Interleukin-18 signaling
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- ALOX5
- FIL1Z
- IGIF
- IL13
- IL18
- IL18BP
- IL18R1
- IL18RAP
- IL1F4
- IL1F7
- IL1H4
- IL1R7
- IL1RP1
- IL1RRP
- IL37
- IL4
- LOG5
- NC30
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Interleukin-23 signaling
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- APRF
- ERBA2L
- IL12B
- IL12R
- IL12RB
- IL12RB1
- IL23A
- IL23R
- JAK2
- NKSF2
- P4HB
- PDI
- PDIA1
- PO4DB
- SGRF
- STAT3
- STAT4
- TYK2
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Interleukin-12 signaling
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- ERBA2L
- IL12A
- IL12B
- IL12R
- IL12RB
- IL12RB1
- IL12RB2
- JAK1
- JAK1A
- JAK1B
- JAK2
- NKSF1
- NKSF2
- P4HB
- PDI
- PDIA1
- PO4DB
- STAT4
- SYBL1
- TYK2
- VAMP7
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Interleukin-33 signaling
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- C9orf26
- DER4
- IL1F11
- IL1RL1
- IL33
- NFHEV
- ST2
- T1
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IRAK2 mediated activation of TAK1 complex
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- IRAK2
- KIAA0733
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- RNF85
- RPS27A
- TAB1
- TAB2
- TAB3
- TAK1
- TRAF6
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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TRAF6-mediated induction of TAK1 complex within TLR4 complex
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- CD14
- ESOP1
- IRAK2
- KIAA0733
- LY96
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MD2
- PRVTIRB
- RNF85
- RPS27A
- TAB1
- TAB2
- TAB3
- TAK1
- TICAM1
- TICAM2
- TIRAP3
- TIRP
- TLR4
- TRAF6
- TRAM
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
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- CD14
- ESOP1
- IRAK2
- KIAA0733
- LY96
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MD2
- PRVTIRB
- RNF85
- RPS27A
- TAB1
- TAB2
- TAB3
- TAK1
- TICAM1
- TICAM2
- TIRAP3
- TIRP
- TLR4
- TRAF6
- TRAM
- TRIF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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MyD88 dependent cascade initiated on endosome
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- IRAK
- IRAK1
- IRAK2
- IRAK4
- MYD88
- RNF85
- TLR7
- TLR9
- TRAF6
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Receptor-type tyrosine-protein phosphatases
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- CXorf2
- IL1R9
- IL1RAPL1
- IL1RAPL2
- KIAA0654
- KIAA0848
- KIAA0897
- KIAA0918
- KIAA1230
- KIAA1854
- KIAA1910
- LAR
- LIP1
- LRIG4
- LRRC11
- LRRC12
- LRRC4B
- NTRK3
- OPHN4
- PPFIA1
- PPFIA2
- PPFIA3
- PPFIA4
- PPFIBP1
- PPFIBP2
- PTPRD
- PTPRF
- PTPRS
- SLITL1
- SLITRK1
- SLITRK2
- SLITRK3
- SLITRK4
- SLITRK5
- SLITRK6
- TRKC
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Interleukin-36 pathway
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- FIL1D
- FIL1E
- FIL1T
- IL1E
- IL1F10
- IL1F5
- IL1F6
- IL1F8
- IL1F9
- IL1H1
- IL1H2
- IL1HY1
- IL1HY2
- IL1L1
- IL1RL2
- IL1RP2
- IL1RP3
- IL1RRP2
- IL36A
- IL36B
- IL36G
- IL36RN
- IL38
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Interleukin-38 signaling
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- FIL1T
- IL1F10
- IL1HY2
- IL1RAPL1
- IL1RL2
- IL1RRP2
- IL38
- JNK1
- MAPK8
- OPHN4
- PRKM8
- SAPK1
- SAPK1C
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Inhibition of PKR
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TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
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- BLU
- CROC1
- IRAK
