GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1501 - 1525** of **2090** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
EPH-ephrin mediated repulsion of cells	72 kDa type IV collagenase AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Disintegrin and metalloproteinase domain-containing protein 10 Dynamin-1 Ephrin type-A receptor 10 Ephrin type-A receptor 1 Ephrin type-A receptor 2 Ephrin type-A receptor 3 Ephrin type-A receptor 4 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-A receptor 8 Ephrin type-B receptor 1 Ephrin type-B receptor 2 Ephrin type-B receptor 3 Ephrin type-B receptor 4 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A4 Ephrin-A5 Ephrin-B1 Ephrin-B2 Ephrin-B3 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Matrix metalloproteinase-9 Nicastrin Presenilin-1 Presenilin-2 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor TIAM1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O14672 O15197 O43921 O94973 O95782 P06241 P07947 P07948 P08253 P09496 P09497 P14780 P20827 P21709 P29317 P29320 P29322 P29323 P49768 P49810 P52735 P52797 P52798 P52799 P52803 P53675 P53680 P54753 P54756 P54760 P54762 P54764 P63000 P63010 P98172 Q00610 Q05193 Q13009 Q15375 Q15768 Q5JZY3 Q8WW43 Q92542 Q96BI3 Q96CW1 Q9NZ42 Q9UF33 Q9UKW4	AD3 AD4 ADAM10 ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APH1A APH1B BSK CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLG4A CLG4B CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD DNM DNM1 DRT ECK EEK EFL2 EFL3 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EHK1 EHK2 EHK3 ELK EPH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPHT EPHT1 EPHT2 EPHT3 EPLG1 EPLG2 EPLG3 EPLG4 EPLG5 EPLG6 EPLG7 EPLG8 EPTH3 ERK ETK ETK1 ETK2 FYN HEK HEK11 HEK12 HEK2 HEK3 HEK5 HEK6 HEK7 HEK8 HIP9 HTK HTKL HYPJ JTK8 KIAA0034 KIAA0109 KIAA0253 KIAA0899 KIAA1459 KUZ LERK1 LERK2 LERK3 LERK4 LERK5 LERK6 LERK7 LERK8 LYN MADM MMP2 MMP9 MYK1 NCSTN NET PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RAC1 SEK STM2 TC25 TIAM1 TNFAIP4 TYRO1 TYRO11 TYRO4 TYRO5 TYRO6 VAV2 VAV3 YES YES1	Homo sapiens (human)
EPH-Ephrin signaling	Ephrin type-A receptor 10 Ephrin type-A receptor 1 Ephrin type-A receptor 2 Ephrin type-A receptor 3 Ephrin type-A receptor 4 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-A receptor 8 Ephrin type-B receptor 1 Ephrin type-B receptor 2 Ephrin type-B receptor 3 Ephrin type-B receptor 4 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A4 Ephrin-A5 Ephrin-B1 Ephrin-B2 Ephrin-B3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O15197 O43921 P06241 P07947 P07948 P20827 P21709 P29317 P29320 P29322 P29323 P52797 P52798 P52799 P52803 P54753 P54756 P54760 P54762 P54764 P98172 Q15375 Q15768 Q5JZY3 Q9UF33	BSK DRT ECK EEK EFL2 EFL3 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EHK1 EHK2 EHK3 ELK EPH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPHT EPHT1 EPHT2 EPHT3 EPLG1 EPLG2 EPLG3 EPLG4 EPLG5 EPLG6 EPLG7 EPLG8 EPTH3 ERK ETK ETK1 ETK2 FYN HEK HEK11 HEK12 HEK2 HEK3 HEK5 HEK6 HEK7 HEK8 HTK HTKL JTK8 KIAA1459 LERK1 LERK2 LERK3 LERK4 LERK5 LERK6 LERK7 LERK8 LYN MYK1 NET SEK TNFAIP4 TYRO1 TYRO11 TYRO4 TYRO5 TYRO6 YES YES1	Homo sapiens (human)
