GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **501 - 525** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
Regulation of localization of FOXO transcription factors	14-3-3 protein beta/alpha 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Forkhead box protein O6 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	A8MYZ6 O43524 P27348 P31749 P31751 P31946 P31947 P61981 P63104 P98177 Q12778 Q9Y243	AFX AFX1 AKT1 AKT2 AKT3 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 FOXO6 HME1 MLLT7 PKB PKBG RAC SFN YWHAB YWHAG YWHAQ YWHAZ	Homo sapiens (human)
FOXO-mediated transcription of cell death genes	B-cell lymphoma 6 protein Bcl-2-binding component 3, isoforms 1/2 Bcl-2-like protein 11 CREB-binding protein Cbp/p300-interacting transactivator 2 DNA damage-inducible transcript 3 protein Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Histone acetyltransferase p300 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Serine/threonine-protein kinase PINK1, mitochondrial Serine/threonine-protein kinase STK11 Tumor necrosis factor ligand superfamily member 6	O43521 O43524 P23511 P25208 P35638 P41182 P48023 P98177 Q09472 Q12778 Q13952 Q15831 Q92793 Q99967 Q9BXH1 Q9BXM7	AFX AFX1 APT1LG1 BBC3 BCL2L11 BCL5 BCL6 BIM CBP CD95L CHOP CHOP10 CITED2 CREBBP DDIT3 EP300 FASL FASLG FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 GADD153 HAP3 LAZ3 LKB1 MLLT7 MRG1 NFYA NFYB NFYC P300 PINK1 PJS PUMA STK11 TNFSF6 ZBTB27 ZNF51	Homo sapiens (human)
Cardiogenesis	Catenin beta-1 Eomesodermin homolog Forkhead box protein O4 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Heart- and neural crest derivatives-expressed protein 1 Heart- and neural crest derivatives-expressed protein 2 Histone acetyltransferase KAT2A Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase SMYD1 Homeobox protein Nkx-2.5 Insulin gene enhancer protein ISL-1 LIM domain-binding protein 1 Lymphoid enhancer-binding factor 1 Mesoderm posterior protein 1 Mothers against decapentaplegic homolog 1 Mothers against decapentaplegic homolog 4 Myocardin Myocyte-specific enhancer factor 2C Serum response factor T-box transcription factor T T-box transcription factor TBX1 T-box transcription factor TBX20 T-box transcription factor TBX5 Transcription factor GATA-4 Transcription factor GATA-6 WD repeat-containing protein 5	O15178 O43435 O95936 O96004 P11831 P35222 P43694 P52952 P61296 P61371 P61964 P98177 Q06413 Q13485 Q15797 Q86U70 Q8IZQ8 Q8NB12 Q92830 Q92908 Q92993 Q99593 Q9BRJ9 Q9UBP5 Q9UJU2 Q9UMR3 Q9Y5J3	AFX AFX1 BHLHA26 BHLHA27 BHLHB31 BHLHB32 BHLHC5 BIG3 BSP1 CHF1 CHF2 CLIM2 CSX CTNNB CTNNB1 DHAND DPC4 EHAND EOMES FOXO4 GATA4 GATA6 GCN5 GCN5L2 GRL HAND1 HAND2 HERP HERP1 HERP2 HESR1 HEY1 HEY2 HRT1 HRT2 HTATIP ISL1 KAT2A KAT5 LDB1 LEF1 MADH1 MADH4 MADR1 MEF2C MESP1 MLLT7 MYCD MYOCD NKX2-5 NKX2.5 NKX2E SMAD1 SMAD4 SMYD1 SRF T TBR2 TBX1 TBX20 TBX5 TBXT TIP60 WDR5	Homo sapiens (human)
FOXO-mediated transcription of cell cycle genes	Caveolin-1 Cyclin-G2 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Forkhead box protein G1 Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Growth arrest and DNA damage-inducible protein GADD45 alpha Growth/differentiation factor 8 Krueppel-like factor 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Poly(rC)-binding protein 4 Protein BTG1 Retinoblastoma-like protein 2	O14793 O43474 O43524 P24522 P38936 P46527 P55316 P57723 P62324 P84022 P98177 Q03135 Q08999 Q12778 Q13485 Q15796 Q16589	AFX AFX1 BTG1 CAP20 CAV CAV1 CCNG2 CDKN1 CDKN1A CDKN1B CIP1 DDIT1 DPC4 EZF FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FKHR FKHRL1 FOXG1 FOXG1A FOXG1B FOXG1C FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 GADD45 GADD45A GDF8 GKLF KIP1 KLF4 MADH2 MADH3 MADH4 MADR2 MDA6 MLLT7 MSTN PCBP4 PIC1 RB2 RBL2 SDI1 SMAD2 SMAD3 SMAD4 WAF1 p27	Homo sapiens (human)
