GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1451 - 1475** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism	GlyTouCan ID
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal-like protein Alsin Ankyrin repeat domain-containing protein 27 BLOC-3 complex member HPS1 BLOC-3 complex member HPS4 C-myc promoter-binding protein DENN domain-containing protein 1A DENN domain-containing protein 1B DENN domain-containing protein 1C DENN domain-containing protein 2A DENN domain-containing protein 2B DENN domain-containing protein 2C DENN domain-containing protein 2D DENN domain-containing protein 3 DENN domain-containing protein 4B DENN domain-containing protein 4C DENN domain-containing protein 5A DENN domain-containing protein 5B GTPase-activating protein and VPS9 domain-containing protein 1 Guanine nucleotide exchange factor for Rab-3A Guanine nucleotide exchange factor subunit RIC1 Myotubularin-related protein 13 Myotubularin-related protein 5 Protein DENND6A Protein DENND6B RAB6A-GEF complex partner protein 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein non-catalytic subunit Rab5 GDP/GTP exchange factor Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like protein Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-35 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B Serine/threonine-protein kinase ULK1 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Vacuolar fusion protein CCZ1 homolog B Vacuolar fusion protein CCZ1 homolog Vacuolar fusion protein MON1 homolog A Vacuolar fusion protein MON1 homolog B	A2RUS2 A5PLN9 O00194 O43617 O75064 O75385 O75865 O95248 P0DI81 P20336 P20339 P20340 P24386 P26374 P31150 P31749 P31751 P48553 P50395 P51148 P51149 P51151 P51153 P51159 P57729 P61006 P61020 P61026 P61106 P62258 P62820 P78524 P86790 P86791 Q13636 Q13637 Q13671 Q14964 Q14C86 Q15042 Q15286 Q4ADV7 Q5VZ89 Q60I27 Q68D51 Q6IQ22 Q6IQ26 Q6P3S1 Q6ZS11 Q6ZUT9 Q7L1V2 Q7Z392 Q7Z401 Q86SZ2 Q86VX9 Q86WG5 Q8IUR0 Q8IV53 Q8IWF6 Q8NEG7 Q8TB24 Q8TBN0 Q8TEH3 Q8WVT3 Q8WYP3 Q92546 Q92902 Q92930 Q96AH8 Q96DA2 Q96NW4 Q96Q05 Q96Q42 Q96QF0 Q9H0U4 Q9H2M9 Q9H6A0 Q9NP72 Q9NP90 Q9NQG7 Q9NRW1 Q9UJ41 Q9UL25 Q9UL33 Q9ULE3 Q9Y243 Q9Y296 Q9Y2L5 Q9Y5R8	AKT1 AKT2 AKT3 ALS2 ALS2CL ALS2CR6 ANKRD27 BET3 BET5 C1orf218 C4orf41 C5orf44 C7orf28A C7orf28B C9orf55 C9orf55B CCZ1 CCZ1B CHM CHML CIP150 CMT4B2 DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B EHOC1 FAM116A FAM116B FAM31A FAM31B FAM31C GAPEX5 GAPVD1 GDI1 GDI2 GDIL HPS HPS1 HPS4 HSRG1 HTS1 IRLB KIAA0066 KIAA0118 KIAA0258 KIAA0476 KIAA0722 KIAA0839 KIAA0870 KIAA0872 KIAA1012 KIAA1091 KIAA1277 KIAA1432 KIAA1521 KIAA1563 KIAA1608 KIAA1667 KIAA1766 KIAA1882 MEL MON1A MON1B MTMR13 MTMR5 MUM2 MYCPBP NIBP OPHN2 PKB PKBG RAB1 RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB1C RAB21 RAB22B RAB27 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3GAP RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB6IP1 RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABEX5 RABGDIA RABGDIB RABGEF1 RABIN8 RABL RAC RAP6 RASSF4 RAY REP1 REP2 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SAND1 SAND2 SBDN SBF1 SBF2 SEDL ST5 TCD TMEM1 TRAMM TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TTC15 ULK1 XAP4 YWHAE	Homo sapiens (human)
