GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1551 - 1575** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
Interferon alpha/beta signaling	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 2 2'-5'-oligoadenylate synthase 3 2'-5'-oligoadenylate synthase-like protein 2-5A-dependent ribonuclease ATP-binding cassette sub-family E member 1 Bone marrow stromal antigen 2 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Double-stranded RNA-specific adenosine deaminase Early growth response protein 1 Guanylate-binding protein 2 HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G Importin subunit alpha-5 Importin subunit beta-1 Inositol hexakisphosphate kinase 2 Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon alpha-inducible protein 27, mitochondrial Interferon alpha-inducible protein 6 Interferon alpha/beta receptor 1 Interferon beta Interferon regulatory factor 1 Interferon regulatory factor 2 Interferon regulatory factor 3 Interferon regulatory factor 4 Interferon regulatory factor 5 Interferon regulatory factor 6 Interferon regulatory factor 7 Interferon regulatory factor 8 Interferon regulatory factor 9 Interferon-induced 35 kDa protein Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx2 Interferon-induced protein with tetratricopeptide repeats 1 Interferon-induced protein with tetratricopeptide repeats 2 Interferon-induced protein with tetratricopeptide repeats 3 Interferon-induced protein with tetratricopeptide repeats 5 Interferon-induced transmembrane protein 1 Interferon-induced transmembrane protein 2 Interferon-induced transmembrane protein 3 Interferon-induced, double-stranded RNA-activated protein kinase Interferon-stimulated gene 20 kDa protein Non-receptor tyrosine-protein kinase TYK2 Nucleoprotein Polyubiquitin-B Polyubiquitin-C Proteasome subunit beta type-8 Putative HLA class I histocompatibility antigen, alpha chain H S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6 Ubiquitin-like protein ISG15 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein XIAP-associated factor 1	O14543 O14879 O14896 O15524 P00973 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P01889 P01893 P04439 P05013 P05014 P05015 P05161 P09912 P09913 P09914 P0CG47 P0CG48 P0DTC9 P10321 P10914 P13164 P13747 P14316 P17181 P17693 P18146 P19525 P20591 P20592 P23458 P28062 P29350 P29597 P29728 P30511 P32456 P32881 P40305 P42224 P52294 P52630 P55265 P61221 P62979 P62987 P80217 Q00978 Q01628 Q01629 Q02556 Q05823 Q06124 Q10589 Q13325 Q13568 Q14653 Q14974 Q15306 Q15646 Q6GPH4 Q8WXG1 Q92985 Q96AZ6 Q9UHH9 Q9Y3Z3 Q9Y6K5	ABCE1 ADAR ADAR1 BIRC4BP BST2 CD225 CIG-42 CIG-49 CIG5 CIS3 DSRAD EGR1 EIF2AK2 G10P1 G10P2 G1P1 G1P2 G1P3 GBP2 HCP HEM45 HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH ICSBP1 IFB IFI17 IFI27 IFI35 IFI4 IFI54 IFI56 IFI6 IFI60 IFIT1 IFIT2 IFIT3 IFIT4 IFIT5 IFITM1 IFITM2 IFITM3 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAI1 IFNAR IFNAR1 IFNB IFNB1 IFP35 IHPK2 IP6K2 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISG15 ISG20 ISG54 ISG56 ISG58 ISG60 ISGF3G JAK1 JAK1A JAK1B KPNA1 KPNB1 KROX24 LMP7 MOP5 MUM1 MX1 MX2 N NTF97 OAS1 OAS2 OAS3 OASL OIAS PKR PRKR PSMB5i PSMB8 PTP1C PTP2C PTPN11 PTPN6 RCH2 RI58 RING10 RLI RNASEL RNASEL1 RNASELI RNS4 RNS4I RPS27A RSAD2 SAMHD1 SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT2 TIP3 TRIP14 TYK2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCRP XAF1 XIAPAF1 Y2 ZNF225	Homo sapiens (human)
