Toll Like Receptor TLR1:TLR2 Cascade
|
|
|
- CD14
- KIAA0012
- TIL4
- TLR1
- TLR2
- porB
|
|
Transfer of LPS from LBP carrier to CD14
|
|
|
|
|
FCGR activation
|
|
|
- CD16A
- CD32
- CD3G
- FCG1
- FCG2
- FCG3
- FCGR1
- FCGR1A
- FCGR2A
- FCGR2A1
- FCGR3
- FCGR3A
- FGR
- FYN
- HCK
- IGFR1
- IGFR2
- IGFR3
- IGHG1
- IGHG2
- IGHG3
- IGHG4
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- JTK8
- LYN
- SRC2
- SYK
- T3G
- V1-11
- V1-13
- V1-16
- V1-20
- V1-3
- V1-5
- V1-7
- V1-9
- V2-11
- V2-15
- V2-17
- V2-19
- V2-8
- V3-2
- V3-3
- V3-4
- V4-1
- V4-2
- V4-6
- V5-1
- V5-4
- V5-6
- YES
- YES1
|
|
CD28 dependent Vav1 pathway
|
|
|
- CD28
- CD28LG
- CD28LG1
- CD28LG2
- CD80
- CD86
- CDC42
- FYN
- LAB7
- LCK
- OPHN3
- PAK1
- PAK2
- PAK3
- RAC1
- TC25
- VAV
- VAV1
|
|
CD28 co-stimulation
|
|
|
- CD28
- CD28LG
- CD28LG1
- CD28LG2
- CD80
- CD86
- FYN
- GADS
- GRAP2
- GRB2L
- GRID
- JTK8
- LAB7
- LCK
- LYN
- YES
- YES1
|
|
Cross-presentation of particulate exogenous antigens (phagosomes)
|
|
|
- CD36
- CYBA
- CYBB
- GP3B
- GP4
- ITGAV
- ITGB5
- MSK8
- NCF1
- NCF2
- NCF4
- NOX2
- NOXA2
- NOXO2
- P67PHOX
- SH3PXD1A
- SH3PXD4
- VNRA
- VTNR
|
|
Phosphate bond hydrolysis by NTPDase proteins
|
|
|
- CD39
- CD39L1
- CD39L2
- CD39L3
- CD39L4
- ENTPD1
- ENTPD2
- ENTPD3
- ENTPD4
- ENTPD5
- ENTPD6
- ENTPD7
- ENTPD8
- IL6ST2
- KIAA0392
- LALP1
- LALP70
- LYSAL1
- PCPH
|
|
Translocation of ZAP-70 to Immunological synapse
|
- HLA class II histocompatibility antigen, DP alpha 1 chain
- HLA class II histocompatibility antigen, DP beta 1 chain
- HLA class II histocompatibility antigen, DQ alpha 1 chain
- HLA class II histocompatibility antigen, DQ alpha 2 chain
- HLA class II histocompatibility antigen, DQ beta 1 chain
- HLA class II histocompatibility antigen, DQ beta 2 chain
- HLA class II histocompatibility antigen, DR alpha chain
- HLA class II histocompatibility antigen, DR beta 3 chain
- HLA class II histocompatibility antigen, DR beta 4 chain
- HLA class II histocompatibility antigen, DR beta 5 chain
- HLA class II histocompatibility antigen, DRB1 beta chain
- T cell receptor alpha chain constant
- T cell receptor alpha variable 19
- T cell receptor alpha variable 29/delta variable 5
- T cell receptor alpha variable 8-4
- T cell receptor beta constant 1
- T cell receptor beta variable 12-3
- T cell receptor beta variable 7-9
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD4
- Tyrosine-protein kinase Lck
- Tyrosine-protein kinase ZAP-70
- Tyrosine-protein phosphatase non-receptor type 22
|
|
- CD3D
- CD3E
- CD3G
- CD4
- HLA-DP1A
- HLA-DP1B
- HLA-DPA1
- HLA-DPB1
- HLA-DQA1
- HLA-DQA2
- HLA-DQB
- HLA-DQB1
- HLA-DQB2
- HLA-DRA
- HLA-DRA1
- HLA-DRB1
- HLA-DRB3
- HLA-DRB4
- HLA-DRB5
- HLA-DXA
- HLA-DXB
- HLASB
- LCK
- PTPN22
- PTPN8
- SRK
- T3D
- T3E
- T3G
- TCRA
- TCRBV12S3
- TCRBV8S1
- TRAC
- TRAV19
- TRAV29DV5
- TRAV8-4
- TRBC1
- TRBV12-3
- TRBV7-9
- ZAP70
|
|
Laminin interactions
|
|
|
- CD49B
- COL18A1
- FNRB
- HSPG2
- ITGA1
- ITGA2
- ITGA3
- ITGA6
- ITGA7
- ITGAV