EML4 and NUDC in mitotic spindle formation	Aurora kinase B B9 domain-containing protein 2 Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 1 CLIP-associating protein 2 Cell division cycle protein 20 homolog Centromere protein C Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein S Centromere protein T Centromere protein U Centromere-associated protein E Centromere/kinetochore protein zw10 homolog Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoskeleton-associated protein 5 DNA excision repair protein ERCC-6-like Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 SUMO-protein ligase RanBP2 Echinoderm microtubule-associated protein-like 4 Exportin-1 Histone H3-like centromeric protein A Inner centromere protein Kinesin-like protein KIF18A Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinetochore protein NDC80 homolog Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 Kinetochore-associated protein 1 Kinetochore-associated protein DSN1 homolog Kinetochore-associated protein NSL1 homolog Microtubule-associated protein RP/EB family member 1 Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic checkpoint serine/threonine-protein kinase BUB1 Mitotic spindle assembly checkpoint protein MAD1 Mitotic spindle assembly checkpoint protein MAD2A Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup85 Nucleoporin Nup37 Nucleoporin Nup43 Platelet-activating factor acetylhydrolase IB subunit beta Polyamine-modulated factor 1 Protein ELYS Protein MIS12 homolog Protein RCC2 Protein SEC13 homolog Protein Spindly Protein zwilch homolog Ran GTPase-activating protein 1 Serine/threonine-protein kinase Nek6 Serine/threonine-protein kinase Nek7 Serine/threonine-protein kinase Nek9 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 1 Spindle and kinetochore-associated protein 2 ZW10 interactor	O00139 O14576 O14777 O14980 O15392 O43237 O43264 O43683 O43684 O60566 O75122 O95229 P30153 P30154 P30622 P36873 P42677 P43034 P46060 P49450 P49454 P49792 P50748 P53350 P55735 P57740 P62714 P63167 P67775 Q02224 Q03188 Q12769 Q12834 Q13257 Q13352 Q13362 Q13409 Q14008 Q14204 Q14738 Q15172 Q15173 Q15691 Q16537 Q2NKX8 Q53HL2 Q562F6 Q5FBB7 Q6IPU0 Q6P1K2 Q71F23 Q7L2Z9 Q7L7X3 Q7Z460 Q8N0S6 Q8N2Z9 Q8N4N8 Q8NBT2 Q8NFH3 Q8NFH4 Q8NG31 Q8NI77 Q8TD19 Q8TDX7 Q8WUM0 Q8WVK7 Q8WYP5 Q92674 Q96BD8 Q96BT3 Q96EA4 Q96FJ2 Q96GD4 Q96H22 Q96IY1 Q99661 Q9BPU9 Q9BS16 Q9BU64 Q9BW27 Q9BZD4 Q9GZM8 Q9H081 Q9H3R5 Q9H410 Q9H900 Q9HBM1 Q9HC35 Q9HC98 Q9NQS7 Q9NSP4 Q9NXR1 Q9P258 Q9Y266 Q9Y6D9 Q9Y6G9	AHCTF1 AIK2 AIM1 AIRK2 API4 APITD1 ARK2 AURKB B9D2 BIRC5 BUB1 BUB1B BUB1L BUB3 BUBR1 C16orf56 C16orf60 C18orf24 C1orf155 C1orf48 C20orf172 C22orf18 C2orf2 C6orf139 CASC5 CCDC99 CDC20 CDCA1 CDCA8 CENPA CENPC CENPC1 CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPR CENPS CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CRM1 CYLN1 D3S1231E DHC1 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DSN1 DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ELYS EMAPL4 EML4 EOPA ERCC6L FAAP16 FAM33A FSHPRH1 HDLC1 HEC HEC1 IAP4 ICEN19 ICEN22 ICEN24 ICEN32 ICEN33 ICEN35 ICEN36 ICEN37 ICEN39 ICEN7 INCENP ITGB3BP KIAA0044 KIAA0097 KIAA0166 KIAA0197 KIAA0325 KIAA0622 KIAA0627 KIAA1361 KIAA1470 KIAA1570 KIAA1835 KIAA1995 KIF18A KIF2 KIF2A KIF2B KIF2C KLIP1 KNL1 KNS2 KNSL6 KNTC1 KNTC2 LIC2 LIS1 LRPR1 MAD1 MAD1L1 