CRMPs in Sema3A signaling	Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 Dihydropyrimidinase-related protein 1 Dihydropyrimidinase-related protein 2 Dihydropyrimidinase-related protein 3 Dihydropyrimidinase-related protein 4 Dihydropyrimidinase-related protein 5 Glycogen synthase kinase-3 beta Neuropilin-1 Plexin-A1 Plexin-A2 Plexin-A3 Plexin-A4 Semaphorin-3A Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn	O14531 O14786 O75051 P06241 P07332 P49841 P51805 Q00535 Q14194 Q14195 Q14563 Q15078 Q16555 Q9BPU6 Q9HCM2 Q9UIW2	CDK5 CDK5R CDK5R1 CDKN5 CRMP1 CRMP2 CRMP3 CRMP4 CRMP5 DPYSL1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 DRP3 FES FPS FYN GSK3B KIAA0463 KIAA1550 NCK5A NOV NRP NRP1 OCT PLXN1 PLXN2 PLXN4 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNA4A PLXNA4B PSSALRE SEMA3A SEMAD SEX ULIP ULIP1 ULIP2 ULIP3 ULIP4 ULIP6 VEGF165R	Homo sapiens (human)
Cargo recognition for clathrin-mediated endocytosis	AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma AP2-associated protein kinase 1 Adaptin ear-binding coat-associated protein 1 Adaptin ear-binding coat-associated protein 2 Amphiregulin Apolipoprotein B-100 Arf-GAP domain and FG repeat-containing protein 1 Beta-2 adrenergic receptor Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7b COP9 signalosome complex subunit 8 Cation-dependent mannose-6-phosphate receptor Cation-independent mannose-6-phosphate receptor Clathrin coat assembly protein AP180 Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Cystic fibrosis transmembrane conductance regulator Disabled homolog 2 Dyslexia-associated protein KIAA0319 E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Epsin-2 F-BAR domain only protein 1 F-BAR domain only protein 2 Frizzled-4 G protein-coupled receptor kinase 3 Hepatocyte growth factor-regulated tyrosine kinase substrate Interleukin-7 receptor subunit alpha Intersectin-1 Intersectin-2 Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Low-density lipoprotein receptor Lysosome membrane protein 2 Muscarinic acetylcholine receptor M2 NEDD8 Phosphatidylinositol-binding clathrin assembly protein Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein Wnt-5a Protransforming growth factor alpha RalBP1-associated Eps domain-containing protein 1 RalBP1-associated Eps domain-containing protein 2 SH3 domain-containing kinase-binding protein 1 SH3-containing GRB2-like protein 3-interacting protein 1 Segment polarity protein dishevelled homolog DVL-2 Serotransferrin Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Solute carrier family 2, facilitated glucose transporter member 8 Stonin-1 Stonin-2 Substance-P receptor Synaptotagmin-11 Synaptotagmin-1 Synaptotagmin-2 Synaptotagmin-8 Synaptotagmin-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Torsin-1A Torsin-1B Trans-Golgi network integral membrane protein 2 Transferrin receptor protein 1 Type-1 angiotensin II receptor Ubiquilin-1 Ubiquilin-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin Vesicle-associated membrane protein 2 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-associated