspase-9 Cell death regulator Aven Cytochrome c Methylthioribulose-1-phosphate dehydratase	O14727 P55211 P99999 Q96GX9 Q9NQS1 Q9Y2G2	APAF1 APIP AVEN CARD8 CASP9 CYC CYCS DACAR KIAA0413 KIAA0955 MCH6 NDPP1	Homo sapiens (human)
Activation of caspases through apoptosome-mediated cleavage	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS IAP3 KIAA0413 MCH3 MCH6 XIAP	Homo sapiens (human)
SMAC (DIABLO) binds to IAPs	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c Diablo IAP-binding mitochondrial protein E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999 Q9NR28	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS DIABLO IAP3 KIAA0413 MCH3 MCH6 SMAC XIAP	Homo sapiens (human)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c Diablo IAP-binding mitochondrial protein E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999 Q9NR28	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS DIABLO IAP3 KIAA0413 MCH3 MCH6 SMAC XIAP	Homo sapiens (human)
Regulation of the apoptosome activity	Apoptotic protease-activating factor 1 Caspase recruitment domain-containing protein 8 Caspase-9 Cell death regulator Aven Cytochrome c Diablo IAP-binding mitochondrial protein E3 ubiquitin-protein ligase XIAP Methylthioribulose-1-phosphate dehydratase Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Uveal autoantigen with coiled-coil domains and ankyrin repeats	O14727 P27361 P28482 P55211 P98170 P99999 Q96GX9 Q9BZF9 Q9NQS1 Q9NR28 Q9Y2G2	APAF1 API3 APIP AVEN BIRC4 CARD8 CASP9 CYC CYCS DACAR DIABLO ERK1 ERK2 IAP3 KIAA0413 KIAA0955 KIAA1561 MAPK1 MAPK3 MCH6 NDPP1 PRKM1 PRKM2 PRKM3 SMAC UACA XIAP	Homo sapiens (human)
TP53 Regulates Transcription of Caspase Activators and Caspases	Apoptotic protease-activating factor 1 Caspase-10 Caspase-1 Caspase-2 Caspase-6 Cellular tumor antigen p53 Death domain-containing protein CRADD NLR family CARD domain-containing protein 4 Serine-protein kinase ATM Tumor protein 63 Tumor protein p73 p53-induced death domain-containing protein 1	O14727 O15350 P04637 P29466 P42575 P55212 P78560 Q13315 Q92851 Q9H3D4 Q9HB75 Q9NPP4	APAF1 ATM CARD12 CASP1 CASP10 CASP2 CASP6 CLAN CLAN1 CRADD ICH1 IL1BC IL1BCE IPAF KET KIAA0413 LRDD MCH2 MCH4 NEDD2 NLRC4 P53 P63 P73 P73H P73L PIDD PIDD1 RAIDD TP53 TP63 TP73 TP73L	Homo sapiens (human)
Opsins	Long-wave-sensitive opsin 1 Medium-wave-sensitive opsin 1 Melanopsin Opsin-3 Opsin-5 RPE-retinal G protein-coupled receptor Rhodopsin Short-wave-sensitive opsin 1 Visual pigment-like receptor peropsin	O14718 P03999 P04000 P04001 P08100 P47804 Q6U736 Q9H1Y3 Q9UHM6	BCP ECPN GCP GPR136 MOP OPN1LW OPN1MW OPN1SW OPN2 OPN3 OPN4 OPN5 PGR12 RCP RGR RHO RRH TMEM13	Homo sapiens (human)
tRNA modification in the nucleus and cytosol	Alkylated DNA repair protein alkB homolog 8 Bifunctional glutamate/proline--tRNA ligase Cytoplasmic tRNA 2-thiolation protein 1 Cytoplasmic tRNA 2-thiolation protein 2 EKC/KEOPS complex subunit LAGE3 EKC/KEOPS complex subunit TP53RK EKC/KEOPS complex subunit TPRKB Multifunctional methyltransferase subunit TRM112-like protein Probable inactive tRNA-specific adenosine deaminase-like protein 3 Probable tRNA (uracil-O(2)-)-methyltransferase Probable