GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1401 - 1425** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Phospholipase C-mediated cascade; FGFR3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9	O43320 O76093 P05230 P08620 P09038 P19174 P31371 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB HST HSTF1 HYPF KS3 PLC1 PLCG1	Homo sapiens (human)
Defective GGT1 causes GLUTH	Glutathione hydrolase 1 proenzyme	P19440	GGT GGT1	Homo sapiens (human)
Carboxyterminal post-translational modifications of tubulin	Cytosolic carboxypeptidase 1 Cytosolic carboxypeptidase 2 Cytosolic carboxypeptidase 3 Cytosolic carboxypeptidase 4 Cytosolic carboxypeptidase 6 Cytosolic carboxypeptidase-like protein 5 Inactive polyglycylase TTLL10 Leucine-rich repeat-containing protein 49 Nicolin-1 Polyglutamylase complex subunit TTLL1 Probable tubulin polyglutamylase TTLL2 Probable tubulin polyglutamylase TTLL9 Protein monoglycylase TTLL8 Small vasohibin-binding protein Tubulin alpha-1A chain Tubulin alpha-1B chain Tubulin alpha-1C chain Tubulin alpha-3C chain Tubulin alpha-3D chain Tubulin alpha-3E chain Tubulin beta 8B Tubulin beta-1 chain Tubulin beta-2A chain Tubulin beta-2B chain Tubulin beta-3 chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin beta-6 chain Tubulin beta-8 chain Tubulin monoglutamylase TTLL4 Tubulin monoglycylase TTLL3 Tubulin polyglutamylase TTLL11 Tubulin polyglutamylase TTLL13 Tubulin polyglutamylase TTLL5 Tubulin polyglutamylase TTLL6 Tubulin polyglutamylase TTLL7 Tubulin polyglutamylase complex subunit 1 Tubulin polyglutamylase complex subunit 2 Tubulin--tyrosine ligase-like protein 12 Tubulin--tyrosine ligase Tubulinyl-Tyr carboxypeptidase 1 Tubulinyl-Tyr carboxypeptidase 2	A6NNM8 A6NNZ2 A6PVC2 O95922 P04350 P0DPH7 P0DPH8 P68363 P68371 Q13509 Q13885 Q14166 Q14679 Q3SXZ7 Q3ZCM7 Q5U5Z8 Q5VU57 Q68CL5 Q6EMB2 Q6PEY2 Q6ZT98 Q6ZTW0 Q6ZVT0 Q71U36 Q7L8A9 Q86V25 Q8IUZ0 Q8N300 Q8N841 Q8NDL9 Q8NEM8 Q8NG68 Q8NHH1 Q96MI9 Q9BQE3 Q9BSH3 Q9BUF5 Q9BVA1 Q9BWV7 Q9H4B7 Q9UPW5 Q9Y4R7	AGBL1 AGBL2 AGBL3 AGBL4 AGBL5 AGTPBP1 C18orf10 C19orf20 C20orf125 C22orf7 C6orf104 C9orf20 CCDC23 CCP1 CCP2 CCP3 CCP4 CCP5 CCP6 CSTPP2 KIAA0153 KIAA0173 KIAA0998 KIAA1035 KIAA1036 LRRC49 NICN1 NNA1 STAMP SVBP TPGS1 TPGS2 TTL TTL.6 TTLL1 TTLL10 TTLL11 TTLL12 TTLL13 TTLL13P TTLL2 TTLL3 TTLL4 TTLL5 TTLL6 TTLL7 TTLL8 TTLL9 TUBA1A TUBA1B TUBA1C TUBA2 TUBA3 TUBA3C TUBA3D TUBA3E TUBA6 TUBB1 TUBB2 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4A TUBB4B TUBB5 TUBB6 TUBB8 TUBB8B VASH VASH1 VASH2 VASHL	Homo sapiens (human)
Oxidative demethylation of DNA	G/T mismatch-specific thymine DNA glycosylase Methylcytosine dioxygenase TET1 Methylcytosine dioxygenase TET2 Methylcytosine dioxygenase TET3	O43151 Q13569 Q6N021 Q8NFU7	CXXC6 KIAA0401 KIAA1546 KIAA1676 LCX TDG TET1 TET2 TET3	Homo sapiens (human)
Defective CYP11A1 causes AICSR	Adrenodoxin, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Ferredoxin-2, mitochondrial NADPH	P05108 P10109 P22570 Q6P4F2	ADX ADXR CYP11A CYP11A1 FDX1 FDX1L FDX2 FDXR	Homo sapiens (human)
