GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1601 - 1625** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
PERK regulates gene expression	Cyclic AMP-dependent transcription factor ATF-4 Endoplasmic reticulum chaperone BiP Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 3	P05198 P11021 P18848 P20042 P41091 Q9NZJ5	ATF4 CREB2 EIF2A EIF2AK3 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GRP78 HSPA5 PEK PERK TXREB	Homo sapiens (human)
Budding	Hemagglutinin Matrix protein 1 Matrix protein 2 Neuraminidase Nuclear export protein Nucleoprotein Polymerase acidic protein Polymerase basic protein 2 RNA-directed RNA polymerase catalytic subunit	P03428 P03431 P03433 P03452 P03466 P03468 P03485 P03508 P06821	HA M NA NP NS PA PB1 PB2	Homo sapiens (human)
Attachment and Entry	Agrin Angiotensin-converting enzyme 2 Basement membrane-specific heparan sulfate proteoglycan core protein Envelope small membrane protein Furin Glypican-1 Glypican-2 Glypican-3 Glypican-4 Glypican-5 Glypican-6 Hepatitis A virus cellular receptor 1 Membrane protein Neuropilin-1 Nucleoprotein ORF3a protein ORF7a protein Procathepsin L Spike glycoprotein Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Transitional endoplasmic reticulum ATPase Transmembrane protease serine 2	O00468 O14786 O15393 O75056 O75487 P07711 P09958 P0DTC2 P0DTC3 P0DTC4 P0DTC5 P0DTC7 P0DTC9 P18827 P31431 P34741 P35052 P51654 P55072 P78333 P98160 Q8N158 Q96D42 Q9BYF1 Q9Y625	3a 7a ACE2 AGRIN AGRN CTSL CTSL1 E FUR FURIN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HAVCR1 HEL-220 HEL-S-70 HSPG1 HSPG2 KIAA0468 KIM1 M N NRP NRP1 OCI5 PACE PCSK3 PRSS10 S SDC SDC1 SDC2 SDC3 SDC4 TIM1 TIMD1 TMPRSS2 VCP VEGF165R	Homo sapiens (human)
Formation of paraxial mesoderm	Bone morphogenetic protein 4 CREB-binding protein Catenin beta-1 Delta-like protein 1 Delta-like protein 3 Fibroblast growth factor receptor 1 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Lymphoid enhancer-binding factor 1 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Mesogenin-1 Neurogenic locus notch homolog protein 1 Noggin Protein Wnt-3a Recombining binding protein suppressor of hairless SNW domain-containing protein 1 T-box transcription factor T T-box transcription factor TBX6	A6NI15 O00548 O15178 O95947 P11362 P12644 P35222 P46531 P56704 Q06330 Q09472 Q13253 Q13495 Q13573 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9NYJ7 Q9UJU2	BFGFR BMP2B BMP4 CBP CEK CG1 CREBBP CTNNB CTNNB1 CXorf6 DLL1 DLL3 DVR4 EP300 FGFBR FGFR1 FLG FLT2 GCN5 GCN5L2 HBGFR IGKJRB IGKJRB1 KAT2A KAT2B KIAA0200 KIAA1816 KIAA1819 LEF1 MAML1 MAML2 MAML3 MAMLD1 MSGN1 NOG NOTCH1 P300 PCAF RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 T TAN1 TBX6 TBXT WNT3A	Homo sapiens (human)
Ciprofloxacin ADME	Albumin Broad substrate specificity ATP-binding cassette transporter ABCG2 Organic anion transporter 3 Solute carrier family 22 member 1 Solute carrier organic anion transporter family member 1A2	O15245 P02768 P46721 Q8TCC7 Q9UNQ0	ABCG2 ABCP ALB BCRP BCRP1 MXR OAT3 OATP OATP1 OATP1A2 OCT1 SLC21A3 SLC22A1 SLC22A8 SLCO1A2	Homo sapiens (human)
