GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **526 - 550** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol
GRB2 events in ERBB2 signaling	Epidermal growth factor receptor GTPase HRas GTPase NRas Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Son of sevenless homolog 1	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK SMDF SOS1
Signaling by ERBB2	Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Yes	O14511 O14944 P00533 P01133 P04626 P06241 P07900 P07947 P12931 P35070 P56975 Q02297 Q16543 Q8WWG1 Q96RT1 Q99075	BTC CDC37 CDC37A DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG FYN GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK SMDF SRC SRC1 YES YES1
Downregulation of ERBB2 signaling	Cullin-5 E3 ubiquitin-protein ligase CHIP Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Megakaryocyte-associated tyrosine-protein kinase Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 18 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 O14944 P00533 P01133 P04626 P07900 P0CG47 P0CG48 P35070 P42679 P56975 P62979 P62987 Q02297 Q05209 Q16543 Q8WWG1 Q93034 Q96RT1 Q99075 Q99952 Q9UNE7	BDP1 BTC CDC37 CDC37A CHIP CTK CUL5 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA HYL KIAA1225 LAP2 MATK MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTPN12 PTPN18 RPS27A SMDF STUB1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VACM1
PI3K events in ERBB2 signaling	Epidermal growth factor receptor GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P27986 P35070 P42336 P56975 Q02297 Q13480 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF
ERBB2 Activates PTK6 Signaling	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein-tyrosine kinase 6 Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P35070 P56975 Q02297 Q13882 Q8WWG1 Q99075	BRK BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTK6 SMDF
Signaling by ERBB4	Disks large homolog 4 Epidermal growth factor receptor Gamma-aminobutyric acid receptor subunit alpha-1 Gamma-aminobutyric acid receptor subunit beta-1 Gamma-aminobutyric acid receptor subunit beta-2 Gamma-aminobutyric acid receptor subunit beta-3 Gamma-aminobutyric acid receptor subunit gamma-2 Gamma-aminobutyric acid receptor subunit gamma-3 Gamma-aminobutyric acid receptor subunit theta Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P00533 P01133 P14867 P18505 P18507 P28472 P35070 P47870 P56975 P78352 Q02297 Q8WWG1 Q99075 Q99928 Q9UN88	BTC DLG4 DTR DTS EGF EGFR ERBB ERBB1 EREG GABRA1 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GGF HBEGF HEGFL HER1 HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PSD95 SMDF
SHC1 events in ERBB4 signaling	GTPase HRas GTPase NRas Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P01111 P01112 P29353 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EREG GGF HBEGF HEGFL HGL HRAS HRAS1 HRGA NDF NRAS NRG1 NRG2 NRG3 NRG4 NTAK SHC SHC1 SHCA SMDF SOS1
PI3K events in ERBB4 signaling	Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P27986 P35070 P42336 P56975 Q02297 Q8WWG1 Q99075	BTC DTR DTS EREG GGF GRB1 HBEGF HEGFL HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8
GRB7 events in ERBB2 signaling	Growth factor receptor-bound protein 7 Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Receptor tyrosine-protein kinase erbB-2	O14511 P04626 Q02297 Q14451	ERBB2 GGF GRB7 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NTAK SMDF
Passive transport by Aquaporins	Aquaporin-10 Aquaporin-11 Aquaporin-12A Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Aquaporin-5 Aquaporin-6 Aquaporin-7 Aquaporin-8 Aquaporin-9 Lens fiber major intrinsic protein	O14520 O43315 O94778 P29972 P30301 P41181 P55064 P55087 Q13520 Q8IXF9 Q8NBQ7 Q92482 Q96PS8	AQP0 AQP1 AQP10 AQP11 AQP12 AQP12A AQP2 AQP2L AQP3 AQP4 AQP5 AQP6 AQP7 AQP7L AQP8 AQP9 AQPX1 AQPX2 CHIP28 MIP SSC1
