GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1876 - 1900** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Activation of caspases through apoptosome-mediated cleavage	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS IAP3 KIAA0413 MCH3 MCH6 XIAP	Homo sapiens (human)
EGFR interacts with phospholipase C-gamma	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P19174 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 PLC1 PLCG1 SDGF TGFA	Homo sapiens (human)
STAT3 nuclear events downstream of ALK signaling	Cytokine receptor common subunit gamma DNA (cytosine-5)-methyltransferase 1 Histone acetyltransferase p300 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Hypoxia-inducible factor 1-alpha PR domain zinc finger protein 1 Paired amphipathic helix protein Sin3a Programmed cell death 1 ligand 1 Signal transducer and activator of transcription 3	O15379 O75626 P26358 P31785 P40763 Q09472 Q13547 Q16665 Q92769 Q96ST3 Q9NZQ7	AIM APRF B7H1 BHLHE78 BLIMP1 CD274 CXXC9 DNMT DNMT1 EP300 HDAC1 HDAC2 HDAC3 HIF1A IL2RG MOP1 P300 PASD8 PDCD1L1 PDCD1LG1 PDL1 PRDM1 RPD3L1 SIN3A STAT3	Homo sapiens (human)
Defective regulation of TLR7 by endogenous ligand	Toll-like receptor 7	Q9NYK1	TLR7	Homo sapiens (human)
Attachment and Entry	Angiotensin-converting enzyme 2 Envelope small membrane protein Membrane protein Nucleoprotein ORF3a protein ORF7a protein Procathepsin L Spike glycoprotein Transitional endoplasmic reticulum ATPase Transmembrane protease serine 2	O15393 P07711 P55072 P59594 P59595 P59596 P59632 P59635 P59637 Q9BYF1	3a 7a ACE2 CTSL CTSL1 E HEL-220 HEL-S-70 M N PRSS10 S TMPRSS2 VCP sM	Homo sapiens (human)
Platelet Aggregation (Plug Formation)	Platelet glycoprotein IX Platelet glycoprotein Ib alpha chain Platelet glycoprotein Ib beta chain Platelet glycoprotein V Prothrombin Thrombopoietin receptor Thrombopoietin von Willebrand factor	P00734 P04275 P07359 P13224 P14770 P40197 P40225 P40238	F2 F8VWF GP1BA GP1BB GP5 GP9 MGDF MPL THPO TPOR VWF	Homo sapiens (human)
Cytochrome P450 - arranged by substrate type	NADPH--cytochrome P450 reductase	P16435	CYPOR POR	Homo sapiens (human)
BDNF activates NTRK2 (TRKB) signaling	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor	P23560 Q16620	BDNF NTRK2 TRKB	Homo sapiens (human)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox protein homolog 2 Chromobox protein homolog 6 Chromobox protein homolog 8 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 2A Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 6 Dual specificity mitogen-activated protein kinase kinase 7 E3 SUMO-protein ligase CBX4 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Helicase MOV-10 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Interferon beta Lysine-specific demethylase 6B MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 5 Misshapen-like kinase 1 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase kinase 4 Polycomb complex protein BMI-1 Polycomb protein EED Polycomb protein SUZ12 Polyhomeotic-like protein 1 Polyhomeotic-like protein 2 Polyhomeotic-like protein 3 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Protein c-Fos TRAF2 and NCK-interacting protein kinase Thioredoxin Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3 Transcription factor Jun Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00257 O00716 O14733 O15054 O15151 O60814 