Tryptophan catabolism	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 3-hydroxyanthranilate 3,4-dioxygenase Amino acid transporter heavy chain SLC3A2 Indoleamine 2,3-dioxygenase 1 Indoleamine 2,3-dioxygenase 2 Kynureninase Kynurenine 3-monooxygenase Kynurenine formamidase Kynurenine--oxoglutarate transaminase 1 Kynurenine--oxoglutarate transaminase 3 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Large neutral amino acids transporter small subunit 1 Neutral amino acid uniporter 4 Tryptophan 2,3-dioxygenase	O15229 P08195 P14902 P46952 P48775 Q01650 Q16719 Q16773 Q63HM1 Q6YBV0 Q6YP21 Q6ZQW0 Q8N5Z0 Q8TDX5	AADAT ACMSD AFMID CCBL1 CCBL2 CD98LC HAAO IDO IDO1 IDO2 INDO INDOL1 KAT2 KAT3 KMO KYAT1 KYAT2 KYAT3 KYNU LAT1 MDU1 MPE16 PAT4 SLC36A4 SLC3A2 SLC7A5 TDO TDO2	Homo sapiens (human)
SARS-CoV-2 targets PDZ proteins in cell-cell junction	Envelope small membrane protein Gap junction alpha-1 protein InaD-like protein Protein PALS1 Protein crumbs homolog 3 Tight junction protein ZO-1	P0DTC4 P17302 Q07157 Q8N3R9 Q8NI35 Q9BUF7	CIPP CRB3 E GJA1 GJAL INADL MPP5 PALS1 PATJ TJP1 ZO1	Homo sapiens (human)
E3 ubiquitin ligases ubiquitinate target proteins	B-cell lymphoma/leukemia 10 DNA-dependent protein kinase catalytic subunit Derlin-1 E3 ubiquitin-protein ligase BRE1A E3 ubiquitin-protein ligase BRE1B E3 ubiquitin-protein ligase RAD18 E3 ubiquitin-protein ligase RNF144A E3 ubiquitin-protein ligase RNF152 E3 ubiquitin-protein ligase RNF181 E3 ubiquitin-protein ligase SHPRH E3 ubiquitin-protein ligase TM129 HLA class I histocompatibility antigen, A alpha chain Helicase-like transcription factor Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O MHC Class I antigen (B60) (Fragment) Parafibromin Peroxisomal membrane protein PEX13 Peroxisomal membrane protein PEX14 Peroxisome assembly protein 12 Peroxisome biogenesis factor 10 Peroxisome biogenesis factor 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Ras-related GTP-binding protein A Selenoprotein S Superkiller complex protein 8 Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 A Ubiquitin-conjugating enzyme E2 B Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 J2 Ubiquitin-conjugating enzyme E2 L3 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unique short US11 glycoprotein WW domain-containing adapter protein with coiled-coil	A0AVI4 O00623 O60683 O60814 O75150 O75381 O95999 P04439 P06899 P09727 P0CG47 P0CG48 P12004 P23527 P28328 P33778 P49459 P50876 P51668 P51965 P55072 P58876 P61077 P61088 P62807 P62837 P62979 P62987 P63146 P68036 P78527 Q14527 Q149N8 Q15819 Q5VTR2 Q6P1J9 Q6PD62 Q7L523 Q8N2K1 Q8N7H5 Q8N8N0 Q8WVC0 Q92541 Q92968 Q93079 Q96A08 Q99877 Q99879 Q99880 Q9BQE4 Q9BTA9 Q9BUN8 Q9GZS3 Q9MY60 Q9NS91 Q9P0P0	BCL10 BLU BRE1A BRE1B C1orf28 CDC73 CIPER CLAP CTR9 DER1 DERL1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFR H2BFT HEL-220 HEL-S-70 HIP116A HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HLA-A HLA-B HLAA HLTF HRPT2 HYRC HYRC1 KIAA0155 KIAA0161 KIAA0252 KIAA0661 KIAA1844 