Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
|
|
- AGMX1
- AHCYL1
- ATK
- B29
- BAM32
- BASH
- BCAP
- BLK
- BLNK
- BPK
- BTK
- C7orf19
- CALM
- CALM1
- CAM
- CAM1
- CBCIP2
- CD19
- CD22
- CD79A
- CD79B
- CIN85
- CRACM1
- DAPP1
- DCAL
- FYN
- GOK
- GRB1
- HCP
- IGA
- IGB
- IGHD
- IGHM
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- JTK8
- LYN
- MB1
- NCK
- NCK1
- ORAI1
- ORAI2
- PIK3AP1
- PIK3CD
- PIK3R1
- PLCG2
- PTP1C
- PTPN6
- SH3KBP1
- SIGLEC2
- SLP65
- SOS1
- STIM1
- SYK
- TMEM142A
- TMEM142B
- TRP1
- TRPC1
- VAV
- VAV1
- XPVKONA
|
Homo sapiens (human)
|
|
Potential therapeutics for SARS
|
|
|
- ACE2
- ADTAA
- ADTAB
- ADTB2
- AGMX1
- AOF2
- AP17
- AP2A1
- AP2A2
- AP2B1
- AP2M1
- AP2S1
- ARID4A
- ARID4B
- ATK
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1A4
- ATP1AL2
- ATP1B
- ATP1B1
- ATP1B2
- ATP1B3
- ATP1C
- ATP1G1
- B29
- BASH
- BHC80
- BLNK
- BPK
- BRAF35
- BRCAA1
- BRD4
- BRMS1
- BTK
- C20orf183
- CD49D
- CD79A
- CD79B
- CHD3
- CHD4
- CHEDG1
- CIN85
- CLAPA1
- CLAPA2
- CLAPB1
- CLAPM1
- CLAPS2
- COMT
- CRBN
- CUL3
- CYSLT1
- CYSLTR1
- DLM1
- EDG1
- FKBP1
- FKBP12
- FKBP1A
- FKBP4
- FKBP52
- FNRB
- FNTA
- FNTB
- FUR
- FURIN
- FXYD1
- FXYD2
- FXYD3
- FXYD4
- FXYD6
- FXYD7
- GATAD2A
- GATAD2B
- GRL
- HDAC1
- HDAC2
- HIP9
- HMG20B
- HMGX2
- HMGXB2
- HSP90A
- HSP90AA1
- HSP90AB1
- HSP90B
- HSPC1
- HSPC2
- HSPC3
- HSPCA
- HSPCB
- HUNK1
- HYPJ
- IFNAR
- IFNAR1
- IFNGR1
- IFNGR2
- IFNGT1
- IGA
- IGB
- IGHD
- IGHM
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- IL1R
- IL1R1
- IL1RA
- IL1RT1
- IL6R
- IMPD1
- IMPD2
- IMPDH1
- IMPDH2
- INRF2
- ITGA4
- ITGB1
- JAK1
- JAK1A
- JAK1B
- JAK2
- JAK3
- KDM1
- KDM1A
- KEAP1
- KIAA0071
- KIAA0109
- KIAA0132
- KIAA0601
- KIAA0617
- KIAA0619
- KIAA0778
- KIAA0899
- KIAA1150
- KIAA1266
- KIAA1696
- KLHL19
- LSD1
- MAT8
- MB1
- MBD3
- MDF2
- MSK12
- MTA1
- MTA1L1
- MTA2
- MTA3
- NAK
- NCK
- NCK1
- NFE2L2
- NR3C1
- NRF2
- NRSF
- NS4ATP2
- NS5B
- OPRS1
- P23
- PACE
- PCSK3
- PD1
- PDCD1
- PHF21A
- PID
- PLCG2
- PLM
- PLML
- PTGES3
- RBAP46
- RBAP48
- RBBP1
- RBBP1L1
- RBBP4
- RBBP7
- RBP1
- RBP1L1
- RBX1
- RCOR
- RCOR1
- REST
- RIP
- RIP1
- RIPK1
- RNF75
- ROC1
- ROCK1
- ROCK2
- RPD3L1
- S1PR1
- SAP18
- SAP180
- SAP30
- SAP30L
- SAP45
- SDS3
- SH3KBP1
- SIGMAR1
- SLP65
- SMARCE1R
- SOS1
- SRBP
- STAT2
- SUDS3
- SYK
- TBK1
- TEBP
- TLR7
- TLR9
- TUBB
- TUBB5
- TYK2
- VAV
- VAV1
- XBR
- ZBP1
|
Homo sapiens (human)
|
|
GPVI-mediated activation cascade
|
|
|
- ARH12
- ARH6
- ARHA
- ARHB
- ARHG
- C17orf38
- C6orf25
- CDC42
- CLEC1B
- CLEC2
- FCER1G
- FYN
- G6B
- G6B-B
- GP36
- GP6
- GRB1
- HCP
- JTK8
- LAT
- LCK
- LCP2
- LYN
- MPIG6B
- PDK1
- PDPK1
- PDPN
- PIK3C1
- PIK3CA
- PIK3CB
- PIK3CG
- PIK3R1
- PIK3R2
- PIK3R3
- PIK3R5
- PIK3R6
- PKC2
- PLCG2
- PRKCZ
- PTP1C
- PTP2C
- PTPN11
- PTPN6
- RAC1
- RAC2
- RHO12
- RHOA
- RHOB
- RHOG
- SHPTP2
- SYK
- TC25
- VAV
- VAV1
- VAV2
- VAV3
|
Homo sapiens (human)
|
|
CLEC7A (Dectin-1) signaling
|
|
|
- BCL10
- BGR
- BLU
- BTRC
- BTRCP
- BTRCP2
- C7orf76
- CARD11
- CARD9
- CARMA1
- CDC34
- CHUK
- CIPER
- CLAP
- CLEC7A
- CLECSF12
- CROC1
- CUL1
- DECTIN1
- DSS1