membrane protein 7 Vesicle-associated membrane protein 8 Vesicular acetylcholine transporter	O14526 O14641 O14656 O14657 O14944 O14964 O43493 O60641 O75379 O75886 O94973 O95208 O95782 P00533 P01130 P01133 P01135 P01185 P01730 P02786 P02787 P04114 P04234 P07550 P08172 P09496 P09497 P09693 P0CG47 P0CG48 P11717 P13569 P15514 P16871 P20645 P21579 P22681 P25098 P25103 P30518 P30556 P32121 P35070 P35626 P41221 P42566 P49407 P51809 P52594 P53675 P53680 P61201 P62979 P62987 P63010 P63027 P98082 P98164 Q00610 Q0JRZ9 Q13098 Q13492 Q14108 Q15811 Q15836 Q15843 Q16572 Q2M2I8 Q5SW96 Q5VV43 Q6UW88 Q7L5N1 Q86SS6 Q8N9I0 Q8NBV8 Q8NC96 Q8NFH8 Q8WXE9 Q92783 Q92905 Q96B97 Q96CW1 Q96D71 Q99075 Q99627 Q99961 Q99962 Q99963 Q9BQI5 Q9BT78 Q9BT88 Q9BV40 Q9H9Q2 Q9NVZ3 Q9NY64 Q9NZM3 Q9UBC2 Q9UBW8 Q9UHD9 Q9ULV1 Q9UMX0 Q9UNS2 Q9Y6I3 Q9Y6Q2	AAK1 ABCC7 ADHR ADRB2 ADRB2R ADRBK1 ADRBK2 ADTAA ADTAB ADTB2 AF1P AGFG1 AGTR1 AGTR1A AGTR1B AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB ARB2 AREG AREGB ARH ARR1 ARR2 ARRB1 ARRB2 ARVP AT2R1 AT2R1B AVP AVPR2 B2AR BARK BARK1 BARK2 BTC CALM CBL CBL2 CD36L2 CD3D CD3G CD4 CFTR CHRM2 CIN85 CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD CNSA1 CNSA2 CNSA3 COPS1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSN1 CSN2 CSN3 CSN4 CSN5 CSN6 CSN7A CSN7B CSN8 DA41 DAB2 DERP10 DIR DIR3 DOC2 DQ1 DQ2 DTR DTS DVL2 DYT1 EGF EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG FCHO1 FCHO2 FZD4 GLUT8 GLUTX1 GPS1 GRK2 GRK3 HBEGF HBP HEGFL HER1 HGS HIP9 HRB HRS HVIP HYPJ IGF2R IL7R ITSN ITSN1 ITSN2 JAB1 KIAA0034 KIAA0080 KIAA0109 KIAA0290 KIAA0319 KIAA0656 KIAA0899 KIAA1048 KIAA1065 KIAA1256 LDLR LDLRAP1 LIMP2 LIMPII LRP2 M6PR MPR46 MPRD MPRI N4BP4 NECAP1 NECAP2 NEDD8 NK1R PICALM PLIC1 PLIC2 POB1 RAB REPS1 REPS2 RIP RNF55 RPS27A SALF SBLF SCARB2 SDGF SGIP1 SH3D1A SH3D1B SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SLC18A3 SLC2A8 SNAP91 STAM STAM1 STAM2 STN1 STN2 STNB STON1 STON2 SVP65 SWAP SYB2 SYB3 SYBL1 SYT SYT1 SYT11 SYT2 SYT8 SYT9 T3D T3G TA TAC1R TACR1 TF TFRC TGFA TGN46 TGN51 TGOLN2 TOR1A TOR1B TORA TRIP15 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBQLN1 UBQLN2 V2R VACHT VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VP WNT5A	Homo sapiens (human)
Citric acid cycle (TCA cycle)	Aconitate hydratase, mitochondrial Citrate synthase, mitochondrial Fumarate hydratase, mitochondrial Heat shock protein 75 kDa, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Malate dehydrogenase, mitochondrial NAD(P) transhydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	O14521 O43837 O75390 P07954 P21912 P31040 P40926 P48735 P50213 P51553 P53597 Q12931 Q13423 Q96I99 Q99643 Q99798 Q9P2R7	ACO2 CS CYB560 FH HSP75 HSPC5 IDH2 IDH3A IDH3B IDH3G MDH2 NNT SDH SDH1 SDH2 SDH3 SDH4 SDHA SDHB SDHC SDHD SDHF SUCLA2 SUCLG1 SUCLG2 TRAP1	Homo sapiens (human)
Passive transport by Aquaporins	Aquaporin-10 Aquaporin-11 Aquaporin-12A Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Aquaporin-5 Aquaporin-6 Aquaporin-7 Aquaporin-8 Aquaporin-9 Lens fiber major intrinsic protein	O14520 O43315 O94778 P29972 P30301 P41181 P55064 P55087 Q13520 Q8IXF9 Q8NBQ7 Q92482 Q96PS8	AQP0 AQP1 AQP10 AQP11 AQP12 AQP12A AQP2 AQP2L AQP3 AQP4 AQP5 AQP6 AQP7 AQP7L AQP8 AQP9 AQPX1 AQPX2 CHIP28 MIP SSC1	Homo sapiens (human)