Regulation of FOXO transcriptional activity by acetylation	CREB-binding protein Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Histone acetyltransferase KAT2B Histone acetyltransferase p300 NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Thioredoxin-interacting protein Thioredoxin	O43524 P10599 P98177 Q09472 Q12778 Q92793 Q92831 Q96EB6 Q9H3M7 Q9NTG7	AFX AFX1 CBP CREBBP EP300 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 KAT2B MLLT7 P300 PCAF SIR2L1 SIR2L3 SIRT1 SIRT3 TRDX TRX TRX1 TXN TXNIP VDUP1	Homo sapiens (human)
Netrin-1 signaling	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 E3 ubiquitin-protein ligase SIAH1 E3 ubiquitin-protein ligase SIAH2 Ezrin Hemojuvelin Neogenin Netrin receptor DCC Netrin receptor UNC5A Netrin receptor UNC5B Netrin-1 Netrin-4 Protein kinase C theta type Repulsive guidance molecule A Repulsive guidance molecule B Roundabout homolog 1 Slit homolog 1 protein Slit homolog 2 protein Slit homolog 3 protein Unconventional myosin-X	O43255 O75093 O75094 O94813 O95631 P15311 P43146 Q04759 Q6NW40 Q6ZN44 Q6ZVN8 Q8IUQ4 Q8IZJ1 Q92859 Q96B86 Q99490 Q9HB63 Q9HD67 Q9Y6N7	AGAP2 CENTG1 DCC DUTT1 EZR HFE2 HJV HUMSIAH IGDCC1 IGDCC2 KIAA0167 KIAA0799 KIAA0813 KIAA0814 KIAA1976 MEGF4 MEGF5 MYO10 NEO1 NGN NTN1 NTN1L NTN4 P53RDL1 PRKCQ PRKCT RGM RGMA RGMB RGMC ROBO1 SIAH1 SIAH2 SLIL1 SLIL2 SLIL3 SLIT1 SLIT2 SLIT3 UNC5A UNC5B UNC5H1 UNC5H2 VIL2	Homo sapiens (human)
Creatine metabolism	Creatine kinase B-type Creatine kinase M-type Creatine kinase S-type, mitochondrial Creatine kinase U-type, mitochondrial Glycine amidinotransferase, mitochondrial Guanidinoacetate N-methyltransferase Sodium- and chloride-dependent GABA transporter 3 Sodium- and chloride-dependent betaine transporter Sodium- and chloride-dependent creatine transporter 1 Sodium-dependent proline transporter	P06732 P12277 P12532 P17540 P48029 P48065 P48066 P50440 Q14353 Q99884	AGAT BGT1 CKB CKBB CKM CKMM CKMT CKMT1A CKMT1B CKMT2 GABT3 GAMT GAT3 GATM PROT SLC6A11 SLC6A12 SLC6A7 SLC6A8	Homo sapiens (human)
Carboxyterminal post-translational modifications of tubulin	Cytosolic carboxypeptidase 1 Cytosolic carboxypeptidase 2 Cytosolic carboxypeptidase 3 Cytosolic carboxypeptidase 4 Cytosolic carboxypeptidase 6 Cytosolic carboxypeptidase-like protein 5 Inactive polyglycylase TTLL10 Leucine-rich repeat-containing protein 49 Nicolin-1 Polyglutamylase complex subunit TTLL1 Probable tubulin polyglutamylase TTLL2 Probable tubulin polyglutamylase TTLL9 Protein monoglycylase TTLL8 Small vasohibin-binding protein Tubulin alpha-1A chain Tubulin alpha-1B chain Tubulin alpha-1C chain Tubulin alpha-3C chain Tubulin alpha-3D chain Tubulin alpha-3E chain Tubulin beta 8B Tubulin beta-1 chain Tubulin beta-2A chain Tubulin beta-2B chain Tubulin beta-3 chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin beta-6 chain Tubulin beta-8 chain Tubulin monoglutamylase TTLL4 Tubulin monoglycylase TTLL3 Tubulin polyglutamylase TTLL11 Tubulin polyglutamylase TTLL13 Tubulin polyglutamylase TTLL5 Tubulin polyglutamylase TTLL6 Tubulin polyglutamylase TTLL7 Tubulin polyglutamylase complex subunit 1 Tubulin polyglutamylase complex subunit 2 Tubulin--tyrosine ligase-like protein 12 Tubulin--tyrosine ligase Tubulinyl-Tyr carboxypeptidase 1 Tubulinyl-Tyr carboxypeptidase 2	A6NNM8 A6NNZ2 A6PVC2 O95922 P04350 P0DPH7 P0DPH8 P68363 P68371 Q13509 Q13885 Q14166 Q14679 Q3SXZ7 Q3ZCM7 Q5U5Z8 Q5VU57 Q68CL5 Q6EMB2 Q6PEY2 Q6ZT98 Q6ZTW0 Q6ZVT0 Q71U36 Q7L8A9 Q86V25 Q8IUZ0 Q8N300 Q8N841 Q8NDL9 Q8NEM8 Q8NG68 Q8NHH1 Q96MI9 Q9BQE3 Q9BSH3 Q9BUF5 Q9BVA1 Q9BWV7 Q9H4B7 Q9UPW5 Q9Y4R7	AGBL1 AGBL2 AGBL3 AGBL4 AGBL5 AGTPBP1 C18orf10 C19orf20 C20orf125 C22orf7 C6orf104 C9orf20 CCDC23 CCP1 CCP2 CCP3 CCP4 CCP5 CCP6 CSTPP2 KIAA0153 KIAA0173 KIAA0998 KIAA1035 KIAA1036 LRRC49 NICN1 NNA1 STAMP SVBP TPGS1 TPGS2 TTL TTL.6 TTLL1 TTLL10 TTLL11 TTLL12 TTLL13 TTLL13P TTLL2 TTLL3 TTLL4 TTLL5 TTLL6 TTLL7 TTLL8 TTLL9 TUBA1A TUBA1B TUBA1C TUBA2 TUBA3 TUBA3C TUBA3D TUBA3E TUBA6 TUBB1 TUBB2 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4A TUBB4B TUBB5 TUBB6 TUBB8 TUBB8B VASH VASH1 VASH2 VASHL	Homo sapiens (human)