- EMC19
- FBW1A
- FBW1B
- FBXW11
- FBXW1A
- FBXW1B
- FIP3
- HC2
- HC3
- HC8
- HC9
- HSPC
- IFI5111
- IKBA
- IKBKB
- IKBKG
- IKKA
- IKKB
- KIAA0072
- KIAA0077
- KIAA0107
- KIAA0696
- KIAA0733
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MAD3
- MALT1
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MB1
- MCB1
- MECL1
- MIP224
- MLT
- MOV34L
- MSS1
- NEMO
- NFKB1
- NFKB3
- NFKBI
- NFKBIA
- NU
- OCP2
- PDK1
- PDPK1
- PFAAP4
- PKCD
- PLCG2
- POH1
- PRKCD
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- PUBC1
- RELA
- RING10
- RING12
- RNF85
- RPS27A
- SEM1
- SFT
- SHFDG1
- SHFM1
- SKP1
- SKP1A
- SUG1
- SUG2
- SYK
- TAB1
- TAB2
- TAB3
- TAK1
- TBP1
- TBP7
- TCEB1L
- TCF16
- TRAF6
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBC5A
- UBC5B
- UBCEP1
- UBCEP2
- UBCH3
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBE2D1
- UBE2D2
- UBE2N
- UBE2R1
- UBE2V
- UBE2V1
- UEV1
- X
- Y
- Y2
- Z
|
Homo sapiens (human)
|
|
Role of second messengers in netrin-1 signaling
|
|
|
- DCC
- IGDCC1
- NTN1
- NTN1L
- PITPN
- PITPNA
- PLC1
- PLCG1
- TRP1
- TRP3
- TRP5
- TRP6
- TRP7
- TRPC1
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
|
Homo sapiens (human)
|
|
Activated NTRK3 signals through PLCG1
|
|
|
- NTF3
- NTRK3
- PLC1
- PLCG1
- TRKC
|
Homo sapiens (human)
|
|
PECAM1 interactions
|
|
|
- FYN
- GP3A
- HCP
- INPP5D
- ITGAV
- ITGB3
- JTK8
- LCK
- LYN
- MSK8
- PECAM1
- PLC1
- PLCG1
- PTP1C
- PTP2C
- PTPN11
- PTPN6
- SHIP
- SHIP1
- SHPTP2
- VNRA
- VTNR
- YES
- YES1
|
Homo sapiens (human)
|
|
DAG and IP3 signaling
|
|
|
- AHCYL1
- DCAL
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- PKCD
- PKCE
- PLC1
- PLCG1
- PRKCD
- PRKCE
- XPVKONA
|
Homo sapiens (human)
|
|
Signaling by FGFR4 in disease
|
|
|
- FGFR4
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- JTK2
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
- TKF
|
Homo sapiens (human)
|
|
Phospholipase C-mediated cascade; FGFR3
|
|
|
- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- HST
- HSTF1
- HYPF
- KS3
- PLC1
- PLCG1
|
Homo sapiens (human)
|
|
Signaling by FGFR3 in disease
|
|
|
- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FGFR3
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- HST
- HSTF1
- HYPF
- JTK4
- KS3
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
|
Homo sapiens (human)
|
|
Phospholipase C-mediated cascade; FGFR2
|
|
|
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KS3
- PLC1
- PLCG1
|
Homo sapiens (human)
|
|
Signaling by FGFR2 in disease
|
|
|
- BEK
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FGFR2
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KGFR
- KS3
- KSAM
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
|
Homo sapiens (human)
|
|
Phospholipase C-mediated cascade: FGFR1
|
|
|
- FGF1
- FGF10
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KS3
- PLC1
- PLCG1
|
Homo sapiens (human)
|
|
PLCG1 events in ERBB2 signaling
|
|
|
- EGF
- EGFR
- ERBB
- ERBB1
- ERBB2
- HER1
- HER2
- MLN19
- NEU
- NGL
- PLC1
- PLCG1
|
Homo sapiens (human)
|
|
Signaling by ERBB2 TMD/JMD mutants
|
|
|
- BTC
- CDC37
- CDC37A
- DTR
- DTS
- EGF