MAD2 MAD2L1 MAD3L MAP3K16 MAPRE1 MARKK MAST1 MCM21R MDCR MDS MHF1 MIS12 MIS13 MITAP1 MKSR2 MLF1IP MPS1 NDC80 NDE1 NDEL1 NEK6 NEK7 NEK8 NEK9 NERCC NRIF3 NSL1 NUDC NUDE NUDEL NUF2 NUF2R NUP107 NUP120 NUP133 NUP160 NUP358 NUP37 NUP43 NUP75 NUP85 PAFAH1B1 PAFAHA PANE1 PBIP1 PCNT1 PESCRG3 PICH PLK PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 RSN SD SEC13 SEC13A SEC13L1 SEC13R SGO1 SGO2 SGOL1 SGOL2 SKA1 SKA2 SPBC24 SPBC25 SPC24 SPC25 SPDL1 SSK1 STK1 STK12 STK5 TAOK1 TD60 TMBS62 TXBP181 XPO1 ZW10 ZWILCH ZWINT	Homo sapiens (human)
EGR2 and SOX10-mediated initiation of Schwann cell myelination	3-hydroxy-3-methylglutaryl-coenzyme A reductase Adhesion G-protein coupled receptor G6 Adhesion G-protein coupled receptor V1 Dystroglycan 1 Dystrophin-related protein 2 E3 SUMO-protein ligase EGR2 Histone deacetylase 2 Laminin subunit alpha-2 Laminin subunit beta-1 Laminin subunit gamma-1 Lanosterol 14-alpha demethylase Myelin basic protein Myelin protein P0 Myelin-associated glycoprotein NGFI-A-binding protein 1 NGFI-A-binding protein 2 POU domain, class 3, transcription factor 1 POU domain, class 3, transcription factor 2 Periaxin Peripheral myelin protein 22 Stearoyl-CoA desaturase 5 Sterol regulatory element-binding protein 2 Transcription activator BRG1 Transcription factor SOX-10 Transcriptional coactivator YAP1 Transcriptional enhancer factor TEF-1 Utrophin WW domain-containing transcription regulator protein 1	P02686 P04035 P07942 P11047 P11161 P20265 P20916 P24043 P25189 P28347 P46937 P46939 P51532 P56693 Q01453 Q03052 Q12772 Q13474 Q13506 Q14118 Q15742 Q16850 Q86SK9 Q86SQ4 Q8WXG9 Q92769 Q9BXM0 Q9GZV5	ACOD4 ADGRG6 ADGRV1 BAF190A BHLHD2 BRG1 BRN2 CYP51 CYP51A1 DAG1 DMDL DREG DRP1 DRP2 EGR2 GAS3 GMA GPR126 GPR98 HDAC2 HMGCR KIAA0686 KIAA1620 KIAA1943 KROX20 LAMA2 LAMB1 LAMB2 LAMC1 LAMM MADER MAG MASS1 MBP MPZ NAB1 NAB2 OCT6 OCT7 OTF6 OTF7 PMP22 POU3F1 POU3F2 PRX SCD2 SCD4 SCD5 SMARCA4 SNF2B SNF2L4 SOX10 SREBF2 SREBP2 TAZ TCF13 TEAD1 TEF1 UTRN VIGR VLGR1 WWTR1 YAP1 YAP65	Homo sapiens (human)
EGFR interacts with phospholipase C-gamma	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P19174 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 PLC1 PLCG1 SDGF TGFA	Homo sapiens (human)
EGFR downregulation	Amphiregulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor-type tyrosine-protein phosphatase kappa Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14944 O14964 O43597 O43609 O75886 P00533 P01133 P01135 P0CG47 P0CG48 P15514 P22681 P26045 P35070 P42566 P60953 P62979 P62987 Q05209 Q14155 Q15262 Q6UW88 Q92783 Q96B97 Q99075 Q99961 Q99962 Q99963 Q9UBC2 Q9Y6I3	AF1P AREG AREGB ARHGEF7 BTC CBL CBL2 CDC42 CIN85 CNSA1 CNSA2 CNSA3 COOL1 DTR DTS EGF EGFR EPGN EPN1 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG HBEGF HBP HEGFL HER1 HGS HRS KIAA0142 P85SPR PAK3BP PIXB PTPH1 PTPK PTPN12 PTPN3 PTPRK RNF55 RPS27A SDGF SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SPRY1 SPRY2 STAM STAM1 STAM2 TGFA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
EGFR Transactivation by Gastrin	Epidermal growth factor receptor GTPase HRas GTPase NRas Proheparin-binding EGF-like growth factor Protein kinase C alpha type Son of sevenless homolog 1 Stromelysin-1	P00533 P01111 P01112 P08254 P17252 Q07889 Q99075	DTR DTS EGFR ERBB ERBB1 HBEGF HEGFL HER1 HRAS HRAS1 MMP3 NRAS PKCA PRKACA PRKCA SOS1 STMY1	Homo sapiens (human)