Malate-aspartate shuttle	Aspartate aminotransferase, cytoplasmic Aspartate aminotransferase, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial Malate dehydrogenase, cytoplasmic Malate dehydrogenase, mitochondrial Mitochondrial 2-oxoglutarate/malate carrier protein Mitochondrial glutamate carrier 1 Mitochondrial glutamate carrier 2	O75746 P00505 P17174 P40925 P40926 Q02978 Q9H1K4 Q9H936 Q9UJS0	AGC1 ARALAR1 GC1 GC2 GOT1 GOT2 KYAT4 MDH1 MDH2 MDHA SLC20A4 SLC25A11 SLC25A12 SLC25A13 SLC25A18 SLC25A22	Homo sapiens (human)
Glycerophospholipid biosynthesis	Acylglycerol kinase, mitochondrial Copine-1 Copine-3 Copine-6 Copine-7	O75131 O95741 Q53H12 Q99829 Q9UBL6	AGK CPN1 CPN3 CPNE1 CPNE3 CPNE6 CPNE7 KIAA0636 MULK	Homo sapiens (human)
Glycogen breakdown (glycogenolysis)	Calmodulin-1 Glycogen debranching enzyme Glycogen phosphorylase, brain form Glycogen phosphorylase, liver form Glycogen phosphorylase, muscle form Glycogenin-1 Glycogenin-2 Lysosomal alpha-glucosidase Phosphoglucomutase-1 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Phosphorylase b kinase regulatory subunit alpha, liver isoform Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform Phosphorylase b kinase regulatory subunit beta	O15488 P06737 P0DP23 P10253 P11216 P11217 P15735 P35573 P36871 P46019 P46020 P46976 Q16816 Q93100	AGL CALM CALM1 CAM CAM1 GAA GDE GYG GYG1 GYG2 PGM1 PHKA PHKA1 PHKA2 PHKB PHKG PHKG1 PHKG2 PHKLA PYGB PYGL PYGM PYK	Homo sapiens (human)	G58161NS
Synthesis of UDP-N-acetyl-glucosamine	Glucosamine 6-phosphate N-acetyltransferase Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 N-acetyl-D-glucosamine kinase N-acetylglucosamine-6-phosphate deacetylase N-acylglucosamine 2-epimerase Phosphoacetylglucosamine mutase UDP-N-acetylhexosamine pyrophosphorylase	O94808 O95394 P51606 Q06210 Q16222 Q96EK6 Q9UJ70 Q9Y303	AGM1 AMDHD2 GFAT GFPT GFPT1 GFPT2 GNA1 GNPNAT1 NAGK PGM3 RENBP SPAG2 UAP1	Homo sapiens (human)
Triglyceride biosynthesis	2-acylglycerol O-acyltransferase 1 2-acylglycerol O-acyltransferase 2 2-acylglycerol O-acyltransferase 3 Alkylglycerol monooxygenase Diacylglycerol O-acyltransferase 1 Diacylglycerol O-acyltransferase 2 Glycerol kinase 2 Glycerol kinase 3 Glycerol kinase Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate acyltransferase 2, mitochondrial Phosphatidate phosphatase LPIN1 Phosphatidate phosphatase LPIN2 Phosphatidate phosphatase LPIN3	O75907 P32189 Q14409 Q14410 Q14693 Q3SYC2 Q6NUI2 Q6ZNB7 Q86VF5 Q92539 Q96PD6 Q96PD7 Q9BQK8 Q9HCL2	AGMO AGRP1 DC2 DC5 DC7 DGAT DGAT1 DGAT2 DGAT2L1 DGAT2L5 DGAT2L7 GK GK2 GK3 GK3P GKP2 GKP3 GKTA GKTB GPAM GPAT1 GPAT2 KIAA0188 KIAA0249 KIAA1560 LIPN3L LPIN1 LPIN2 LPIN3 MOGAT1 MOGAT2 MOGAT3 TMEM195	Homo sapiens (human)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 B-cell antigen receptor complex-associated protein alpha chain B-cell antigen receptor complex-associated protein beta chain B-cell linker protein B-cell receptor CD22 B-lymphocyte antigen CD19 Calcium release-activated calcium channel protein 1 Calmodulin-1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide IGHV7-81 protein Immunoglobulin heavy constant delta Immunoglobulin heavy constant mu Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Protein orai-2 Proto-oncogene vav S-adenosylhomocysteine hydrolase-like protein 1 SH2/SH3 adapter protein NCK1 SH3 domain-containing kinase-binding protein 1 Short transient receptor potential channel 1 Son of sevenless homolog 1 Stromal interaction molecule 1 Tyrosine-protein kinase BTK Tyrosine-protein kinase Blk Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 6 UGa8H (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 O00329 O43865 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01871 P01880 P04211 P04430 P04432 P04433 P06241 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0DOY2 P0DOY3 P0DP23 P11912 P15391 P15498 P16333 P16885 P20273 P23083 P27986 P29350 P40259 P43405 P48995 P51451 P80748 Q06187 Q07889 Q13586 Q14571 Q14573 Q14643 Q6PIL0 Q6ZUJ8 Q8WV28 Q96B97 Q96D31 Q96SN7 Q9UN19	AGMX1 AHCYL1 ATK B29 BAM32 BASH BCAP BLK BLNK BPK BTK C7orf19 CALM CALM1 CAM CAM1 CBCIP2 CD19 CD22 CD79A CD79B CIN85 CRACM1 DAPP1 DCAL FYN GOK GRB1 HCP IGA IGB IGHD IGHM IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 JTK8 LYN MB1 NCK NCK1 ORAI1 ORAI2 PIK3AP1 PIK3CD PIK3R1 PLCG2 PTP1C PTPN6 SH3KBP1 SIGLEC2 SLP65 SOS1 STIM1 SYK TMEM142A TMEM142B TRP1 TRPC1 VAV VAV1 XPVKONA	Homo sapiens (human)