O75530 O95503 O95819 P01100 P01574 P04637 P04908 P05412 P06899 P0C5Y9 P0CG47 P0CG48 P10599 P11802 P16104 P20671 P23527 P27361 P28482 P33778 P35226 P42771 P42772 P42773 P45983 P45984 P45985 P46734 P49137 P52564 P53779 P55273 P57053 P58876 P62805 P62807 P62979 P62987 P68431 P78364 P84243 Q00534 Q00987 Q01094 Q06587 Q09028 Q14186 Q14188 Q14209 Q14781 Q15022 Q15759 Q15910 Q16539 Q16576 Q16644 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8IW41 Q8IXK0 Q8N257 Q8N4C8 Q8N726 Q8NDV7 Q8NDX5 Q93077 Q93079 Q96A08 Q99496 Q99683 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H9G7 Q9HC52 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKE5 Q9UL18 Q9UPQ9	AGO1 AGO3 AGO4 ASK1 B55 BAP1 BMI1 CAGH26 CBX2 CBX4 CBX6 CBX8 CDK4 CDK6 CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CHET9 CSBP CSBP1 CSBP2 CSPB1 DING DP1 DP2 E2F1 E2F2 E2F3 EDR1 EDR2 EDR3 EED EIF2C1 EIF2C3 EIF2C4 ERK1 ERK2 EZH2 FOS G0S7 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HGK HIPI3 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 IFB IFNB IFNB1 JJAZ1 JMJD3 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 JUN KDM6B KIAA0075 KIAA0160 KIAA0346 KIAA0551 KIAA0687 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 KMT6 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAP4K6 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPKKK5 MDM2 MDM4 MDMX MEK3 MEK4 MEK6 MEK7 MEKK5 MINK MINK1 MKK3 MKK4 MKK6 MKK7 MLM MOV10 MTS1 MTS2 MXI2 NIK P53 PC3 PCGF4 PH1 PH2 PH3 PHC1 PHC2 PHC3 PRAK PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 PRKMK3 PRKMK4 PRKMK6 PRKMK7 RBAP46 RBAP48 RBBP3 RBBP4 RBBP7 RC1 RING1 RING1A RING1B RNF1 RNF2 RNF51 RPS27A SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B SEK1 SERK1 SKK1 SKK2 SKK3 SKK4 SUZ12 TFDP1 TFDP2 TNIK TNRC6 TNRC6A TNRC6B TNRC6C TP53 TRDX TRX TRX1 TSH2B TXN UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 YSK2 ZC3	Homo sapiens (human)
Regulation of CDH11 mRNA translation by microRNAs	Cadherin-11 Helicase MOV-10 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein	P55287 Q8NDV7 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKV8 Q9UL18 Q9UPQ9	AGO1 AGO2 AGO3 AGO4 CAGH26 CDH11 EIF2C1 EIF2C2 EIF2C3 EIF2C4 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 MOV10 TNRC6 TNRC6A TNRC6B TNRC6C	Homo sapiens (human)
Interleukin-4 and Interleukin-13 signaling	72 kDa type IV collagenase Amine oxidase [flavin-containing] A Annexin A1 Apoptosis regulator Bcl-2 B-cell lymphoma 6 protein Baculoviral IAP repeat-containing protein 5 Basic leucine zipper transcriptional factor ATF-like Bcl-2-like protein 1 C-C motif chemokine 22 C-C motif chemokine 2 CCAAT/enhancer-binding protein delta Cellular tumor antigen p53 Coagulation factor XIII A chain Collagen alpha-2(I) chain Cyclin-dependent kinase inhibitor 1 Cytokine receptor common subunit gamma Delta-type opioid receptor Endoplasmin Eotaxin Fascin Fibroblast growth factor 2 Fibronectin Forkhead box protein O1 Forkhead box protein O3 G1/S-specific cyclin-D1 Heat shock cognate 71 kDa protein Heat shock protein HSP 90-alpha Heme oxygenase 1 Hepatocyte growth factor Homeobox protein NANOG Hypoxia-inducible factor 1-alpha Immunoglobulin heavy constant epsilon Immunoglobulin heavy constant gamma 1 Immunoglobulin heavy constant gamma 4 Induced myeloid leukemia cell differentiation protein Mcl-1 Integrin alpha-M Integrin alpha-X Integrin