GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1676 - 1700** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲
FCERI mediated NF-kB activation	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 Caspase recruitment domain-containing protein 11 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A IGHV7-81 protein Immunoglobulin heavy constant epsilon Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein kinase C theta type RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 RAS guanyl-releasing protein 4 S-phase kinase-associated protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Transcription factor p65 Tyrosine-protein kinase Lyn UGa8H (Fragment) Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 A5LHX3 O00231 O00232 O00233 O00487 O14818 O14920 O15111 O15530 O43242 O43318 O75832 O95267 O95999 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01854 P04211 P04430 P04432 P04433 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0CG47 P0CG48 P0DOY2 P0DOY3 P17980 P19838 P20618 P23083 P25786 P25787 P25788 P25789 P25963 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49427 P49720 P49721 P51665 P51668 P55036 P60896 P60900 P61088 P61289 P62191 P62195 P62333 P62837 P62979 P62987 P63208 P80748 Q04206 Q04759 Q06323 Q13200 Q13404 Q13616 Q14997 Q15008 Q15750 Q16401 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q7LDG7 Q8N5C8 Q8TAA3 Q8TDF6 Q92530 Q99436 Q99460 Q9BXL7 Q9NYJ8 Q9UDY8 Q9UKB1 Q9UL46 Q9UNM6 Q9Y297 Q9Y4K3 Q9Y6K9	BCL10 BLU BTRC BTRCP BTRCP2 C7orf76 CARD11 CARMA1 CDC25L CDC34 CHUK CIPER CLAP CROC1 CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 HC2 HC3 HC8 HC9 HSPC IFI5111 IGHE IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 IKBA IKBKB IKBKG IKKA IKKB JTK8 KIAA0072 KIAA0077 KIAA0107 KIAA0696 KIAA0733 LMP10 LMP2 LMP7 LMPX LMPY LYN MAD3 MALT1 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MB1 MCB1 MCG7 MECL1 MIP224 MLT MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NU OCP2 PDK1 PDPK1 PFAAP4 POH1 PRKCQ PRKCT PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PUBC1 RASGRP RASGRP1 RASGRP2 RASGRP4 RELA RING10 RING12 RNF85 RPS27A SEM1 SFT SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TAB1 TAB2 TAB3 TAK1 TBP1 TBP7 TCEB1L TCF16 TRAF6 TRAP2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBCEP1 UBCEP2 UBCH3 UBCH4 UBCH5 UBCH5A UBCH5B UBE2D1 UBE2D2 UBE2N UBE2R1 UBE2V UBE2V1 UEV1 V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 X Y Y2 Z	Homo sapiens (human)
PKMTs methylate histone lysines	Actin-histidine N-methyltransferase Activating transcription factor 7-interacting protein 1 Histone H3.1 Histone H3.2 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase ASH1L Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase KMT5B Histone-lysine N-methyltransferase KMT5C Histone-lysine N-methyltransferase MECOM Histone-lysine N-methyltransferase NSD2 Histone-lysine N-methyltransferase NSD3 Histone-lysine N-methyltransferase PRDM16 Histone-lysine N-methyltransferase PRDM9 Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Histone-lysine N-methyltransferase SETD2 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB1 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase SMYD3 Histone-lysine N-methyltransferase SUV39H1 Histone-lysine N-methyltransferase SUV39H2 Histone-lysine N-methyltransferase, H3 lysine-36 specific Histone-lysine N-methyltransferase, H3 lysine-79 specific N-lysine methyltransferase KMT5A N-lysine methyltransferase