HDL remodeling
|
|
|
- ABC8
- ABCG1
- ALB
- APC2
- APOA1
- APOC2
- APOC3
- APOE
- CETP
- LCAT
- LIPG
- WHT1
|
|
Defective ABCD1 causes ALD
|
|
|
|
|
Linoleic acid (LA) metabolism
|
|
|
- ABCD1
- ACSL1
- ALD
- CIG30
- ELG3
- ELOVL1
- ELOVL2
- ELOVL3
- ELOVL5
- FACL1
- FACL2
- FADS1
- FADS2
- FADSD5
- LACS
- LACS1
- LACS2
- SSC1
- SSC2
|
|
Class I peroxisomal membrane protein import
|
|
|
- ABCD1
- ABCD2
- ABCD3
- ACBD5
- ALD
- ALD1
- ALDL1
- ALDR
- ALDRP
- ATAD1
- FIS1
- GDAP1
- HK33
- KIAA1996
- PAF1
- PAF3
- PEX11B
- PEX12
- PEX13
- PEX14
- PEX16
- PEX19
- PEX2
- PEX26
- PEX3
- PMP22
- PMP24
- PMP3
- PMP34
- PMP35
- PMP70
- PXF
- PXMP1
- PXMP2
- PXMP3
- PXMP4
- RNF72
- SLC25A17
- TTC11
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|
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
|
|
|
|
|
Ion homeostasis
|
|
|
- ABCC9
- AHCYL1
- ASPH
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1A4
- ATP1AL2
- ATP1B
- ATP1B1
- ATP1B2
- ATP1B3
- ATP1C
- ATP1G1
- ATP2A1
- ATP2A2
- ATP2A3
- ATP2B
- ATP2B1
- ATP2B2
- ATP2B3
- ATP2B4
- BAH
- C7orf19
- CALM
- CALM1
- CAM
- CAM1
- CAM2
- CAMK
- CAMK-II
- CAMK2
- CAMK2A
- CAMK2B
- CAMK2D
- CAMK2G
- CAMKA
- CAMKB
- CAMKD
- CAMKG
- CBCIP2
- CLIC2
- CNC
- CRACM1
- DCAL
- DM1PK
- DMPK
- FKBP12.6
- FKBP1B
- FKBP1L
- FKBP9
- FXYD1
- FXYD2
- FXYD3
- FXYD4
- FXYD6
- FXYD7
- GOK
- HBRR
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- KCNJ11
- KIAA0778
- KIAA0968
- KIAA1087
- MAT8
- MDPK
- MXRA1
- NCX1
- NCX2
- NCX3
- NOS1
- ORAI1
- ORAI2
- OTK4
- PKACA
- PLB
- PLM
- PLML
- PLN
- PMCA1
- PMCA2
- PRKACA
- RYDR
- RYR1
- RYR2
- RYR3
- SLC8A1
- SLC8A2
- SLC8A3
- SLN
- SRI
- STIM1
- SUR2
- TMEM142A
- TMEM142B
- TNNC1
- TNNI3
- TRDN
- TRP1
- TRPC1
- XPVKONA
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|
Defective ABCC8 can cause hypo- and hyper-glycemias
|
|
|
- ABCC8
- HRINS
- KCNJ11
- SUR
- SUR1
|
|
Regulation of insulin secretion
|
|
|
- ABCC8
- AHCYL1
- CACH2
- CACH3
- CACH4
- CACH6
- CACN2
- CACN3
- CACN4
- CACNA1A
- CACNA1C
- CACNA1D
- CACNA1E
- CACNA2D2
- CACNB2
- CACNB3
- CACNL1A1
- CACNL1A2
- CACNL1A4
- CACNL1A6
- CACNLB2
- CACNLB3
- CCHL1A1
- CCHL1A2
- CGEF1
- CGEF2
- DCAL
- EPAC
- EPAC1
- EPAC2
- GLUT1
- GLUT2
- GNAI1
- GNAI2
- GNAI2B
- HRINS
- INS
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- KCNJ11
- KIAA0558
- MYSB
- PKACA
- PRKACA
- PRKACB
- PRKACG
- RAPGEF3
- RAPGEF4
- SLC2A1
- SLC2A2
- SNAP
- SNAP25
- STX1
- STX1A
- STXBP1
- SUR
- SUR1
- SYB2
- SYT5
- UNC18A
- VAMP2
- XPVKONA
|
|
ATP sensitive Potassium channels
|
|
|
- ABCC8
- ABCC9
- HRINS
- KCNJ11
- KCNJ8
- SUR