MTOR signalling	14-3-3 protein beta/alpha GTP-binding protein Rheb Neutral amino acid transporter 9 Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O43504 P31749 P31946 P42345 Q0VGL1 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1 AKT1S1 C11orf59 C7orf59 FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PKB PRAS40 RAC RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 URLC11 XIP YWHAB	Homo sapiens (human)
AKT phosphorylates targets in the cytosol	Bcl2-associated agonist of cell death Caspase-9 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase makorin-1 Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tuberin	O15111 P31749 P31751 P38936 P46527 P49815 P49840 P49841 P55211 Q00987 Q92934 Q96B36 Q9UHC7 Q9Y243	AKT1 AKT1S1 AKT2 AKT3 BAD BBC6 BCL2L8 CAP20 CASP9 CDKN1 CDKN1A CDKN1B CHUK CIP1 GSK3A GSK3B IKKA KIP1 MCH6 MDA6 MDM2 MKRN1 PIC1 PKB PKBG PRAS40 RAC RNF61 SDI1 TCF16 TSC2 TSC4 WAF1 p27	Homo sapiens (human)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	15-hydroxyprostaglandin dehydrogenase [NAD(+)] 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C3 Carbonyl reductase [NADPH] 1 Hematopoietic prostaglandin D synthase Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase 3 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin reductase 2 Prostaglandin-H2 D-isomerase Prostamide/prostaglandin F synthase Thromboxane-A synthase	O14684 O60760 P15428 P16152 P23219 P24557 P35354 P41222 P42330 Q15185 Q16647 Q8N8N7 Q8TBF2 Q9H7Z7 Q9UNU6	AKR1C3 C1orf93 C9orf15 CBR CBR1 COX1 COX2 CRN CYP12 CYP5 CYP5A1 CYP8 CYP8A1 CYP8B1 DDH1 FAM213B GSTS HPGD HPGDS HSD17B5 KIAA0119 MGST1L1 MPGES1 P23 PDS PGDH1 PGDS PGES PGES2 PGFS PIG12 PRXL2B PTGDS PTGDS2 PTGES PTGES2 PTGES3 PTGIS PTGR2 PTGS1 PTGS2 SDR21C1 SDR36C1 TBXAS1 TEBP TXAS ZADH1	Homo sapiens (human)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Bile acid receptor Cytochrome P450 7A1 Cytochrome P450 7B1 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O75881 P17516 P19793 P22680 P42330 P51857 P52895 Q02318 Q04828 Q15596 Q15788 Q16647 Q96RI1 Q9H2F3 Q9UNU6	AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 BAR BHLHE74 BHLHE75 CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 FXR HRR1 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTGIS RIP14 RXRA SRC1 SRC2 SRD5B1 TIF2	Homo sapiens (human)
Estrogen biosynthesis	17-beta-hydroxysteroid dehydrogenase 14 17-beta-hydroxysteroid dehydrogenase type 1 17-beta-hydroxysteroid dehydrogenase type 2 Aldo-keto reductase family 1 member B15 Aromatase Estradiol 17-beta-dehydrogenase 11	C9JRZ8 P11511 P14061 P37059 Q8NBQ5 Q9BPX1	AKR1B15 ARO1 CYAR CYP19 CYP19A1 DHRS10 DHRS8 E17KSR EDH17B1 EDH17B2 EDHB17 HSD17B1 HSD17B11 HSD17B14 HSD17B2 PAN1B SDR16C2 SDR28C1 SDR3 SDR47C1 SDR9C2	Homo sapiens (human)