FCERI mediated Ca+2 mobilization	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Calcineurin subunit B type 1 Calmodulin-1 GRB2-related adapter protein 2 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 IGHV7-81 protein Immunoglobulin heavy constant epsilon Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Lymphocyte cytosolic protein 2 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 3 Protein phosphatase 3 catalytic subunit alpha Proto-oncogene vav S-adenosylhomocysteine hydrolase-like protein 1 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Son of sevenless homolog 1 Tyrosine-protein kinase BTK Tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein kinase TXK Tyrosine-protein kinase Tec UGa8H (Fragment) V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 O43865 O75791 O95644 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01854 P04211 P04430 P04432 P04433 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0DOY2 P0DOY3 P0DP23 P15498 P16298 P16885 P19174 P23083 P42680 P42681 P43405 P52735 P63098 P80748 Q06187 Q07889 Q08209 Q08881 Q12968 Q13094 Q13469 Q14571 Q14573 Q14643 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q9UKW4	AGMX1 AHCYL1 ATK BPK BTK CALM CALM1 CALNA CALNA2 CALNB CAM CAM1 CNA CNA2 CNB DCAL EMT GADS GRAP2 GRB2L GRID IGHE IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 INSP3R1 IRBIT ITK ITPR1 ITPR2 ITPR3 JTK8 LCP2 LYK LYN NFAT1 NFAT2 NFAT4 NFATC NFATC1 NFATC2 NFATC3 NFATP PLC1 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 PSCTK4 PTK4 RLK SOS1 SYK TEC TXK V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 VAV VAV1 VAV2 VAV3 XPVKONA	Homo sapiens (human)
DAP12 signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Beta-2-microglobulin GRB2-related adapter protein 2 GTPase HRas GTPase NRas Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 HLA class I histocompatibility antigen, alpha chain E Lymphocyte cytosolic protein 2 NKG2-C type II integral membrane protein NKG2-D type II integral membrane protein Natural killer cells antigen CD94 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Ras-related C3 botulinum toxin substrate 1 Son of sevenless homolog 1 TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 2 Tyrosine-protein kinase BTK Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase SYK	O00459 O43914 O75791 P01111 P01112 P06239 P06241 P13747 P16885 P19174 P26717 P26718 P27986 P42336 P42338 P43405 P52735 P61769 P63000 Q06187 Q07889 Q13094 Q13241 Q9NZC2 Q9UKW4	AGMX1 ATK B2M BPK BTK CD94 D12S2489E DAP12 FYN GADS GRAP2 GRB1 GRB2L GRID HLA-6.2 HLA-E HLAE HRAS HRAS1 KARAP KLRC2 KLRD1 KLRK1 LCK LCP2 NKG2C NKG2D NRAS PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PLCG2 RAC1 SOS1 SYK TC25 TREM2 TYROBP VAV2 VAV3	Homo sapiens (human)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain High mobility group protein B1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 3 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Lymphocyte antigen 96 Major outer membrane protein P.IB Mitogen-activated protein kinase kinase kinase 1 Monocyte differentiation antigen CD14 Myeloid differentiation primary response protein MyD88 Peptidyl-prolyl cis-trans isomerase Mip Platelet glycoprotein 4 Protein S100-A1 Protein S100-A8 Protein S100-A9 Single Ig IL-1-related receptor Suppressor of cytokine signaling 1 TNF receptor-associated factor 6 Toll-like receptor 1 Toll-like receptor 2 Toll-like receptor 4 Toll-like receptor 6 Toll/interleukin-1 receptor domain-containing adapter protein Tyrosine-protein kinase BTK	O00206 O15524 O43187 O60603 P02671 P02675 P02679 P05109 P06702 P08571 P09429 P16671 P23297 P26623 P30690 P51617 P58753 Q06187 Q13233 Q15399 Q6IA17 Q99836 Q9BQ95 Q9NWZ3 Q9Y2C9 Q9Y4K3 Q9Y616 Q9Y6Y9	AGMX1 ATK BPK BTK CAGA CAGB CD14 CD36 CFAG ECSIT ESOP1 FGA FGB FGG GP3B GP4 HMG1 HMGB1 IRAK IRAK1 IRAK2 IRAK3 IRAK4 KIAA0012 LY96 MAL MAP3K1 MAPKKK1 MD2 MEKK MEKK1 MRP14 MRP8 MYD88 RNF85 S100A S100A1 S100A8 S100A9 SIGIRR SOCS1 SSI1 TIL4 TIP3 TIRAP TLR1 TLR2 TLR4 TLR6 TRAF6 mip porB	Homo sapiens (human)