Citric acid cycle (TCA cycle)	Aconitate hydratase, mitochondrial Citrate synthase, mitochondrial Fumarate hydratase, mitochondrial Heat shock protein 75 kDa, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Malate dehydrogenase, mitochondrial NAD(P) transhydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	O14521 O43837 O75390 P07954 P21912 P31040 P40926 P48735 P50213 P51553 P53597 Q12931 Q13423 Q96I99 Q99643 Q99798 Q9P2R7	ACO2 CS CYB560 FH HSP75 HSPC5 IDH2 IDH3A IDH3B IDH3G MDH2 NNT SDH SDH1 SDH2 SDH3 SDH4 SDHA SDHB SDHC SDHD SDHF SUCLA2 SUCLG1 SUCLG2 TRAP1
Cargo recognition for clathrin-mediated endocytosis	AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma AP2-associated protein kinase 1 Adaptin ear-binding coat-associated protein 1 Adaptin ear-binding coat-associated protein 2 Amphiregulin Apolipoprotein B-100 Arf-GAP domain and FG repeat-containing protein 1 Beta-2 adrenergic receptor Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7b COP9 signalosome complex subunit 8 Cation-dependent mannose-6-phosphate receptor Cation-independent mannose-6-phosphate receptor Clathrin coat assembly protein AP180 Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Cystic fibrosis transmembrane conductance regulator Disabled homolog 2 Dyslexia-associated protein KIAA0319 E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Epsin-2 F-BAR domain only protein 1 F-BAR domain only protein 2 Frizzled-4 G protein-coupled receptor kinase 3 Hepatocyte growth factor-regulated tyrosine kinase substrate Interleukin-7 receptor subunit alpha Intersectin-1 Intersectin-2 Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Low-density lipoprotein receptor Lysosome membrane protein 2 Muscarinic acetylcholine receptor M2 NEDD8 Phosphatidylinositol-binding clathrin assembly protein Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein Wnt-5a Protransforming growth factor alpha RalBP1-associated Eps domain-containing protein 1 RalBP1-associated Eps domain-containing protein 2 SH3 domain-containing kinase-binding protein 1 SH3-containing GRB2-like protein 3-interacting protein 1 Segment polarity protein dishevelled homolog DVL-2 Serotransferrin Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Solute carrier family 2, facilitated glucose transporter member 8 Stonin-1 Stonin-2 Substance-P receptor Synaptotagmin-11 Synaptotagmin-1 Synaptotagmin-2 Synaptotagmin-8 Synaptotagmin-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Torsin-1A Torsin-1B Trans-Golgi network integral membrane protein 2 Transferrin receptor protein 1 Type-1 angiotensin II receptor Ubiquilin-1 Ubiquilin-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 Vesicular acetylcholine transporter	O14526 O14641 O14656 O14657 O14944 O14964 O43493 O60641 O75379 O75886 O94973 O95208 O95782 P00533 P01130 P01133 P01135 P01185 P01730 P02786 P02787 P04114 P04234 P07550 P08172 P09496 P09497 P09693 P0CG47 P0CG48 P11717 P13569 P15514 P16871 P20645 P21579 P22681 P25098 P25103 P30518 P30556 P32121 P35070 P35626 P41221 P42566 P49407 P51809 P52594 P53675 P53680 P61201 P62979 P62987 P63010 P63027 P98082 P98164 Q00610 Q0JRZ9 Q13098 Q13492 Q14108 Q15811 Q15836 Q15843 Q16572 Q2M2I8 Q5SW96 Q5VV43 Q6UW88 Q7L5N1 Q86SS6 Q8N9I0 Q8NBV8 Q8NC96 Q8NFH8 Q8WXE9 Q92783 Q92905 Q96B97 Q96CW1 Q96D71 Q99075 Q99627 Q99961 Q99962 Q99963 Q9BQI5 Q9BT78 Q9BT88 Q9BV40 Q9H9Q2 Q9NVZ3 Q9NY64 Q9NZM3 Q9UBC2 Q9UBW8 Q9UHD9 Q9ULV1 Q9UMX0 Q9UNS2 Q9Y6I3 Q9Y6Q2	AAK1 ABCC7 ADHR ADRB2 ADRB2R ADRBK1 ADRBK2 ADTAA ADTAB ADTB2 AF1P AGFG1 AGTR1 AGTR1A AGTR1B AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB ARB2 AREG AREGB ARH ARR1 ARR2 ARRB1 ARRB2 ARVP AT2R1 AT2R1B AVP AVPR2 B2AR BARK BARK1 BARK2 BTC CALM CBL CBL2 CD36L2 CD3D CD3G CD4 CFTR CHRM2 CIN85 CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD CNSA1 CNSA2 CNSA3 COPS1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSN1 CSN2 CSN3 CSN4 CSN5 CSN6 CSN7A CSN7B CSN8 DA41 DAB2 DERP10 DIR DIR3 DOC2 DQ1 DQ2 DTR DTS DVL2 DYT1 EGF EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG FCHO1 FCHO2 FZD4 GLUT8 GLUTX1 GPS1 GRK2 GRK3 HBEGF HBP HEGFL HER1 HGS HIP9 HRB HRS HVIP HYPJ IGF2R IL7R ITSN ITSN1 ITSN2 JAB1 KIAA0034 KIAA0080 KIAA0109 KIAA0290 KIAA0319 KIAA0656 KIAA0899 KIAA1048 KIAA1065 KIAA1256 LDLR LDLRAP1 LIMP2 LIMPII LRP2 M6PR MPR46 MPRD MPRI N4BP4 NECAP1 NECAP2 NEDD8 NK1R PICALM PLIC1 PLIC2 POB1 RAB REPS1 REPS2 RIP RNF55 RPS27A SALF SBLF SCARB2 SDGF SGIP1 SH3D1A SH3D1B SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SLC18A3 SLC2A8 SNAP91 STAM STAM1 STAM2 STN1 STN2 STNB STON1 STON2 SVP65 SWAP SYB2 SYB3 SYBL1 SYT SYT1 SYT11 SYT2 SYT8 SYT9 T3D T3G TA TAC1R TACR1 TF TFRC TGFA TGN46 TGN51 TGOLN2 TOR1A TOR1B TORA TRIP15 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBQLN1 UBQLN2 V2R VACHT VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VP WNT5A
CRMPs in Sema3A signaling	Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 Dihydropyrimidinase-related protein 1 Dihydropyrimidinase-related protein 2 Dihydropyrimidinase-related protein 3 Dihydropyrimidinase-related protein 4 Dihydropyrimidinase-related protein 5 Glycogen synthase kinase-3 beta Neuropilin-1 Plexin-A1 Plexin-A2 Plexin-A3 Plexin-A4 Semaphorin-3A Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn	O14531 O14786 O75051 P06241 P07332 P49841 P51805 Q00535 Q14194 Q14195 Q14563 Q15078 Q16555 Q9BPU6 Q9HCM2 Q9UIW2	CDK5 CDK5R CDK5R1 CDKN5 CRMP1 CRMP2 CRMP3 CRMP4 CRMP5 DPYSL1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 DRP3 FES FPS FYN GSK3B KIAA0463 KIAA1550 NCK5A NOV NRP NRP1 OCT PLXN1 PLXN2 PLXN4 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNA4A PLXNA4B PSSALRE SEMA3A SEMAD SEX ULIP ULIP1 ULIP2 ULIP3 ULIP4 ULIP6 VEGF165R
Interferon alpha/beta signaling	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 2 2'-5'-oligoadenylate synthase 3 2'-5'-oligoadenylate synthase-like protein 2-5A-dependent ribonuclease ATP-binding cassette sub-family E member 1 Bone marrow stromal antigen 2 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Double-stranded RNA-specific adenosine deaminase Early growth response protein 1 Guanylate-binding protein 2 HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G Importin subunit alpha-5 Importin subunit beta-1 Inositol hexakisphosphate kinase 2 Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon alpha-inducible protein 27, mitochondrial Interferon alpha-inducible protein 6 Interferon alpha/beta receptor 1 Interferon beta Interferon regulatory factor 1 Interferon regulatory factor 2 Interferon regulatory factor 3 Interferon regulatory factor 4 Interferon regulatory factor 5 Interferon regulatory factor 6 Interferon regulatory factor 7 Interferon regulatory factor 8 Interferon regulatory factor 9 Interferon-induced 35 kDa protein Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx2 Interferon-induced protein with tetratricopeptide repeats 1 Interferon-induced protein with tetratricopeptide repeats 2 Interferon-induced protein with tetratricopeptide repeats 3 Interferon-induced protein with tetratricopeptide repeats 5 Interferon-induced transmembrane protein 1 Interferon-induced transmembrane protein 2 Interferon-induced transmembrane protein 3 Interferon-induced, double-stranded