Fructose biosynthesis	Aldo-keto reductase family 1 member B1 Sorbitol dehydrogenase	P15121 Q00796	AKR1B1 ALDR1 ALR2 SORD	Homo sapiens (human)	G58161NS
Glutathione conjugation	Aldo-keto reductase family 1 member A1 Glutathione S-transferase 3, mitochondrial Glutathione S-transferase A1 Glutathione S-transferase A2 Glutathione S-transferase A3 Glutathione S-transferase A4 Glutathione S-transferase A5 Glutathione S-transferase Mu 1 Glutathione S-transferase Mu 2 Glutathione S-transferase Mu 3 Glutathione S-transferase Mu 4 Glutathione S-transferase Mu 5 Glutathione S-transferase P Glutathione S-transferase kappa 1 Glutathione S-transferase omega-1 Glutathione S-transferase omega-2 Glutathione S-transferase theta-1 Glutathione S-transferase theta-2 Glutathione S-transferase theta-2B Hematopoietic prostaglandin D synthase Maleylacetoacetate isomerase Microsomal glutathione S-transferase 1 Microsomal glutathione S-transferase 2 S-formylglutathione hydrolase	O14880 O15217 O43708 O60760 P08263 P09210 P09211 P09488 P0CG29 P0CG30 P10620 P10768 P14550 P21266 P28161 P30711 P46439 P78417 Q03013 Q16772 Q7RTV2 Q99735 Q9H4Y5 Q9Y2Q3	AKR1A1 ALDR1 ALR ESD FAEES3 GST1 GST12 GST2 GST3 GST4 GST5 GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTS GSTT1 GSTT2 GSTT2B GSTTLP28 GSTZ1 HPGDS MAAI MGST MGST1 MGST2 MGST3 PGDS PTGDS2	Homo sapiens (human)
Formation of xylulose-5-phosphate	Aldo-keto reductase family 1 member A1 L-xylulose reductase Lambda-crystallin homolog Sorbitol dehydrogenase Xylulose kinase	O75191 P14550 Q00796 Q7Z4W1 Q9Y2S2	AKR1A1 ALDR1 ALR CRY CRYL1 DCXR SDR20C1 SORD XYLB	Homo sapiens (human)
ROBO receptors bind AKAP5	A-kinase anchor protein 5 Protein kinase C alpha type Roundabout homolog 2 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type II-alpha regulatory subunit	P13861 P16298 P17252 P17612 P22612 P22694 P24588 Q9HCK4	AKAP5 AKAP79 CALNA2 CALNB CNA2 KIAA1568 PKACA PKCA PKR2 PPP3CB PRKACA PRKACB PRKACG PRKAR2 PRKAR2A PRKCA ROBO2	Homo sapiens (human)
Trafficking of AMPA receptors	A-kinase anchor protein 5 Band 4.1-like protein 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Disks large homolog 1 Disks large homolog 4 E3 ubiquitin-protein ligase Mdm2 Glutamate receptor 1 Glutamate receptor 3 Glutamate receptor 4 Unconventional myosin-VI Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-3 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-8 subunit	O60359 P24588 P42261 P42263 P48058 P78352 Q00987 Q12959 Q13554 Q13555 Q13557 Q8WXS5 Q9H4G0 Q9UBN1 Q9UM54 Q9UQM7 Q9Y698	AKAP5 AKAP79 CACNG2 CACNG3 CACNG4 CACNG6 CACNG8 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG DLG1 DLG4 EPB41L1 GLUA1 GLUH1 GLUR1 GLUR3 GLUR4 GLURC GRIA1 GRIA3 GRIA4 GluA3 GluA4 KIAA0338 KIAA0389 KIAA0968 MDM2 MYO6 PSD95	Homo sapiens (human)
Phase 3 - rapid repolarisation	A-kinase anchor protein 9 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E member 3 Potassium voltage-gated channel subfamily E member 4 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Potassium voltage-gated channel subfamily H member 2 Potassium voltage-gated channel subfamily KQT member 1	P15382 P22460 P51787 Q12809 Q8WWG9 Q99996 Q9UJ90 Q9Y6H6 Q9Y6J6	AKAP350 AKAP450 AKAP9 AMMECR2 ERG ERG1 HERG KCNA5 KCNA8 KCNA9 KCNE1 KCNE1L KCNE2 KCNE3 KCNE4 KCNE5 KCNH2 KCNQ1 KIAA0803 KVLQT1	Homo sapiens (human)