Cam-PDE 1 activation	Calmodulin-1 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	P0DP23 P54750 Q01064 Q14123	CALM CALM1 CAM CAM1 PDE1A PDE1B PDE1C PDES1B	Homo sapiens (human)
Transcriptional Regulation by VENTX	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 CCAAT/enhancer-binding protein beta Catenin beta-1 Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cellular tumor antigen p53 Cyclin-dependent kinase inhibitor 2A Fizzy-related protein homolog G1/S-specific cyclin-D1 Helicase MOV-10 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Homeobox protein VENTX Interleukin-6 Lymphoid enhancer-binding factor 1 Macrophage colony-stimulating factor 1 receptor Nuclear factor NF-kappa-B p105 subunit Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Transcription factor 7-like 2 Transcription factor p65 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O95231 P04637 P05231 P07333 P17676 P19838 P24385 P30260 P35222 P42771 P51668 P51965 P60006 Q04206 Q13042 Q16763 Q8NDV7 Q8NHZ8 Q96DE5 Q96KQ7 Q9H1A4 Q9H9B1 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NQB0 Q9NYG5 Q9UJU2 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UL18 Q9UM11 Q9UM13 Q9UPQ9	AGO1 AGO3 AGO4 ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BAT8 BCL1 C10orf104 C11orf51 C6orf30 C9orf17 CAGH26 CCND1 CDC16 CDC23 CDC26 CDC27 CDH1 CDKN2 CDKN2A CEBPB CENP-27 CSF1R CTNNB CTNNB1 D0S1430E D17S978E E2EPF EHMT1 EHMT2 EIF2C1 EIF2C3 EIF2C4 EUHMTASE1 FMS FYR FZR FZR1 G9A GLP HPX42B IFNB2 IL6 KIAA1093 KIAA1242 KIAA1406 KIAA1460 KIAA1567 KIAA1582 KIAA1631 KIAA1876 KMT1C KMT1D LEF1 MOV10 MTS1 NFKB1 NFKB3 NG36 P53 PRAD1 RELA SFT TCF4 TCF5 TCF7L2 TNRC6 TNRC6A TNRC6B TNRC6C TP53 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S VENTX VENTX2	Homo sapiens (human)
Synthesis of PIPs at the late endosome membrane	1-phosphatidylinositol 3-phosphate 5-kinase Myotubularin-related protein 2 Myotubularin-related protein 4 Myotubularin-related protein 7 Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphoinositide 3-kinase regulatory subunit 4 Polyphosphoinositide phosphatase Protein VAC14 homolog	O00443 Q08AM6 Q13496 Q13614 Q8NEB9 Q92562 Q96QG7 Q99570 Q9NYA4 Q9Y216 Q9Y2I7	C8orf9 CG2 FIG4 KIAA0274 KIAA0647 KIAA0981 KIAA1073 MTM1 MTMR2 MTMR4 MTMR7 MTMR8 MTMR9 PIK3C2A PIK3C3 PIK3R4 PIKFYVE PIP5K3 SAC3 TAX1BP2 TRX VAC14 VPS15 VPS34 ZFYVE11	Homo sapiens (human)
RND1 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain-containing protein 26 Carboxypeptidase D Caveolin-1 DEP domain-containing protein 1B Desmoplakin Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Epithelial-stromal interaction protein 1 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Flotillin-2 Girdin Growth factor receptor-bound protein 7 Inner nuclear membrane protein Man1 Kinase D-interacting substrate of 220 kDa Kinesin-like protein KIF14 Mucin-13 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin-4 Pleckstrin homology domain-containing family G member 5 Plexin-A1 Protein FAM135A Protein FAM83B RNA-binding motif protein, X chromosome Ras GTPase-activating protein nGAP Ras-related protein R-Ras2 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein Rho6 Stathmin-2 Stress-induced-phosphoprotein 