RNA-activated protein kinase Interferon-stimulated gene 20 kDa protein Non-receptor tyrosine-protein kinase TYK2 Nucleoprotein Polyubiquitin-B Polyubiquitin-C Proteasome subunit beta type-8 Putative HLA class I histocompatibility antigen, alpha chain H S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6 Ubiquitin-like protein ISG15 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein XIAP-associated factor 1	O14543 O14879 O14896 O15524 P00973 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P01889 P01893 P04439 P05013 P05014 P05015 P05161 P09912 P09913 P09914 P0CG47 P0CG48 P0DTC9 P10321 P10914 P13164 P13747 P14316 P17181 P17693 P18146 P19525 P20591 P20592 P23458 P28062 P29350 P29597 P29728 P30511 P32456 P32881 P40305 P42224 P52294 P52630 P55265 P61221 P62979 P62987 P80217 Q00978 Q01628 Q01629 Q02556 Q05823 Q06124 Q10589 Q13325 Q13568 Q14653 Q14974 Q15306 Q15646 Q6GPH4 Q8WXG1 Q92985 Q96AZ6 Q9UHH9 Q9Y3Z3 Q9Y6K5	ABCE1 ADAR ADAR1 BIRC4BP BST2 CD225 CIG-42 CIG-49 CIG5 CIS3 DSRAD EGR1 EIF2AK2 G10P1 G10P2 G1P1 G1P2 G1P3 GBP2 HCP HEM45 HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH ICSBP1 IFB IFI17 IFI27 IFI35 IFI4 IFI54 IFI56 IFI6 IFI60 IFIT1 IFIT2 IFIT3 IFIT4 IFIT5 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAI1 IFNAR IFNAR1 IFNB IFNB1 IFP35 IHPK2 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 ISG54 ISG56 ISG58 ISG60 ISGF3G JAK1 JAK1A JAK1B KPNA1 KPNB1 KROX24 LMP7 MOP5 MUM1 MX1 MX2 N NTF97 OAS1 OAS2 OAS3 OASL OIAS PKR PRKR PSMB5i PSMB8 PTP1C PTP2C PTPN11 PTPN6 RCH2 RI58 RING10 RLI RNASEL RNASEL1 RNASELI RNS4 RNS4I RPS27A RSAD2 SAMHD1 SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT2 TIP3 TRIP14 TYK2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCRP XAF1 XIAPAF1 Y2 ZNF225
Regulation of IFNG signaling	E3 SUMO-protein ligase PIAS1 Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Small ubiquitin-related modifier 1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6	O14543 O15524 O60674 O75925 P01579 P15260 P18031 P23458 P29350 P38484 P63165 Q06124	CIS3 DDXBP1 HCP IFNG IFNGR1 IFNGR2 IFNGT1 JAK1 JAK1A JAK1B JAK2 PIAS1 PTP1B PTP1C PTP2C PTPN1 PTPN11 PTPN6 SHPTP2 SMT3C SMT3H3 SOCS1 SOCS3 SSI1 SSI3 SUMO1 TIP3 UBL1
Signaling by CSF3 (G-CSF)	GRB2-associated-binding protein 2 GTPase KRas Granulocyte colony-stimulating factor receptor Granulocyte colony-stimulating factor Growth factor receptor-bound protein 2 Non-receptor tyrosine-protein kinase TYK2 SHC-transforming protein 1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase HCK Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 11	O14543 O15524 O60674 P01116 P07948 P08631 P09919 P23458 P29353 P29597 P40763 P42224 P42229 P43405 P51692 P62993 Q06124 Q99062 Q9UQC2	APRF ASH C17orf33 CIS3 CSF3 CSF3R GAB2 GCSF GCSFR GRB2 HCK JAK1 JAK1A JAK1B JAK2 JTK8 KIAA0571 KRAS KRAS2 LYN PTP2C PTPN11 RASK2 SHC SHC1 SHCA SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B SYK TIP3 TYK2
Inactivation of CSF3 (G-CSF) signaling	Cullin-5 Elongin-B Elongin-C Granulocyte colony-stimulating factor receptor Granulocyte colony-stimulating factor Non-receptor tyrosine-protein kinase TYK2 Polyubiquitin-B Polyubiquitin-C RING-box protein 2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase HCK Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14543 O15524 O60674 P07948 P08631 P09919 P0CG47 P0CG48 P23458 P29597 P40763 P42224 P42229 P43405 P51668 P51692 P61077 P62837 P62979 P62987 Q15369 Q15370 Q93034 Q99062 Q9UBF6	APRF C17orf33 CIS3 CSF3 CSF3R CUL5 ELOB ELOC GCSF GCSFR HCK JAK1 JAK1A JAK1B JAK2 JTK8 LYN PUBC1 RBX2 RNF7 ROC2 RPS27A SAG SFT SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B SYK TCEB1 TCEB2 TIP3 TYK2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBE2D1 UBE2D2 UBE2D3 VACM1