Phase 2 - plateau phase	A-kinase anchor protein 9 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E member 3 Potassium voltage-gated channel subfamily E member 4 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Potassium voltage-gated channel subfamily KQT member 1 Voltage-dependent L-type calcium channel subunit alpha-1C Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit Voltage-dependent calcium channel subunit alpha-2/delta-2	P15382 P51787 P62955 Q02641 Q08289 Q13936 Q8WWG9 Q8WXS5 Q99996 Q9BXT2 Q9NY47 Q9UBN1 Q9UJ90 Q9Y6H6 Q9Y6J6	AKAP350 AKAP450 AKAP9 AMMECR2 CACH2 CACN2 CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8 CACNL1A1 CACNLB1 CACNLB2 CCHL1A1 KCNA8 KCNA9 KCNE1 KCNE1L KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 KIAA0558 KIAA0803 KVLQT1 MYSB	Homo sapiens (human)
Mitochondrial calcium ion transport	A-kinase anchor protein 1, mitochondrial Calcium uniporter protein, mitochondrial Calcium uniporter regulatory subunit MCUb, mitochondrial Calcium uptake protein 1, mitochondrial Calcium uptake protein 2, mitochondrial Calcium uptake protein 3, mitochondrial Essential MCU regulator, mitochondrial Mitochondrial proton/calcium exchanger protein Mitochondrial sodium/calcium exchanger protein Sodium/calcium exchanger 3 Voltage-dependent anion-selective channel protein 1 Voltage-dependent anion-selective channel protein 2 Voltage-dependent anion-selective channel protein 3	O95202 P21796 P45880 P57103 Q6J4K2 Q86XE3 Q8IYU8 Q8NE86 Q92667 Q9BPX6 Q9H4I9 Q9NWR8 Q9Y277	AKAP1 AKAP149 C10orf42 C22orf32 CALC CBARA1 CCDC109A CCDC109B EFHA1 EFHA2 EMRE LETM1 MCU MCUB MICU1 MICU2 MICU3 NCKX6 NCLX NCX3 PRKA1 SLC24A6 SLC8A3 SLC8B1 SMDT1 VDAC VDAC1 VDAC2 VDAC3	Homo sapiens (human)
Interleukin-20 family signaling	Interferon lambda receptor 1 Interferon lambda-1 Interferon lambda-2 Interferon lambda-3 Interleukin-10 receptor subunit beta Interleukin-19 Interleukin-20 receptor subunit alpha Interleukin-20 receptor subunit beta Interleukin-20 Interleukin-22 receptor subunit alpha-1 Interleukin-22 receptor subunit alpha-2 Interleukin-22 Interleukin-24 Interleukin-26 Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 11	O60674 P23458 P29597 P40763 P42224 P42229 P51692 P52333 P52630 Q06124 Q08334 Q13007 Q14765 Q6UXL0 Q8IU54 Q8IU57 Q8IZI9 Q8IZJ0 Q8N6P7 Q969J5 Q9GZX6 Q9NPH9 Q9NYY1 Q9UHD0 Q9UHF4	AK155 APRF CRFB4 D21S58 D21S66 DIRS1 IFNL1 IFNL2 IFNL3 IFNLR1 IL10RB IL19 IL20 IL20RA IL20RB IL22 IL22R IL22RA1 IL22RA2 IL24 IL26 IL28A IL28B IL28C IL28RA IL29 ILTIF JAK1 JAK1A JAK1B JAK2 JAK3 LICR2 MDA7 PTP2C PTPN11 SHPTP2 ST16 STAT1 STAT2 STAT3 STAT4 STAT5 STAT5A STAT5B TYK2 ZCYTO10 ZCYTO18 ZCYTO20 ZCYTO21 ZCYTO22 ZMDA1	Homo sapiens (human)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-2 E3 