GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **401 - 425** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
SUMOylation of chromatin organization proteins	Aladin Chromobox protein homolog 2 Chromobox protein homolog 5 Chromobox protein homolog 8 Chromodomain-helicase-DNA-binding protein 3 DNA-binding protein SATB1 DNA-binding protein SATB2 E3 SUMO-protein ligase CBX4 E3 SUMO-protein ligase PIAS1 E3 SUMO-protein ligase RanBP2 E3 SUMO-protein ligase ZBED1 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Histone H4 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 4 Lethal(3)malignant brain tumor-like protein 2 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Polycomb complex protein BMI-1 Polycomb group RING finger protein 2 Polycomb protein SUZ12 Polyhomeotic-like protein 1 Polyhomeotic-like protein 2 Polyhomeotic-like protein 3 Protein SEC13 homolog SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3 mRNA export factor RAE1	A8CG34 O00257 O15504 O75694 O75925 O96006 P12270 P35226 P35227 P35658 P37198 P45973 P49790 P49792 P55735 P55854 P56524 P57740 P61956 P62805 P63165 P63279 P78364 P78406 Q01826 Q06587 Q12769 Q12873 Q13547 Q14781 Q15022 Q5SRE5 Q7Z3B4 Q8IXK0 Q8N1F7 Q8NDX5 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q92769 Q969R5 Q96HA1 Q99496 Q99567 Q9BTX1 Q9BW27 Q9HC52 Q9NRG9 Q9UKX7 Q9UPW6	AAAS ADRACALA ALTE BAP1 BMI1 C7orf14 CAIN CAN CBX2 CBX4 CBX5 CBX8 CG1 CHD3 CHET9 D3S1231E DDXBP1 DING DREF EDR1 EDR2 EDR3 H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HDAC2 HDAC4 HIPI3 HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 HP1A JJAZ1 KIAA0023 KIAA0095 KIAA0160 KIAA0169 KIAA0197 KIAA0225 KIAA0288 KIAA0618 KIAA0785 KIAA0791 KIAA0906 KIAA1034 L3MBTL2 MEL18 MP44 MRNP41 NDC1 NPAP60L NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 PC3 PCGF2 PCGF4 PCNT1 PH1 PH2 PH3 PHC1 PHC2 PHC3 PIAS1 POM121 POM121A POM121C RAE1 RANBP2 RC1 RING1 RING1A RING1B RNF1 RNF110 RNF2 RNF51 RPD3L1 SATB1 SATB2 SEC13 SEC13A SEC13L1 SEC13R SMT3A SMT3B SMT3C SMT3H1 SMT3H2 SMT3H3 SUMO1 SUMO2 SUMO3 SUZ12 TMEM48 TPR TRAMP UBC9 UBCE9 UBE2I UBL1 ZBED1 ZNF144 hDREF	Homo sapiens (human)
Interleukin-10 signaling	C-C chemokine receptor type 1 C-C chemokine receptor type 2 C-C chemokine receptor type 5 C-C motif chemokine 19 C-C motif chemokine 20 C-C motif chemokine 22 C-C motif chemokine 2 C-C motif chemokine 3-like 1 C-C motif chemokine 3 C-C motif chemokine 4 C-C motif chemokine 5 C-X-C motif chemokine 10 C-X-C motif chemokine 2 Granulocyte colony-stimulating factor Granulocyte-macrophage colony-stimulating factor Growth-regulated alpha protein Intercellular adhesion molecule 1 Interleukin-1 alpha Interleukin-1 beta Interleukin-1 receptor antagonist protein Interleukin-1 receptor type 1 Interleukin-1 receptor type 2 Interleukin-10 receptor subunit alpha Interleukin-10 receptor subunit beta Interleukin-10 Interleukin-12 subunit alpha Interleukin-12 subunit beta Interleukin-18 Interleukin-6 Interleukin-8 Leukemia inhibitory factor Low affinity immunoglobulin epsilon Fc receptor Macrophage colony-stimulating factor 1 Metalloproteinase inhibitor 1 Non-receptor tyrosine-protein kinase TYK2 Platelet-activating factor receptor Prostaglandin G/H synthase 2 Signal transducer and activator of