GRB7 events in ERBB2 signaling	Growth factor receptor-bound protein 7 Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Receptor tyrosine-protein kinase erbB-2	O14511 P04626 Q02297 Q14451	ERBB2 GGF GRB7 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NTAK SMDF	Homo sapiens (human)
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
PI3K events in ERBB4 signaling	Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P27986 P35070 P42336 P56975 Q02297 Q8WWG1 Q99075	BTC DTR DTS EREG GGF GRB1 HBEGF HEGFL HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF	Homo sapiens (human)
SHC1 events in ERBB4 signaling	GTPase HRas GTPase NRas Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P01111 P01112 P29353 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EREG GGF HBEGF HEGFL HGL HRAS HRAS1 HRGA NDF NRAS NRG1 NRG2 NRG3 NRG4 NTAK SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Signaling by ERBB4	Disks large homolog 4 Epidermal growth factor receptor Gamma-aminobutyric acid receptor subunit alpha-1 Gamma-aminobutyric acid receptor subunit beta-1 Gamma-aminobutyric acid receptor subunit beta-2 Gamma-aminobutyric acid receptor subunit beta-3 Gamma-aminobutyric acid receptor subunit gamma-2 Gamma-aminobutyric acid receptor subunit gamma-3 Gamma-aminobutyric acid receptor subunit theta Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P00533 P01133 P14867 P18505 P18507 P28472 P35070 P47870 P56975 P78352 Q02297 Q8WWG1 Q99075 Q99928 Q9UN88	BTC DLG4 DTR DTS EGF EGFR ERBB ERBB1 EREG GABRA1 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GGF HBEGF HEGFL HER1 HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PSD95 SMDF	Homo sapiens (human)
ERBB2 Activates PTK6 Signaling	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein-tyrosine kinase 6 Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P35070 P56975 Q02297 Q13882 Q8WWG1 Q99075	BRK BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTK6 SMDF	Homo sapiens (human)
PI3K events in ERBB2 signaling	Epidermal growth factor receptor GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P27986 P35070 P42336 P56975 Q02297 Q13480 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF	Homo sapiens (human)
Downregulation of ERBB2 signaling	Cullin-5 E3 ubiquitin-protein ligase CHIP Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Megakaryocyte-associated tyrosine-protein kinase Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 18 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 O14944 P00533 P01133 P04626 P07900 P0CG47 P0CG48 P35070 P42679 P56975 P62979 P62987 Q02297 Q05209 Q16543 Q8WWG1 Q93034 Q96RT1 Q99075 Q99952 Q9UNE7	BDP1 BTC CDC37 CDC37A CHIP CTK CUL5 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA HYL KIAA1225 LAP2 MATK MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTPN12 PTPN18 RPS27A SMDF STUB1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VACM1	Homo sapiens (human)
Signaling by ERBB2	Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Yes	O14511 O14944 P00533 P01133 P04626 P06241 P07900 P07947 P12931 P35070 P56975 Q02297 Q16543 Q8WWG1 Q96RT1 Q99075	BTC CDC37 CDC37A DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG FYN GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK SMDF SRC SRC1 YES YES1	Homo sapiens (human)