- ITGB1
- ITGB4
- KIAA0533
- KIAA1907
- LAMA
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- LAMB1
- LAMB2
- LAMB2T
- LAMB3
- LAMC1
- LAMC2
- LAMC3
- LAMM
- LAMNA
- LAMNB1
- LAMNB2
- LAMS
- MDF2
- MSK12
- MSK18
- MSK8
- NID
- NID1
- NID2
- VNRA
- VTNR
|
|
MET activates PTK2 signaling
|
|
|
- CD49B
- FAK
- FAK1
- FNRB
- HGF
- HPTA
- ITGA2
- ITGA3
- ITGB1
- KIAA0533
- KIAA1907
- LAMA
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- LAMB1
- LAMB2
- LAMB2T
- LAMB3
- LAMC1
- LAMC2
- LAMC3
- LAMM
- LAMNA
- LAMNB1
- LAMNB2
- LAMS
- MDF2
- MET
- MSK12
- MSK18
- PTK2
- SRC
- SRC1
|
|
Uptake and function of diphtheria toxin
|
|
|
- CD9
- DTR
- DTS
- EEF2
- EF2
- GRIM12
- HBEGF
- HEGFL
- HSP90A
- HSP90AA1
- HSP90AB1
- HSP90B
- HSPC1
- HSPC2
- HSPC3
- HSPCA
- HSPCB
- KDRF
- MIC3
- TSPAN29
- TXNRD1
|
|
Pyrimidine salvage
|
|
|
- CDA
- CDD
- DCK
- DXF68S1E
- ECGF1
- FAM16AX
- GS1
- HDHD1
- HDHD1A
- PUDP
- TK1
- TK2
- TYMP
- UCK1
- UCK2
- UCKL1
- UMPK
- UP
- UPP1
- UPP2
- URK1
- URKL1
|
|
MAPK3 (ERK1) activation
|
|
|
- CDC2
- CDC28A
- CDK1
- CDKN1
- ERK1
- IFNB2
- IL6
- IL6R
- JAK1
- JAK1A
- JAK1B
- JAK2
- MAP2K1
- MAPK3
- MEK1
- P34CDC2
- PRKM3
- PRKMK1
- PTP2C
- PTPN11
- SHPTP2
- TYK2
|
|
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
|
|
|
|
|
Rap1 signalling
|
|
|
- CDC25L
- CGEF1
- CGEF2
- EPAC
- EPAC1
- EPAC2
- GARNL4
- KIAA0474
- KIAA1039
- KREV1
- MCG7
- PKACA
- PRKACA
- PRKACB
- PRKACG
- RAF
- RAF1
- RAP1A
- RAP1B
- RAP1GA1
- RAP1GA2
- RAP1GAP
- RAP1GAP2
- RAPGEF3
- RAPGEF4
- RASGRP
- RASGRP1
- RASGRP2
- SIPA1
- SPA1
- YWHAB
- YWHAZ
|
|
Effects of PIP2 hydrolysis
|
|
|
- CDC25L
- DAGK
- DAGK1
- DAGK2
- DAGK3
- DAGK4
- DAGK5
- DAGK6
- DGKA
- DGKB
- DGKD
- DGKE
- DGKG
- DGKH
- DGKI
- DGKK
- DGKQ
- DGKZ
- INSP3R1
- ITPR1
- ITPR2
- ITPR3
- KIAA0145
- KIAA0718
- MCG7
- PKCD
- PKCE
- PKCL
- PRKCD
- PRKCE
- PRKCH
- PRKCL
- PRKCQ
- PRKCT
- RASGRP
- RASGRP1
- RASGRP2
- TRP3
- TRP6
- TRP7
- TRPC3
- TRPC6
- TRPC7
|
|
Signaling by ERBB2 ECD mutants
|
|
|
- CDC37
- CDC37A
- EGF
- EGFR
- ERBB
- ERBB1
- ERBB2
- ERBB2IP
- ERBIN
- GAB1
- GRB1
- HER1
- HER2
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SHC
- SHC1
- SHCA
- SOS1
|
|
Constitutive Signaling by Overexpressed ERBB2
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
- NRAS
- PTPN12
- SHC
- SHC1
- SHCA
- SOS1
|
|
Resistance of ERBB2 KD mutants to lapatinib
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Resistance of ERBB2 KD mutants to sapitinib
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Resistance of ERBB2 KD mutants to AEE788
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Drug-mediated inhibition of ERBB2 signaling
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Resistance of ERBB2 KD mutants to tesevatinib
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Drug resistance in ERBB2 TMD/JMD mutants
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|
Resistance of ERBB2 KD mutants to trastuzumab
|
|
|
- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
|
|