ubiquitin-protein ligase RBX1 Egl nine homolog 1 Elongin-B Elongin-C Endothelial PAS domain-containing protein 1 Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 3-alpha LIM domain-containing protein 1 LIM domain-containing protein ajuba Polyubiquitin-B Polyubiquitin-C Prolyl hydroxylase EGLN2 Prolyl hydroxylase EGLN3 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Wilms tumor protein 1-interacting protein von Hippel-Lindau disease tumor suppressor	A5LHX3 A6NIX2 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P40337 P43686 P48556 P49720 P49721 P51665 P51668 P55036 P60896 P60900 P61077 P61289 P62191 P62195 P62333 P62837 P62877 P62979 P62987 Q06323 Q13200 Q13617 Q14997 Q15008 Q15369 Q15370 Q16401 Q16665 Q8TAA3 Q92530 Q96IF1 Q96KS0 Q99436 Q99460 Q99814 Q9GZT9 Q9H6Z9 Q9UGP4 Q9UL46 Q9UNM6 Q9Y2N7	AJUBA BHLHE17 BHLHE73 BHLHE78 C1orf12 C7orf76 CUL2 DSS1 EGLN1 EGLN2 EGLN3 EIT6 ELOB ELOC EPAS1 HC2 HC3 HC8 HC9 HIF1A HIF2A HIF3A HSPC IFI5111 JUB KIAA0072 KIAA0077 KIAA0107 LIMD1 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOP1 MOP2 MOP7 MOV34L MSS1 NU PASD2 PASD7 PASD8 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PUBC1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SFT SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TCEB1 TCEB2 TRAP2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBE2D1 UBE2D2 UBE2D3 VHL WTIP X Y Y2 Z	Homo sapiens (human)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Complement receptor type 1 Core-binding factor subunit beta Cytotoxic T-lymphocyte protein 4 Forkhead box protein P3 Interferon gamma Interleukin-2 receptor subunit alpha Interleukin-2 Nuclear factor of activated T-cells, cytoplasmic 2 Runt-related transcription factor 1 Tumor necrosis factor receptor superfamily member 18	P01579 P01589 P16410 P17927 P60568 Q01196 Q13469 Q13951 Q9BZS1 Q9Y5U5	AITR AML1 C3BR CBFA2 CBFB CD152 CR1 CTLA4 FOXP3 GITR IFNG IL2 IL2RA IPEX NFAT1 NFATC2 NFATP RUNX1 TNFRSF18	Homo sapiens (human)
TNFs bind their physiological receptors	CD27 antigen CD70 antigen Ectodysplasin-A receptor-associated adapter protein Ectodysplasin-A Lymphotoxin-alpha Tumor necrosis factor ligand superfamily member 11 Tumor necrosis factor ligand superfamily member 13 Tumor necrosis factor ligand superfamily member 13B Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 15 Tumor necrosis factor ligand superfamily member 18 Tumor necrosis factor ligand superfamily member 4 Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 8 Tumor necrosis factor ligand superfamily member 9 Tumor necrosis factor receptor superfamily member 11B Tumor necrosis factor receptor superfamily member 13B Tumor necrosis factor receptor superfamily member 14 Tumor necrosis factor receptor superfamily member 17 Tumor necrosis factor receptor superfamily member 18 Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor receptor superfamily member 25 Tumor necrosis factor receptor superfamily member 27 Tumor necrosis factor receptor superfamily member 4 Tumor necrosis factor receptor