- SUR1
- SUR2
|
|
Defective ABCC6 causes PXE
|
|
|
|
|
Hyaluronan biosynthesis and export
|
|
|
- ABCC5
- CEMIP
- HAS
- HAS1
- HAS2
- HAS3
- HYBID
- KIAA1199
- MRP5
|
|
Platelet degranulation
|
|
|
- A1BG
- A2M
- A4
- AACT
- AAP
- AAT
- ABCC4
- ACTBL3
- ACTN1
- ACTN2
- ACTN4
- AD1
- AGP1
- AGP2
- AHSG
- ALB
- ALDA
- ALDOA
- ANX5
- ANXA5
- APLP2
- APOA1
- APOH
- APOJ
- APOOL
- APP
- APPL2
- ARMET
- ARP
- AXLLG
- B2G1
- BCG1
- BDK
- BHPCDH
- BRPF3
- C1IN
- C1NH
- C6orf21
- C6orf56
- C9orf167
- CALM
- CALM1
- CALU
- CAM
- CAM1
- CAP
- CAP1
- CD109
- CD36
- CD63
- CD9
- CDC37B
- CDC37L1
- CFD
- CFL
- CFL1
- CHID1
- CLEC3B
- CLGI
- CLI
- CLU
- CPAMD5
- CPAMD7
- CTAP3
- CTSW
- CXCL4
- CXCL7
- CXorf33
- CYB5R1
- CYPA
- CYRI
- CYRIB
- DF
- EBAF
- ECM
- ECM1
- EGF
- EMILIN4
- ENDOD1
- ENX2
- F13A
- F13A1
- F5
- F8
- F8C
- F8VWF
- FAM121A
- FAM3C
- FAM49B
- FERMT3
- FETUA
- FGA
- FGB
- FGG
- FIGF
- FLN
- FLN1
- FLNA
- FN
- FN1
- G6F
- GAS6
- GLBA
- GMRP
- GP2B
- GP3A
- GP3B
- GP4
- GPIA*
- GRMP
- GRP78
- GTPBP2
- GTPBP9
- HABP4
- HARC
- HGF
- HPTA
- HRG
- HSPA5
- IBP1
- IGF1
- IGF2
- IHRP
- ILEI
- ISLR
- ITGA2B
- ITGAB
- ITGB3
- ITIH3
- ITIH4
- ITIHL1
- KIAA0120
- KIAA0206
- KIAA0680
- KIAA0830
- KIAA1027
- KIAA1286
- KIAA1830
- KIND3
- KNG
- KNG1
- KST
- KUB1
- LAMP2
- LEFTA
- LEFTY2
- LEFTYA
- LGALS3BP
- LHFPL2
- LY6G6D
- LY6G6F
- M2BP
- MAGED2
- MANF
- MIC27
- MIC3
- MIG2B
- MLA1
- MMRN
- MMRN1
- MOATB
- MRP4
- NG32
- NHLRC2
- NQO3A2
- OLA1
- ON
- ORM1
- ORM2
- P47
- PAI1
- PCDH7
- PCYOX1L
- PDGF2
- PDGFB
- PECAM1
- PF4
- PFD
- PFN1
- PHACTR2
- PI
- PI4
- PK120
- PLANH1
- PLEK
- PLG
- PLI
- POTEKP
- PP4
- PPBP
- PPIA
- PRG
- PRG1
- PROS
- PROS1
- PSAP
- QSCN6
- QSOX1
- RAB27B
- RARRES2
- SAP1
- SCCPDH
- SCG3
- SCYB4
- SCYB7
- SELENOP
- SELP
- SEPP1
- SERPINA1
- SERPINA3
- SERPINA4
- SERPINE1
- SERPINF2
- SERPING1
- SIS
- SOD1
- SPARC
- SPP2
- SPP24
- SRGN
- STXBP2
- SYTL4
- TAGLN2
- TB4X
- TEX264
- TF
- TGB1
- TGFB
- TGFB1
- TGFB2
- TGFB3
- TGFB4
- THBGB1
- THBS1
- THYB4
- TIG2
- TIMP
- TIMP1
- TIMP3
- TLN
- TLN1
- TMSB4
- TMSB4X
- TMX3
- TNA
- TOR4A
- TSP
- TSP1
- TSPAN29
- TSPAN30
- TTN
- TUBA1
- TUBA4A
- TXNDC10
- UNC18B
- URP2
- VCL
- VEGF
- VEGFA
- VEGFB
- VEGFC
- VEGFD
- VRF
- VTI1
- VTI1B
- VTI1L
- VTI1L1
- VTI2
- VWF
- WDR1
- ZSIG11
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|
Azathioprine ADME
|
|
|
- ABCC4
- ABCC5
- CNT2
- CNT3
- DER12
- ENT1
- ENT2
- GMK
- GMPK
- GMPS
- GST1
- GST2
- GSTA1
- GSTA2
- GSTM1
- GUK1
- HNP36
- HPRT
- HPRT1
- IMPD1
- IMPD2
- IMPDH1
- IMPDH2
- MOATB
- MRP4
- MRP5
- MTH2
- NDPKA
- NM23
- NM23B
