Negative regulation of the PI3K/AKT network
|
|
|
- AKT1
- AKT2
- AKT3
- C20orf97
- CTMP
- KIAA0606
- KIAA0931
- MMAC1
- NIPK
- PHLPP
- PHLPP1
- PHLPP2
- PHLPPL
- PKB
- PKBG
- PLEKHE1
- PTEN
- RAC
- SCOP
- SKIP3
- TEP1
- THEM4
- TRB3
- TRIB3
|
|
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
|
|
|
- AP2TF
- C18orf5
- FOR
- KCTD1
- KCTD15
- SDR41C1
- SMT3C
- SMT3H3
- SUMO1
- TFAP2
- TFAP2A
- TFAP2B
- TFAP2BL1
- TFAP2C
- TFAP2D
- TFAP2E
- UBC9
- UBCE9
- UBE2I
- UBL1
- WOX1
- WWOX
|
|
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
|
|
|
- DKK1
- DKK2
- DKK4
- FRP
- FRP1
- FRP2
- KREMEN
- KREMEN1
- KREMEN2
- KRM1
- KRM2
- LR3
- LRP5
- LRP6
- LRP7
- SARP1
- SARP2
- SFRP1
- SFRP2
- SOST
- WIF1
- WNT14
- WNT3A
- WNT4
- WNT5A
- WNT9A
|
|
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
|
|
|
- CCDC88C
- CXXC4
- DAPLE
- DVL1
- DVL2
- DVL3
- IDAX
- KIAA0208
- KIAA1509
|
|
Negative regulation of NOTCH4 signaling
|
|
|
- AKT1
- C7orf76
- CUL1
- DSS1
- EMC19
- ERIC1
- HC2
- HC3
- HC8
- HC9
- HSPC
- IFI5111
- INT3
- KIAA0072
- KIAA0107
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MB1
- MCB1
- MECL1
- MIP224
- MOV34L
- MSS1
- NOTCH4
- NU
- OCP2
- PFAAP4
- PKB
- POH1
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSMF1
- RAC
- RBX1
- RING10
- RING12
- RNF75
- ROC1
- RPS27A
- SEM1
- SHFDG1
- SHFM1
- SKP1
- SKP1A
- SUG1
- SUG2
- TACC3
- TBP1
- TBP7
- TCEB1L
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- X
- Y
- Y2
- YWHAZ
- Z
|
|
Negative regulation of NMDA receptor-mediated neuronal transmission
|
|
|
- ACTN2
- CALM
- CALM1
- CAM
- CAM1
- CAM2
- CAMK
- CAMK-GR
- CAMK-II
- CAMK1
- CAMK2
- CAMK2A
- CAMK2B
- CAMK2D
- CAMK2G
- CAMK4
- CAMKA
- CAMKB
- CAMKD
- CAMKG
- CAMKIV
- CAMKN
- DLG1
- DLG2
- DLG3
- DLG4
- GRIN1
- GRIN2A
- GRIN2B
- GRIN2C
- GRIN2D
- GluN2D
- KIAA0015
- KIAA0968
- KIAA1072
- KIAA1232
- KIAA1365
- LAP1
- LRRC7
- NEFL
- NF68
- NFL
- NMDAR1
- NMDAR2A
- NMDAR2B
- NMDAR2C
- NMDAR2D
- POPX1
- POPX2
- PPM1E
- PPM1F
- PSD95
|
|
Negative regulation of MET activity
|
|
|
- AF1P
- CBL
- CBL2
- CIN85
- CNSA1
- CNSA2
- CNSA3
- DEP1
- EPS15
- HBP
- HGF
- HGS
- HPTA
- HRS
- KIAA0055
- LIG1
- LRIG1
- MET
- PTP1B
- PTPN1
- PTPN2
- PTPRJ
- PTPT
- RNF55
- RPS27A
- SH3D2A
- SH3D2B
- SH3D2C
- SH3GL1
- SH3GL2
- SH3GL3
- SH3KBP1
- STAM
- STAM1
- STAM2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBPY
- USP8
|
|
Negative regulation of MAPK pathway
|
|
|
- ARAF
- ARAF1
- BRAF
- BRAF1
- BRAP
- C11orf81
- CL100
- CTAK1
- DUSP1
- DUSP10
- DUSP16
- DUSP2
- DUSP4
- DUSP5
- DUSP6
- DUSP7
- DUSP8
- DUSP9
- EMK2
- ERK1
- ERK2
- ERK6
- HRAS
- HRAS1
- KIAA0044
- KIAA1700
- KSR
- KSR1
- MAPK1
- MAPK12
- MAPK3
- MARK3
- MKP1
- MKP2
- MKP3
- MKP4
- MKP5
- MKP7
- NRAS
- PAC1