IRAK4 deficiency (TLR2/4)	Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain High mobility group protein B1 Interleukin-1 receptor-associated kinase 4 Lymphocyte antigen 96 Major outer membrane protein P.IB Monocyte differentiation antigen CD14 Myeloid differentiation primary response protein MyD88 Peptidyl-prolyl cis-trans isomerase Mip Platelet glycoprotein 4 Protein S100-A1 Protein S100-A8 Protein S100-A9 Toll-like receptor 1 Toll-like receptor 2 Toll-like receptor 4 Toll-like receptor 6 Toll/interleukin-1 receptor domain-containing adapter protein Tyrosine-protein kinase BTK	O00206 O60603 P02671 P02675 P02679 P05109 P06702 P08571 P09429 P16671 P23297 P26623 P30690 P58753 Q06187 Q15399 Q99836 Q9NWZ3 Q9Y2C9 Q9Y6Y9	AGMX1 ATK BPK BTK CAGA CAGB CD14 CD36 CFAG ESOP1 FGA FGB FGG GP3B GP4 HMG1 HMGB1 IRAK4 KIAA0012 LY96 MAL MD2 MRP14 MRP8 MYD88 S100A S100A1 S100A8 S100A9 TIL4 TIRAP TLR1 TLR2 TLR4 TLR6 mip porB	Homo sapiens (human)
MyD88 deficiency (TLR2/4)	Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain High mobility group protein B1 Lymphocyte antigen 96 Major outer membrane protein P.IB Monocyte differentiation antigen CD14 Myeloid differentiation primary response protein MyD88 Peptidyl-prolyl cis-trans isomerase Mip Platelet glycoprotein 4 Protein S100-A1 Protein S100-A8 Protein S100-A9 Toll-like receptor 1 Toll-like receptor 2 Toll-like receptor 4 Toll-like receptor 6 Toll/interleukin-1 receptor domain-containing adapter protein Tyrosine-protein kinase BTK	O00206 O60603 P02671 P02675 P02679 P05109 P06702 P08571 P09429 P16671 P23297 P26623 P30690 P58753 Q06187 Q15399 Q99836 Q9Y2C9 Q9Y6Y9	AGMX1 ATK BPK BTK CAGA CAGB CD14 CD36 CFAG ESOP1 FGA FGB FGG GP3B GP4 HMG1 HMGB1 KIAA0012 LY96 MAL MD2 MRP14 MRP8 MYD88 S100A S100A1 S100A8 S100A9 TIL4 TIRAP TLR1 TLR2 TLR4 TLR6 mip porB	Homo sapiens (human)
G beta:gamma signalling through BTK	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Tyrosine-protein kinase BTK	O14610 O14775 O60262 P16520 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 Q06187 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08	AGMX1 ATK BPK BTK GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9	Homo sapiens (human)
Estrogen-dependent gene expression	Apoptosis regulator Bcl-2 Axin-1 BTB/POZ domain-containing protein KCTD6 CREB-binding protein CXXC-type zinc finger protein 5 Cathepsin D Cbp/p300-interacting transactivator 1 Chromodomain-helicase-DNA-binding protein 1 Cohesin subunit SA-1 Cohesin subunit SA-2 Core-binding factor subunit beta Cyclic AMP-dependent transcription factor ATF-2 Cyclin-T1 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Double-strand-break repair protein rad21 homolog Estrogen receptor G1/S-specific cyclin-D1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Glycerol-3-phosphate acyltransferase 1, mitochondrial Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Helicase MOV-10 Hepatocyte nuclear factor 3-alpha Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase KAT2B Histone acetyltransferase KAT5 Histone acetyltransferase p300 Histone deacetylase 1 Histone-arginine methyltransferase CARM1 Importin subunit alpha-1 KN motif and ankyrin repeat domain-containing protein 1 Lysine-specific demethylase 4B Lysine-specific histone demethylase 1A Mediator of RNA polymerase II transcription subunit 1 Myc proto-oncogene protein Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 