1 Thioredoxin-like protein 1 Transferrin receptor protein 1 Transmembrane protein 59 Tyrosine-protein phosphatase non-receptor type 13 UBX domain-containing protein 11 Vang-like protein 1 Vang-like protein 2 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00459 O43396 O43559 O75976 O94827 P02786 P15924 P27986 P29317 P31948 P38159 P51648 P62070 Q03001 Q03135 Q12923 Q13017 Q14254 Q14451 Q15058 Q3V6T2 Q5T0W9 Q5T124 Q8TAA9 Q8TDM6 Q8WU20 Q8WUY9 Q92730 Q93045 Q96J88 Q99569 Q9BXS4 Q9H3R2 Q9NNW5 Q9NRY4 Q9P2D6 Q9UIW2 Q9UJF2 Q9ULH0 Q9ULK5 Q9UPS8 Q9Y2U8	ALDH10 ALDH3A2 ANKRD26 APE ARHGAP35 ARHGAP5 ARMS BP230 BP240 BPAG1 C1orf8 C6orf143 CAV CAV1 CCDC88A CPD DEPDC1B DLG5 DMH DRCC1 DSP DST DT ECK EPHA2 EPSTI1 ESA1 FALDH FAM135A FAM83B FLOT2 FRS2 FRS3 GRB1 GRB7 GRDN GRF1 GRLF1 HNRPG KIAA0042 KIAA0583 KIAA0720 KIAA0728 KIAA1074 KIAA1212 KIAA1215 KIAA1250 KIAA1411 KIAA1722 KIDINS220 KIF14 LEMD3 M17S1 MAN1 MUC13 NGAP NOV P190A PDLG PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXN1 PLXNA1 PNP1 PTP1E PTPL1 PTPN13 RASAL2 RBMX RBMXP1 RECC RHO6 RHOGAP5 RND1 RRAS2 SCG10 SCGN10 SOC STB1 STB2 STIP1 STMN2 TC21 TFRC TMEM59 TRP32 TXL TXNL TXNL1 UBXD5 UBXN11 VANGL1 VANGL2 WDR6 XTP8 p190ARHOGAP	Homo sapiens (human)
Receptor Mediated Mitophagy	Autophagy protein 5 Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta FUN14 domain-containing protein 1 Microtubule-associated proteins 1A/1B light chain 3A Microtubule-associated proteins 1A/1B light chain 3B Serine/threonine-protein kinase ULK1 Ubiquitin-like protein ATG12	O75385 O94817 P19784 P67870 P68400 Q8IVP5 Q9GZQ8 Q9H1Y0 Q9H492	APG12 APG12L APG5L ASP ATG12 ATG5 CK2A1 CK2A2 CK2N CSNK2A1 CSNK2A2 CSNK2B FUNDC1 G5A KIAA0722 MAP1ALC3 MAP1LC3A MAP1LC3B ULK1	Homo sapiens (human)
Biosynthesis of DPAn-6 SPMs	Polyunsaturated fatty acid lipoxygenase ALOX12 Polyunsaturated fatty acid lipoxygenase ALOX15	P16050 P18054	12LO ALOX12 ALOX15 LOG12 LOG15	Homo sapiens (human)
Masitinib-resistant KIT mutants	Mast/stem cell growth factor receptor Kit	P10721	KIT SCFR	Homo sapiens (human)
RHOQ GTPase cycle	ADP-ribosylation factor-like protein 13B ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Actin nucleation-promoting factor WASL Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 2 Cdc42 effector protein 3 Cdc42 effector protein 4 Cdc42-interacting protein 4 Cell division control protein 42 homolog Copine-8 Cystic fibrosis transmembrane conductance regulator DEP domain-containing protein 1B Formin-binding protein 1 Gap junction alpha-1 protein Glucose-fructose oxidoreductase domain-containing protein 1 Golgi-associated PDZ and coiled-coil motif-containing protein Intersectin-1 Junction plakoglobin MAGUK p55 subfamily member 7 Metalloreductase STEAP3 NEDD4-like E3 ubiquitin-protein ligase WWP2 Neutral amino acid transporter B(0) Obscurin Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Pleckstrin homology domain-containing family G member 3 Protein diaphanous homolog 3 Protein scribble homolog Ragulator complex protein LAMTOR1 Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP3 Ras-related protein Rab-7a Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 