- PAQR3
- PBP
- PEBP
- PEBP1
- PKS
- PKS2
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- PPP5
- PPP5C
- PRKM1
- PRKM2
- PRKM3
- PTPH1
- PTPN10
- PTPN3
- PTPN7
- PYST1
- PYST2
- RAF
- RAF1
- RAFB1
- RNF52
- RPS27A
- SAPK3
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VH1
- VH2
- VH3
- VH5
- YWHAB
|
|
Negative regulation of FLT3
|
|
|
- ABL2
- ABLL
- ARG
- C20orf156
- CBL
- CBL2
- CD135
- CIS2
- CIS4
- CSK
- DEP1
- FLK2
- FLT3
- FLT3LG
- LNK
- PTPRJ
- RNF55
- RPS27A
- SH2B3
- SLA
- SLA2
- SLAP
- SLAP1
- SLAP2
- SOCS2
- SOCS4
- SOCS6
- SSI2
- STATI2
- STK1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Negative regulation of FGFR4 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- TKF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Negative regulation of FGFR3 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HSTF1
- HYPF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Negative regulation of FGFR2 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Negative regulation of FGFR1 signaling
|
|
|
- ADMLX
- ANOS1
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF10
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KAL
- KAL1
- KALIG1
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Negative feedback regulation of MAPK pathway
|
|
|
- BRAF
- BRAF1
- ERK1
- ERK2
- MAP2K1
- MAP2K2
- MAPK1
- MAPK3
- MEK1
- MEK2
- MKK2
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
- RAF
- RAF1
- RAFB1
|
|
Nef mediated downregulation of MHC class I complex cell surface expression
|
|
|
- ADTB1
- ADTG
- AP19
- AP1B1
- AP1G1
- AP1M1
- AP1M2
- AP1S1
- AP1S2
- AP1S3
- B2M
- BAM22
- CLAPB2
- CLAPG1
- CLAPS1
- CLTNM
- HLA-A
- HLAA
- KIAA1175
- PACS1
- nef
|
|
Nef mediated downregulation of CD28 cell surface expression
|
|
|
- AP2M1
- CD28
- CLAPM1
- KIAA0109
- nef
|
|
Nef and signal transduction
|
|
|
- DOCK2
- ELMO1
- FYN
- HCK
- KIAA0209
- KIAA0281
- LCK
- PAK2
- RAC1
- TC25
- nef
|
|
Nef Mediated CD8 Down-regulation
|
|
|
- ADTAA
- ADTAB
- ADTB2
- AP17
- AP2A1
- AP2A2
- AP2B1
- AP2M1
- AP2S1
- ATP6V1H
- CD8B
- CD8B1
- CLAPA1
- CLAPA2
- CLAPB1
- CLAPM1
- CLAPS2
- HIP9
- HYPJ
- KIAA0109
- KIAA0899
- nef
|
|
Nef Mediated CD4 Down-regulation
|
|
|
- ADTAA
- ADTAB
- ADTB2
- AP17
- AP2A1
- AP2A2
- AP2B1
- AP2M1
- AP2S1
- ARF1
- ATP6V1H
- CD4
- CLAPA1
- CLAPA2
- CLAPB1
- CLAPM1
- CLAPS2
- HIP9
- HYPJ
- KIAA0109
- KIAA0899
- LCK
- nef
|
|
Neddylation
|
|
|
- AMER1
- ANKRD9
- API4
- APPBP1
- ASB1
- ASB10
- ASB11
- ASB12
- ASB13
- ASB14
- ASB15
- ASB16
- ASB17
- ASB18
- ASB2
- ASB3
- ASB4
- ASB5
- ASB6
- ASB7
- ASB8
- ASB9
- BCRG2
- BDPL
- BHLHE17
- BHLHE73
- BHLHE78
- BIG3
- BIRC5
- BKLHD2
- BRCA1
- BTBD1
- BTBD6
- BTRC
- BTRCP
- BTRCP2
- BUP
- C10orf8
- C13orf17
- C15orf1