3 Nuclear receptor subfamily 5 group A member 2 Nuclear receptor-interacting protein 1 POU domain, class 2, transcription factor 1 Peptidyl-prolyl cis-trans isomerase FKBP4 Probable ATP-dependent RNA helicase DDX5 Progesterone receptor Prostaglandin E synthase 3 Protein FosB Protein GREB1 Protein arginine N-methyltransferase 1 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Protein c-Fos Protransforming growth factor alpha Receptor-binding cancer antigen expressed on SiSo cells Runt-related transcription factor 1 Stromal cell-derived factor 1 Structural maintenance of chromosomes protein 1A Structural maintenance of chromosomes protein 3 TATA-box-binding protein Trans-acting T-cell-specific transcription factor GATA-3 Transcription factor Jun Transcription factor JunD Transcription factor Sp1 Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcriptional activator Myb Transcriptional repressor protein YY1 Transducin-like enhancer protein 3 Trefoil factor 1 Trefoil factor 3 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Upstream stimulatory factor 1 Upstream stimulatory factor 2 Zinc finger protein 217	O00482 O00559 O14646 O15169 O15514 O60216 O60341 O60563 O60814 O75362 O94953 P01100 P01106 P01135 P03372 P04155 P04908 P05412 P06401 P06899 P07339 P07900 P08047 P08238 P0C5Y9 P10242 P10415 P13984 P14859 P15336 P16104 P17535 P17844 P19387 P19388 P20226 P20671 P22415 P23527 P23771 P24385 P24928 P25490 P30876 P33778 P35269 P36954 P48061 P48552 P50750 P52292 P52434 P52435 P52655 P52657 P53539 P53803 P55317 P57053 P58876 P61218 P62487 P62805 P62807 P62875 P68431 P84243 Q01196 Q02790 Q04726 Q07654 Q09472 Q13547 Q13951 Q14678 Q14683 Q15185 Q15596 Q15648 Q15788 Q15853 Q16777 Q16778 Q4ZG55 Q6FI13 Q71DI3 Q71UI9 Q7LFL8 Q86X55 Q8N257 Q8N3U4 Q8NC69 Q8NDV7 Q8WVM7 Q92793 Q92831 Q92993 Q93077 Q93079 Q96A08 Q99873 Q99877 Q99878 Q99879 Q99880 Q99966 Q9BTM1 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9HCL2 Q9UKV8 Q9UL18 Q9UPQ9 Q9UQE7 Q9Y6Q9	AGO1 AGO2 AGO3 AGO4 AIB1 AML1 ANKRD15 AOF2 ARC205 ATF2 AXIN AXIN1 B1F BAM BCEI BCL1 BCL2 BHLHB11 BHLHB12 BHLHE39 BHLHE42 BHLHE74 BHLHE75 BMH CAGH26 CARM1 CBFA2 CBFB CBP CCND1 CCNT1 CDC2L4 CDK9 CHD1 CITED1 CPF CPSD CREB2 CREBBP CREBP1 CRSP1 CRSP200 CSPG6 CTSD CXCL12 CXXC5 DDX5 DRIP205 DRIP230 DXS423E EBAG9 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EP300 ESR ESR1 FKBP4 FKBP52 FOS FOSB FOXA1 FTF G0S3 G0S7 G17P1 GATA3 GPAM GPAT1 GREB1 GTF2A1 GTF2A2 GTF2D1 GTF2F1 GTF2F2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HELR HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HLR1 HMT2 HNF3A HR21 HRMT1L2 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB HTATIP INO80S IR1B4 ITF JHDM3B JMJD2B JUN JUND KANK KANK1 KAT2B KAT5 KCTD6 KDM1 KDM1A KDM4B KIAA0078 KIAA0172 KIAA0178 KIAA0575 KIAA0601 KIAA0876 KIAA1093 KIAA1460 KIAA1547 KIAA1560 KIAA1567 KIAA1582 KIAA1631 KPNA2 LSD1 MED1 MOV10 MSG1 MYB MYC NCOA1 NCOA2 NCOA3 NR3A1 NR3C3 NR5A2 NRIP1 NXP1 OCT1 OTF1 P23 P300 PBP PCAF PGR POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF POU2F1 PPARBP PPARGBP PRAD1 PRMT1 PRMT4 PS2 PTGES3 RAC3 RAD21 RAP30 RAP74 RB18A RCAS1 RCH1 RPB7 RPD3L1 RUNX1 SA1 SA2 SB1.8 SCC1 SCC3 SDF1 SDF1A SDF1B SMC1 SMC1A SMC1L1 SMC3 SMC3L1 SP1 SRC1 SRC2 SRP1 STAG1 STAG2 TAK TBP TCF3A TEBP TF2A1 TF2A2 TF2D TFF1 TFF3 TFI TFIID TGFA TIF2 TIP60 TLE3 TNRC6 TNRC6A TNRC6B TNRC6C TRAM1 TRAP220 TRIP2 TSFP1 TSH2B USF USF1 USF2 YY1 ZABC1 ZNF217	Homo sapiens (human)