SETD6 N-lysine methyltransferase SMYD2 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Polycomb protein EED Polycomb protein SUZ12 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Transcription factor p65 WD repeat-containing protein 5 Zinc finger protein AEBP2	O14686 O15047 O43463 O75530 O96028 P19838 P61964 P62805 P68431 Q00653 Q03112 Q03164 Q04206 Q09028 Q15022 Q15047 Q15291 Q15910 Q16576 Q4FZB7 Q6VMQ6 Q6ZN18 Q71DI3 Q86TU7 Q86Y97 Q8NEZ4 Q8TBK2 Q8TEK3 Q8WTS6 Q96KQ7 Q96L73 Q96T68 Q9BYW2 Q9BZ95 Q9C005 Q9H5I1 Q9H7B4 Q9H9B1 Q9HAZ2 Q9NQR1 Q9NQV7 Q9NR48 Q9NRG4 Q9UBL3 Q9UMN6 Q9UPS6	AEBP2 ALL1 ALR ARA267 ASH1L ASH2L ASH2L1 ATF7IP BAT8 BIG3 C13orf4 C14orf154 C6orf30 CHET9 CLLD8 CXXC7 DOT1L DPY30 EED EHMT1 EHMT2 ESET EUHMTASE1 EVI1 EZH2 G9A GLP H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HIF1 HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST4H4 HRX HRX2 HTRX HYPB JJAZ1 KIAA0067 KIAA0160 KIAA0304 KIAA0339 KIAA1076 KIAA1090 KIAA1420 KIAA1506 KIAA1675 KIAA1717 KIAA1732 KIAA1814 KIAA1876 KMT1A KMT1B KMT1C KMT1D KMT1E KMT1F KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G KMT2H KMT3A KMT3B KMT3C KMT4 KMT5A KMT5B KMT5C KMT6 KMT7 LYT10 MCAF MCAF1 MDS1 MECOM MEL1 MLL MLL1 MLL2 MLL3 MLL4 MMSET NFKB1 NFKB2 NFKB3 NG36 NSD1 NSD2 NSD3 PFM13 PFM6 PRDM16 PRDM3 PRDM9 PRSET7 RBAP46 RBAP48 RBBP4 RBBP5 RBBP7 RBQ3 RELA SET07 SET1 SET1A SET1B SET2 SET7 SET8 SET9 SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETD8 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H SUV39H1 SUV39H2 SUV420H1 SUV420H2 SUZ12 TRX1 TRX2 TRX5 WBP7 WDR5 WHSC1 WHSC1L1 ZMYND1 ZNFN3A1	Homo sapiens (human)
Signaling by juxtamembrane domain KIT mutants	Mast/stem cell growth factor receptor Kit	P10721	KIT SCFR	Homo sapiens (human)
Response of EIF2AK1 (HRI) to heme deficiency	Asparagine synthetase [glutamine-hydrolyzing] CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein gamma Cyclic AMP-dependent transcription factor ATF-3 Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-5 DNA damage-inducible transcript 3 protein Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 1 Glutathione-specific gamma-glutamylcyclotransferase 1 Growth factor receptor-bound protein 10 Protein phosphatase 1 regulatory subunit 15A Tribbles homolog 3	O75807 P05198 P08243 P17676 P18847 P18848 P20042 P35638 P41091 P53567 Q13322 Q96RU7 Q9BQI3 Q9BUX1 Q9Y2D1	ASNS ATF3 ATF4 ATF5 ATFX BOTCH C20orf97 CEBPB CEBPG CHAC1 CHOP CHOP10 CREB2 DDIT3 EIF2A EIF2AK1 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GADD153 GADD34 GRB10 GRBIR HRI KIAA0207 KIAA1369 NIPK PPP1R15A SKIP3 TCF5 TRB3 TRIB3 TS11 TXREB	Homo sapiens (human)
Retrograde neurotrophin signalling	AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Beta-nerve growth factor Clathrin heavy chain 1 Clathrin light chain A Dynamin-1 Dynamin-2 Dynamin-3 Dynein axonemal light chain 4 Endophilin-A1 High affinity nerve growth factor receptor	O94973 O95782 O96015 P01138 P04629 P09496 P50570 P53680 P63010 Q00610 Q05193 Q96CW1 Q99962 Q9UQ16	ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLH17 CLTA CLTC CLTCL2 CNSA2 DNAL4 DNM DNM1 DNM2 DNM3 DYN2 HIP9 HYPJ KIAA0034 KIAA0109 KIAA0820 KIAA0899 MTC NGF NGFB NTRK1 SH3D2A SH3GL2 TRK TRKA	Homo sapiens (human)
