GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1326 - 1350** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism
Signaling by RAS GTPase mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2	Homo sapiens (human)
Signaling by RAS GAP mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2	Homo sapiens (human)
Signalling to RAS	Beta-nerve growth factor GTPase HRas GTPase NRas High affinity nerve growth factor receptor SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 Son of sevenless homolog 1	P01111 P01112 P01138 P04629 P29353 P98077 Q07889 Q92529	HRAS HRAS1 MTC NGF NGFB NRAS NSHC NTRK1 SCK SHC SHC1 SHC2 SHC3 SHCA SHCB SHCC SOS1 TRK TRKA	Homo sapiens (human)
Insulin receptor signalling cascade	GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Insulin receptor Insulin SHC-transforming protein 1 Son of sevenless homolog 1	P01111 P01112 P01308 P06213 P29353 Q07889 Q13322	GRB10 GRBIR HRAS HRAS1 INS INSR KIAA0207 NRAS SHC SHC1 SHCA SOS1	Homo sapiens (human)
SHC-related events triggered by IGF1R	GTPase HRas GTPase NRas Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II Son of sevenless homolog 1	P01111 P01112 P01344 P05019 P08069 Q07889	HRAS HRAS1 IBP1 IGF1 IGF1R IGF2 NRAS SOS1	Homo sapiens (human)
MAP2K and MAPK activation	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Interleukin-17 receptor D Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin WD repeat domain-containing protein 83 von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8NFM7 Q8WXI2 Q969H4 Q9BRX9 Q9UHA4 Q9Y2Q5 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IL17RD IL17RLM IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K1IP1 MAP2K2 MAPBPIP MAPK1 MAPK3 MAPKSP1 MARK3 MEK1 MEK2 MKK2 MORG1 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM ROBLD3 SEF SRC SRC1 TLN TLN1 VCL VWF WDR83 YWHAB	Homo sapiens (human)
Signaling by high-kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB	Homo sapiens (human)
Negative regulation of MAPK pathway	14-3-3 protein beta/alpha BRCA1-associated protein Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Polyubiquitin-B Polyubiquitin-C Progestin and adipoQ receptor family member 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase non-receptor type 3 Tyrosine-protein phosphatase non-receptor type 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01111 P01112 P04049 P0CG47 P0CG48 P10398 P15056 P26045 P27361 P27448 P28482 P28562 P30086 P30153 P30154 P31946 P35236 P53041 P53778 P62714 P62979 P62987 P67775 Q05923 Q13115 Q13202 Q13362 Q14738 Q15172 Q15173 Q16537 Q16690 Q16828 Q16829 Q6TCH7 Q7Z569 Q8IVT5 Q99956 Q9BY84 Q9Y6W6	ARAF ARAF1 BRAF BRAF1 BRAP C11orf81 CL100 CTAK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 EMK2 ERK1 ERK2 ERK6 HRAS HRAS1 KIAA0044 KIAA1700 KSR KSR1 MAPK1 MAPK12 MAPK3 MARK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 NRAS PAC1 PAQR3 PBP PEBP PEBP1 PKS PKS2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTPH1 PTPN10 PTPN3 PTPN7 PYST1 PYST2 RAF RAF1 RAFB1 RNF52 RPS27A SAPK3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VH1 VH2 VH3 VH5 YWHAB	Homo sapiens (human)
Constitutive Signaling by Overexpressed ERBB2	Erbin GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 12	P01111 P01112 P04626 P07900 P29353 Q05209 Q07889 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HRAS HRAS1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL NRAS PTPN12 SHC SHC1 SHCA SOS1	Homo sapiens (human)