GRB2 events in ERBB2 signaling	Epidermal growth factor receptor GTPase HRas GTPase NRas Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Son of sevenless homolog 1	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK SMDF SOS1	Homo sapiens (human)
SHC1 events in ERBB2 signaling	Epidermal growth factor receptor GTPase HRas GTPase NRas Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein kinase C alpha type Protein kinase C delta type Protein kinase C epsilon type Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 12	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P17252 P29353 P35070 P56975 Q02156 Q02297 Q05209 Q05655 Q07889 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PKCA PKCD PKCE PRKACA PRKCA PRKCD PRKCE PTPN12 SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Signaling by ERBB2 TMD/JMD mutants	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Epidermal growth factor receptor Erbin GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P07900 P19174 P29353 P35070 P56975 Q02297 Q07889 Q16543 Q8WWG1 Q96RT1 Q99075	BTC CDC37 CDC37A DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PLC1 PLCG1 SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Signaling by ERBB2 KD Mutants	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Epidermal growth factor receptor Erbin GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P07900 P19174 P27986 P29353 P35070 P42336 P56975 Q02297 Q07889 Q13480 Q16543 Q8WWG1 Q96RT1 Q99075	BTC CDC37 CDC37A DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 PLC1 PLCG1 SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Nuclear signaling by ERBB4	Apolipoprotein E Arf-GAP with dual PH domain-containing protein 1 Beta-casein Disintegrin and metalloproteinase domain-containing protein 17 Estrogen receptor Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Glial fibrillary acidic protein Max dimerization protein 4 Nicastrin Nuclear receptor corepressor 1 Presenilin-1 Presenilin-2 Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Progesterone receptor Proheparin-binding EGF-like growth factor Protein S100-B Proto-oncogene tyrosine-protein kinase Src SPARC Signal transducer and activator of transcription 5A Stathmin Stromal cell-derived factor 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Transcriptional coactivator YAP1 WW domain-containing oxidoreductase	O14511 O14944 O75376 O75689 P02649 P03372 P04271 P05814 P06401 P09486 P12931 P14136 P16949 P35070 P42229 P46937 P48061 P49768 P49810 P56975 P78536 Q02297 Q14582 Q8WW43 Q8WWG1 Q92542 Q96BI3 Q99075 Q9NYJ8 Q9NZ42 Q9NZC7	AD3 AD4 ADAM17 ADAP1 APH1A APH1B APOE BHLHC12 BTC C1orf215 CASB CENTA1 CSN2 CSVP CXCL12 DTR DTS EREG ESR ESR1 FOR GFAP GGF HBEGF HEGFL HGL HRGA KIAA0253 KIAA0733 KIAA1047 LAP18 MAD4 MAP3K7IP2 MXD4 NCOR1 NCSTN NDF NR3A1 NR3C3 NRG1 NRG2 NRG3 NRG4 NTAK ON OP18 PEN2 PGR PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 S100B SDF1 SDF1A SDF1B SDR41C1 SMDF SPARC SRC SRC1 STAT5 STAT5A STM2 STMN1 TAB2 TACE WOX1 WWOX YAP1 YAP65	Homo sapiens (human)
