GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1701 - 1725** of **2090** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
Signaling by FGFR3 fusions in cancer	Fibroblast growth factor receptor 3	P22607	FGFR3 JTK4	Homo sapiens (human)
Signaling by FGFR3 in disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Son of sevenless homolog 1	O43320 O76093 P01111 P01112 P05230 P08620 P09038 P19174 P22607 P27986 P31371 P42336 Q07889 Q13480 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB FGFR3 FRS2 GAB1 GRB1 HRAS HRAS1 HST HSTF1 HYPF JTK4 KS3 NRAS PIK3CA PIK3R1 PLC1 PLCG1 SOS1	Homo sapiens (human)
Signaling by FGFR4 in disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Son of sevenless homolog 1	P01111 P01112 P19174 P22455 P27986 P42336 Q07889 Q13480 Q8WU20	FGFR4 FRS2 GAB1 GRB1 HRAS HRAS1 JTK2 NRAS PIK3CA PIK3R1 PLC1 PLCG1 SOS1 TKF	Homo sapiens (human)
Signaling by FLT3 ITD and TKD mutants	GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	P01111 P01112 P27986 P36888 P42336 P62993 Q06124 Q07889 Q9UQC2	ASH CD135 FLK2 FLT3 GAB2 GRB1 GRB2 HRAS HRAS1 KIAA0571 NRAS PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 SOS1 STK1	Homo sapiens (human)
Signaling by FLT3 fusion proteins	Cyclin-dependent kinase inhibitor 1 GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Golgin subfamily B member 1 NADPH oxidase 4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Serine/threonine-protein kinase pim-1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Spectrin beta chain, non-erythrocytic 1 Thyroid receptor-interacting protein 11 Transcription factor ETV6 Unconventional myosin-XVIIIa Zinc finger MYM-type protein 2	P01111 P01112 P11309 P27986 P38936 P41212 P42229 P42336 P51692 Q01082 Q07889 Q14789 Q15643 Q92614 Q9NPH5 Q9UBW7 Q9UQC2	CAP20 CD245 CDKN1 CDKN1A CEV14 CIP1 ETV6 FIM GAB2 GOLGB1 GRB1 HRAS HRAS1 KIAA0216 KIAA0571 MDA6 MYO18A MYSPDZ NOX4 NRAS PIC1 PIK3CA PIK3R1 PIM1 RAMP RENOX SDI1 SOS1 SPTB2 SPTBN1 STAT5 STAT5A STAT5B TEL TEL1 TIAF1 TRIP11 WAF1 ZMYM2 ZNF198	Homo sapiens (human)
Signaling by GSK3beta mutants	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Signaling by Hippo	14-3-3 protein beta/alpha 14-3-3 protein epsilon Angiomotin-like protein 1 Angiomotin-like protein 2 Caspase-3 MOB kinase activator 1A MOB kinase activator 1B Nephrocystin-4 Protein KIBRA Protein salvador homolog 1 Segment polarity protein dishevelled homolog DVL-2 Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 4 Serine/threonine-protein kinase LATS1 Serine/threonine-protein kinase LATS2 Tight junction protein ZO-1 Tight junction protein ZO-2 Transcriptional coactivator YAP1 WW domain-containing transcription regulator protein 1	O14641 O75161 O95835 P31946 P42574 P46937 P62258 Q07157 Q13043 Q13188 Q7L9L4 Q8IX03 Q8IY63 Q9GZV5 Q9H4B6 Q9H8S9 Q9NRM7 Q9UDY2 Q9Y2J4	AMOTL1 AMOTL2 C2orf6 CASP3 CPP32 DVL2 KIAA0673 KIAA0869 KIAA0989 KIBRA KPM KRS1 KRS2 LATS1 LATS2 MOB1A MOB1B MOB4A MOB4B MOBK1B MOBKL1A MOBKL1B MST1 MST2 NPHP4 SAV1 STK3 STK4 TAZ TJP1 TJP2 WARTS WW45 WWC1 WWTR1 X104 YAP1 YAP65 YWHAB YWHAE ZO1 ZO2	Homo sapiens (human)
Signaling by Insulin receptor	Insulin receptor Insulin	P01308 P06213	INS INSR	Homo sapiens (human)