- NME1
- NME2
- NUDT15
- RAC1
- SLC28A2
- SLC28A3
- SLC29A1
- SLC29A2
- TC25
- TPMT
- VAV
- VAV1
- VAV2
- VAV3
- XDH
- XDHA
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Recycling of bile acids and salts
|
|
|
- ABCB11
- ABCC3
- ACSB
- ACSVL6
- ALB
- ASBT
- BAAT
- BAR
- BHLHE74
- BHLHE75
- BSEP
- CMOAT2
- FABP6
- FACVL3
- FATP5
- FXR
- HRR1
- ILBP
- ILLBP
- ISBT
- LST1
- LST2
- MLP2
- MRP3
- NCOA1
- NCOA2
- NR1H4
- NR2B1
- NTCP
- NTCP2
- OATP
- OATP1
- OATP1A2
- OATP1B1
- OATP1B3
- OATP2
- OATP8
- OATPC
- OSTA
- OSTB
- RIP14
- RXRA
- SLC10A1
- SLC10A2
- SLC21A3
- SLC21A6
- SLC21A8
- SLC27A5
- SLC51A
- SLC51B
- SLCO1A2
- SLCO1B1
- SLCO1B3
- SRC1
- SRC2
- STARD5
- TIF2
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|
NFE2L2 regulating MDR associated enzymes
|
|
|
- ABCC1
- ABCC3
- ABCF2
- ABCG2
- ABCP
- BCRP
- BCRP1
- CBP
- CMOAT2
- CREBBP
- EP300
- MAFK
- MLP2
- MRP
- MRP1
- MRP3
- MXR
- NFE2L2
- NRF2
- P300
|
|
Defective ABCC2 causes DJS
|
|
|
- ABCC2
- CMOAT
- CMOAT1
- CMRP
- MRP2
|
|
Heme degradation
|
|
|
- ABCC1
- ABCC2
- ABCG2
- ABCP
- ALB
- BCRP
- BCRP1
- BLVR
- BLVRA
- BLVRB
- BVR
- CMOAT
- CMOAT1
- CMRP
- FABP1
- FABPL
- FLR
- GNT1
- GSTA1
- HMOX1
- HMOX2
- HO
- HO1
- HO2
- LST1
- LST2
- MRP
- MRP1
- MRP2
- MXR
- OATP1B1
- OATP1B3
- OATP2
- OATP8
- OATPC
- SCAN
- SLC21A6
- SLC21A8
- SLCO1B1
- SLCO1B3
- UGT1
- UGT1A1
- UGT1A4
|
|
Atorvastatin ADME
|
|
|
- ABCB1
- ABCC2
- CMOAT
- CMOAT1
- CMRP
- CYP3A3
- CYP3A4
- GNT1
- LST1
- LST2
- MDR1
- MRP2
- OATP1B1
- OATP1B3
- OATP2
- OATP8
- OATPC
- PGY1
- PON
- PON1
- PON3
- SLC21A6
- SLC21A8
- SLCO1B1
- SLCO1B3
- UGT1
- UGT1A3
|
|
Aspirin ADME
|
|
|
- ABCC2
- ABCC3
- ACGNAT
- ACSM2
- ACSM2A
- ACSM2B
- ACSM4
- ACSM5
- ALB
- BCHE
- BSG
- C6orf140
- CAT
- CES1
- CES2
- CHE1
- CMOAT
- CMOAT1
- CMOAT2
- CMRP
- CYP2C10
- CYP2C19
- CYP2C8
- CYP2C9
- CYP2D6
- CYP2DL1
- CYP2E
- CYP2E1
- CYP3A3
- CYP3A4
- GAT
- GLYAT
- GLYATL1
- GLYATL2
- GLYATL3
- GNAT
- GNT1
- ICE
- MACS2
- MACS3
- MCT1
- MLP2
- MRP2
- MRP3
- NLT
- OAT2
- SES1
- SLC16A1
- SLC22A7
- UGT1
- UGT1A1
- UGT1A3
- UGT1A4
- UGT1A5
- UGT1A6
- UGT1A7
- UGT1A8
- UGT1A9
- UGT2A1
- UGT2A2
- UGT2A3
- UGT2B10
- UGT2B11
- UGT2B15
- UGT2B17
- UGT2B28
- UGT2B4
- UGT2B7
- UGT2B8
- UGT3A1
- UGT3A2
- UGTB2B9
|
|
APAP ADME
|
|
|
- AAC1
- AAC2
- ABCC1
- ABCC2
- ABCC3
- ABCC4
- ABCC5
- ABCG2
- ABCP
- ACY1
- BCRP
- BCRP1
- CMOAT
- CMOAT1
- CMOAT2
- CMRP
- CN2
- CNDP2
- CPGL
- CYP2E
- CYP2E1
- FAEES3
- GGT
- GGT1
- GGT3
- GGT3P
- GGT5
- GGT6
- GGT7
- GGTL3
- GGTL5
- GGTLA1
- GNT1
- GST1
- GST3
- GSTM1
- GSTP1
- GSTT1
- HEL-S-13
- HST
- MLP2
- MOATB