tRNA methyltransferase 9B Probable tRNA(His) guanylyltransferase Pseudouridylate synthase 7 homolog Queuine tRNA-ribosyltransferase accessory subunit 2 Queuine tRNA-ribosyltransferase catalytic subunit 1 RNA cytosine C(5)-methyltransferase NSUN2 Threonylcarbamoyladenosine tRNA methylthiotransferase Ubiquitin-related modifier 1 tRNA (32-2'-O)-methyltransferase regulator THADA tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase tRNA (cytosine(38)-C(5))-methyltransferase tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 tRNA (guanine(10)-N2)-methyltransferase homolog tRNA (guanine(26)-N(2))-dimethyltransferase tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 tRNA (guanine-N(7)-)-methyltransferase tRNA N6-adenosine threonylcarbamoyltransferase tRNA dimethylallyltransferase tRNA methyltransferase 10 homolog A tRNA pseudouridine(38/39) synthase tRNA-dihydrouridine(20) synthase [NAD(P)+]-like tRNA-specific adenosine deaminase 1 tRNA-specific adenosine deaminase 2 tRNA	O14717 P07814 P57081 Q08J23 Q14657 Q2VPK5 Q5VV42 Q6YHU6 Q7Z4G4 Q7Z6V5 Q7Z7A3 Q8IYL2 Q8TBZ6 Q8TEA1 Q96BT7 Q96EY9 Q96FX7 Q96PZ0 Q96S44 Q9BTM9 Q9BUB4 Q9BXR0 Q9BZE2 Q9H3H1 Q9H974 Q9NPF4 Q9NUP7 Q9NWX6 Q9NX74 Q9NXH9 Q9P272 Q9UBP6 Q9UET6 Q9UI30 Q9UJA5 Q9Y3C4	ABH8 ADAT1 ADAT2 ADAT3 ALKBH8 ATPBD3 C12orf1 C14orf172 C16orf84 C20orf64 C4orf23 C6orf75 C8orf79 C9orf74 CCDC76 CDKAL1 CTU1 CTU2 DEADC1 DNMT2 DUS2 DUS2L DXS9879E EPRS EPRS1 ESO3 FTSJ1 GCPL1 GITA GLNS ICF45 IPT ITBA2 KIAA1153 KIAA1456 KIAA1767 KIAA1897 LAGE3 METTL1 METTL19 MOD5 NCS2 NCS6 NOPD1 NSUN2 NSUN6 OSGEP PARS PRPK PUS3 PUS7 QARS QPRS QTRT1 QTRT2 QTRTD1 RG9MTD2 SAKI TAD3 TGT TGUT THADA THG1L TP53RK TPRKB TRDMT1 TRIT1 TRM4 TRM6 TRM61 TRM9L TRMT1 TRMT10A TRMT11 TRMT112 TRMT13 TRMT44 TRMT6 TRMT61A TRMT9B URM1 WDR4	Homo sapiens (human)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Core-binding factor subunit beta Erythroid transcription factor Helicase MOV-10 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase KAT2B Histone acetyltransferase p300 Histone deacetylase 1 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Integrin alpha-IIb Myosin regulatory light polypeptide 9 Nuclear receptor subfamily 4 group A member 3 Paired amphipathic helix protein Sin3a Paired amphipathic helix protein Sin3b Platelet factor 4 Platelet glycoprotein Ib alpha chain Protein arginine N-methyltransferase 1 Protein arginine N-methyltransferase 6 Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Protein dpy-30 homolog Protein kinase C theta type Retinoblastoma-binding protein 5 Runt-related transcription factor 1 Set1/Ash2 histone methyltransferase complex subunit ASH2 Thrombospondin-1 Transcription factor NF-E2 45 kDa subunit Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein WD repeat-containing protein 5 Zinc finger protein ZFPM1	O14686 O15047 O60814 O75182 P02776 P04908 P06899 P07359 P07996 P08514 P0C5Y9 P15976 P16104 P20671 P23527 P24844 P33778 P57053 P58876 P61964 P62805 P62807 P68431 P84243 Q01196 Q03164 Q04759 Q09472 Q13547 Q13951 Q15291 Q16621 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8IX07 Q8N257 Q8NDV7 Q8NEZ4 Q92570 Q92831 Q93077 Q93079 Q96A08 Q96LA8 Q96ST3 