Regulation of IFNA/IFNB signaling	Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon alpha/beta receptor 1 Interferon beta Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 2 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6 Ubl carboxyl-terminal hydrolase 18	O14543 O15524 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P05013 P05014 P05015 P17181 P18031 P23458 P29350 P29597 P32881 P52630 Q06124 Q9UMW8	CIS3 HCP IFB IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR IFNAR1 IFNB IFNB1 ISG43 JAK1 JAK1A JAK1B PTP1B PTP1C PTP2C PTPN1 PTPN11 PTPN6 SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT2 TIP3 TYK2 USP18
Interleukin-6 signaling	E3 ubiquitin-protein ligase CBL Interleukin-6 receptor subunit alpha Interleukin-6 receptor subunit beta Interleukin-6 Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O14543 O60674 P05231 P08887 P22681 P23458 P29597 P40189 P40763 P42224 Q06124	APRF CBL CBL2 CIS3 IFNB2 IL6 IL6R IL6ST JAK1 JAK1A JAK1B JAK2 PTP2C PTPN11 RNF55 SHPTP2 SOCS3 SSI3 STAT1 STAT3 TYK2
Signaling by Leptin	Insulin receptor substrate 1 Insulin receptor substrate 2 Leptin Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O14543 O60674 P35568 P40763 P41159 P42229 P51692 Q06124 Q9Y4H2	APRF CIS3 IRS1 IRS2 JAK2 LEP OB OBS PTP2C PTPN11 SHPTP2 SOCS3 SSI3 STAT3 STAT5 STAT5A STAT5B
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Cathepsin K Cathepsin L2 Core-binding factor subunit beta Procathepsin L Runt-related transcription factor 1 Serpin B13 Suppressor of cytokine signaling 3 Suppressor of cytokine signaling 4	O14543 O60911 P07711 P43235 Q01196 Q13951 Q8WXH5 Q9UIV8	AML1 CATL2 CBFA2 CBFB CIS3 CTSK CTSL CTSL1 CTSL2 CTSO CTSO2 CTSU CTSV PI13 RUNX1 SERPINB13 SOCS3 SOCS4 SOCS7 SSI3
PTK6 Activates STAT3	Protein-tyrosine kinase 6 Signal transducer and activator of transcription 3 Signal-transducing adaptor protein 2 Suppressor of cytokine signaling 3	O14543 P40763 Q13882 Q9UGK3	APRF BKS BRK CIS3 PTK6 SOCS3 SSI3 STAP2 STAT3
Aggrephagy	ADP-ribosylation factor-like protein 13B Centrin-1 Cystic fibrosis transmembrane conductance regulator Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 ubiquitin-protein ligase parkin Heat shock factor protein 1 Heat shock protein HSP 90-alpha Histone deacetylase 6 Intraflagellar transport protein 88 homolog Parkinson disease protein 7 Pericentrin Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14576 O43237 O60260 O95613 P07900 P0CG47 P0CG48 P13569 P55072 P61088 P62979 P62987 P63167 Q00613 Q12798 Q13099 Q13404 Q13409 Q14204 Q3SXY8 Q96FJ2 Q99497 Q9UBN7 Q9Y6G9	ABCC7 ARL13B ARL2L1 BLU CEN1 CETN CETN1 CFTR CROC1 DHC1 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HDAC6 HDLC1 HEL-220 HEL-S-70 HSF1 HSP90A HSP90AA1 HSPC1 HSPCA HSTF1 IFT88 KIAA0325 KIAA0402 KIAA0901 LIC2 PARK2 PARK7 PCNT PCNT2 PRKN RPS27A TG737 TTC10 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBE2N UBE2V UBE2V1 UEV1 VCP
RHO GTPases activate CIT	Citron Rho-interacting kinase Cyclin-dependent kinase inhibitor 1B Disks large homolog 4 Kinesin-like protein KIF14 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Protein regulator of cytokinesis 1 Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14578 O14950 O14974 O43663 O60237 P08134 P24844 P35579 P35580 P35749 P46527 P60660 P61586 P62140 P62745 P63000 P78352 Q15058 Q7Z406	ARH12 ARH6 ARH9 ARHA ARHB ARHC CDKN1B CIT CRIK DLG4 KIAA0042 KIAA0866 KIAA0949 KIAA2034 KIF14 KIP1 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PPP1CB PPP1R12A PPP1R12B PRC1 PSD95 RAC1 RHO12 RHOA RHOB RHOC STK21 TC25 p27

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