33 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho-related GTP-binding protein RhoQ SLIT-ROBO Rho GTPase-activating protein 2 Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase MRCK beta Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Sodium bicarbonate cotransporter 3 Stomatin Synaptosomal-associated protein 23 Transferrin receptor protein 1 Vang-like protein 1 Vesicle-associated membrane protein 3	A1L390 A7KAX9 O00161 O00308 O00401 O14559 O14613 O43307 O60890 O75044 O96013 P02786 P13569 P14923 P17081 P17302 P27105 P46940 P51149 P60953 Q00587 Q03135 Q07960 Q13017 Q13153 Q13177 Q14155 Q14160 Q14161 Q15642 Q15758 Q15811 Q15836 Q3SXY8 Q5T2T1 Q5T5U3 Q5VST9 Q5VT25 Q658P3 Q68EM7 Q6IAA8 Q6ZW31 Q86VI3 Q86YQ8 Q8TAA9 Q8TCU6 Q8WUY9 Q96QB1 Q96RU3 Q9H3Q1 Q9HD26 Q9NRY4 Q9NSV4 Q9NXC2 Q9UKI2 Q9UNA1 Q9Y2X7 Q9Y5S2 Q9Y6M7	ABCC7 ARHDH9 ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP33 ARHGAP34 ARHGAP35 ARHGAP5 ARHGAP7 ARHGEF7 ARHGEF9 ARHQ ARL13B ARL2L1 ASCT2 BND7 BORG1 BORG2 BORG4 BORG5 BT C11orf59 C6orf114 CAL CAV CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42GAP CEP1 CEP2 CEP3 CEP4 CFTR CIP4 COOL1 CPNE8 CRIB1 CTNNG DEPDC1B DIAP3 DIAPH3 DLC1 DP3 EPB72 FBP17 FIG FNBP1 FNBP2 GFOD1 GIT1 GIT2 GJA1 GJAL GOPC GRAF GRF1 GRIT GRLF1 IQGAP1 IQGAP3 ITSN ITSN1 JUP KIAA0051 KIAA0142 KIAA0147 KIAA0148 KIAA0424 KIAA0451 KIAA0456 KIAA0554 KIAA0599 KIAA0621 KIAA0712 KIAA1124 KIAA1142 KIAA1415 KIAA1424 KIAA1556 KIAA1639 KIAA1722 KIAA1723 LAMTOR1 LAP4 M7V1 MPP7 MSE55 NBC2 NBC2B NBC3 NBCn1 OBSCN OPHN1 OPHN1L P190A P85SPR PAK1 PAK2 PAK3BP PAK4 PDRO PIXB PLEKHG3 PREX1 RAB7 RAB7A RASL7A RDR RDRC RHOGAP1 RHOGAP5 RHOQ RICH1 RICS SBC2 SCRB1 SCRIB SH3D1A SLC1A5 SLC4A6 SLC4A7 SNAP23 SNX26 SRGAP2 SRGAP2A STARD12 STB2 STEAP3 STOM STOT STP SYB3 SYDE1 TC10 TCGAP TFRC TRIP10 TSAP6 VAMP3 VANGL1 VARTUL WASL WWP2 XTP8 p190ARHOGAP	Homo sapiens (human)
Digestion of dietary lipid	Bile salt-activated lipase Colipase Gastric triacylglycerol lipase Inactive pancreatic lipase-related protein 1 Pancreatic lipase-related protein 2 Pancreatic lipase-related protein 3 Pancreatic triacylglycerol lipase	P04118 P07098 P16233 P19835 P54315 P54317 Q17RR3	BAL CEL CLPS LIPF PLRP1 PLRP2 PNLIP PNLIPRP1 PNLIPRP2 PNLIPRP3	Homo sapiens (human)
RHOU GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Cell division control protein 42 homolog Clathrin heavy chain 1 Cytoplasmic protein NCK2 DEP domain-containing protein 1B Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Inactive tyrosine-protein kinase PEAK1 Intersectin-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Partitioning defective 6 homolog alpha Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein-tyrosine kinase 2-beta Proto-oncogene tyrosine-protein kinase Src Ras GTPase-activating-like protein IQGAP1 Rho GTPase-activating protein 30 Rho GTPase-activating protein 31 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho-related GTP-binding protein RhoU SH2/SH3 adapter protein NCK1 SLIT-ROBO Rho GTPase-activating protein 2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 1 Thioredoxin-like protein 1 Ubiquitin carboxyl-terminal