transcription 3 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor Tyrosine-protein kinase JAK1 fMet-Leu-Phe receptor	O00626 P01033 P01375 P01583 P01584 P02778 P04141 P05231 P05362 P06734 P09341 P09603 P09919 P10145 P10147 P13236 P13500 P13501 P14778 P15018 P16619 P18510 P19438 P19875 P20333 P21462 P22301 P23458 P25105 P27930 P29459 P29460 P29597 P32246 P33681 P35354 P40763 P41597 P42081 P51681 P78556 Q08334 Q13651 Q14116 Q99731	APRF C17orf33 CCL19 CCL2 CCL20 CCL22 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCR1 CCR2 CCR5 CD23A CD28LG CD28LG1 CD28LG2 CD80 CD86 CLEC4J CLGI CMKBR1 CMKBR2 CMKBR5 CMKR1 COX2 CRFB4 CSF1 CSF2 CSF3 CXCL1 CXCL10 CXCL2 CXCL8 D17S136E D17S1718 D21S58 D21S66 ELC FCE2 FCER2 FPR1 G0S19-1 G0S19-2 GCSF GMCSF GRO GRO1 GRO2 GROA GROB HILDA ICAM1 IFNB2 IGEBF IGIF IL10 IL10R IL10RA IL10RB IL12A IL12B IL18 IL1A IL1B IL1F1 IL1F2 IL1F3 IL1F4 IL1R IL1R1 IL1R2 IL1RA IL1RB IL1RN IL1RT1 IL6 IL8 INP10 JAK1 JAK1A JAK1B LAB7 LAG1 LARC LIF MCP1 MDC MGSA MIP1A MIP1B MIP2A MIP3A MIP3B NKSF1 NKSF2 PAFR PTAFR PTGS2 SCYA19 SCYA2 SCYA20 SCYA22 SCYA3 SCYA3L1 SCYA4 SCYA5 SCYAR1 SCYB1 SCYB10 SCYB2 STAT3 TIMP TIMP1 TNF TNFA TNFAR TNFBR TNFR1 TNFR2 TNFRSF1A TNFRSF1B TNFSF2 TYK2	Homo sapiens (human)
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial Enoyl-CoA delta isomerase 1, mitochondrial Long-chain specific acyl-CoA dehydrogenase, mitochondrial Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Trifunctional enzyme subunit alpha, mitochondrial Trifunctional enzyme subunit beta, mitochondrial	P11310 P28330 P40939 P42126 P55084 Q16698	ACADL ACADM DCI DECR DECR1 ECI1 HADH HADHA HADHB SDR18C1	Homo sapiens (human)
HDR through MMEJ (alt-NHEJ)	Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA ligase 3 DNA polymerase theta DNA repair protein RAD50 DNA repair protein RAD52 homolog DNA repair protein XRCC1 Double-strand break repair protein MRE11 Flap endonuclease 1 Nibrin Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 2	O60934 O75417 P09874 P18887 P39748 P43351 P49916 P49959 P51587 Q92878 Q99708 Q9UGN5	ADPRT ADPRT2 ADPRTL2 BRCA2 CTIP FACD FANCD1 FEN1 HNGS1 LIG3 MRE11 MRE11A NBN NBS NBS1 P95 PARP1 PARP2 POLH POLQ PPOL RAD2 RAD50 RAD52 RBBP8 XRCC1	Homo sapiens (human)
Nucleotide catabolism	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Q9Y3Z3	MOP5 SAMHD1	Homo sapiens (human)
POLB-Dependent Long Patch Base Excision Repair	ADP-ribosylhydrolase ARH3 DNA ligase 1 DNA polymerase beta DNA repair nuclease/redox regulator APEX1 Flap endonuclease 1 Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 2 Poly(ADP-ribose) glycohydrolase	P06746 P09874 P18858 P27695 P39748 Q86W56 Q9NX46 Q9UGN5	ADPRHL2 ADPRS ADPRT ADPRT2 ADPRTL2 APE APE1 APEX APEX1 APX ARH3 FEN1 HAP1 LIG1 PARG PARP1 PARP2 POLB PPOL RAD2 REF1	Homo sapiens (human)
Transport to the Golgi and subsequent modification	Multiple coagulation factor deficiency protein 2 Protein ERGIC-53	P49257 Q8NI22	ERGIC53 F5F8D LMAN1 MCFD2 SDNSF	Homo sapiens (human)
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B	Homo sapiens (human)