Q99873 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9C005 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UBL3 Q9UL18 Q9UMN6 Q9UPQ9 Q9UPS6	AGO1 AGO3 AGO4 ALL1 ALR AML1 ASH2L ASH2L1 BIG3 CAGH26 CBFA2 CBFB CHN CSMF CXCL4 CXXC7 DPY30 EIF2C1 EIF2C3 EIF2C4 EP300 ERYF1 FOG1 GATA1 GF1 GP1BA GP2B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HDAC1 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HMT2 HRMT1L2 HRMT1L6 HRX HRX2 HTRX IR1B4 ITGA2B ITGAB KAT2B KIAA0304 KIAA0339 KIAA0700 KIAA1076 KIAA1093 KIAA1460 KIAA1506 KIAA1567 KIAA1582 KIAA1631 KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G MINOR MLC2 MLL MLL1 MLL2 MLL3 MLL4 MOV10 MRLC1 MYL9 MYRL2 NFE2 NOR1 NR4A3 P300 PCAF PF4 PRKCQ PRKCT PRMT1 PRMT6 RBBP5 RBQ3 RPD3L1 RUNX1 SCYB4 SET1 SET1A SET1B SETD1A SETD1B SIN3A SIN3B TEC THBS1 TNRC6 TNRC6A TNRC6B TNRC6C TRX1 TRX2 TSH2B TSP TSP1 WBP7 WDR5 ZFN89A ZFPM1	Homo sapiens (human)
PKMTs methylate histone lysines	Actin-histidine N-methyltransferase Activating transcription factor 7-interacting protein 1 Histone H3.1 Histone H3.2 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase ASH1L Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase KMT5B Histone-lysine N-methyltransferase KMT5C Histone-lysine N-methyltransferase MECOM Histone-lysine N-methyltransferase NSD2 Histone-lysine N-methyltransferase NSD3 Histone-lysine N-methyltransferase PRDM16 Histone-lysine N-methyltransferase PRDM9 Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Histone-lysine N-methyltransferase SETD2 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB1 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase SMYD3 Histone-lysine N-methyltransferase SUV39H1 Histone-lysine N-methyltransferase SUV39H2 Histone-lysine N-methyltransferase, H3 lysine-36 specific Histone-lysine N-methyltransferase, H3 lysine-79 specific N-lysine methyltransferase KMT5A N-lysine methyltransferase SETD6 N-lysine methyltransferase SMYD2 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Polycomb protein EED Polycomb protein SUZ12 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Transcription factor p65 WD repeat-containing protein 5 Zinc finger protein AEBP2	O14686 O15047 O43463 O75530 O96028 P19838 P61964 P62805 P68431 Q00653 Q03112 Q03164 Q04206 Q09028 Q15022 Q15047 Q15291 Q15910 Q16576 Q4FZB7 Q6VMQ6 Q6ZN18 Q71DI3 Q86TU7 Q86Y97 Q8NEZ4 Q8TBK2 Q8TEK3 Q8WTS6 Q96KQ7 Q96L73 Q96T68 Q9BYW2 Q9BZ95 Q9C005 Q9H5I1 Q9H7B4 Q9H9B1 Q9HAZ2 Q9NQR1 Q9NQV7 Q9NR48 Q9NRG4 Q9UBL3 Q9UMN6 Q9UPS6	AEBP2 ALL1 ALR ARA267 ASH1L ASH2L ASH2L1 ATF7IP BAT8 BIG3 C13orf4 C14orf154 C6orf30 CHET9 CLLD8 CXXC7 DOT1L DPY30 EED EHMT1 EHMT2 ESET EUHMTASE1 EVI1 EZH2 G9A GLP H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HIF1 HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST4H4 HRX HRX2 HTRX HYPB JJAZ1 KIAA0067 KIAA0160 KIAA0304 KIAA0339 KIAA1076 KIAA1090 KIAA1420 KIAA1506 KIAA1675 KIAA1717 KIAA1732 KIAA1814 KIAA1876 KMT1A KMT1B KMT1C KMT1D KMT1E KMT1F KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G KMT2H KMT3A KMT3B KMT3C KMT4 KMT5A KMT5B KMT5C KMT6 KMT7 LYT10 MCAF MCAF1 MDS1 MECOM MEL1 MLL MLL1 MLL2 MLL3 MLL4 MMSET NFKB1 NFKB2 NFKB3 NG36 NSD1 