beta-1 Integrin beta-2 Intercellular adhesion molecule 1 Interferon regulatory factor 4 Interleukin-1 alpha Interleukin-1 beta Interleukin-10 Interleukin-12 subunit alpha Interleukin-12 subunit beta Interleukin-13 receptor subunit alpha-1 Interleukin-13 receptor subunit alpha-2 Interleukin-13 Interleukin-17A Interleukin-17F Interleukin-18 Interleukin-23 receptor Interleukin-23 subunit alpha Interleukin-4 receptor subunit alpha Interleukin-4 Interleukin-6 receptor subunit alpha Interleukin-6 Interleukin-8 Interstitial collagenase Laminin subunit alpha-5 Leukemia inhibitory factor Lipopolysaccharide-binding protein Low affinity immunoglobulin epsilon Fc receptor Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Mu-type opioid receptor Mucin-1 Myc proto-oncogene protein Necdin Neutrophil gelatinase-associated lipocalin Nitric oxide synthase, inducible Non-receptor tyrosine-protein kinase TYK2 Nuclear receptor ROR-alpha Nuclear receptor ROR-gamma Oncostatin-M POU domain, class 2, transcription factor 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Platelet glycoprotein 4 Polyunsaturated fatty acid 5-lipoxygenase Polyunsaturated fatty acid lipoxygenase ALOX15 Pro-opiomelanocortin Prostaglandin G/H synthase 2 Protein c-Fos RAC-alpha serine/threonine-protein kinase Rho-related GTP-binding protein RhoU Serine/threonine-protein kinase pim-1 Serum amyloid A-1 protein Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 6 Sphingosine 1-phosphate receptor 1 Stromelysin-1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Suppressor of cytokine signaling 5 Trans-acting T-cell-specific transcription factor GATA-3 Transcription factor JunB Transcription factor SOX-2 Transforming growth factor beta-1 proprotein Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor Twist-related protein 1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Vascular cell adhesion protein 1 Vascular endothelial growth factor A, long form Vimentin Zinc finger E-box-binding homeobox 1	O00626 O14543 O15230 O15392 O15524 O43524 O60674 O75159 P00488 P01033 P01100 P01106 P01137 P01189 P01375 P01583 P01584 P01854 P01857 P01861 P02751 P03956 P04083 P04637 P05107 P05112 P05231 P05362 P05556 P06734 P07900 P08123 P08253 P08254 P08670 P08887 P09038 P09601 P09917 P0DJI8 P10145 P10415 P11142 P11215 P11309 P13500 P13725 P14210 P14625 P14780 P14859 P15018 P15692 P15941 P16050 P16671 P17275 P18428 P19320 P20333 P20702 P21397 P21453 P22301 P23458 P23771 P24385 P24394 P27986 P29459 P29460 P29597 P31749 P31785 P35225 P35228 P35354 P35372 P35398 P37275 P38936 P40763 P41143 P41182 P42224 P42226 P48023 P48431 P49716 P51449 P51671 P52333 P78552 P80188 Q07817 Q07820 Q12778 Q14116 Q14627 Q15306 Q15672 Q16520 Q16552 Q16658 Q16665 Q5VWK5 Q7L0Q8 Q96PD4 Q99608 Q9H9S0 Q9NPF7	AKT1 ALOX15 ALOX5 ANX1 ANXA1 API4 APRF APT1LG1 AREB6 ARHU BATF BCL1 BCL2 BCL2L BCL2L1 BCL2L3 BCL5 BCL6 BCLX BHLHA38 BHLHE39 BHLHE78 BIRC5 CAP20 CCL11 CCL2 CCL22 CCND1 CD11B CD11C CD18 CD23A CD36 CD95L CDC42L1 CDKN1 CDKN1A CEBPD CHEDG1 CIP1 CIS3 CIS6 CISH5 CISH6 CLEC4J CLG CLG4A CLG4B CLGI COL1A2 COX2 CR3A CTLA8 CXCL8 EDG1 F13A F13A1 FAN1 FASL FASLG FCE2 FCER2 FGF2 FGFB FKHR FKHRL1 FN FN1 FNRB FOS FOXO1 FOXO1A FOXO3 FOXO3A FSCN1 G0S7 G28K GATA3 GP3B GP4 GRB1 GRP94 HGF HIF1A HILDA HMOX1 HNL HO HO1 HPTA HSC70 HSN HSP73 HSP90A HSP90AA1 HSP90B1 HSPA10 HSPA8 HSPC1 HSPC4 HSPCA IAP4 ICAM1 IFNB2 