Signaling by PDGF	Collagen alpha-1(IV) chain Collagen alpha-1(IX) chain Collagen alpha-1(VI) chain Collagen alpha-2(IV) chain Collagen alpha-2(IX) chain Collagen alpha-2(VI) chain Collagen alpha-3(IV) chain Collagen alpha-3(IX) chain Collagen alpha-3(VI) chain Collagen alpha-4(IV) chain Collagen alpha-5(IV) chain Collagen alpha-5(VI) chain Collagen alpha-6(VI) chain Furin Osteopontin Plasminogen Platelet-derived growth factor D Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Thrombospondin-1 Thrombospondin-2 Thrombospondin-3 Thrombospondin-4 Tissue-type plasminogen activator Tyrosine-protein phosphatase non-receptor type 12	A6NMZ7 A8TX70 P00747 P00750 P01127 P02462 P07996 P08572 P09619 P09958 P10451 P12109 P12110 P12111 P16234 P20849 P29400 P35442 P35443 P49746 P53420 Q01955 Q05209 Q14050 Q14055 Q9GZP0	BNSP COL29A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 FUR FURIN IEGF OPN PACE PCSK3 PDGF2 PDGFB PDGFD PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PLAT PLG PTPN12 RHEPDGFRA SCDGFB SIS SPP1 THBS1 THBS2 THBS3 THBS4 TSP TSP1 TSP2 TSP3 TSP4 VWA4	Homo sapiens (human)
TLR3 deficiency - HSE	Toll-like receptor 3	O15455	TLR3	Homo sapiens (human)
NFE2L2 regulating anti-oxidant/detoxification enzymes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Cystine/glutamate transporter Extracellular superoxide dismutase [Cu-Zn] Glutamate--cysteine ligase catalytic subunit Glutamate--cysteine ligase regulatory subunit Glutathione S-transferase A1 Glutathione S-transferase A3 Heme oxygenase 1 Histone acetyltransferase p300 NAD(P)H dehydrogenase [quinone] 1 Nuclear factor erythroid 2-related factor 2 Peroxiredoxin-1 Sulfiredoxin-1 Thioredoxin reductase 1, cytoplasmic Thioredoxin Transcription factor MafK Transcription regulator protein BACH1	O14867 O60675 P08263 P08294 P09601 P10599 P15559 P18848 P48506 P48507 Q06830 Q09472 Q16236 Q16772 Q16881 Q92793 Q9BYN0 Q9UPY5	ATF4 BACH1 C20orf139 CBP CREB2 CREBBP DIA4 EP300 GCLC GCLM GLCL GLCLC GLCLR GRIM12 GSTA1 GSTA3 HMOX1 HO HO1 KDRF MAFK NFE2L2 NMOR1 NQO1 NRF2 P300 PAGA PAGB PRDX1 SLC7A11 SOD3 SRX SRX1 SRXN1 TDPX2 TRDX TRX TRX1 TXN TXNRD1 TXREB	Homo sapiens (human)
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Glutamine synthetase Sodium-coupled neutral amino acid symporter 1	P15104 P43003 P43004 Q9H2H9	ATA1 EAAT1 EAAT2 GLAST GLAST1 GLNS GLT1 GLUL NAT2 SAT1 SLC1A2 SLC1A3 SLC38A1 SNAT1	Homo sapiens (human)
Succinyl-CoA Biosynthesis	2-oxoglutarate dehydrogenase complex component E1 Alpha-ketoglutarate dehydrogenase component 4 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	P09622 P36957 P82909 Q02218	DLD DLST DLTS GCSL KGD4 LAD MRPS36 OGDH PHE3	Homo sapiens (human)
Defective SLC17A5 causes Salla disease (SD) and ISSD	Sialin	Q9NRA2	SLC17A5	Homo sapiens (human)
Separation of Sister Chromatids	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Aurora kinase B B9 domain-containing protein 2 Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 1 CLIP-associating protein 2 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Centromere protein C Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein S Centromere protein T Centromere protein U Centromere-associated protein E Centromere/kinetochore protein zw10 homolog Cohesin subunit SA-1 Cohesin subunit SA-2 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoskeleton-associated protein 5 DNA excision repair protein ERCC-6-like Double-strand-break repair protein rad21 homolog Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 