superfamily member 6B Tumor necrosis factor receptor superfamily member 8 Tumor necrosis factor receptor superfamily member 9 Tumor necrosis factor receptor superfamily member EDAR	O00300 O14788 O14836 O43557 O75888 O95150 O95407 P01374 P19438 P20333 P23510 P26842 P28908 P32970 P32971 P41273 P43489 Q02223 Q07011 Q53ZZ1 Q8WWZ3 Q92838 Q92956 Q93038 Q9HAV5 Q9UNE0 Q9UNG2 Q9Y275 Q9Y5U5	AITR AITRL APO3 APRIL BAFF BCM BCMA BLYS CD137 CD27 CD27L CD27LG CD30 CD30L CD30LG CD70 D1S166E DCR3 DDR3 DL DR3 ED1 EDA EDA2 EDA2R EDAR EDARADD FASLG GITR GITRL HVEA HVEM HVEML ILA LIGHT LTA OCIF OPG OPGL RANKL TACI TALL1 TALL2 TL1 TL6 TNFAR TNFB TNFBR TNFR1 TNFR2 TNFRSF11B TNFRSF12 TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF27 TNFRSF4 TNFRSF6B TNFRSF7 TNFRSF8 TNFRSF9 TNFSF1 TNFSF11 TNFSF13 TNFSF13B TNFSF14 TNFSF15 TNFSF18 TNFSF20 TNFSF4 TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNLG1A TR6 TRANCE TXGP1 TXGP1L VEGI WSL WSL1 XEDAR ZTNF2 ZTNF4	Homo sapiens (human)
Organic anion transporters	Mitochondrial 2-oxoglutarate/malate carrier protein Mitochondrial dicarboxylate carrier Mitochondrial glutamate carrier 1 Mitochondrial glutamate carrier 2 Sialin Sodium-coupled monocarboxylate transporter 1 Sodium-dependent phosphate transport protein 1 Sodium/iodide cotransporter Tricarboxylate transport protein, mitochondrial Vesicular glutamate transporter 1 Vesicular glutamate transporter 2 Vesicular glutamate transporter 3	P53007 Q02978 Q14916 Q8N695 Q8NDX2 Q92911 Q9H1K4 Q9H936 Q9NRA2 Q9P2U7 Q9P2U8 Q9UBX3	AIT BNPI DIC DNPI GC1 GC2 NIS NPT1 SLC17A1 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC20A3 SLC20A4 SLC25A1 SLC25A10 SLC25A11 SLC25A18 SLC25A22 SLC5A5 SLC5A8 SMCT SMCT1 VGLUT1 VGLUT2 VGLUT3	Homo sapiens (human)
Purine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'-nucleotidase 5-hydroxymethyl-dUMP N-hydrolase Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 1B Cytosolic purine 5'-nucleotidase Guanine deaminase Inosine triphosphate pyrophosphatase Purine nucleoside phosphorylase Xanthine dehydrogenase/oxidase	O43598 P00491 P21589 P47989 P49902 Q8TCD5 Q96P26 Q9BXI3 Q9BY32 Q9Y2T3	AIRP C20orf37 C6orf108 DNPH1 DNT1 GDA ITPA KIAA1258 NP NT5 NT5B NT5C NT5C1A NT5C1B NT5C2 NT5CP NT5E NTE PNP PNT5 RCL UMPH2 XDH XDHA	Homo sapiens (human)
Ion transport by P-type ATPases	Calcium-transporting ATPase type 2C member 1 Calcium-transporting ATPase type 2C member 2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cardiac phospholamban Copper homeostasis protein cutC homolog Copper-transporting ATPase 1 Copper-transporting ATPase 2 Endoplasmic reticulum transmembrane helix translocase FXYD domain-containing ion transport regulator 3 FXYD domain-containing ion transport regulator 4 FXYD domain-containing ion transport regulator 6 FXYD domain-containing ion transport regulator 7 PDZ domain-containing protein 11 Phospholemman Phospholipid-transporting ATPase IA Phospholipid-transporting ATPase IB Phospholipid-transporting ATPase IC Phospholipid-transporting ATPase ID