MET activates RAS signaling	GTPase HRas GTPase NRas Hepatocyte growth factor receptor Hepatocyte growth factor Mucin-20 Ran-binding protein 10 Ran-binding protein 9 Son of sevenless homolog 1	P01111 P01112 P08581 P14210 Q07889 Q6VN20 Q8N307 Q96S59	HGF HPTA HRAS HRAS1 KIAA1359 KIAA1464 MET MUC20 NRAS RANBP10 RANBP9 RANBPM SOS1	Homo sapiens (human)
Signaling by FLT3 fusion proteins	Cyclin-dependent kinase inhibitor 1 GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Golgin subfamily B member 1 NADPH oxidase 4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Serine/threonine-protein kinase pim-1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Spectrin beta chain, non-erythrocytic 1 Thyroid receptor-interacting protein 11 Transcription factor ETV6 Unconventional myosin-XVIIIa Zinc finger MYM-type protein 2	P01111 P01112 P11309 P27986 P38936 P41212 P42229 P42336 P51692 Q01082 Q07889 Q14789 Q15643 Q92614 Q9NPH5 Q9UBW7 Q9UQC2	CAP20 CD245 CDKN1 CDKN1A CEV14 CIP1 ETV6 FIM GAB2 GOLGB1 GRB1 HRAS HRAS1 KIAA0216 KIAA0571 MDA6 MYO18A MYSPDZ NOX4 NRAS PIC1 PIK3CA PIK3R1 PIM1 RAMP RENOX SDI1 SOS1 SPTB2 SPTBN1 STAT5 STAT5A STAT5B TEL TEL1 TIAF1 TRIP11 WAF1 ZMYM2 ZNF198	Homo sapiens (human)
Signaling by FGFR4 in disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Son of sevenless homolog 1	P01111 P01112 P19174 P22455 P27986 P42336 Q07889 Q13480 Q8WU20	FGFR4 FRS2 GAB1 GRB1 HRAS HRAS1 JTK2 NRAS PIK3CA PIK3R1 PLC1 PLCG1 SOS1 TKF	Homo sapiens (human)
Activated NTRK3 signals through RAS	GTPase HRas GTPase NRas NT-3 growth factor receptor Neurotrophin-3 Son of sevenless homolog 1	P01111 P01112 P20783 Q07889 Q16288	HRAS HRAS1 NRAS NTF3 NTRK3 SOS1 TRKC	Homo sapiens (human)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Dedicator of cytokinesis protein 1 Engulfment and cell motility protein 1 Engulfment and cell motility protein 2 GTPase HRas GTPase NRas Paxillin Protein-tyrosine kinase 6 Ras GTPase-activating protein 1 Ras-related C3 botulinum toxin substrate 1 Rho GTPase-activating protein 35 Transforming protein RhoA	P01111 P01112 P20936 P46108 P49023 P56945 P61586 P63000 Q13882 Q14185 Q92556 Q96JJ3 Q9NRY4	ARH12 ARHA ARHGAP35 BCAR1 BRK CAS CASS1 CED12A CRK CRKAS DOCK1 ELMO1 ELMO2 GAP GRF1 GRLF1 HRAS HRAS1 KIAA0281 KIAA1722 KIAA1834 NRAS P190A PTK6 PXN RAC1 RASA RASA1 RHO12 RHOA TC25 p190ARHOGAP	Homo sapiens (human)
RAS signaling downstream of NF1 loss-of-function variants	GTPase HRas GTPase NRas Neurofibromin Sprouty-related, EVH1 domain-containing protein 1 Sprouty-related, EVH1 domain-containing protein 2 Sprouty-related, EVH1 domain-containing protein 3	P01111 P01112 P21359 Q2MJR0 Q7Z698 Q7Z699	EVE-3 HRAS HRAS1 NF1 NRAS SPRED1 SPRED2 SPRED3	Homo sapiens (human)
Activated NTRK2 signals through RAS	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor GTPase HRas GTPase NRas Neurotrophin-4 Son of sevenless homolog 1	P01111 P01112 P23560 P34130 Q07889 Q16620	BDNF HRAS HRAS1 NRAS NTF4 NTF5 NTRK2 SOS1 TRKB	Homo sapiens (human)
Signaling by FLT3 ITD and TKD mutants	GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	P01111 P01112 P27986 P36888 P42336 P62993 Q06124 Q07889 Q9UQC2	ASH CD135 FLK2 FLT3 GAB2 GRB1 GRB2 HRAS HRAS1 KIAA0571 NRAS PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 SOS1 STK1	Homo sapiens (human)
SOS-mediated signalling	GTPase HRas GTPase NRas Insulin receptor substrate 1 Insulin receptor substrate 2 Son of sevenless homolog 1	P01111 P01112 P35568 Q07889 Q9Y4H2	HRAS HRAS1 IRS1 IRS2 NRAS SOS1	Homo sapiens (human)