IGEBF IGHE IGHG1 IGHG4 IGIF IL10 IL12A IL12B IL13 IL13R IL13RA IL13RA1 IL13RA2 IL17 IL17A IL17F IL18 IL1A IL1B IL1F1 IL1F2 IL1F4 IL23A IL23R IL2RG IL4 IL4R IL4RA IL6 IL6R IL8 IRF4 ITGAM ITGAX ITGB1 ITGB2 JAK1 JAK1A JAK1B JAK2 JAK3 JUNB KIAA0533 KIAA0671 KIAA1907 LAMA5 LAZ3 LBP LCN2 LIF LOG15 LOG5 LPC1 MAOA MCL1 MCP1 MDA6 MDC MDF2 MFI7 MMP1 MMP2 MMP3 MMP9 MOP1 MOR1 MSK12 MUC1 MUM1 MYC NANOG NC30 NDN NGAL NKSF1 NKSF2 NOS2 NOS2A NR1F1 NR1F3 OCT1 OPRD OPRD1 OPRM1 OSM OTF1 P53 PASD8 PIC1 PIK3R1 PIM1 PKB POMC POU2F1 PRAD1 PTGS2 PUM RAC RHOU RORA RORC RORG RZRA RZRG S1PR1 SAA1 SCYA11 SCYA2 SCYA22 SDI1 SGRF SNL SOCS1 SOCS3 SOCS5 SOX2 SSI1 SSI3 STAT1 STAT3 STAT6 STMY1 TCF8 TGFB TGFB1 TIMP TIMP1 TIP3 TNF TNFA TNFBR TNFR2 TNFRSF1B TNFSF2 TNFSF6 TP53 TRA1 TWIST TWIST1 TYK2 VCAM1 VEGF VEGFA VIM WAF1 WRCH1 ZBTB27 ZEB1 ZNF51	Homo sapiens (human)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Aurora kinase A Cullin-1 E3 ubiquitin-protein ligase RBX1 F-box/LRR-repeat protein 18 F-box/LRR-repeat protein 7 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O14965 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P63208 Q06323 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q96ME1 Q99436 Q99460 Q9UJT9 Q9UL46 Q9UNM6	AIK AIRK1 ARK1 AURA AURKA AYK1 BTAK C7orf76 CUL1 DSS1 EMC19 FBL18 FBL6 FBL7 FBXL18 FBXL7 HC2 HC3 HC8 HC9 HSPC IAK1 IFI5111 KIAA0072 KIAA0077 KIAA0107 KIAA0840 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A STK15 STK6 SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z	Homo sapiens (human)
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	Dystroglycan 1 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	Q14118 Q8WZA1	DAG1 MGAT1.2 POMGNT1	Homo sapiens (human)
STAT5 Activation	Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 2 Receptor-type tyrosine-protein kinase FLT3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein phosphatase non-receptor type 11	P36888 P42229 P49771 P51692 Q06124 Q9UQC2	CD135 FLK2 FLT3 FLT3LG GAB2 KIAA0571 PTP2C PTPN11 SHPTP2 STAT5 STAT5A STAT5B STK1	Homo sapiens (human)
Complex I biogenesis	Acyl carrier protein, mitochondrial Arginine-hydroxylase NDUFAF5, mitochondrial Complex I assembly factor ACAD9, mitochondrial Complex I assembly factor TIMMDC1, mitochondrial Complex I assembly factor TMEM126B, mitochondrial Complex I intermediate-associated protein 30, mitochondrial Cytochrome c oxidase assembly factor 1 homolog Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Iron-sulfur cluster transfer protein NUBPL NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NADH dehydrogenase [ubiquinone] 1 subunit C2 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NADH-ubiquinone oxidoreductase chain 1 NADH-ubiquinone oxidoreductase chain 2 NADH-ubiquinone oxidoreductase chain 3 NADH-ubiquinone oxidoreductase chain 4 NADH-ubiquinone oxidoreductase chain 5 NADH-ubiquinone oxidoreductase chain 6 Protein arginine methyltransferase NDUFAF7, mitochondrial Transmembrane protein 186	O00217 O14561 O15239 O43181 O43674 O43676 O43677 O43678 O43920 O75251 O75306 O75380 O75438 O75489 O95139 O95167 O95168 O95169 O95178 O95182 O95298 O95299 O96000 P03886 P03891 P03897 P03905 P03915 P03923 P17568 P19404 P28331 P49821 P51970 P56181 P56556 Q16718 Q16795 Q330K2 Q5TEU4 Q7L592 Q86Y39 Q8IUX1 Q8N183 Q8TB37 Q96B77 Q9BQ95 Q9BU61 Q9GZY4 Q9H845 Q9NPL8 Q9NX14 Q9P032 Q9P0J0 Q9UI09 