- EGFR
- ERBB
- ERBB1
- ERBB2
- ERBB2IP
- ERBIN
- EREG
- GGF
- HBEGF
- HEGFL
- HER1
- HER2
- HGL
- HRAS
- HRAS1
- HRGA
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NDF
- NEU
- NGL
- NRAS
- NRG1
- NRG2
- NRG3
- NRG4
- NTAK
- PLC1
- PLCG1
- SHC
- SHC1
- SHCA
- SMDF
- SOS1
|
Homo sapiens (human)
|
|
Signaling by ERBB2 ECD mutants
|
|
|
- CDC37
- CDC37A
- EGF
- EGFR
- ERBB
- ERBB1
- ERBB2
- ERBB2IP
- ERBIN
- GAB1
- GRB1
- HER1
- HER2
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SHC
- SHC1
- SHCA
- SOS1
|
Homo sapiens (human)
|
|
Signaling by ERBB2 KD Mutants
|
|
|
- BTC
- CDC37
- CDC37A
- DTR
- DTS
- EGF
- EGFR
- ERBB
- ERBB1
- ERBB2
- ERBB2IP
- ERBIN
- EREG
- GAB1
- GGF
- GRB1
- HBEGF
- HEGFL
- HER1
- HER2
- HGL
- HRAS
- HRAS1
- HRGA
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NDF
- NEU
- NGL
- NRAS
- NRG1
- NRG2
- NRG3
- NRG4
- NTAK
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SHC
- SHC1
- SHCA
- SMDF
- SOS1
|
Homo sapiens (human)
|
|
Constitutive Signaling by EGFRvIII
|
|
|
- CBL
- CBL2
- CDC37
- CDC37A
- EGF
- EGFR
- ERBB
- ERBB1
- GAB1
- GRB1
- HER1
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- RNF55
- SHC
- SHC1
- SHCA
- SOS1
|
Homo sapiens (human)
|
|
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
|
|
- CBL
- CBL2
- CDC37
- CDC37A
- EGF
- EGFR
- ERBB
- ERBB1
- GAB1
- GRB1
- HER1
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- RNF55
- RPS27A
- SHC
- SHC1
- SHCA
- SOS1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
PLC-gamma1 signalling
|
|
|
- MTC
- NGF
- NGFB
- NTRK1
- PLC1
- PLCG1
- TRK
- TRKA
|
Homo sapiens (human)
|
|
Phospholipase C-mediated cascade; FGFR4
|
|
|
- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- PLC1
- PLCG1
- TKF
|
Homo sapiens (human)
|
|
Activated NTRK2 signals through PLCG1
|
|
|
- BDNF
- NTF4
- NTF5
- NTRK2
- PLC1
- PLCG1
- TRKB
|
Homo sapiens (human)
|
|
Signaling by FGFR1 in disease
|
|
|
- BAG4
- BCR
- BCR1
- BFGFR
- C8orf2
- CD245
- CEK
- CEP43
- CFIM68
- CPSF6
- CUTL1
- CUX1
- D22S11
- ERLIN2
- FGF1
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFBR
- FGFR1
- FGFR1OP
- FGFR1OP2
- FIM
- FLG
- FLT2
- FOP
- FRS2
- GAB1
- GCF2
- GRB1
- HBGFR
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- KIAA0216
- KS3
- LRRFIP1
- MYO18A
- MYSPDZ
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- RAMP
- RNF82
- SODD
- SOS1
- SPFH2
- TIAF1
- TIF1
- TIF1A
- TRIM24
- TRIP
- ZMYM2
- ZNF198
|
Homo sapiens (human)
|
|
RET signaling
|
|
|
- ARTN
- BMK1
- C20orf180
- CDHF12
- CDHR16
- DOK1
- DOK2
- DOK4
- DOK5
- DOK5L
- DOK6
- ENIGMA
- ERK5
- EVN
- FRS2
- GAB1
- GAB2
- GDNF
- GDNFRA
- GDNFRB
- GFRA1
- GFRA2
- GFRA3
- GFRA4
- GRB1
- GRB10
- GRB7
- GRBIR
- IRS2
- KIAA0207
- KIAA0474
- KIAA0571
- KIAA1650
- MAPK7
- NRTN
- NSHC
- PDLIM7
- PIK3C1
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3R1
- PIK3R2
- PIK3R3
- PKACA
- PKCA
- PLC1
- PLCG1
- PRKACA
- PRKACB
- PRKACG
- PRKCA
- PRKM7
- PROSAP2
- PSAP2
- PSPN
- PTC
- PTP2C
- PTPN11
- RAP1GA1
- RAP1GAP
- RET
- RETL1
- RETL2
- SHANK3
- SHC
- SHC1
- SHC3
- SHCA
- SHCC
- SHPTP2
- SOS1
- TRNR1
- TRNR2
|
Homo sapiens (human)
|
|