Signaling by LRP5 mutants	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5	O75197 O94907 Q8NCW0 Q96MU8 Q9UBT3 Q9UBU2	DKK1 DKK2 DKK4 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP7	Homo sapiens (human)
Signaling by LTK	ALK and LTK ligand 1 ALK and LTK ligand 2 Activated CDC42 kinase 1 Growth factor receptor-bound protein 2 Insulin receptor substrate 1 Leukocyte tyrosine kinase receptor Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Son of sevenless homolog 1	O00459 P27986 P29376 P35568 P42336 P42338 P62993 Q07889 Q07912 Q6UX46 Q6UXT8	ACK1 ALKAL1 ALKAL2 ASH FAM150A FAM150B GRB1 GRB2 IRS1 LTK PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 TNK2 TYK1	Homo sapiens (human)
Signaling by LTK in cancer	CAP-Gly domain-containing linker protein 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O00459 P27361 P27986 P28482 P30622 P42336 P42338	CLIP1 CYLN1 ERK1 ERK2 GRB1 MAPK1 MAPK3 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 RSN	Homo sapiens (human)
Signaling by Leptin	Insulin receptor substrate 1 Insulin receptor substrate 2 Leptin Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O14543 O60674 P35568 P40763 P41159 P42229 P51692 Q06124 Q9Y4H2	APRF CIS3 IRS1 IRS2 JAK2 LEP OB OBS PTP2C PTPN11 SHPTP2 SOCS3 SSI3 STAT3 STAT5 STAT5A STAT5B	Homo sapiens (human)
Signaling by MAP2K mutants	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P36507 Q02750	ERK1 ERK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2	Homo sapiens (human)
Signaling by MAPK mutants	Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 Mitogen-activated protein kinase 1	P28482 Q13202 Q16828 Q16829 Q99956 Q9BY84 Q9Y6W6	C11orf81 DUSP10 DUSP16 DUSP6 DUSP7 DUSP8 DUSP9 ERK2 KIAA1700 MAPK1 MKP3 MKP4 MKP5 MKP7 PRKM1 PRKM2 PYST1 PYST2 VH5	Homo sapiens (human)
Signaling by MST1	Hepatocyte growth factor-like protein Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 2 Macrophage-stimulating protein receptor Serine protease hepsin	O43278 O43291 P05981 P26927 Q04912	D3F15S2 DNF15S2 HAI1 HAI2 HGFL HPN KOP MST1 MST1R PTK8 RON SPINT1 SPINT2 TMPRSS1	Homo sapiens (human)
Signaling by NODAL	Activin receptor type-1B Activin receptor type-1C Activin receptor type-2A Activin receptor type-2B Cerberus Cryptic protein DAN domain family member 5 Dr1-associated corepressor Embryonic growth/differentiation factor 1 Forkhead box protein H1 Forkhead box protein O3 Furin Left-right determination factor 1 Left-right determination factor 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nodal homolog Proprotein convertase subtilisin/kexin type 6 Protein Cripto Putative protein CRIPTO3	O00292 O43524 O75593 O75610 O95813 P09958 P0CG37 P13385 P27037 P27361 P27539 P28482 P29122 P36896 P51864 P84022 Q13485 Q13705 Q14919 Q15796 Q8N907 Q8NER5 Q96S42	ACVR1B ACVR1C ACVR2 ACVR2A ACVR2B ACVRLK4 ALK4 ALK7 CER1 CER2 CFC1 CKTSF1B3 CRIPTO CRIPTO-1 CRIPTO-3 CRIPTO3 DAND4 DAND5 DPC4 DRAP1 EBAF ERK1 ERK2 FAST1 FAST2 FKHRL1 FOXH1 FOXO3 FOXO3A FUR FURIN GDF1 GREM3 LEFTA LEFTB LEFTY1 LEFTY2 LEFTYA LEFTYB MADH2 MADH3 MADH4 MADR2 MAPK1 MAPK3 NODAL PACE PACE4 PCSK3 PCSK6 PRKM1 PRKM2 PRKM3 SMAD2 SMAD3 SMAD4 SP1 TDGF1 TDGF1P3 TDGF2 TDGF3 TGFB4	Homo sapiens (human)