ERBB2 Regulates Cell Motility	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein MEMO1 Protein diaphanous homolog 1 Receptor tyrosine-protein kinase erbB-2 Transforming protein RhoA	O14511 O14944 O60610 P00533 P01133 P04626 P35070 P56975 P61586 Q02297 Q8WWG1 Q99075 Q9Y316	ARH12 ARHA BTC C2orf4 DIAP1 DIAPH1 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MEMO MEMO1 MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NS5ATP7 NTAK RHO12 RHOA SMDF	Homo sapiens (human)
Negative regulation of FLT3	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase eta SH2B adapter protein 3 Src-like-adapter 2 Src-like-adapter Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 6 Tyrosine-protein kinase ABL2 Tyrosine-protein kinase CSK Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14508 O14544 P0CG47 P0CG48 P22681 P36888 P41240 P42684 P49771 P62979 P62987 Q12913 Q13239 Q9H6Q3 Q9UQQ2	ABL2 ABLL ARG C20orf156 CBL CBL2 CD135 CIS2 CIS4 CSK DEP1 FLK2 FLT3 FLT3LG LNK PTPRJ RNF55 RPS27A SH2B3 SLA SLA2 SLAP SLAP1 SLAP2 SOCS2 SOCS4 SOCS6 SSI2 STATI2 STK1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Growth hormone receptor signaling	Chorionic somatomammotropin hormone 1 Cytokine-inducible SH2-containing protein Disintegrin and metalloproteinase domain-containing protein 17 Growth hormone receptor Growth hormone variant Insulin receptor substrate 1 Insulin receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Prolactin receptor Prolactin Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Somatotropin Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6	O14508 O14543 O15524 O60674 P01236 P01241 P01242 P07948 P0DML2 P10912 P16471 P18031 P27361 P28482 P29350 P35568 P40763 P42224 P42229 P51692 P78536 Q9NSE2 Q9Y4H2	ADAM17 APRF CIS2 CIS3 CISH CSH1 CSVP ERK1 ERK2 G18 GH1 GH2 GHR HCP IRS1 IRS2 JAK2 JTK8 LYN MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 PRL PRLR PTP1B PTP1C PTPN1 PTPN6 SOCS1 SOCS2 SOCS3 SSI1 SSI2 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B STATI2 TACE TIP3	Homo sapiens (human)
Regulation of MITF-M-dependent genes involved in pigmentation	5,6-dihydroxyindole-2-carboxylic acid oxidase AT-rich interactive domain-containing protein 1A AT-rich interactive domain-containing protein 1B Actin, cytoplasmic 1 Actin-like protein 6A B-cell CLL/lymphoma 7 protein family member A B-cell CLL/lymphoma 7 protein family member B B-cell CLL/lymphoma 7 protein family member C Calcium-responsive transactivator Catenin beta-1 G-protein coupled receptor 143 L-dopachrome tautomerase Lymphoid enhancer-binding factor 1 Melanocyte protein PMEL Melanoma antigen recognized by T-cells 1 Probable global transcription activator SNF2L2 Protein SSXT RAC-beta serine/threonine-protein kinase Ras-related protein Rab-27A SWI/SNF complex subunit SMARCC1 SWI/SNF complex subunit SMARCC2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Transcription activator BRG1 Transcription factor SOX-10 Tyrosinase Unconventional myosin-Va Upstream stimulatory factor 1 Zinc finger protein DPF3 Zinc finger protein neuro-d4 Zinc finger protein ubi-d4	O14497 O75177 O96019 P14679 P17643 P22415 P31751 P35222 P40126 P40967 P51159 P51531 P51532 P51810 P56693 P60709 Q12824 Q15532 Q16655 Q4VC05 Q6STE5 Q8NFD5 Q8TAQ2 Q8WUZ0 Q92782 Q92784 Q92785 Q92922 Q92925 Q969G3 Q96GM5 Q9BQE9 Q9UJU2 Q9Y4I1	ACTB ACTL6A AKT2 ARID1A ARID1B BAF155 BAF170 BAF190A BAF190B BAF250 BAF250A BAF250B BAF45B BAF45C BAF45D BAF47 BAF53 BAF53A BAF57 BAF60A BAF60B BAF60C BCL7A BCL7B BCL7C BHLHB11 BRG1 BRM C1orf4 CAS2 CERD4 CREST CTNNB CTNNB1 D12S53E DAN15 DCT DPF1 DPF2 DPF3 GPR143 INI1 INO80K KIAA0693 KIAA1235 LEF1 MART1 MLANA MYH12 MYO5A NEUD4 OA1 OSA1 OSA2 PMEL PMEL17 RAB27 RAB27A REQ SILV SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMARCF1 SNF2A SNF2B SNF2L2 SNF2L4 SNF5L1 SOX10 SS18 SS18L1 SSXT SYT TYR TYRP TYRP1 TYRP2 TYRRP UBID4 USF USF1	Homo sapiens (human)