Chaperone Mediated Autophagy	ADP-ribosylation factor-like protein 13B Centrin-1 Cystic fibrosis transmembrane conductance regulator Elongation factor 1-alpha 1 Glial fibrillary acidic protein Heat shock cognate 71 kDa protein Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Hemoglobin subunit beta Histone deacetylase 6 Intraflagellar transport protein 88 homolog Lysosome-associated membrane glycoprotein 2 Parkinson disease protein 7 Pericentrin Perilipin-2 Perilipin-3 Polyubiquitin-B Polyubiquitin-C Ribonuclease pancreatic Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60664 O95613 P07900 P07998 P08238 P0CG47 P0CG48 P11142 P13473 P13569 P14136 P62979 P62987 P68104 P68871 Q12798 Q13099 Q3SXY8 Q99497 Q99541 Q9UBN7	ABCC7 ADFP ARL13B ARL2L1 CEN1 CETN CETN1 CFTR EEF1A EEF1A1 EF1A GFAP HBB HDAC6 HSC70 HSP73 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPA10 HSPA8 HSPC1 HSPC2 HSPC3 HSPCA HSPCB IFT88 KIAA0402 KIAA0901 LAMP2 LENG7 M6PRBP1 PARK7 PCNT PCNT2 PLIN2 PLIN3 RIB1 RNASE1 RNS1 RPS27A TG737 TIP47 TTC10 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Defective CP causes aceruloplasminemia (ACERULOP)	Ceruloplasmin Solute carrier family 40 member 1	P00450 Q9NP59	CP FPN FPN1 IREG1 SLC11A3 SLC40A1	Homo sapiens (human)
IL-6-type cytokine receptor ligand interactions	Cardiotrophin-1 Cardiotrophin-like cytokine factor 1 Ciliary neurotrophic factor receptor subunit alpha Ciliary neurotrophic factor Cytokine receptor-like factor 1 Interleukin-11 receptor subunit alpha Interleukin-11 Interleukin-31 receptor subunit alpha Interleukin-31 Interleukin-6 receptor subunit beta Leukemia inhibitory factor receptor Leukemia inhibitory factor Non-receptor tyrosine-protein kinase TYK2 Oncostatin-M-specific receptor subunit beta Oncostatin-M Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 O75462 P13725 P15018 P20809 P23458 P26441 P26992 P29597 P40189 P42702 Q14626 Q16619 Q6EBC2 Q8NI17 Q99650 Q9UBD9	BSF3 CLC CLCF1 CNTF CNTFR CRL3 CRLF1 CTF1 GPL HILDA IL11 IL11RA IL31 IL31RA IL6ST JAK1 JAK1A JAK1B JAK2 LIF LIFR NNT1 OSM OSMR OSMRB TYK2	Homo sapiens (human)
Interleukin-9 signaling	Cytokine receptor common subunit gamma Interleukin-9 receptor Interleukin-9 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK3	P15248 P23458 P31785 P40763 P42224 P42229 P51692 P52333 Q01113	APRF IL2RG IL9 IL9R JAK1 JAK1A JAK1B JAK3 STAT1 STAT3 STAT5 STAT5A STAT5B	Homo sapiens (human)
RHO GTPases activate PKNs	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 M-phase inducer phosphatase 3 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Protein phosphatase 1 regulatory subunit 14A Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14950 O14974 O15530 O60237 P08134 P24844 P27348 P30307 P31946 P31947 P35579 P35580 P35749 P60660 P61586 P61981 P62140 P62258 P62745 P63000 P63104 Q04917 Q13153 Q16512 Q16513 Q6P5Z2 Q7Z406 Q96A00	ARH12 ARH6 ARH9 ARHA ARHB ARHC CDC25C CPI17 HME1 KIAA0866 KIAA2034 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PAK1 PDK1 PDPK1 PKN PKN1 PKN2 PKN3 PKNBETA PPP1CB PPP1INL PPP1R12A PPP1R12B PPP1R14A PRK1 PRK2 PRKCL1 PRKCL2 RAC1 RHO12 RHOA RHOB RHOC SFN TC25 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Activated NTRK2 signals through RAS	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor GTPase HRas GTPase NRas Neurotrophin-4 Son of sevenless homolog 1	P01111 P01112 P23560 P34130 Q07889 Q16620	BDNF HRAS HRAS1 NRAS NTF4 NTF5 NTRK2 SOS1 TRKB	Homo sapiens (human)