- IRAK1
- IRAK4
- IRF7
- MYD88
- RNF85
- TLR7
- TLR9
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
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Interleukin-20 family signaling
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- AK155
- APRF
- CRFB4
- D21S58
- D21S66
- DIRS1
- IFNL1
- IFNL2
- IFNL3
- IFNLR1
- IL10RB
- IL19
- IL20
- IL20RA
- IL20RB
- IL22
- IL22R
- IL22RA1
- IL22RA2
- IL24
- IL26
- IL28A
- IL28B
- IL28C
- IL28RA
- IL29
- ILTIF
- JAK1
- JAK1A
- JAK1B
- JAK2
- JAK3
- LICR2
- MDA7
- PTP2C
- PTPN11
- SHPTP2
- ST16
- STAT1
- STAT2
- STAT3
- STAT4
- STAT5
- STAT5A
- STAT5B
- TYK2
- ZCYTO10
- ZCYTO18
- ZCYTO20
- ZCYTO21
- ZCYTO22
- ZMDA1
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IFNG signaling activates MAPKs
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- ERK1
- ERK2
- IFNG
- IFNGR1
- IFNGR2
- IFNGT1
- JAK1
- JAK1A
- JAK1B
- JAK2
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- RAF
- RAF1
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Regulation of IFNA/IFNB signaling
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- CIS3
- HCP
- IFB
- IFNA1
- IFNA10
- IFNA13
- IFNA14
- IFNA16
- IFNA17
- IFNA2
- IFNA21
- IFNA2A
- IFNA2B
- IFNA2C
- IFNA4
- IFNA5
- IFNA6
- IFNA7
- IFNA8
- IFNAR
- IFNAR1
- IFNB
- IFNB1
- ISG43
- JAK1
- JAK1A
- JAK1B
- PTP1B
- PTP1C
- PTP2C
- PTPN1
- PTPN11
- PTPN6
- SHPTP2
- SOCS1
- SOCS3
- SSI1
- SSI3
- STAT2
- TIP3
- TYK2
- USP18
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Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
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- CRDBP
- IGF2BP1
- IGF2BP2
- IGF2BP3
- IMP2
- IMP3
- KOC1
- VICKZ1
- VICKZ2
- VICKZ3
- ZBP1
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Relaxin receptors
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- GPCR135
- GPCR142
- GPR100
- GPR106
- GREAT
- INSL3
- INSL5
- INSL7
- LGR7
- LGR8
- RLF
- RLN2
- RLN3
- RLN3R1
- RLN3R2
- RLNL
- RXFP1
- RXFP2
- RXFP3
- RXFP4
- RXN3
- SALPR
- ZINS4
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Signaling by Insulin receptor
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Activated NTRK3 signals through PI3K
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- GRB1
- IRS1
- NTF3
- NTRK3
- PIK3CA
- PIK3R1
- SRC
- SRC1
- TRKC
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IRS-mediated signalling
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- GRB1
- IRS1
- IRS2
- PIK3C1
- PIK3CA
- PIK3CB
- PIK3R1
- PIK3R2
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Signaling by Leptin
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- APRF
- CIS3
- IRS1
- IRS2
- JAK2
- LEP
- OB
- OBS
- PTP2C
- PTPN11
- SHPTP2
- SOCS3
- SSI3
- STAT3
- STAT5
- STAT5A
- STAT5B
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IRS-related events triggered by IGF1R
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- IBP1
- IGF1
- IGF1R
- IGF2
- IRS1
- IRS2
- IRS4
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Synthesis of IP2, IP, and Ins in the cytosol
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- 5PTASE
- ALDRL6
- C8orf9
- IMP.18P
- IMPA
- IMPA1
- IMPA2
- INO1
- INPP1
- INPP4A
- INPP4B
- INPP5A
- INPP5B
- INPP5J
- ISYNA1
- KIAA0910
- KSP32
- MIOX
- MTMR7
- MTMR8
- MTMR9
- OCRL
- OCRL1
- OCRL2
- PIB5PA
- PIPP
- RSOR
- SYNJ1
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Synthesis of IPs in the nucleus
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- C9orf12
- IHPK1
- IHPK2
- IMPK
- IP6K1
- IP6K2
- IPMK
- IPPK
- KIAA0263
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