- MRP
- MRP1
- MRP2
- MRP3
- MRP4
- MRP5
- MXR
- NAT1
- NAT2
- PEPA
- STD
- STE
- STM
- STP
- STP1
- SULT1A1
- SULT1A3
- SULT1A4
- SULT1C2
- SULT1C4
- SULT1E1
- SULT2A1
- UGT1
- UGT1A1
- UGT1A10
- UGT1A6
- UGT1A9
- UGT2B15
- UGT2B8
|
|
Defective ABCB6 causes MCOPCB7
|
|
|
|
|
Mitochondrial ABC transporters
|
|
|
- ABC7
- ABCB10
- ABCB6
- ABCB7
- ABCB8
- MABC1
- MITOSUR
- MTABC3
- PRP
- UMAT
|
|
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
|
|
|
- ABCA6
- AFX
- AFX1
- AGRP
- AGRT
- ART
- ATX3
- ATXN3
- BHLHD1
- CAT
- DPC4
- FBXO32
- FIZZ3
- FKHR
- FKHRL1
- FOXO1
- FOXO1A
- FOXO3
- FOXO3A
- FOXO4
- FOXO6
- G6PC
- G6PC1
- G6PT
- GCK
- GRL
- HDAC1
- HDAC2
- HXCP1
- IBP1
- IGFBP1
- INS
- IRF
- KIAA1550
- LEM6
- MADH2
- MADH3
- MADH4
- MADR2
- MJD
- MJD1
- MLLT7
- MURF1
- NPY
- NR3C1
- PCK1
- PEPCK1
- PGC1
- PGC1A
- PLXNA4
- PLXNA4A
- PLXNA4B
- POMC
- PPARGC1
- PPARGC1A
- RETN
- RNF28
- RPD3L1
- RSTN
- SCA3
- SIN3A
- SIR2L3
- SIRT3
- SMAD2
- SMAD3
- SMAD4
- SMRZ
- SOD2
- SREBF1
- SREBP1
- TRIM63
|
|
ABC transporters in lipid homeostasis
|
|
|
- ABC12
- ABC2
- ABC3
- ABC8
- ABCA10
- ABCA12
- ABCA2
- ABCA3
- ABCA5
- ABCA6
- ABCA7
- ABCA9
- ABCD1
- ABCD2
- ABCD3
- ABCG1
- ABCG4
- ABCG5
- ABCG8
- ALD
- ALD1
- ALDL1
- ALDR
- ALDRP
- APOA1
- HK33
- KIAA1062
- KIAA1888
- PEX19
- PEX3
- PMP70
- PXF
- PXMP1
- WHITE2
- WHT1
|
|
Formation of ATP by chemiosmotic coupling
|
- ATP synthase F(0) complex subunit B1, mitochondrial
- ATP synthase F(0) complex subunit C1, mitochondrial
- ATP synthase F(0) complex subunit C2, mitochondrial
- ATP synthase F(0) complex subunit C3, mitochondrial
- ATP synthase protein 8
- ATP synthase subunit O, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit alpha, mitochondrial
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit d, mitochondrial
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit e, mitochondrial
- ATP synthase subunit epsilon, mitochondrial
- ATP synthase subunit f, mitochondrial
- ATP synthase subunit g, mitochondrial
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit s, mitochondrial
- ATP synthase-coupling factor 6, mitochondrial
|
|
- ATP5A
- ATP5A1
- ATP5AL2
- ATP5B
- ATP5C
- ATP5C1
- ATP5CL1
- ATP5D
- ATP5E
- ATP5F1
- ATP5F1A
- ATP5F1B
- ATP5F1C
- ATP5F1D
- ATP5F1E
- ATP5G1
- ATP5G2
- ATP5G3
- ATP5H
- ATP5I
- ATP5J
- ATP5J2
- ATP5JL
- ATP5K
- ATP5L
- ATP5MC1
- ATP5MC2
- ATP5MC3
- ATP5ME
- ATP5MF
- ATP5MG
- ATP5O
- ATP5PB
- ATP5PD
- ATP5PF
- ATP5PO
- ATP5S
- ATP6
- ATP8
- ATPASE6
- ATPASE8
- ATPM
- ATPMB
- ATPO
- ATPSB
- ATPW
- DMAC2L
- MT-ATP6
- MT-ATP8
- MTATP6
- MTATP8
|
|