MAPK6/MAPK4 signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cdc42 effector protein 2 Cdc42 effector protein 3 Cdc42 effector protein 5 Cell division control protein 42 homolog Cyclin-dependent kinase 1 DnaJ homolog subfamily B member 1 Dual specificity protein phosphatase CDC14A Dual specificity protein phosphatase CDC14B ETS translocation variant 4 Exportin-1 Forkhead box protein O1 Forkhead box protein O3 G1/S-specific cyclin-D3 Heat shock protein beta-1 Helicase MOV-10 Insulin-like growth factor 2 mRNA-binding protein 1 Kalirin MAP kinase-activated protein kinase 5 Mitogen-activated protein kinase 4 Mitogen-activated protein kinase 6 Myc proto-oncogene protein Nuclear receptor coactivator 3 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Ras-related C3 botulinum toxin substrate 1 Septin-7 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Transcription factor Jun Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	A5LHX3 O00231 O00232 O00233 O00487 O14613 O14818 O14980 O43242 O43524 O60229 O60729 O75832 O75914 P01106 P04792 P05412 P06493 P0CG47 P0CG48 P15918 P17612 P17980 P20618 P22612 P22694 P25685 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P30281 P31152 P35998 P40306 P43268 P43686 P48556 P49720 P49721 P51665 P55036 P55895 P60896 P60900 P60953 P61289 P62191 P62195 P62333 P62979 P62987 P63000 Q06323 Q12778 Q13153 Q13177 Q13200 Q14997 Q15008 Q16181 Q16401 Q16659 Q6NZY7 Q8IW41 Q8NDV7 Q8TAA3 Q92530 Q99436 Q99460 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NZI8 Q9UKI2 Q9UKV8 Q9UL18 Q9UL46 Q9UNH5 Q9UNM6 Q9UPQ9 Q9Y6Q9	AGO1 AGO2 AGO3 AGO4 AIB1 BHLHE39 BHLHE42 BORG1 BORG2 BORG3 C7orf76 CAGH26 CCND3 CDC10 CDC14A CDC14B CDC2 CDC28A CDC42 CDC42EP2 CDC42EP3 CDC42EP5 CDK1 CDKN1 CEP2 CEP3 CEP5 CRDBP CRM1 DNAJ1 DNAJB1 DSS1 DUET DUO E1AF EIF2C1 EIF2C2 EIF2C3 EIF2C4 ERK3 ERK4 ETV4 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A HAPIP HC2 HC3 HC8 HC9 HDJ1 HSP27 HSP28 HSPB1 HSPC HSPF1 IFI5111 IGF2BP1 JUN KALRN KIAA0072 KIAA0077 KIAA0107 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 LMP10 LMP2 LMP7 LMPX LMPY MAPK4 MAPK6 MAPKAPK5 MB1 MCB1 MECL1 MIP224 MOV10 MOV34L MSS1 MYC NCOA3 NU OPHN3 P34CDC2 PAK1 PAK2 PAK3 PEA3 PFAAP4 PKACA POH1 PRAK PRKACA PRKACB PRKACG PRKM4 PRKM6 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC1 RAC3 RAG1 RAG2 RING10 RING12 RNF74 RPS27A SEM1 SEPT7 SEPTIN7 SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TC25 TNRC6 TNRC6A TNRC6B TNRC6C TRAD TRAM1 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VICKZ1 X XPO1 Y Y2 Z ZBP1	Homo sapiens (human)
Regulation of MECP2 expression and activity	Aurora kinase B Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calcium/calmodulin-dependent protein kinase type IV Calmodulin-1 Delta(14)-sterol reductase LBR F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Forkhead box protein G1 G protein pathway suppressor 2 Helicase MOV-10 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Homeodomain-interacting protein kinase 2 Huntingtin Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Paired amphipathic helix protein Sin3a Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein cAMP-dependent protein kinase catalytic subunit alpha	O15379 O60907 O75376 P0DP23 P17612 P42858 P55316 Q13227 Q13547 Q13554 Q13555 Q13557 Q14739 Q16566 Q8NDV7 Q92769 Q96GD4 Q96ST3 Q9BZK7 Q9H2X6 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKV8 Q9UL18 Q9UPQ9 Q9UQM7 Q9Y618	AGO1 AGO2 AGO3 AGO4 AIK2 AIM1 AIRK2 ARK2 AURKB CAGH26 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-GR CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKA CAMKB CAMKD CAMKG CAMKIV CTG26 EIF2C1 EIF2C2 EIF2C3 EIF2C4 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1 FOXG1A FOXG1B FOXG1C GPS2 HD HDAC1 HDAC2 HDAC3 HIPK2 HTT IRA1 IT15 KIAA0968 KIAA1047 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 LBR MOV10 NCOR1 NCOR2 PKACA PRKACA RPD3L1 SIN3A STK1 STK12 STK5 TBL1 TBL1X TBL1XR1 TBLR1 TNRC6 TNRC6A TNRC6B TNRC6C	Homo sapiens (human)