Q9Y375 Q9Y6M9	ACAD9 C14orf127 C16orf51 C20orf7 C2orf56 C3orf1 C3orf60 C6orf66 C7orf44 C8orf38 CIA30 COA1 DAP13 ECSIT GRIM19 HRPAP20 LYRM3 LYRM6 MITRAC15 MT-ND1 MT-ND2 MT-ND3 MT-ND4 MT-ND5 MT-ND6 MTND1 MTND2 MTND3 MTND4 MTND5 MTND6 NADH1 NADH2 NADH3 NADH4 NADH5 NADH6 NADHB14 ND1 ND2 ND3 ND4 ND5 ND6 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA12L NDUFA13 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFAF1 NDUFAF2 NDUFAF3 NDUFAF4 NDUFAF5 NDUFAF6 NDUFAF7 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS2L NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NUBPL TIMMDC1 TMEM126B TMEM186 UQOR1 UQOR22	Homo sapiens (human)
Pregnenolone biosynthesis	Adrenodoxin, mitochondrial Aldo-keto reductase family 1 member B1 Cholesterol side-chain cleavage enzyme, mitochondrial Ferredoxin-2, mitochondrial NADPH Peripheral-type benzodiazepine receptor-associated protein 1 STARD3 N-terminal-like protein StAR-related lipid transfer protein 3 StAR-related lipid transfer protein 4 StAR-related lipid transfer protein 6 Steroidogenic acute regulatory protein, mitochondrial Translocator protein	O95153 O95772 P05108 P10109 P15121 P22570 P30536 P49675 P59095 Q14849 Q6P4F2 Q96DR4	ADX ADXR AKR1B1 ALDR1 ALR2 BZRAP1 BZRP CAB1 CYP11A CYP11A1 FDX1 FDX1L FDX2 FDXR KIAA0612 MBR MENTHO MLN64 RBP1 RIMBP1 STAR STARD1 STARD3 STARD3NL STARD4 STARD6 TSPO TSPOAP1	Homo sapiens (human)
Defective DPM3 causes CDG-1o	Dolichol phosphate-mannose biosynthesis regulatory protein Dolichol-phosphate mannosyltransferase subunit 1 Dolichol-phosphate mannosyltransferase subunit 3	O60762 O94777 Q9P2X0	DPM1 DPM2 DPM3	Homo sapiens (human)
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator	O14920 O15111 Q9Y6K9	CHUK FIP3 IKBKB IKBKG IKKA IKKB NEMO TCF16	Homo sapiens (human)
Acyl chain remodelling of PE	(Lyso)-N-acylphosphatidylethanolamine lipase 85/88 kDa calcium-independent phospholipase A2 Calcium-independent phospholipase A2-gamma Cytosolic phospholipase A2 beta Cytosolic phospholipase A2 delta Cytosolic phospholipase A2 epsilon Cytosolic phospholipase A2 gamma Cytosolic phospholipase A2 zeta Cytosolic phospholipase A2 Group 10 secretory phospholipase A2 Group 3 secretory phospholipase A2 Group IID secretory phospholipase A2 Group IIE secretory phospholipase A2 Group IIF secretory phospholipase A2 Group XIIA secretory phospholipase A2 Lysophospholipid acyltransferase 1 Lysophospholipid acyltransferase 2 Lysophospholipid acyltransferase 5 Lysophospholipid acyltransferase LPCAT4 Phospholipase A and acyltransferase 1 Phospholipase A and acyltransferase 2 Phospholipase A and acyltransferase 3 Phospholipase A and acyltransferase 4 Phospholipase A and acyltransferase 5 Phospholipase A2 group V Phospholipase A2, membrane associated Phospholipase A2 Phospholipase B-like 1 Secretory phospholipase A2 receptor	O15496 O60733 P04054 P0C869 P14555 P39877 P47712 P53816 Q13018 Q3MJ16 Q643R3 Q68DD2 Q6P1A2 Q6P4A8 Q6ZNC8 Q6ZWT7 Q86XP0 Q8TB40 Q96KN8 Q9BZM1 Q9BZM2 Q9HDD0 Q9NP80 Q9NWW9 Q9NZ20 Q9NZK7 Q9UL19 Q9UNK4 Q9UP65	ABHD4 AGPAT7 AYTL3 CLEC13C CPLA2 HRASLS HRASLS2 HRASLS3 HRASLS5 HREV107 HRLP5 IPLA22 IPLA2G LPCAT3 LPCAT4 LPEAT2 MBOAT1 MBOAT2 MBOAT5 OACT1 OACT2 OACT5 PLA2 PLA2A PLA2B PLA2G10 PLA2G12 PLA2G12A PLA2G16 PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2L PLA2R1 PLAAT1 PLAAT2 PLAAT3 PLAAT4 PLAAT5 PLBD1 PLPLA9 PNPLA8 PPLA2 RARRES3 RASF-A RIG1 SPLASH TIG3	Homo sapiens (human)