KIAA2023 LEO1 MMS2 NCUBE2 PAF1 PAF3 PCNA PD2 PEX10 PEX12 PEX13 PEX14 PEX2 PMP3 PMP35 PRKDC PUBC1 PXMP3 RAD18 RAD6A RAD6B RDL RNF144 RNF144A RNF152 RNF181 RNF20 RNF40 RNF69 RNF72 RNF73 RNF80 RPS27A RRAGA RTF1 SELENOS SELS SFT SH2BP1 SHPRH SKIC8 SMARCA3 SNF2L3 TMEM129 TSH2B UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCE7 UBCE7IP4 UBCEP1 UBCEP2 UBCH1 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBCH6 UBCH7 UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2L3 UBE2N UBE2V2 UEV2 US11 VCP VIMP WAC WDR61 ZBU1	Homo sapiens (human)
NTF3 activates NTRK3 signaling	NT-3 growth factor receptor Neurotrophin-3	P20783 Q16288	NTF3 NTRK3 TRKC	Homo sapiens (human)
Macroautophagy	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Activating molecule in BECN1-regulated autophagy protein 1 Autophagy protein 5 Autophagy-related protein 101 Autophagy-related protein 13 Autophagy-related protein 16-1 Autophagy-related protein 9A Autophagy-related protein 9B Beclin 1-associated autophagy-related key regulator Beclin-1 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cysteine protease ATG4A Cysteine protease ATG4B Cysteine protease ATG4C Cysteine protease ATG4D Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic GTP-binding protein Rheb Gamma-aminobutyric acid receptor-associated protein-like 1 Gamma-aminobutyric acid receptor-associated protein-like 2 Gamma-aminobutyric acid receptor-associated protein-like 3 Gamma-aminobutyric acid receptor-associated protein Hamartin Microtubule-associated proteins 1A/1B light chain 3A Microtubule-associated proteins 1A/1B light chain 3B Microtubule-associated proteins 1A/1B light chain 3C Myotubularin-related protein 14 Myotubularin-related protein 3 Neutral amino acid transporter 9 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 RB1-inducible coiled-coil protein 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase ULK1 Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8 Tuberin UV radiation resistance-associated gene protein Ubiquitin-like modifier-activating enzyme ATG7 Ubiquitin-like protein ATG12 Ubiquitin-like-conjugating enzyme ATG10 Ubiquitin-like-conjugating enzyme ATG3 WD repeat domain phosphoinositide-interacting protein 1 WD repeat domain phosphoinositide-interacting protein 2 WD repeat domain phosphoinositide-interacting protein 3 WD repeat domain phosphoinositide-interacting protein 4	O43504 O43633 O43741 O75143 O75385 O94817 O95166 O95352 P42345 P49815 P54619 P54646 P60520 P63167 Q0VGL1 Q13131 Q13615 Q14457 Q15382 Q5MNZ6 Q5MNZ9 Q5VZM2 Q674R7 Q676U5 Q6IAA8 Q6ZNE5 Q7L523 Q7Z3C6 Q86TL0 Q8N122 Q8NBW4 Q8NCE2 Q8NEB9 Q8TDY2 Q8WUX9 Q8WYN0 Q92574 Q96CF2 Q96DT6 Q96FJ2 Q96FZ7 Q99570 Q9BSB4 Q9BVC4 Q9BXW4 Q9BY43 Q9BY60 Q9C0C7 Q9GZQ8 Q9H0R8 Q9H0Y0 Q9H1Y0 Q9H444 Q9H492 Q9HB90 Q9NQL2 Q9NT62 Q9P2Y5 Q9UGI9 Q9UGJ0 Q9UHA4 Q9UQN3 Q9Y2Q5 Q9Y3E7 Q9Y478 Q9Y484 Q9Y4P1 Q9Y4P8	AMBRA1 AMPK AMPK1 AMPK2 AMPKG3 APG10L APG12 APG12L APG16L APG3 APG3L APG4A APG4B APG4C APG4D APG5L APG7L APG9L1 APG9L2 ASP ATG10 ATG101 ATG12 ATG13 ATG14 ATG14L ATG16L1 