SUMO-protein ligase RanBP2 Exportin-1 Histone H3-like centromeric protein A Inner centromere protein Kinesin-like protein KIF18A Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinetochore protein NDC80 homolog Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 Kinetochore-associated protein 1 Kinetochore-associated protein DSN1 homolog Kinetochore-associated protein NSL1 homolog Microtubule-associated protein RP/EB family member 1 Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic checkpoint serine/threonine-protein kinase BUB1 Mitotic spindle assembly checkpoint protein MAD1 Mitotic spindle assembly checkpoint protein MAD2A Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup85 Nucleoporin Nup37 Nucleoporin Nup43 Platelet-activating factor acetylhydrolase IB subunit beta Polyamine-modulated factor 1 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein ELYS Protein MIS12 homolog Protein RCC2 Protein SEC13 homolog Protein Spindly Protein zwilch homolog Ran GTPase-activating protein 1 Securin Separin Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Shugoshin 1 Shugoshin 2 Sister chromatid cohesion protein PDS5 homolog A Sister chromatid cohesion protein PDS5 homolog B Small ribosomal subunit protein eS27 Sororin Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 Structural maintenance of chromosomes protein 1A Structural maintenance of chromosomes protein 3 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Wings apart-like protein homolog ZW10 interactor	A5LHX3 O00139 O00231 O00232 O00233 O00487 O00762 O14576 O14777 O14818 O14980 O15392 O43237 O43242 O43264 O43683 O43684 O60216 O60566 O75122 O75832 O95229 O95997 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P30153 P30154 P30260 P30622 P35998 P36873 P40306 P42677 P43034 P43686 P46060 P48556 P49450 P49454 P49720 P49721 P49792 P50748 P51665 P51668 P51965 P53350 P55036 P55735 P57740 P60006 P60896 P60900 P61289 P62191 P62195 P62333 P62714 P62979 P62987 P63167 P67775 Q02224 Q03188 Q06323 Q12769 Q12834 Q13042 Q13200 Q13257 Q13352 Q13362 Q13409 Q14008 Q14204 Q14674 Q14683 Q14738 Q14997 Q15008 Q15172 Q15173 Q15691 Q16401 Q16537 Q16763 Q29RF7 Q2NKX8 Q53HL2 Q562F6 Q5FBB7 Q6IPU0 Q6P1K2 Q71F23 Q7L2Z9 Q7L7X3 Q7Z460 Q7Z5K2 Q8N0S6 Q8N2Z9 Q8N3U4 Q8N4N8 Q8NBT2 Q8NFH3 Q8NFH4 Q8NG31 Q8NHZ8 Q8NI77 Q8TAA3 Q8WUM0 Q8WVK7 Q8WVM7 Q8WYP5 Q92530 Q92674 Q96BD8 Q96BT3 Q96DE5 Q96EA4 Q96FF9 Q96FJ2 Q96GD4 Q96H22 Q96IY1 Q99436 Q99460 Q99661 Q9BPU9 Q9BS16 Q9BU64 Q9BW27 Q9BZD4 Q9GZM8 Q9H081 Q9H1A4 Q9H3R5 Q9H410 Q9H900 Q9HBM1 Q9NQS7 Q9NSP4 Q9NTI5 Q9NXR1 Q9NYG5 Q9P258 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UL46 Q9UM13 Q9UNM6 Q9UQE7 Q9Y266 Q9Y6D9 Q9Y6G9	AHCTF1 AIK2 AIM1 AIRK2 ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 API4 APITD1 APRIN ARK2 AS3 AURKB B9D2 BAM BIRC5 BMH BUB1 BUB1B BUB1L BUB3 BUBR1 C10orf104 C11orf51 C16orf56 C16orf60 C18orf24 C1orf155 C1orf48 C20orf172 C22orf18 C6orf139 C7orf76 C9orf17 CASC5 CCDC99 CDC16 CDC20 CDC23 CDC26 CDC27 CDCA1 CDCA5 CDCA8 CENP-27 CENPA CENPC CENPC1 CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPR CENPS CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CRM1 CSPG6 CYLN1 D0S1430E D17S978E D3S1231E DHC1 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DSN1 DSS1 DXS423E DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 E2EPF EAP1 ELYS EOPA ERCC6L ESP1 ESPL1 FAAP16 FAM33A FOE FSHPRH1 HC2 HC3 HC8 HC9 HDLC1 HEC HEC1 HR21 HSPC IAP4 ICEN19 ICEN22 ICEN24 ICEN32 ICEN33 ICEN35 ICEN36 ICEN37 ICEN39 ICEN7 IFI5111 INCENP ITGB3BP KIAA0044 KIAA0072 KIAA0077 KIAA0078 KIAA0097 KIAA0107 KIAA0165 KIAA0166 KIAA0178 KIAA0197 KIAA0261 KIAA0325 KIAA0622 KIAA0627 KIAA0648 KIAA0979 KIAA1361 KIAA1406 KIAA1470 KIAA1570 KIAA1835 KIF18A KIF2 KIF2A KIF2B KIF2C KLIP1 KNL1 KNS2 KNSL6 KNTC1 KNTC2 LIC2 LIS1 LMP10 LMP2 LMP7 LMPX LMPY LRPR1 MAD1 MAD1L1 MAD2 MAD2L1 MAD3L MAP3K16 MAPRE1 MARKK MAST1 MB1 MCB1 MCM21R MDCR MDS MECL1 MHF1 MIP224 MIS12 MIS13 MITAP1 MKSR2 MLF1IP MOV34L MPS1 MSS1 NDC80 NDE1 NDEL1 NRIF3 NSL1 NU NUDC NUDE NUDEL NUF2 NUF2R NUP107 NUP120 NUP133 NUP160 NUP358 NUP37 NUP43 NUP75 NUP85 NXP1 PAFAH1B1 PAFAHA PANE1 PBIP1 PCNT1 PDS5 PDS5A PDS5B PESCRG3 PFAAP4 PICH PLK PLK1 PMF1 POH1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTTG PTTG1 RAD21 RANBP2 RANGAP1 RCC2 RING10 RING12 RPS27 RPS27A RSN SA1 SA2 SB1.8 SCC1 SCC3 SD SEC13 SEC13A SEC13L1 SEC13R SEM1 SFT SGO1 SGO2 SGOL1 SGOL2 SHFDG1 SHFM1 SKA1 SKA2 SMC1 SMC1A SMC1L1 SMC3 SMC3L1 SPBC24 SPBC25 SPC24 SPC25 SPDL1 SSK1 STAG1 STAG2 STK1 STK12 STK5 SUG1 SUG2 TAOK1 TBP1 TBP7 TD60 TMBS62 TRAP2 TSG24 TUTR1 TXBP181 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S WAPAL WAPL X XPO1 Y Y2 Z ZW10 ZWILCH ZWINT	Homo sapiens (human)
Heme degradation	ATP-binding cassette sub-family C member 2 Albumin Beta-glucuronidase Biliverdin reductase A Broad substrate specificity ATP-binding cassette transporter ABCG2 Fatty acid-binding protein, liver Flavin reductase (NADPH) Glutathione S-transferase A1 Heme oxygenase 1 Heme oxygenase 2 Multidrug resistance-associated protein 1 Solute carrier organic anion transporter family member 1B1 Solute carrier organic anion transporter family member 1B3 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A4	P02768 P07148 P08263 P09601 P22309 P22310 P30043 P30519 P33527 P53004 Q8VNV4 Q92887 Q9NPD5 Q9UNQ0 Q9Y6L6	ABCC1 ABCC2 ABCG2 ABCP ALB BCRP BCRP1 BLVR BLVRA BLVRB BVR CMOAT CMOAT1 CMRP FABP1 FABPL FLR GNT1 GSTA1 HMOX1 HMOX2 HO HO1 HO2 LST1 LST2 MRP MRP1 MRP2 MXR OATP1B1 OATP1B3 OATP2 OATP8 OATPC SCAN SLC21A6 SLC21A8 SLCO1B1 SLCO1B3 UGT1 UGT1A1 UGT1A4	Homo sapiens (human)
APC/C:Cdc20 mediated degradation of mitotic proteins	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O43684 O60566 P30260 P51668 P51965 P60006 Q12834 Q13042 Q13257 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C9orf17 CDC16 CDC20 CDC23 CDC26 CDC27 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 MAD2 MAD2L1 MAD3L SFT SSK1 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Organic anion transport	Organic anion transporter 3 Solute carrier family 22 member 11 Solute carrier family 22 member 12 Solute carrier family 22 member 6 Solute carrier family 22 member 7	Q4U2R8 Q8TCC7 Q96S37 Q9NSA0 Q9Y694	NLT OAT1 OAT2 OAT3 OAT4 OATL4 PAHT SLC22A11 SLC22A12 SLC22A6 SLC22A7 SLC22A8 URAT1	Homo sapiens (human)
NR1D1 (REV-ERBA) represses gene expression	Histone deacetylase 3 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1	O15379 O75376 P20393	EAR1 HDAC3 HREV KIAA1047 NCOR1 NR1D1 THRAL	Homo sapiens (human)