hydrolase 9X Unconventional myosin-VI Vang-like protein 1 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00308 O00459 O14964 O43396 O43639 O75044 O75886 O75914 O96013 P12931 P16333 P27986 P29317 P46940 P60953 Q00610 Q01082 Q03001 Q13153 Q13177 Q13813 Q14155 Q14161 Q14289 Q15052 Q2M1Z3 Q7L0Q8 Q7Z6I6 Q8TAA9 Q8TDM6 Q8WUY9 Q92783 Q93008 Q9H792 Q9NNW5 Q9NPB6 Q9NZM3 Q9UM54 Q9Y2X7	ARHGAP30 ARHGAP31 ARHGAP34 ARHGEF6 ARHGEF7 ARHU BP230 BP240 BPAG1 CDC42 CDC42L1 CDGAP CLH17 CLTC CLTCL2 COOL1 COOL2 DEPDC1B DFFRX DLG5 DMH DST DT ECK EPHA2 FAK2 FAM FNBP2 G28K GIT1 GIT2 GRB1 GRB4 HBP HGS HRS IQGAP1 ITSN2 KIAA0006 KIAA0034 KIAA0051 KIAA0142 KIAA0148 KIAA0389 KIAA0456 KIAA0583 KIAA0728 KIAA1142 KIAA1204 KIAA1256 KIAA2002 MYO6 NCK NCK1 NCK2 NEAS OPHN3 P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PAR6A PARD6A PDLG PEAK1 PIK3R1 PIK3R2 PIXA PIXB PTK2B PYK2 RAFTK RHOU SH3D1B SPTA2 SPTAN1 SPTB2 SPTBN1 SRC SRC1 SRGAP2 SRGAP2A STAM STAM1 STAM2 STB2 SWAP TRP32 TXL TXNL TXNL1 USP9 USP9X VANGL1 WDR6 WRCH1 WWP2 XTP8	Homo sapiens (human)
Hormone ligand-binding receptors	Follicle-stimulating hormone receptor Follitropin subunit beta Glycoprotein hormone alpha-2 Glycoprotein hormone beta-5 Glycoprotein hormones alpha chain Gonadotropin-releasing hormone receptor Lutropin subunit beta Lutropin-choriogonadotropic hormone receptor Progonadoliberin-1 Progonadoliberin-2 Putative gonadotropin-releasing hormone II receptor Thyrotropin receptor Thyrotropin subunit beta	O43555 P01148 P01215 P01222 P01225 P01229 P16473 P22888 P23945 P30968 Q86YW7 Q96P88 Q96T91	CGA FSHB FSHR GNRH GNRH1 GNRH2 GNRHR GNRHR2 GPA2 GPB5 GPHA2 GPHB5 GRH GRHR LCGR LGR1 LGR2 LGR3 LHB LHCGR LHRH LHRHR TSHB TSHR ZLUT1 ZSIG51	Homo sapiens (human)
Membrane binding and targetting of GAG proteins	Gag polyprotein Glycylpeptide N-tetradecanoyltransferase 2 Multivesicular body subunit 12A Multivesicular body subunit 12B Polyubiquitin-B Polyubiquitin-C Tumor susceptibility gene 101 protein Ubiquitin-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vacuolar protein sorting-associated protein 28 homolog Vacuolar protein sorting-associated protein 37A Vacuolar protein sorting-associated protein 37B Vacuolar protein sorting-associated protein 37C Vacuolar protein sorting-associated protein 37D	A5D8V6 O60551 P04591 P0CG47 P0CG48 P62979 P62987 Q86XT2 Q8NEZ2 Q96EY5 Q99816 Q9H7P6 Q9H9H4 Q9NZ09 Q9UK41	C9orf28 CFBP FAM125A FAM125B HCRP1 MVB12A MVB12B NMT2 PML39 RPS27A TSG101 UBA52 UBA80 UBAP1 UBB UBC UBCEP1 UBCEP2 VPS28 VPS37A VPS37B VPS37C VPS37D WBSCR24 gag	Homo sapiens (human)
ERK/MAPK targets	ETS domain-containing protein Elk-1 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Myocyte-specific enhancer factor 2A Myocyte-specific enhancer factor 2C Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-5 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O75582 P19419 P27361 P28482 P30153 P30154 P51812 P62714 P67775 Q02078 Q06413 Q13164 Q14738 Q15349 Q15418 Q15759 Q16539	BMK1 CSBP CSBP1 CSBP2 CSPB1 ELK1 ERK1 ERK2 ERK5 ISPK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MAPKAPK1A MAPKAPK1B MAPKAPK1C MEF2 MEF2A MEF2C MSK1 MXI2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKM1 PRKM11 PRKM2 PRKM3 PRKM7 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RSK1 RSK2 RSK3 SAPK2 SAPK2A SAPK2B	Homo sapiens (human)