NSD2 NSD3 PFM13 PFM6 PRDM16 PRDM3 PRDM9 PRSET7 RBAP46 RBAP48 RBBP4 RBBP5 RBBP7 RBQ3 RELA SET07 SET1 SET1A SET1B SET2 SET7 SET8 SET9 SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETD8 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H SUV39H1 SUV39H2 SUV420H1 SUV420H2 SUZ12 TRX1 TRX2 TRX5 WBP7 WDR5 WHSC1 WHSC1L1 ZMYND1 ZNFN3A1	Homo sapiens (human)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	15-hydroxyprostaglandin dehydrogenase [NAD(+)] 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C3 Carbonyl reductase [NADPH] 1 Hematopoietic prostaglandin D synthase Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase 3 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin reductase 2 Prostaglandin-H2 D-isomerase Prostamide/prostaglandin F synthase Thromboxane-A synthase	O14684 O60760 P15428 P16152 P23219 P24557 P35354 P41222 P42330 Q15185 Q16647 Q8N8N7 Q8TBF2 Q9H7Z7 Q9UNU6	AKR1C3 C1orf93 C9orf15 CBR CBR1 COX1 COX2 CRN CYP12 CYP5 CYP5A1 CYP8 CYP8A1 CYP8B1 DDH1 FAM213B GSTS HPGD HPGDS HSD17B5 KIAA0119 MGST1L1 MPGES1 P23 PDS PGDH1 PGDS PGES PGES2 PGFS PIG12 PRXL2B PTGDS PTGDS2 PTGES PTGES2 PTGES3 PTGIS PTGR2 PTGS1 PTGS2 SDR21C1 SDR36C1 TBXAS1 TEBP TXAS ZADH1	Homo sapiens (human)
Defective ABCD4 causes MAHCJ	Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4	O14678 Q9NUN5	ABCD4 C6orf209 LMBRD1 NESI PXMP1L	Homo sapiens (human)
Transport of RCbl within the body	CD320 antigen Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4 Multidrug resistance-associated protein 1 Transcobalamin-1 Transcobalamin-2	O14678 P20061 P20062 P33527 P98164 Q5SW96 Q9NPF0 Q9NUN5	8D6A ABCC1 ABCD4 ARH C6orf209 CD320 LDLRAP1 LMBRD1 LRP2 MRP MRP1 NESI PXMP1L TC1 TC2 TCN1 TCN2	Homo sapiens (human)
Uptake of dietary cobalamins into enterocytes	Chymotrypsinogen B2 Chymotrypsinogen B Cobalamin binding intrinsic factor Cubilin Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4 Protein amnionless Serine protease 1 Transcobalamin-1 Trypsin-3	O14678 O60494 P07477 P17538 P20061 P27352 P35030 Q6GPI1 Q9BXJ7 Q9NUN5	ABCD4 AMN C6orf209 CBLIF CTRB CTRB1 CTRB2 CUBN GIF IFCR IFMH LMBRD1 NESI PRSS1 PRSS3 PRSS4 PXMP1L TC1 TCN1 TRP1 TRY1 TRY3 TRY4 TRYP1	Homo sapiens (human)
NOTCH4 Activation and Transmission of Signal to the Nucleus	14-3-3 protein zeta/delta Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 4 Nicastrin Presenilin-1 Presenilin-2 Protein jagged-1	O14672 P49768 P49810 P63104 P78504 Q8WW43 Q92542 Q96BI3 Q99466 Q9NR61 Q9NZ42	AD3 AD4 ADAM10 APH1A APH1B DLL4 INT3 JAG1 JAGL1 KIAA0253 KUZ MADM NCSTN NOTCH4 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 STM2 YWHAZ	Homo sapiens (human)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Cathepsin K Collagen alpha-1(IX) chain Collagen alpha-1(XII) chain Collagen alpha-1(XIII) chain Collagen alpha-1(XIV) chain Collagen alpha-1(XIX) chain Collagen alpha-1(XV) chain Collagen alpha-1(XVI) chain Collagen alpha-1(XVII) chain Collagen alpha-1(XVIII) chain Collagen alpha-1(XXIII) chain Collagen alpha-1(XXV) chain Collagen alpha-1(XXVI) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Collagenase 3 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 Disintegrin and