Phospholipid-transporting ATPase IF Phospholipid-transporting ATPase IG Phospholipid-transporting ATPase IH Phospholipid-transporting ATPase IK Phospholipid-transporting ATPase VA Phospholipid-transporting ATPase VB Phospholipid-transporting ATPase VD Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Polyamine-transporting ATPase 13A2 Potassium-transporting ATPase alpha chain 1 Potassium-transporting ATPase alpha chain 2 Potassium-transporting ATPase subunit beta Probable cation-transporting ATPase 13A4 Probable cation-transporting ATPase 13A5 Probable phospholipid-transporting ATPase IIA Probable phospholipid-transporting ATPase IIB Probable phospholipid-transporting ATPase IM Sarcolipin Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-2 Sodium/potassium-transporting ATPase subunit alpha-3 Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit gamma Sorcin	O00168 O00631 O14983 O43520 O43861 O60312 O60423 O75110 O75185 O94823 P05023 P05026 P0DP23 P13637 P14415 P16615 P20020 P20648 P23634 P26678 P30626 P35670 P50993 P51164 P54707 P54709 P54710 P58549 P59646 P98194 P98196 P98198 Q01814 Q04656 Q13554 Q13555 Q13557 Q13733 Q14802 Q16720 Q4VNC0 Q4VNC1 Q5EBL8 Q8NB49 Q8TF62 Q93084 Q9H0Q3 Q9HD20 Q9NQ11 Q9NTI2 Q9NTM9 Q9P241 Q9UQM7 Q9Y2G3 Q9Y2Q0	AIPP1 ATP10A ATP10B ATP10C ATP10D ATP11A ATP11B ATP11C ATP12A ATP13A ATP13A1 ATP13A2 ATP13A4 ATP13A5 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1AL1 ATP1AL2 ATP1B ATP1B1 ATP1B2 ATP1B3 ATP1C ATP1G1 ATP1K ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B ATPIA ATPIB ATPIC ATPID ATPIF ATPIG ATPIH ATPIIA ATPIIB ATPIQ ATPIR ATPIS ATPVA ATPVB ATPVC ATPVD CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CUTC FIC1 FOS37502_2 FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 KIAA0566 KIAA0611 KIAA0703 KIAA0715 KIAA0778 KIAA0956 KIAA0968 KIAA1021 KIAA1137 KIAA1347 KIAA1487 KIAA1825 KIAA1939 MAT8 MC1 MNK MXRA1 NEO1L PARK9 PDZD11 PDZK11 PFIC PISP PLB PLM PLML PLN PMCA1 PMCA2 PMR1L PWD SLN SPCA2 SRI WC1 WND	Homo sapiens (human)
Ion influx/efflux at host-pathogen interface	Copper transport protein ATOX1 Copper-transporting ATPase 1 Natural resistance-associated macrophage protein 1 PDZ domain-containing protein 11	O00244 P49279 Q04656 Q5EBL8	AIPP1 ATOX1 ATP7A HAH1 LSH MC1 MNK NRAMP NRAMP1 PDZD11 PDZK11 PISP SLC11A1	Homo sapiens (human)
Uptake and function of anthrax toxins	Calmodulin-1 Calmodulin-sensitive adenylate cyclase Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 Furin Lethal factor Programmed cell death 6-interacting protein Protective antigen	O14733 P09958 P0DP23 P13423 P15917 P36507 P40136 P45985 Q02750 Q8WUM4	AIP1 ALIX CALM CALM1 CAM CAM1 FUR FURIN JNKK1 JNKK2 KIAA1375 MAP2K1 MAP2K2 MAP2K4 MAP2K7 MEK1 MEK2 MEK4 MEK7 MKK2 MKK4 MKK7 PACE PCSK3 PDCD6IP PRKMK1 PRKMK2 PRKMK4 PRKMK7 SEK1 SERK1 SKK1 SKK4 cya lef pag pagA	Homo sapiens (human)