RMTs methylate histone arginines	AT-rich interactive domain-containing protein 1A AT-rich interactive domain-containing protein 1B AT-rich interactive domain-containing protein 2 Actin-like protein 6A Actin-like protein 6B Coordinator of PRMT5 and differentiation stimulator Cyclin-dependent kinase 4 DNA (cytosine-5)-methyltransferase 3A G1/S-specific cyclin-D1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H3.1 Histone H3.2 Histone H4 Histone-arginine methyltransferase CARM1 Histone-binding protein RBBP7 Methylosome protein WDR77 Probable global transcription activator SNF2L2 Protein arginine N-methyltransferase 1 Protein arginine N-methyltransferase 3 Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 6 Protein arginine N-methyltransferase 7 Protein polybromo-1 SWI/SNF complex subunit SMARCC1 SWI/SNF complex subunit SMARCC2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Small ribosomal subunit protein uS5 Transcription activator BRG1 Tyrosine-protein kinase JAK2 WD repeat-containing protein 5	O14497 O14744 O60674 O60678 O94805 O96019 P04908 P0C0S8 P0C5Y9 P11802 P15880 P16104 P20671 P24385 P51531 P51532 P61964 P62805 P68431 Q12824 Q16576 Q16777 Q68CP9 Q6FI13 Q6STE5 Q71DI3 Q71UI9 Q7L7L0 Q86U86 Q86X55 Q8IUE6 Q8NFD5 Q8TAQ2 Q92922 Q92925 Q93077 Q969G3 Q96GM5 Q96KK5 Q96LA8 Q96QV6 Q99873 Q99878 Q9BQA1 Q9BTM1 Q9NQ92 Q9NVM4 Q9Y6K1	ACTL6 ACTL6A ACTL6B ARID1A ARID1B ARID2 BAF155 BAF170 BAF180 BAF190A BAF190B BAF200 BAF250 BAF250A BAF250B BAF47 BAF53 BAF53A BAF53B BAF57 BAF60A BAF60B BAF60C BCL1 BIG3 BRG1 BRM C17orf79 C1orf4 CARM1 CCND1 CDK4 COPR5 COPRS DAN15 DNMT3A H2AB1 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFC H2AFD H2AFE H2AFG H2AFI H2AFJ H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AFV H2AFX H2AJ H2AV H2AW H2AX H2AZ2 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2A HIST4H4 HMT2 HRMT1L2 HRMT1L3 HRMT1L5 HRMT1L6 IBP72 INI1 INO80K IR1B4 JAK2 JBP1 KIAA1235 KIAA1557 KIAA1933 MEP50 OSA1 OSA2 PB1 PBRM1 PRAD1 PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 RBAP46 RBBP7 RPS2 RPS4 SKB1 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMARCF1 SNF2A SNF2B SNF2L2 SNF2L4 SNF5L1 WD45 WDR5 WDR77	Homo sapiens (human)
Sphingolipid catabolism	Aldehyde dehydrogenase family 3 member B1 Aldehyde dehydrogenase family 3 member B2 Alkaline ceramidase 1 Alkaline ceramidase 2 Alkaline ceramidase 3 Phospholipid phosphatase 1 Phospholipid phosphatase 2 Phospholipid phosphatase 3 Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate phosphatase 1 Sphingosine-1-phosphate phosphatase 2	O14494 O14495 O43688 O95470 P43353 P48448 Q5QJU3 Q8IWX5 Q8TDN7 Q9BX95 Q9NUN7	ACER1 ACER2 ACER3 ALDH3B1 ALDH3B2 ALDH7 ALDH8 APHC ASAH3 ASAH3L KIAA1252 LPP1 LPP2 LPP3 PHCA PLPP1 PLPP2 PLPP3 PPAP2A PPAP2B PPAP2C SGPL1 SGPP1 SGPP2 SPP1	Homo sapiens (human)

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