Hedgehog 'on' state	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cilium assembly protein DZIP1 Cullin-3 Desert hedgehog protein E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 EvC complex member EVC G-protein coupled receptor 161 Indian hedgehog protein Kinesin-like protein KIF7 Limbin Parafibromin Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein numb homolog Protein patched homolog 1 Protein smoothened Serine/threonine-protein kinase ULK3 Sonic hedgehog protein Speckle-type POZ protein-like Speckle-type POZ protein Suppressor of fused homolog Transcriptional activator GLI3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein GLI1 Zinc finger protein GLI2	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O43323 O43791 O75832 P08151 P0CG47 P0CG48 P10070 P10071 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P49757 P51665 P55036 P57679 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 Q06323 Q13200 Q13618 Q13635 Q14623 Q14997 Q15008 Q15465 Q16401 Q2M1P5 Q6IQ16 Q6P1J9 Q6PHR2 Q86UK5 Q86YF9 Q8N6U8 Q8TAA3 Q92530 Q96J02 Q99436 Q99460 Q99835 Q9HAU4 Q9HCE7 Q9UL46 Q9UMX1 Q9UNM6	C14orf41 C1orf28 C7orf76 CDC73 CUL3 DHH DSS1 DZIP DZIP1 DZIP2 EVC EVC2 GLI GLI1 GLI2 GLI3 GPR161 HC2 HC3 HC8 HC9 HRPT2 HSPC IFI5111 IHH ITCH KIAA0072 KIAA0077 KIAA0107 KIAA0617 KIAA0996 KIAA1625 KIF7 LBN LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU NUMB PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTCH PTCH1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SHH SMO SMOH SMURF1 SMURF2 SPOP SPOPL SUFU SUG1 SUG2 TBP1 TBP7 THP TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ULK3 X Y Y2 Z	Homo sapiens (human)
NOD1/2 Signaling Pathway	Angio-associated migratory cell protein Baculoviral IAP repeat-containing protein 2 Baculoviral IAP repeat-containing protein 3 Caspase recruitment domain-containing protein 9 Caspase-1 Caspase-2 Caspase-4 Caspase-8 Caspase-9 Dual specificity mitogen-activated protein kinase kinase 6 E3 ubiquitin-protein ligase Itchy homolog Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleoprotein Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Tumor necrosis factor alpha-induced protein 3 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14920 O15111 O15264 O43187 O43318 O43353 P0DTC9 P21580 P29466 P42575 P49662 P51617 P52564 P53778 P55211 P61088 Q13404 Q13489 Q13490 Q13685 Q14790 Q15750 Q15759 Q16539 Q8N5C8 Q96J02 Q9H257 Q9HC29 Q9NQC7 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	AAMP API1 API2 BIRC2 BIRC3 BLU CARD15 CARD4 CARD9 CARDIAK CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CROC1 CSBP CSBP1 CSBP2 CSPB1 CYLD CYLD1 ERK6 FIP3 ICH1 ICH2 IKBKB IKBKG IKKA IKKB IL1BC IL1BCE IRAK IRAK1 IRAK2 ITCH KIAA0733 KIAA0849 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK12 MAPK13 MAPK14 MCH5 MCH6 MEK6 MIHB MIHC MKK6 MXI2 N NEDD2 NEMO NOD1 NOD2 OTUD7C PRKM11 PRKM13 PRKMK6 RICK RIP2 RIPK2 RNF48 RNF49 RNF85 SAPK2 SAPK2A SAPK2B SAPK3 SAPK4 SKK3 TAB1 TAB2 TAB3 TAK1 TCF16 TNFAIP3 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Intracellular metabolism of fatty acids regulates insulin secretion	Fatty acid CoA ligase Acsl3 Long-chain-fatty-acid--CoA ligase 4 Platelet glycoprotein 4	O60488 O95573 P16671	ACS3 ACS4 ACSL3 ACSL4 CD36 FACL3 FACL4 GP3B GP4 LACS3 LACS4	Homo sapiens (human)