RUNX3 regulates p14-ARF	Bromodomain-containing protein 2 Core-binding factor subunit beta G1/S-specific cyclin-D1 GTPase KRas Histone acetyltransferase p300 Histone deacetylase 4 Runt-related transcription factor 1 Runt-related transcription factor 3 Transforming growth factor beta-1 proprotein	P01116 P01137 P24385 P25440 P56524 Q01196 Q09472 Q13761 Q13951	AML1 AML2 BCL1 BRD2 CBFA2 CBFA3 CBFB CCND1 EP300 HDAC4 KIAA0288 KIAA9001 KRAS KRAS2 P300 PEBP2A3 PRAD1 RASK2 RING3 RUNX1 RUNX3 TGFB TGFB1	Homo sapiens (human)
Chylomicron clearance	Apolipoprotein B-100 Apolipoprotein E Hepatic triacylglycerol lipase Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor	P01130 P02649 P04114 P11150 Q5SW96	APOB APOE ARH HTGL LDLR LDLRAP1 LIPC	Homo sapiens (human)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin	Pro-epidermal growth factor	P01133	EGF	Homo sapiens (human)
Influenza Virus Induced Apoptosis	ADP/ATP translocase 3 Neuraminidase Protein PB1-F2 Transforming growth factor beta-1 proprotein	P01137 P03468 P0C0U1 P12236	AAC3 ANT3 NA PB1 SLC25A6 TGFB TGFB1	Homo sapiens (human)
RUNX3 regulates CDKN1A transcription	Cellular tumor antigen p53 Cyclin-dependent kinase inhibitor 1 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Runt-related transcription factor 3 Transforming growth factor beta-1 proprotein Zinc finger homeobox protein 3	P01137 P04637 P38936 P84022 Q13485 Q13761 Q15911	AML2 ATBF1 C16orf47 CAP20 CBFA3 CDKN1 CDKN1A CIP1 DPC4 MADH3 MADH4 MDA6 P53 PEBP2A3 PIC1 RUNX3 SDI1 SMAD3 SMAD4 TGFB TGFB1 TP53 WAF1 ZFHX3	Homo sapiens (human)
TGF-beta receptor signaling activates SMADs	E3 ubiquitin-protein ligase CBL Furin Integrin alpha-8 Integrin alpha-V Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin beta-8 Latent-transforming growth factor beta-binding protein 1 Latent-transforming growth factor beta-binding protein 2 Latent-transforming growth factor beta-binding protein 3 Latent-transforming growth factor beta-binding protein 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 NEDD8-conjugating enzyme Ubc12 NEDD8 Peptidyl-prolyl cis-trans isomerase FKBP1A TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta receptor type 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein	P01137 P05106 P05556 P06756 P09958 P10600 P18084 P18564 P22681 P26012 P36897 P37173 P53708 P61081 P61812 P62942 P84022 Q03167 Q13485 Q14766 Q14767 Q15796 Q15843 Q8N2S1 Q9NS15	ALK5 C14orf141 CBL CBL2 DPC4 FKBP1 FKBP12 FKBP1A FNRB FUR FURIN GP3A ITGA8 ITGAV ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 LTBP1 LTBP2 LTBP3 LTBP4 MADH2 MADH3 MADH4 MADR2 MDF2 MSK12 MSK8 NEDD8 PACE PCSK3 RNF55 SKR4 SMAD2 SMAD3 SMAD4 TGFB TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 UBC12 UBE2M VNRA VTNR	Homo sapiens (human)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Cingulin E3 ubiquitin-protein ligase SMURF1 Junctional adhesion molecule A Partitioning defective 3 homolog Partitioning defective 6 homolog alpha Peptidyl-prolyl cis-trans isomerase FKBP1A Polyubiquitin-B Polyubiquitin-C Protein kinase C zeta type Rho guanine nucleotide exchange factor 18 TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Transforming protein RhoA Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01137 P0CG47 P0CG48 P36897 P37173 P61586 P62942 P62979 P62987 Q05513 Q6ZSZ5 Q8TEW0 Q9HCE7 Q9NPB6 Q9P2M7 Q9Y624	ALK5 ARH12 ARHA ARHGEF18 CGN F11R FKBP1 FKBP12 FKBP1A JAM1 JCAM KIAA0521 KIAA1319 KIAA1625 PAR3 PAR3A PAR6A PARD3 PARD6A PKC2 PRKCZ RHO12 RHOA RPS27A SKR4 SMURF1 TGFB TGFB1 TGFBR1 TGFBR2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)

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