- C16orf22
- C16orf31
- C19orf58
- C1orf166
- C20orf163
- C20orf92
- C2orf37
- C2orf5
- C4orf30
- C7orf76
- CAND1
- CAP20
- CCDC22
- CCDC8
- CCNF
- CDKN1
- CDKN1A
- CDT2
- CDW1
- CIP1
- CIS2
- CIS3
- CIS4
- CIS6
- CISH
- CISH5
- CISH6
- CKN1
- COMMD1
- COMMD10
- COMMD2
- COMMD3
- COMMD4
- COMMD5
- COMMD6
- COMMD7
- COMMD8
- COMMD9
- COP1
- COPS1
- COPS2
- COPS3
- COPS4
- COPS5
- COPS6
- COPS7A
- COPS7B
- COPS8
- CSA
- CSN1
- CSN2
- CSN3
- CSN4
- CSN5
- CSN6
- CSN7A
- CSN7B
- CSN8
- CUL1
- CUL2
- CUL3
- CUL4A
- CUL4B
- CUL5
- CUL7
- CUL9
- CXorf37
- DCAF10
- DCAF11
- DCAF13
- DCAF16
- DCAF17
- DCAF2
- DCAF4
- DCAF5
- DCAF6
- DCAF7
- DCAF8
- DCN1
- DCUN1D1
- DCUN1D2
- DCUN1D3
- DCUN1D4
- DCUN1D5
- DCUN1L1
- DCUN1L2
- DDA1
- DDB1
- DDB2
- DEN1
- DERP10
- DPP3
- DRC6
- DSS1
- DTL
- ELOB
- ELOC
- EMC19
- ENC2
- EPAS1
- EPRAP
- ERCC8
- F1AA
- FAM123B
- FANCN
- FAT10
- FBG2
- FBG3
- FBG4
- FBG5
- FBL12
- FBL13
- FBL14
- FBL16
- FBL18
- FBL19
- FBL2
- FBL21
- FBL3
- FBL3A
- FBL4
- FBL5
- FBL6
- FBL7
- FBL8
- FBS2
- FBW12
- FBW1A
- FBW1B
- FBW2
- FBW4
- FBW5
- FBW6
- FBW7
- FBW8
- FBW9
- FBX1
- FBX10
- FBX11
- FBX14
- FBX15
- FBX17
- FBX2
- FBX20
- FBX21
- FBX22
- FBX26
- FBX27
- FBX29
- FBX30
- FBX31
- FBX4
- FBX40
- FBX41
- FBX44
- FBX6
- FBX6A
- FBX7
- FBX9
- FBXL1
- FBXL12
- FBXL13
- FBXL14
- FBXL15
- FBXL16
- FBXL18
- FBXL19
- FBXL20
- FBXL21
- FBXL21P
- FBXL22
- FBXL3
- FBXL3A
- FBXL3B
- FBXL3P
- FBXL4
- FBXL5
- FBXL7
- FBXL8
- FBXO1
- FBXO10
- FBXO11
- FBXO12
- FBXO15
- FBXO17
- FBXO2
- FBXO20
- FBXO21
- FBXO22
- FBXO26
- FBXO27
- FBXO29
- FBXO30
- FBXO31
- FBXO32
- FBXO35
- FBXO37
- FBXO4
- FBXO40
- FBXO41
- FBXO44
- FBXO6
- FBXO6A
- FBXO7
- FBXO9
- FBXW10
- FBXW11
- FBXW12
- FBXW1A
- FBXW1B
- FBXW2
- FBXW4
- FBXW5
- FBXW6
- FBXW7
- FBXW8
- FBXW9
- FEM1A
- FEM1B
- FEM1C
- FLR1
- FWD2
- G18
- GAN
- GAN1
- GIDE
- GPS1
- GRCC9
- H326
- H7AP1
- HAN11
- HC2
- HC3
- HC8
- HC9
- HEL-220
- HEL-S-70
- HIF1A
- HIF2A
- HIF3A
- HSPC
- HVIP
- IAP4
- IFI5111
- INRF2
- IQWD1
- JAB1
- KBTBD10
- KBTBD13
- KBTBD6
- KBTBD7
- KBTBD8
- KCTD6
- KCTD7
- KEAP1
- KIAA0072
- KIAA0076
- KIAA0077
- KIAA0107
- KIAA0132
- KIAA0235
- KIAA0276
- KIAA0396
- KIAA0469
- KIAA0617
- KIAA0657
- KIAA0671
- KIAA0695
- KIAA0696
- KIAA0708
- KIAA0794
- KIAA0829
- KIAA0840
- KIAA0858
- KIAA0875
- KIAA1037
- KIAA1129
- KIAA1146
- KIAA1195
- KIAA1309
- KIAA1340
- KIAA1354
- KIAA1397
- KIAA1499
- KIAA1785
- KIAA1824
- KIAA1842
- KIAA1940
- KLEIP
- KLHDC5
- KLHL11
- KLHL13
- KLHL16
- KLHL19
- KLHL2
- KLHL20
- KLHL21
- KLHL22
- KLHL25
- KLHL3
- KLHL41
- KLHL42
- KLHL5
- KLHL9
- KLHLX
- KRP1
- L2DTL
- LMO7
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- LRR1
- LRRC41
- MAPL
- MB1
- MCB1
- MDA6
- MECL1
- MIP224
- MOP1
- MOP2
- MOP7