Nephron development	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Delta-like protein 1 Hepatocyte nuclear factor 1-beta Hepatocyte nuclear factor 4-alpha Iroquois-class homeodomain protein IRX-1 Iroquois-class homeodomain protein IRX-2 LIM/homeobox protein Lhx1 POU domain, class 3, transcription factor 3 Protein Wnt-4 Protein Wnt-9b Protein jagged-1 Wilms tumor protein	O00548 O14905 P19544 P20264 P35680 P41235 P48742 P56705 P78414 P78504 Q8NES3 Q9BZI1	BRN1 DLL1 HNF1B HNF4 HNF4A IRX1 IRX2 IRXA1 IRXA2 JAG1 JAGL1 LFNG LHX1 LIM-1 LIM1 NR2A1 OTF8 POU3F3 TCF14 TCF2 WNT14B WNT15 WNT4 WNT9B WT1	Homo sapiens (human)
RUNX1 regulates transcription of genes involved in interleukin signaling	Core-binding factor subunit beta ETS-related transcription factor Elf-1 Interleukin-3 Leukemia inhibitory factor receptor Runt-related transcription factor 1	P08700 P32519 P42702 Q01196 Q13951	AML1 CBFA2 CBFB ELF1 IL3 LIFR RUNX1	Homo sapiens (human)
Activation of SMO	Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Brother of CDO Casein kinase I isoform alpha Cell adhesion molecule-related/down-regulated by oncogenes Desert hedgehog protein Dynein regulatory complex subunit 4 EF-hand calcium-binding domain-containing protein 7 EvC complex member EVC Growth arrest-specific protein 1 IQ domain-containing protein E Indian hedgehog protein Kinesin-like protein KIF3A Limbin Protein patched homolog 1 Protein smoothened Sonic hedgehog protein	A8K855 O43323 O95995 P25098 P32121 P48729 P49407 P54826 P57679 Q13635 Q14623 Q15465 Q4KMG0 Q6IPM2 Q86UK5 Q99835 Q9BWV1 Q9Y496	ADRBK1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BARK BARK1 BOC CDO CDON CSNK1A1 DHH DRC4 EFCAB7 EVC EVC2 GAS1 GAS11 GAS8 GRK2 IHH IQCE KIAA1023 KIAA1799 KIF3 KIF3A LBN PTCH PTCH1 SHH SMO SMOH	Homo sapiens (human)
Mitochondrial calcium ion transport	A-kinase anchor protein 1, mitochondrial Calcium uniporter protein, mitochondrial Calcium uniporter regulatory subunit MCUb, mitochondrial Calcium uptake protein 1, mitochondrial Calcium uptake protein 2, mitochondrial Calcium uptake protein 3, mitochondrial Essential MCU regulator, mitochondrial Mitochondrial proton/calcium exchanger protein Mitochondrial sodium/calcium exchanger protein Sodium/calcium exchanger 3 Voltage-dependent anion-selective channel protein 1 Voltage-dependent anion-selective channel protein 2 Voltage-dependent anion-selective channel protein 3	O95202 P21796 P45880 P57103 Q6J4K2 Q86XE3 Q8IYU8 Q8NE86 Q92667 Q9BPX6 Q9H4I9 Q9NWR8 Q9Y277	AKAP1 AKAP149 C10orf42 C22orf32 CALC CBARA1 CCDC109A CCDC109B EFHA1 EFHA2 EMRE LETM1 MCU MCUB MICU1 MICU2 MICU3 NCKX6 NCLX NCX3 PRKA1 SLC24A6 SLC8A3 SLC8B1 SMDT1 VDAC VDAC1 VDAC2 VDAC3	Homo sapiens (human)

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