Plus-strand DNA synthesis	Gag polyprotein Gag-Pol polyprotein Peptidyl-prolyl cis-trans isomerase A Protein Rev Protein Vpr Protein Vpu Virion infectivity factor	P04585 P04591 P04618 P05919 P62937 P69723 P69726	CYPA PPIA gag gag-pol rev vif vpr vpu	Homo sapiens (human)
G2 Phase	Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Transcription factor E2F1 Transcription factor E2F3	O00716 P20248 P24941 P78396 Q01094	CCN1 CCNA CCNA1 CCNA2 CDK2 CDKN2 E2F1 E2F3 KIAA0075 RBBP3	Homo sapiens (human)
NOTCH3 Activation and Transmission of Signal to the Nucleus	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Epidermal growth factor receptor Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Neurogenic locus notch homolog protein 3 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Pro-epidermal growth factor Protein jagged-1 Protein jagged-2 Transforming acidic coiled-coil-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00308 O00548 O14672 O76050 P00533 P01133 P0CG47 P0CG48 P49768 P49810 P62979 P62987 P78504 Q86YT6 Q8WW43 Q92542 Q96AX9 Q96BI3 Q9NR61 Q9NZ42 Q9UM47 Q9Y219 Q9Y6A5	AD3 AD4 ADAM10 APH1A APH1B DIP1 DLL1 DLL4 EGF EGFR ERBB ERBB1 ERIC1 HER1 JAG1 JAG2 JAGL1 KIAA0253 KIAA1323 KUZ MADM MIB1 MIB2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH3 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF67 RPS27A SKD STM2 TACC3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WWP2 ZZANK1 ZZANK2	Homo sapiens (human)
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	Basigin Monocarboxylate transporter 1	P35613 P53985	BSG MCT1 SLC16A1	Homo sapiens (human)
FLT3 Signaling	Bcl-2-like protein 11 Cyclin-dependent kinase inhibitor 1B Fms-related tyrosine kinase 3 ligand Forkhead box protein O3 GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43521 O43524 O75791 P01111 P01112 P27986 P31749 P31751 P36888 P42336 P46527 P49771 Q06124 Q07889 Q13322 Q9UQC2 Q9Y243	AKT1 AKT2 AKT3 BCL2L11 BIM CD135 CDKN1B FKHRL1 FLK2 FLT3 FLT3LG FOXO3 FOXO3A GAB2 GADS GRAP2 GRB1 GRB10 GRB2L GRBIR GRID HRAS HRAS1 KIAA0207 KIAA0571 KIP1 NRAS PIK3CA PIK3R1 PKB PKBG PTP2C PTPN11 RAC SHPTP2 SOS1 STK1 p27	Homo sapiens (human)
NPAS4 regulates expression of target genes	Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Basic helix-loop-helix ARNT-like protein 1 Brain-derived neurotrophic factor CREB-binding protein Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 E3 ubiquitin-protein ligase Mdm2 Exportin-1 GTP-binding protein GEM IQ motif and SEC7 domain-containing protein 3 Insulin Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neuronal PAS domain-containing protein 4 Nicotinamide phosphoribosyltransferase Protein c-Fos Proto-oncogene tyrosine-protein kinase receptor Ret RNA binding protein fox-1 homolog 3 Serine/threonine-protein kinase PLK2 Synaptotagmin-10	A6NFN3 O00327 O14980 P01100 P01308 P07949 P23560 P27361 P27540 P28482 P43490 P55040 Q00535 Q00987 Q15078 Q6XYQ8 Q8IUM7 Q92793 Q9HBZ2 Q9NYY3 Q9UPP2	ARNT ARNT2 ARNTL BDNF BHLHE1 BHLHE2 BHLHE5 BHLHE79 BMAL1 CBP CDHF12 CDHR16 CDK5 CDK5R CDK5R1 CDKN5 CREBBP CRM1 ERK1 ERK2 FOS G0S7 GEM INS IQSEC3 KIAA0307 KIAA1110 KIR MAPK1 MAPK3 MDM2 MOP3 NAMPT NCK5A NPAS4 NXF PASD10 PASD3 PBEF PBEF1 PLK2 PRKM1 PRKM2 PRKM3 PSSALRE PTC RBFOX3 RET SNK SYT10 XPO1	Homo sapiens (human)

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