Signaling by NTRK3 (TRKC)	NT-3 growth factor receptor Neurotrophin-3 Receptor-type tyrosine-protein phosphatase O Receptor-type tyrosine-protein phosphatase S	P20783 Q13332 Q16288 Q16827	GLEPP1 NTF3 NTRK3 PTPRO PTPRS PTPU2 TRKC	Homo sapiens (human)
Signaling by PDGF	Collagen alpha-1(IV) chain Collagen alpha-1(IX) chain Collagen alpha-1(VI) chain Collagen alpha-2(IV) chain Collagen alpha-2(IX) chain Collagen alpha-2(VI) chain Collagen alpha-3(IV) chain Collagen alpha-3(IX) chain Collagen alpha-3(VI) chain Collagen alpha-4(IV) chain Collagen alpha-5(IV) chain Collagen alpha-5(VI) chain Collagen alpha-6(VI) chain Furin Osteopontin Plasminogen Platelet-derived growth factor D Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Thrombospondin-1 Thrombospondin-2 Thrombospondin-3 Thrombospondin-4 Tissue-type plasminogen activator Tyrosine-protein phosphatase non-receptor type 12	A6NMZ7 A8TX70 P00747 P00750 P01127 P02462 P07996 P08572 P09619 P09958 P10451 P12109 P12110 P12111 P16234 P20849 P29400 P35442 P35443 P49746 P53420 Q01955 Q05209 Q14050 Q14055 Q9GZP0	BNSP COL29A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 FUR FURIN IEGF OPN PACE PCSK3 PDGF2 PDGFB PDGFD PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PLAT PLG PTPN12 RHEPDGFRA SCDGFB SIS SPP1 THBS1 THBS2 THBS3 THBS4 TSP TSP1 TSP2 TSP3 TSP4 VWA4	Homo sapiens (human)
Signaling by PDGFRA extracellular domain mutants	GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Son of sevenless homolog 1	O00459 P01111 P01112 P16234 P27986 P40763 P42224 P42336 P42338 Q07889	APRF GRB1 HRAS HRAS1 NRAS PDGFR2 PDGFRA PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHEPDGFRA SOS1 STAT1 STAT3	Homo sapiens (human)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Son of sevenless homolog 1	O00459 P01111 P01112 P16234 P27986 P40763 P42224 P42336 P42338 Q07889	APRF GRB1 HRAS HRAS1 NRAS PDGFR2 PDGFRA PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHEPDGFRA SOS1 STAT1 STAT3	Homo sapiens (human)
Signaling by RAF1 mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB	Homo sapiens (human)
Signaling by RAS GAP mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2	Homo sapiens (human)
Signaling by RAS GTPase mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2	Homo sapiens (human)
Signaling by RNF43 mutants	E3 ubiquitin-protein ligase RNF43 Frizzled-4 Frizzled-5 Frizzled-6 Frizzled-8 Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Protein Wnt-3a	O60353 O75197 O75581 P56704 Q13467 Q68DV7 Q9H461 Q9ULV1	C2orf31 FZD4 FZD5 FZD6 FZD8 LR3 LRP5 LRP6 LRP7 RNF43 WNT3A	Homo sapiens (human)
Signaling by ROBO receptors	C-X-C chemokine receptor type 4 Ena/VASP-like protein Glypican-1 Leucine-rich repeat transmembrane protein FLRT3 Neuropilin-1 Profilin-1 Profilin-2 Protein enabled homolog Roundabout homolog 1 Roundabout homolog 2 Slit homolog 1 protein Slit homolog 2 protein Slit homolog 3 protein Stromal cell-derived factor 1 Vasodilator-stimulated phosphoprotein	O14786 O75093 O75094 O94813 P07737 P35052 P35080 P48061 P50552 P61073 Q8N8S7 Q9HCK4 Q9NZU0 Q9UI08 Q9Y6N7	CXCL12 CXCR4 DUTT1 ENAH EVL FLRT3 GPC1 KIAA0813 KIAA0814 KIAA1469 KIAA1568 MEGF4 MEGF5 MENA NRP NRP1 PFN1 PFN2 RNB6 ROBO1 ROBO2 SDF1 SDF1A SDF1B SLIL1 SLIL2 SLIL3 SLIT1 SLIT2 SLIT3 VASP VEGF165R	Homo sapiens (human)

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