Phase 1 - inactivation of fast Na+ channels	Calsenilin Kv channel-interacting protein 1 Kv channel-interacting protein 2 Kv channel-interacting protein 4 Potassium voltage-gated channel subfamily D member 1 Potassium voltage-gated channel subfamily D member 2 Potassium voltage-gated channel subfamily D member 3	Q6PIL6 Q9NS61 Q9NSA2 Q9NZI2 Q9NZV8 Q9UK17 Q9Y2W7	CALP CSEN DREAM KCHIP1 KCHIP2 KCHIP3 KCHIP4 KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 KCNIP4 KIAA1044 VABP	Homo sapiens (human)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Nef and signal transduction	Dedicator of cytokinesis protein 2 Engulfment and cell motility protein 1 Protein Nef Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 2 Tyrosine-protein kinase Fyn Tyrosine-protein kinase HCK Tyrosine-protein kinase Lck	P04601 P06239 P06241 P08631 P63000 Q13177 Q92556 Q92608	DOCK2 ELMO1 FYN HCK KIAA0209 KIAA0281 LCK PAK2 RAC1 TC25 nef	Homo sapiens (human)
Metal sequestration by antimicrobial proteins	Lactotransferrin Neutrophil gelatinase-associated lipocalin Protein S100-A7 Protein S100-A7A Protein S100-A8 Protein S100-A9	P02788 P05109 P06702 P31151 P80188 Q86SG5	CAGA CAGB CFAG GIG12 HNL LCN2 LF LTF MRP14 MRP8 NGAL PSOR1 S100A15 S100A7 S100A7A S100A7C S100A7L1 S100A8 S100A9	Homo sapiens (human)
Defective LARGE causes MDDGA6 and MDDGB6	Beta-1,4-glucuronyltransferase 1 Xylosyl- and glucuronyltransferase LARGE1	O43505 O95461	B3GNT1 B3GNT6 B4GAT1 KIAA0609 LARGE LARGE1	Homo sapiens (human)
Switching of origins to a post-replicative state	DNA replication factor Cdt1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 Geminin	O75496 P25205 P33991 P33992 P33993 P49736 Q14566 Q9H211	BM28 CCNL1 CDC21 CDC46 CDC47 CDCL1 CDT1 GMNN KIAA0030 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7	Homo sapiens (human)
Cyclin E associated events during G1/S transition	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Histone-binding protein RBBP4 M-phase inducer phosphatase 1 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	O96020 P01106 P06400 P24864 P24941 P30291 P30304 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCNE CCNE1 CCNE2 CCNH CDC25A CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27	Homo sapiens (human)
Metabolism of polyamines	Ornithine decarboxylase S-adenosylmethionine decarboxylase proenzyme Spermidine synthase Spermine synthase	P11926 P17707 P19623 P52788	AMD AMD1 ODC1 SMS SPS1 SRM SRML1	Homo sapiens (human)
MET activates STAT3	Hepatocyte growth factor receptor Hepatocyte growth factor Signal transducer and activator of transcription 3	P08581 P14210 P40763	APRF HGF HPTA MET STAT3	Homo sapiens (human)
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	Zinc transporter ZIP4	Q6P5W5	SLC39A4 ZIP4	Homo sapiens (human)
Defective binding of VWF variant to GPIb:IX:V	Platelet glycoprotein IX Platelet glycoprotein Ib alpha chain Platelet glycoprotein Ib beta chain Platelet glycoprotein V von Willebrand factor	P04275 P07359 P13224 P14770 P40197	F8VWF GP1BA GP1BB GP5 GP9 VWF	Homo sapiens (human)
Defective ABCB6 causes MCOPCB7	ATP-binding cassette sub-family B member 6	Q9NP58	ABCB6 MTABC3 PRP UMAT	Homo sapiens (human)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Acetylcholine inhibits contraction of outer hair cells	Calcium-activated potassium channel subunit alpha-1 Calcium-activated potassium channel subunit beta-1 Neuronal acetylcholine receptor subunit alpha-10 Neuronal acetylcholine receptor subunit alpha-9 Small conductance calcium-activated potassium channel protein 2	Q12791 Q16558 Q9GZZ6 Q9H2S1 Q9UGM1	CHRNA10 CHRNA9 KCNMA KCNMA1 KCNMB1 KCNN2 NACHRA10 NACHRA9 SLO	Homo sapiens (human)

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