ECM proteoglycans	Aggrecan core protein Agrin Asporin Basement membrane-specific heparan sulfate proteoglycan core protein Biglycan Brevican core protein Cartilage matrix protein Cartilage oligomeric matrix protein Collagen alpha-1(IX) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Dystroglycan 1 Fibromodulin Hyaluronan and proteoglycan link protein 1 Integrin alpha-2 Integrin alpha-7 Integrin alpha-8 Integrin alpha-9 Integrin alpha-IIb Integrin alpha-V Integrin alpha-X Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin-binding sialoprotein Laminin subunit alpha-1 Laminin subunit alpha-2 Laminin subunit alpha-3 Laminin subunit alpha-4 Laminin subunit alpha-5 Laminin subunit beta-1 Laminin subunit beta-2 Laminin subunit gamma-1 Low-density lipoprotein receptor-related protein 4 Lumican Matrilin-3 Matrilin-4 Muscle, skeletal receptor tyrosine-protein kinase Neural cell adhesion molecule 1 Neurocan core protein Plasminogen activator inhibitor 1 Receptor-type tyrosine-protein phosphatase S SPARC Tenascin-N Tenascin-R Tenascin-X Tenascin Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein Versican core protein Vitronectin	O00468 O14594 O15146 O15230 O15232 O75096 O95460 P01137 P04004 P05106 P05121 P05556 P06756 P07585 P07942 P08514 P09486 P10600 P10915 P11047 P13591 P13611 P16112 P17301 P18084 P18564 P20702 P20849 P21810 P21815 P21941 P22105 P24043 P24821 P25391 P49747 P51884 P53708 P55268 P61812 P98160 Q06828 Q13316 Q13332 Q13683 Q13797 Q14050 Q14055 Q14118 Q16363 Q16787 Q92752 Q96GW7 Q9BXN1 Q9NZW4 Q9UQP3	ACAN AGC1 AGRIN AGRN ASPN BCAN BEHAB BGN BNSP CD11C CD49B CMP COL9A1 COL9A2 COL9A3 COMP CRTL1 CRTM CSPG1 CSPG2 CSPG3 CSPG7 DAG1 DCN DMP1 DSPP FM FMOD FNRB GP2B GP3A HAPLN1 HSPG2 HXB HXBL IBSP ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAB ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 KIAA0533 KIAA0816 KIAA1907 LAMA LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMC1 LAMM LAMNA LAMS LDC LRP10 LRP4 LUM MATN1 MATN3 MATN4 MDF2 MEGF7 MSK12 MSK16 MSK8 MUSK NCAM NCAM1 NCAN NEUR ON PAI1 PLANH1 PLAP1 PTPRS SERPINE1 SLRR1A SLRR1B SLRR1C SLRR2D SLRR2E SPARC TGFB TGFB1 TGFB2 TGFB3 TNC TNN TNR TNW TNX TNXB TNXB1 TNXB2 VCAN VNRA VTN VTNR XB	Homo sapiens (human)
E3 ubiquitin ligases ubiquitinate target proteins	B-cell lymphoma/leukemia 10 DNA-dependent protein kinase catalytic subunit Derlin-1 E3 ubiquitin-protein ligase BRE1A E3 ubiquitin-protein ligase BRE1B E3 ubiquitin-protein ligase RAD18 E3 ubiquitin-protein ligase RNF144A E3 ubiquitin-protein ligase RNF152 E3 ubiquitin-protein ligase RNF181 E3 ubiquitin-protein ligase SHPRH E3 ubiquitin-protein ligase TM129 HLA class I histocompatibility antigen, A alpha chain Helicase-like transcription factor Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O MHC Class I antigen (B60) (Fragment) Parafibromin Peroxisomal membrane protein PEX13 Peroxisomal membrane protein PEX14 Peroxisome assembly protein 12 Peroxisome biogenesis factor 10 Peroxisome biogenesis factor 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Ras-related GTP-binding protein A Selenoprotein S Superkiller complex protein 8 Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 