Budding and maturation of HIV virion	Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 5 Charged multivesicular body protein 6 Charged multivesicular body protein 7 E3 ubiquitin-protein ligase NEDD4-like Envelope glycoprotein gp160 Gag polyprotein Gag-Pol polyprotein Multivesicular body subunit 12A Multivesicular body subunit 12B Peptidyl-prolyl cis-trans isomerase A Polyubiquitin-B Polyubiquitin-C Programmed cell death 6-interacting protein Protein Nef Protein Rev Protein Vpr Protein Vpu Tumor susceptibility gene 101 protein Ubiquitin-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vacuolar protein sorting-associated protein 28 homolog Vacuolar protein sorting-associated protein 37A Vacuolar protein sorting-associated protein 37B Vacuolar protein sorting-associated protein 37C Vacuolar protein sorting-associated protein 37D Vacuolar protein sorting-associated protein 4A Vacuolar protein sorting-associated protein 4B Vacuolar protein sorting-associated protein VTA1 homolog Virion infectivity factor	A5D8V6 O43633 O75351 P04578 P04585 P04591 P04601 P04618 P05919 P0CG47 P0CG48 P62937 P62979 P62987 P69723 P69726 Q86XT2 Q8NEZ2 Q8WUM4 Q8WUX9 Q96CF2 Q96EY5 Q96FZ7 Q96PU5 Q99816 Q9BY43 Q9H444 Q9H7P6 Q9H9H4 Q9NP79 Q9NZ09 Q9NZZ3 Q9UK41 Q9UN37 Q9UQN3 Q9Y3E7	AIP1 ALIX BC2 C14orf123 C20orf178 C6orf55 C9orf28 C9orf83 CFBP CGI149 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CYPA FAM125A FAM125B HCRP1 KIAA0439 KIAA1375 MVB12A MVB12B NEDD4L NEDF NEDL3 PDCD6IP PML39 PPIA RPS27A SHAX1 SHAX2 SHAX3 SKD1 SNF7DC2 TSG101 UBA52 UBA80 UBAP1 UBB UBC UBCEP1 UBCEP2 VPS20 VPS24 VPS28 VPS37A VPS37B VPS37C VPS37D VPS4 VPS42 VPS4A VPS4B VTA1 WBSCR24 env gag gag-pol nef rev vif vpr vpu	Homo sapiens (human)
Regulation of necroptotic cell death	Baculoviral IAP repeat-containing protein 2 Baculoviral IAP repeat-containing protein 3 Caspase-8 E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase XIAP E3 ubiquitin-protein ligase parkin E3 ubiquitin-protein ligase pellino homolog 1 FAS-associated death domain protein Flotillin-1 Flotillin-2 Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Mixed lineage kinase domain-like protein Polyubiquitin-B Polyubiquitin-C Programmed cell death 6-interacting protein Receptor-interacting serine/threonine-protein kinase 1 Receptor-interacting serine/threonine-protein kinase 3 Syntenin-1 TNF receptor-associated factor 2 Tumor necrosis factor receptor type 1-associated DEATH domain protein UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Ubiquitin-conjugating enzyme E2 L3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00560 O15294 O60260 O75955 P07900 P0CG47 P0CG48 P62979 P62987 P68036 P98170 Q12933 Q13158 Q13489 Q13490 Q13546 Q14254 Q14790 Q15628 Q16543 Q8NB16 Q8WUM4 Q96FA3 Q96J02 Q9UNE7 Q9Y572	AIP1 ALIX API1 API2 API3 BIRC2 BIRC3 BIRC4 CASP8 CDC37 CDC37A CHIP ESA1 FADD FLOT1 FLOT2 HSP90A HSP90AA1 HSPC1 HSPCA IAP3 ITCH KIAA1375 M17S1 MCH5 MDA9 MIHB MIHC MLKL MORT1 OGT PARK2 PDCD6IP PELI1 PRISM PRKN RIP RIP1 RIP3 RIPK1 RIPK3 RNF48 RNF49 RPS27A SDCBP STUB1 SYCL TRADD TRAF2 TRAP3 UBA52 UBA80 UBB UBC UBCE7 UBCEP1 UBCEP2 UBCH7 UBE2L3 XIAP	Homo sapiens (human)

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