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATG9B AUTL1 AUTL2 AUTL3 AUTL4 BC2 BECN1 C11orf59 C12orf44 C14orf123 C20orf178 C3orf29 C7orf59 CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 DCAF3 DLC1 DLC2 DNCL1 DNCLC1 DYNLL1 DYNLL2 FLC3A FLC3B FRAP FRAP1 FRAP2 GABARAP GABARAPL1 GABARAPL2 GABARAPL3 GBL GEC1 GEF2 GT197 HBXIP HDLC1 KIAA0203 KIAA0243 KIAA0371 KIAA0652 KIAA0722 KIAA0831 KIAA0943 KIAA1303 KIAA1736 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP1ALC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTMR14 MTMR3 MTOR NEDF NOS3AS PDRO PIK3C3 PIK3R4 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAFT1 RAPT1 RAPTOR RB1CC1 RBICC RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SHAX1 SHAX2 SHAX3 SLC38A9 TSC TSC1 TSC2 TSC4 ULK1 URLC11 UVRAG VPS15 VPS20 VPS24 VPS34 WDR45 WDR45B WDR45L WDRX1 WDRXI4 WIPI1 WIPI2 WIPI3 WIPI4 WIPI49 XIP ZFYVE10	Homo sapiens (human)
Ion transport by P-type ATPases	Calcium-transporting ATPase type 2C member 1 Calcium-transporting ATPase type 2C member 2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cardiac phospholamban Copper homeostasis protein cutC homolog Copper-transporting ATPase 1 Copper-transporting ATPase 2 Endoplasmic reticulum transmembrane helix translocase FXYD domain-containing ion transport regulator 3 FXYD domain-containing ion transport regulator 4 FXYD domain-containing ion transport regulator 6 FXYD domain-containing ion transport regulator 7 PDZ domain-containing protein 11 Phospholemman Phospholipid-transporting ATPase IA Phospholipid-transporting ATPase IB Phospholipid-transporting ATPase IC Phospholipid-transporting ATPase ID Phospholipid-transporting ATPase IF Phospholipid-transporting ATPase IG Phospholipid-transporting ATPase IH Phospholipid-transporting ATPase IK Phospholipid-transporting ATPase VA Phospholipid-transporting ATPase VB Phospholipid-transporting ATPase VD Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Polyamine-transporting ATPase 13A2 Potassium-transporting ATPase alpha chain 1 Potassium-transporting ATPase alpha chain 2 Potassium-transporting ATPase subunit beta Probable cation-transporting ATPase 13A4 Probable cation-transporting ATPase 13A5 Probable phospholipid-transporting ATPase IIA Probable phospholipid-transporting ATPase IIB Probable phospholipid-transporting ATPase IM Sarcolipin Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-2 Sodium/potassium-transporting ATPase subunit alpha-3 Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit gamma Sorcin	O00168 O00631 O14983 O43520 O43861 O60312 O60423 O75110 O75185 O94823 P05023 P05026 P0DP23 P13637 P14415 P16615 P20020 P20648 P23634 P26678 P30626 P35670 P50993 P51164 P54707 P54709 P54710 P58549 P59646 P98194 P98196 P98198 Q01814 Q04656 Q13554 Q13555 Q13557 Q13733 Q14802 Q16720 Q4VNC0 Q4VNC1 Q5EBL8 Q8NB49 Q8TF62 Q93084 Q9H0Q3 Q9HD20 Q9NQ11 Q9NTI2 Q9NTM9 Q9P241 Q9UQM7 Q9Y2G3 Q9Y2Q0	AIPP1 ATP10A ATP10B ATP10C ATP10D ATP11A ATP11B ATP11C ATP12A ATP13A ATP13A1 ATP13A2 ATP13A4 ATP13A5 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1AL1 ATP1AL2 ATP1B