FLT3 signaling by CBL mutants	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P22681 P36888 P49771 P62979 P62987	CBL CBL2 CD135 FLK2 FLT3 FLT3LG RNF55 RPS27A STK1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Energy dependent regulation of mTOR by LKB1-AMPK	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Calcium-binding protein 39-like Calcium-binding protein 39 GTP-binding protein Rheb Hamartin Neutral amino acid transporter 9 Protein phosphatase 1A Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR STE20-related kinase adapter protein alpha STE20-related kinase adapter protein beta Serine/threonine-protein kinase STK11 Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8 Tuberin	O43504 O43741 P35813 P42345 P49815 P54619 P54646 Q0VGL1 Q13131 Q15382 Q15831 Q5VZM2 Q6IAA8 Q7L523 Q7RTN6 Q8N122 Q8NBW4 Q92574 Q9BVC4 Q9C0K7 Q9H9S4 Q9HB90 Q9NQL2 Q9UGI9 Q9UGJ0 Q9UHA4 Q9Y2Q5 Q9Y376 Q9Y478	ALS2CR2 AMPK AMPK1 AMPK2 AMPKG3 C11orf59 C7orf59 CAB39 CAB39L FRAP FRAP1 FRAP2 GBL HBXIP ILPIP KIAA0243 KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LKB1 LST8 LYK5 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MO25 MTOR PDRO PJS PPM1A PPPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK11 STRAD STRADA STRADB TSC TSC1 TSC2 TSC4 URLC11 XIP	Homo sapiens (human)
Pyroptosis	Apoptosis regulator BAX Bcl-2 homologous antagonist/killer Caspase-1 Caspase-3 Caspase-4 Caspase-5 Cellular tumor antigen p53 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cytochrome c Gasdermin-D Gasdermin-E Granzyme B High mobility group protein B1 Interferon regulatory factor 1 Interferon regulatory factor 2 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 Neutrophil elastase Tumor protein 63	O43633 O60443 P01583 P01584 P04637 P08246 P09429 P10144 P10914 P14316 P29466 P42574 P49662 P51878 P57764 P99999 Q07812 Q14116 Q16611 Q8WUX9 Q96CF2 Q96FZ7 Q9BY43 Q9H3D4 Q9H444 Q9UQN3 Q9Y3E7	BAK BAK1 BAX BC2 BCL2L4 BCL2L7 C14orf123 C20orf178 CASP1 CASP3 CASP4 CASP5 CDN1 CGI149 CGL1 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CPP32 CSPB CTLA1 CYC CYCS DFNA5 DFNA5L ELA2 ELANE GRB GSDMD GSDMDC1 GSDME GZMB HMG1 HMGB1 ICERE1 ICH2 ICH3 IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 IRF1 IRF2 KET NEDF P53 P63 P73H P73L SHAX1 SHAX2 SHAX3 TP53 TP63 TP73L VPS20 VPS24	Homo sapiens (human)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	Apoptosis regulator Bcl-2 BH3-interacting domain death agonist Bcl-2-binding component 3, isoforms 1/2 Bcl-2-like protein 11 Bcl-2-like protein 1 Bcl-2-modifying factor Bcl2-associated agonist of cell death Phorbol-12-myristate-13-acetate-induced protein 1 Signal transducer and activator of transcription 3	O43521 P10415 P40763 P55957 Q07817 Q13794 Q92934 Q96LC9 Q9BXH1	APRF BAD BBC3 BBC6 BCL2 BCL2L BCL2L1 BCL2L11 BCL2L8 BCLX BID BIM BMF NOXA PMAIP1 PUMA STAT3	Homo sapiens (human)
PRPP biosynthesis	Ribose-phosphate pyrophosphokinase 1 Ribose-phosphate pyrophosphokinase 2 Ribose-phosphate pyrophosphokinase 3	P11908 P21108 P60891	PRPS1 PRPS1L1 PRPS2 PRPS3 PRPSL	Homo sapiens (human)
Signaling by MAP2K mutants	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P36507 Q02750	ERK1 ERK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2	Homo sapiens (human)

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