metalloproteinase domain-containing protein 9 Furin Interstitial collagenase Macrophage metalloelastase Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-19 Matrix metalloproteinase-20 Matrix metalloproteinase-9 Neutrophil collagenase Neutrophil elastase Procathepsin L Stromelysin-1 Stromelysin-2 Stromelysin-3 Transmembrane protease serine 6 Trypsin-2	O14672 O60882 P03956 P07339 P07478 P07711 P07858 P08246 P08253 P08254 P09237 P09238 P09958 P14780 P20849 P22894 P24347 P39059 P39060 P39900 P43235 P45452 P50281 P51511 P78536 Q05707 Q07092 Q13443 Q14050 Q14055 Q14993 Q5TAT6 Q86Y22 Q8IU80 Q8IUZ5 Q96A83 Q99542 Q99715 Q9BXS0 Q9UMD9	ADAM10 ADAM17 ADAM9 AGXT2L2 BP180 BPAG2 CLG CLG1 CLG4A CLG4B COL12A1 COL12A1L COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL23A1 COL25A1 COL26A1 COL9A1 COL9A2 COL9A3 CPSB CPSD CSVP CTSB CTSD CTSK CTSL CTSL1 CTSO CTSO2 ELA2 ELANE EMID2 EMU2 FUR FURIN HME KIAA0021 KUZ MADM MCMP MDC9 MLTNG MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP18 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 MPSL1 PACE PCSK3 PHYKPL PRSS2 PUMP1 RASI STMY1 STMY2 STMY3 TACE TMPRSS6 TRY2 TRYP2 UND	Homo sapiens (human)
EPH-ephrin mediated repulsion of cells	72 kDa type IV collagenase AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Disintegrin and metalloproteinase domain-containing protein 10 Dynamin-1 Ephrin type-A receptor 10 Ephrin type-A receptor 1 Ephrin type-A receptor 2 Ephrin type-A receptor 3 Ephrin type-A receptor 4 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-A receptor 8 Ephrin type-B receptor 1 Ephrin type-B receptor 2 Ephrin type-B receptor 3 Ephrin type-B receptor 4 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A4 Ephrin-A5 Ephrin-B1 Ephrin-B2 Ephrin-B3 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Matrix metalloproteinase-9 Nicastrin Presenilin-1 Presenilin-2 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor TIAM1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O14672 O15197 O43921 O94973 O95782 P06241 P07947 P07948 P08253 P09496 P09497 P14780 P20827 P21709 P29317 P29320 P29322 P29323 P49768 P49810 P52735 P52797 P52798 P52799 P52803 P53675 P53680 P54753 P54756 P54760 P54762 P54764 P63000 P63010 P98172 Q00610 Q05193 Q13009 Q15375 Q15768 Q5JZY3 Q8WW43 Q92542 Q96BI3 Q96CW1 Q9NZ42 Q9UF33 Q9UKW4	AD3 AD4 ADAM10 ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B BSK CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLG4A CLG4B CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD DNM DNM1 DRT ECK EEK EFL2 EFL3 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EHK1 EHK2 EHK3 ELK EPH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPHT EPHT1 EPHT2 EPHT3 EPLG1 EPLG2 EPLG3 EPLG4 EPLG5 EPLG6 EPLG7 EPLG8 EPTH3 ERK ETK ETK1 ETK2 FYN HEK HEK11 HEK12 HEK2 HEK3 HEK5 HEK6 HEK7 HEK8 HIP9 HTK HTKL HYPJ JTK8 KIAA0034 KIAA0109 KIAA0253 KIAA0899 KIAA1459 KUZ LERK1 LERK2 LERK3 LERK4 LERK5 LERK6 LERK7 LERK8 LYN MADM MMP2 MMP9 MYK1 NCSTN NET PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RAC1 SEK STM2 TC25 TIAM1 TNFAIP4 TYRO1 TYRO11 TYRO4 TYRO5 TYRO6 VAV2 VAV3 YES YES1	Homo sapiens (human)

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