ATP1B1 ATP1B2 ATP1B3 ATP1C ATP1G1 ATP1K ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B ATPIA ATPIB ATPIC ATPID ATPIF ATPIG ATPIH ATPIIA ATPIIB ATPIQ ATPIR ATPIS ATPVA ATPVB ATPVC ATPVD CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CUTC FIC1 FOS37502_2 FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 KIAA0566 KIAA0611 KIAA0703 KIAA0715 KIAA0778 KIAA0956 KIAA0968 KIAA1021 KIAA1137 KIAA1347 KIAA1487 KIAA1825 KIAA1939 MAT8 MC1 MNK MXRA1 NEO1L PARK9 PDZD11 PDZK11 PFIC PISP PLB PLM PLML PLN PMCA1 PMCA2 PMR1L PWD SLN SPCA2 SRI WC1 WND	Homo sapiens (human)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Bifunctional epoxide hydrolase 2 Cytochrome P450 1A1 Cytochrome P450 1A2 Cytochrome P450 1B1 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2J2	P04798 P05177 P10632 P11712 P33261 P34913 P51589 Q16678	CYP1A1 CYP1A2 CYP1B1 CYP2C10 CYP2C19 CYP2C8 CYP2C9 CYP2J2 EPHX2	Homo sapiens (human)
TNF signaling	BAG family molecular chaperone regulator 4 Disintegrin and metalloproteinase domain-containing protein 17 Receptor-interacting serine/threonine-protein kinase 1 TNF receptor-associated factor 2 Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	O95429 P01375 P19438 P78536 Q12933 Q13546 Q15628	ADAM17 BAG4 CSVP RIP RIP1 RIPK1 SODD TACE TNF TNFA TNFAR TNFR1 TNFRSF1A TNFSF2 TRADD TRAF2 TRAP3	Homo sapiens (human)
Oligomerization of connexins into connexons	Gap junction alpha-1 protein Gap junction beta-1 protein Gap junction beta-2 protein	P08034 P17302 P29033	CX32 GJA1 GJAL GJB1 GJB2	Homo sapiens (human)
Amino acid transport across the plasma membrane	Amino acid transporter heavy chain SLC3A1 Amino acid transporter heavy chain SLC3A2 Asc-type amino acid transporter 1 Cationic amino acid transporter 3 Cystine/glutamate transporter High affinity cationic amino acid transporter 1 Inactive sodium-dependent neutral amino acid transporter B(0)AT3 Large neutral amino acids transporter small subunit 1 Large neutral amino acids transporter small subunit 2 Large neutral amino acids transporter small subunit 3 Large neutral amino acids transporter small subunit 4 Mitochondrial basic amino acids transporter Monocarboxylate transporter 10 Neutral amino acid transporter A Neutral amino acid transporter B(0) Neutral amino acid uniporter 4 Proton-coupled amino acid transporter 1 Proton-coupled amino acid transporter 2 Sodium- and chloride-dependent betaine transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) Sodium- and chloride-dependent taurine transporter Sodium- and chloride-dependent transporter XTRP3 Sodium-coupled neutral amino acid symporter 1 Sodium-coupled neutral amino acid symporter 2 Sodium-coupled neutral amino acid transporter 3 Sodium-coupled neutral amino acid transporter 4 Sodium-coupled neutral amino acid transporter 5 Sodium-dependent neutral amino acid transporter B(0)AT1 Sodium-dependent neutral amino acid transporter B(0)AT2 Y+L amino acid transporter 1 Y+L amino acid transporter 2 b(0,+)-type amino acid transporter 1	O75387 P08195 P30825 P31641 P43007 P48065 P82251 Q01650 