Nuclear events stimulated by ALK signaling in cancer	Bcl-2-related protein A1 CCAAT/enhancer-binding protein beta Cullin-1 DNA (cytosine-5)-methyltransferase 1 E3 ubiquitin-protein ligase RBX1 Forkhead box protein M1 G2/mitotic-specific cyclin-B1 Granzyme B Helicase MOV-10 Histone deacetylase 1 Inducible T-cell costimulator Interferon regulatory factor 4 Interleukin-10 receptor subunit alpha Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Nucleophosmin Perforin-1 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Retinoblastoma-associated protein S-phase kinase-associated protein 1 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Small ribosomal subunit protein eS6 Transcription factor JunB Trinucleotide repeat-containing gene 6C protein Twist-related protein 1 Tyrosine-protein kinase ZAP-70 Tyrosine-protein phosphatase non-receptor type 6 Zinc finger C3HC-type protein 1	P06400 P06748 P10144 P14222 P14635 P17275 P17676 P26358 P27361 P28482 P29350 P40763 P42229 P43403 P62753 P62877 P63208 Q08050 Q13547 Q13616 Q13651 Q15306 Q15672 Q16548 Q86WB0 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKV8 Q9UL18 Q9Y6W8	AGO1 AGO2 AGO3 AGO4 AILIM AIM APRF BCL2A1 BCL2L5 BFL1 BHLHA38 CCNB CCNB1 CEBPB CGL1 CSPB CTLA1 CUL1 CXXC9 DNMT DNMT1 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EMC19 ERK1 ERK2 FKHL16 FOXM1 GRB GRS GZMB HBPA1 HCP HDAC1 HFH11 ICOS IL10R IL10RA IRF4 JUNB KIAA1567 KIAA1582 KIAA1631 MAPK1 MAPK3 MOV10 MPP2 MUM1 NIPA NPM NPM1 OCP2 PFP PRF1 PRKM1 PRKM2 PRKM3 PTP1C PTPN6 RB1 RBX1 RNF75 ROC1 RPD3L1 RPS6 SKP1 SKP1A SRK STAT3 STAT5 STAT5A TCEB1L TCF5 TNRC6C TWIST TWIST1 WIN ZAP70 ZC3HC1	Homo sapiens (human)
TP53 Regulates Metabolic Genes	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Cellular tumor antigen p53 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX18, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c DNA damage-inducible transcript 4 protein Fructose-2,6-bisphosphatase TIGAR GTP-binding protein Rheb Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Glutathione peroxidase 2 Hamartin Helicase MOV-10 Leucine-rich PPR motif-containing protein, mitochondrial Neutral amino acid transporter 9 Peroxiredoxin-1 Peroxiredoxin-2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribonucleoside-diphosphate reductase subunit M2 B Serine/threonine-protein kinase mTOR Sestrin-2 Sestrin-3 Surfeit locus protein 1 Target of rapamycin complex subunit LST8 Thioredoxin reductase 1, cytoplasmic Thioredoxin Translational activator of cytochrome c oxidase 1 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tuberin Tumor protein 63	O00483 O14548 O43504 O43741 O43819 O75880 O94925 P00395 P00403 P00414 P04637 P06744 P09669 P10176 P10599 P10606 P11413 P12074 P13073 P14854 P15954 P18283 P20674 P24311 P27348 P31749 P31751 P31946 P31947 P32119 P42345 P42704 P49815 P54619 P54646 P58004 P58005 P60484 P61981 P62258 P63104 P99999 Q04917 Q06830 Q0VGL1 Q13131 Q15382 Q15526 Q16881 Q49B96 Q5RI15 Q5VZM2 Q6IAA8 Q7L523 Q7LG56 Q8N122 Q8N8Q8 Q8NBW4 Q8NDV7 Q92574 Q96I36 Q9BSH4 Q9BVC4 Q9H3D4 Q9H9G7 Q9HB90 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NQ88 Q9NQL2 Q9NX09 Q9P0S2 Q9UGI9 Q9UGJ0 Q9UHA4 Q9UI32 Q9UKV8 Q9UL18 Q9UPQ9 Q9Y243 Q9Y2Q5 Q9Y478 Q9Y6N1	AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AKT3 AMPK AMPK1 AMPK2 AMPKG3 C11orf59 C12orf5 C12orf62 C14orf112 C7orf59 CAGH26 CCDC44 COI COII COIII COX11 COX14 COX16 COX18 COX19 COX2 COX20 COX4 COX4I1 COX5A COX5B COX6A1 COX6AL COX6B COX6B1 COX6C COX7A2L COX7AR COX7B COX7C COX7RP COX8 COX8A COX8L COXI COXII COXIII CYC CYCS DDIT4 EIF2C1 EIF2C2 EIF2C3 EIF2C4 FAM36A FRAP FRAP1 FRAP2 G6PD GA GBL GLS GLS1 GLS2 GPI GPX2 GRIM12 HBXIP HME1 Hi95 KDRF KET KIAA0243 KIAA0838 KIAA1093 KIAA1303 KIAA1460 KIAA1567 KIAA1582 KIAA1631 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LRP130 LRPPRC LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MMAC1 MOV10 MT-CO1 MT-CO2 MT-CO3 MTCO1 MTCO2 MTCO3 MTOR NDUFA4 NKEFB OXA1L2 P53 P53R2 P63 P73H P73L PAGA PAGB PDRO PKB PKBG PRDX1 PRDX2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTEN RAC RAFT1 RAPT1 RAPTOR REDD1 RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD RRM2B RTP801 SCO1 SCO2 SCOD1 SESN2 SESN3 SEST2 SEST3 SFN SLC38A9 SURF-1 SURF1 TACO1 TDPX1 TDPX2 TEP1 TIGAR TNRC6 TNRC6A TNRC6B TNRC6C TP53 TP63 TP73L TRDX TRX TRX1 TSC TSC1 TSC2 TSC4 TXN TXNRD1 URLC11 XIP YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)

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