- MOV34L
- MSS1
- MUF1
- MUL1
- MULAN
- MURR1
- NAE1
- NCE2
- NEDD8
- NEDP1
- NEURL2
- NFE2L2
- NPL4
- NPLOC4
- NRF2
- NS5ATP8
- NU
- OBSL1
- OCP2
- ORCA
- OSIL
- PALB2
- PARC
- PASD2
- PASD7
- PASD8
- PCIA1
- PFAAP4
- PIC1
- PLZF
- POH1
- PPIL5
- PRMT11
- PRMT9
- PROS26
- PROS27
- PROS30
- PRSC2
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- PUBC1
- PUM2
- PUMH2
- RAMP
- RBAP46
- RBBP5
- RBBP7
- RBQ3
- RBX1
- RBX2
- RFWD2
- RING10
- RING12
- RNF200
- RNF218
- RNF53
- RNF7
- RNF75
- ROC1
- ROC2
- RP42
- RPS27A
- SAG
- SCCRO
- SCCRO3
- SCCRO5
- SDI1
- SEL10
- SEM1
- SENP8
- SFT
- SHFDG1
- SHFM1
- SHFM3
- SKP1
- SKP1A
- SKP2
- SOCS2
- SOCS3
- SOCS4
- SOCS5
- SOCS6
- SPSB1
- SPSB2
- SPSB3
- SPSB4
- SQSTM1
- SSB1
- SSB2
- SSB3
- SSB4
- SSI2
- SSI3
- STATI2
- SUG1
- SUG2
- SWIP1
- TAKRP
- TBP1
- TBP7
- TCEB1
- TCEB1L
- TCEB2
- TIP120
- TIP120A
- TRAP2
- TRIP15
- TUBL4
- TULP4
- TUSP
- UBA3
- UBA52
- UBA80
- UBB
- UBC
- UBC12
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBD
- UBE1C
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2F
- UBE2M
- UBXD7
- UBXN7
- UCHL3
- UFD1
- UFD1L
- VACM1
- VCIA1
- VCP
- VHL
- VIT1
- WAF1
- WDR21
- WDR21A
- WDR22
- WDR23
- WDR32
- WDR42A
- WDR5
- WDR68
- WDSOF1
- WDTC1
- WSB1
- WSB2
- WTX
- X
- XAP1
- Y
- Y2
- Z
- ZBTB16
- ZNF145
- x
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Nectin/Necl trans heterodimerization
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- CADM1
- CADM3
- HVEB
- HVEC
- IGSF4
- IGSF4A
- IGSF4B
- LNIR
- NECL1
- NECL2
- NECTIN1
- NECTIN2
- NECTIN3
- NECTIN4
- PRR1
- PRR2
- PRR3
- PRR4
- PVR
- PVRL1
- PVRL2
- PVRL3
- PVRL4
- PVS
- SYNCAM
- SYNCAM3
- TSLC1
- TSLL1
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Na+/Cl- dependent neurotransmitter transporters
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- B0AT1
- B0AT2
- B0AT3
- BGT1
- DAT1
- GABATR
- GABT1
- GABT3
- GAT1
- GAT2
- GAT3
- GLYT2
- NAT1
- NET1
- NTT73
- OCT1
- OCT2
- PROT
- SBAT1
- SIT1
- SLC18A1
- SLC18A2
- SLC22A1
- SLC22A2
- SLC6A1
- SLC6A11
- SLC6A12
- SLC6A13
- SLC6A14
- SLC6A15
- SLC6A18
- SLC6A19
- SLC6A2
- SLC6A20
- SLC6A3
- SLC6A5
- SLC6A6
- SLC6A7
- SLC6A9
- SVMT
- VAT1
- VMAT1
- VMAT2
- XT3
- XTRP2
- XTRP3
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NVP-TAE684-resistant ALK mutants
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NTRK3 as a dependence receptor
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- BAX
- BCL2L4
- COBRA1
- KIAA1182
- NELFB
- NTRK3
- TRKC
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NTRK2 activates RAC1
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- BDNF
- DOCK3
- KIAA0299
- MOCA
- NTRK2
- RAC1
- TC25
- TRKB
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