Q07837 Q15758 Q495M3 Q695T7 Q6YBV0 Q7Z2H8 Q8N370 Q8N8R3 Q8TF71 Q8WUX1 Q8WY07 Q92536 Q969I6 Q96N87 Q96QD8 Q99624 Q9H2H9 Q9H2J7 Q9NP91 Q9NS82 Q9UHI5 Q9UM01 Q9UN76 Q9UPY5	ASC1 ASCT1 ASCT2 ATA1 ATA2 ATA3 ATRC1 ATRC3 B0AT1 B0AT2 B0AT3 BAT1 BGT1 C14orf69 CAT3 CD98LC ERR G17 JM24 KIAA0245 KIAA1382 LAT1 LAT2 LAT3 LAT4 M7V1 MCT10 MDU1 MPE16 NAT1 NAT2 NAT3 NBAT NTT73 ORNT3 PAT1 PAT2 PAT4 PB39 POV1 RDR RDRC REC1L SAT1 SAT2 SATT SBAT1 SIT1 SLC16A10 SLC1A4 SLC1A5 SLC25A29 SLC36A1 SLC36A2 SLC36A4 SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC3A1 SLC3A2 SLC43A1 SLC43A2 SLC6A12 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A20 SLC6A6 SLC7A1 SLC7A10 SLC7A11 SLC7A3 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SN1 SN2 SNAT1 SNAT2 SNAT3 SNAT4 SNAT5 TAT1 TRAMD1 XT3 XTRP2 XTRP3	Homo sapiens (human)
Metal ion SLC transporters	Calcium/manganese antiporter SLC30A10 Ceruloplasmin Hephaestin High affinity copper uptake protein 1 Natural resistance-associated macrophage protein 1 Natural resistance-associated macrophage protein 2 Solute carrier family 40 member 1 Solute carrier family 41 member 1 Solute carrier family 41 member 2	O15431 P00450 P49279 P49281 Q6XR72 Q8IVJ1 Q96JW4 Q9BQS7 Q9NP59	COPT1 CP CTR1 DCT1 DMT1 FPN FPN1 HEPH IREG1 KIAA0698 LSH NRAMP NRAMP1 NRAMP2 SLC11A1 SLC11A2 SLC11A3 SLC30A10 SLC31A1 SLC40A1 SLC41A1 SLC41A2 ZNT10 ZNT8	Homo sapiens (human)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Bile acid receptor Cytochrome P450 7A1 Cytochrome P450 7B1 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O75881 P17516 P19793 P22680 P42330 P51857 P52895 Q02318 Q04828 Q15596 Q15788 Q16647 Q96RI1 Q9H2F3 Q9UNU6	AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 BAR BHLHE74 BHLHE75 CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 FXR HRR1 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTGIS RIP14 RXRA SRC1 SRC2 SRD5B1 TIF2	Homo sapiens (human)
Inactivation of APC/C via direct inhibition of the APC/C complex	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O43684 O60566 P30260 P51668 P51965 P60006 Q12834 Q13042 Q13257 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C9orf17 CDC16 CDC20 CDC23 CDC26 CDC27 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 MAD2 MAD2L1 MAD3L SFT SSK1 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
HDL remodeling	ATP-binding cassette sub-family G member 1 Albumin Apolipoprotein A-I Apolipoprotein C-II Apolipoprotein C-III Apolipoprotein E Cholesteryl ester transfer protein Endothelial lipase Phosphatidylcholine-sterol acyltransferase	P02647 P02649 P02655 P02656 P02768 P04180 P11597 P45844 Q9Y5X9	ABC8 ABCG1 ALB APC2 APOA1 APOC2 APOC3 APOE CETP LCAT LIPG WHT1	Homo sapiens (human)
GABA synthesis, release, reuptake and degradation	Complexin-1 DnaJ homolog subfamily C member 5 Glutamate decarboxylase 1 Glutamate decarboxylase 2 Heat shock cognate 71 kDa protein Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2 Vesicular inhibitory amino acid transporter	O14810 P11142 P20336 P21579 P60880 P63027 Q05329 Q16623 Q86UR5 Q99259 Q9H3Z4 Q9H598	CLN4 CPLX1 DNAJC5 GAD GAD1 GAD2 GAD65 GAD67 HSC70 HSP73 HSPA10 HSPA8 KIAA0340 RAB3A RAB3IP2 RIM1 RIMS1 SLC32A1 SNAP SNAP25 STX1 STX1A SVP65 SYB2 SYT SYT1 VAMP2 VGAT VIAAT	Homo sapiens (human)
Regulation of PTEN stability and activity	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4 E3 ubiquitin-protein ligase RNF146 E3 ubiquitin-protein ligase XIAP E3 ubiquitin-protein ligase makorin-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 OTU domain-containing protein 3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Poly [ADP-ribose] polymerase tankyrase-1 Poly [ADP-ribose] polymerase tankyrase-2 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tyrosine-protein kinase FRK Ubiquitin carboxyl-terminal hydrolase 13 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein RFP	A5LHX3 O00231 O00232 O00233 O00308 O00487 O14818 O43242 O75832 O95271 P0CG47 P0CG48 P14373 P17980 P19784 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P31749 P31751 P35998 P40306 P42685 P43686 P46934 P48556 P49720 P49721 P51665 P55036 P60484 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P67870 P68400 P98170 Q06323 Q13200 Q14997 Q15008 Q16401 Q5T2D3 Q70Z35 Q8TAA3 Q92530 Q92995 Q99436 Q99460 Q9H2K2 Q9NTX7 Q9UHC7 Q9UL46 Q9UNE7 Q9UNM6 Q9Y243	AKT1 AKT2 AKT3 API3 BIRC4 C7orf76 CHIP CK2A1 CK2A2 CK2N CSNK2A1 CSNK2A2 CSNK2B DEPDC2 DSS1 FRK G5A HC2 HC3 HC8 HC9 HSPC IAP3 IFI5111 ISOT3 KIAA0072 KIAA0077 KIAA0093 KIAA0107 KIAA0459 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MKRN1 MMAC1 MOV34L MSS1 NEDD4 NEDD4-1 NU OTUD3 PARP5A PARP5B PARPL PFAAP4 PKB PKBG POH1 PREX2 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PTK5 RAC RAK RFP RING10 RING12 RNF146 RNF61 RNF76 RPF1 RPS27A SEM1 SHFDG1 SHFM1 STUB1 SUG1 SUG2 TANK2 TBP1 TBP7 TEP1 TIN1 TINF1 TNKL TNKS TNKS1 TNKS2 TRAP2 TRIM27 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP13 WWP2 X XIAP Y Y2 Z	Homo sapiens (human)
Nitric oxide stimulates guanylate cyclase	Guanylate cyclase soluble subunit alpha-1 Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit beta-1 Guanylate cyclase soluble subunit beta-2 Nitric oxide synthase 1 Nitric oxide synthase 3 Nitric oxide synthase, inducible	O75343 P29474 P29475 P33402 P35228 Q02108 Q02153	GUC1A2 GUC1A3 GUC1B3 GUCSA2 GUCSA3 GUCSB3 GUCY1A1 GUCY1A2 GUCY1A3 GUCY1B1 GUCY1B2 GUCY1B3 NOS1 NOS2 NOS2A NOS3	Homo sapiens (human)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Thioredoxin reductase 1, cytoplasmic	O43252 O95340 Q16881	ATPSK1 ATPSK2 GRIM12 KDRF PAPSS PAPSS1 PAPSS2 TXNRD1	Homo sapiens (human)
IRS-related events triggered by IGF1R	Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor substrate 4 Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II	O14654 P01344 P05019 P08069 P35568 Q9Y4H2	IBP1 IGF1 IGF1R IGF2 IRS1 IRS2 IRS4	Homo sapiens (human)
AKT-mediated inactivation of FOXO1A	Forkhead box protein O1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	P31749 P31751 Q12778 Q9Y243	AKT1 AKT2 AKT3 FKHR FOXO1 FOXO1A PKB PKBG RAC	Homo sapiens (human)

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