A Ubiquitin-conjugating enzyme E2 B Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 J2 Ubiquitin-conjugating enzyme E2 L3 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unique short US11 glycoprotein WW domain-containing adapter protein with coiled-coil	A0AVI4 O00623 O60683 O60814 O75150 O75381 O95999 P04439 P06899 P09727 P0CG47 P0CG48 P12004 P23527 P28328 P33778 P49459 P50876 P51668 P51965 P55072 P58876 P61077 P61088 P62807 P62837 P62979 P62987 P63146 P68036 P78527 Q14527 Q149N8 Q15819 Q5VTR2 Q6P1J9 Q6PD62 Q7L523 Q8N2K1 Q8N7H5 Q8N8N0 Q8WVC0 Q92541 Q92968 Q93079 Q96A08 Q99877 Q99879 Q99880 Q9BQE4 Q9BTA9 Q9BUN8 Q9GZS3 Q9MY60 Q9NS91 Q9P0P0	BCL10 BLU BRE1A BRE1B C1orf28 CDC73 CIPER CLAP CTR9 DER1 DERL1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFR H2BFT HEL-220 HEL-S-70 HIP116A HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HLA-A HLA-B HLAA HLTF HRPT2 HYRC HYRC1 KIAA0155 KIAA0161 KIAA0252 KIAA0661 KIAA1844 KIAA2023 LEO1 MMS2 NCUBE2 PAF1 PAF3 PCNA PD2 PEX10 PEX12 PEX13 PEX14 PEX2 PMP3 PMP35 PRKDC PUBC1 PXMP3 RAD18 RAD6A RAD6B RDL RNF144 RNF144A RNF152 RNF181 RNF20 RNF40 RNF69 RNF72 RNF73 RNF80 RPS27A RRAGA RTF1 SELENOS SELS SFT SH2BP1 SHPRH SKIC8 SMARCA3 SNF2L3 TMEM129 TSH2B UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCE7 UBCE7IP4 UBCEP1 UBCEP2 UBCH1 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBCH6 UBCH7 UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2L3 UBE2N UBE2V2 UEV2 US11 VCP VIMP WAC WDR61 ZBU1	Homo sapiens (human)
E2F-enabled inhibition of pre-replication complex formation	Cyclin-dependent kinase 1 DNA helicase MCM8 G2/mitotic-specific cyclin-B1 Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6	O43913 O43929 P06493 P14635 Q13415 Q13416 Q9UBD5 Q9UJA3 Q9Y5N6	C20orf154 CCNB CCNB1 CDC2 CDC28A CDK1 CDKN1 LATHEO MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L P34CDC2 PARC1	Homo sapiens (human)
Dual incision in TC-NER	CDK-activating kinase assembly factor MAT1 Cullin-4A Cullin-4B Cyclin-H Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-5 DNA excision repair protein ERCC-6 DNA excision repair protein ERCC-8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair endonuclease XPF DNA repair protein complementing XP-A cells DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 E3 ubiquitin-protein ligase RBX1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Peptidyl-prolyl cis-trans isomerase E Polyubiquitin-B Polyubiquitin-C Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor ISY1 homolog Pre-mRNA-splicing factor SYF1 Proliferating cell nuclear antigen RNA helicase aquarius Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Transcription elongation factor A protein 1 UV-stimulated scaffold protein A Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein 830	O15514 O60306 P07992 P0CG47 P0CG48 P12004 P15927 P18074 P19387 P19388 P19447 P23025 P23193 P24928 P27694 P28340 P28715 P30876 P32780 P35244 P35249 P35250 P35251 P36954 P40937 P40938 P49005 P50613 P51946 P51948 P52434 P52435 P53803 P56282 P61218 P62487 P62875 P62877 P62979 P62987 Q03468 Q07864 Q13216 Q13619 Q13620 Q13888 Q13889 Q15054 Q16531 Q2YD98 Q6ZYL4 Q92759 Q92889 Q93009 Q96NB3 Q9HCS7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9ULR0 Q9UMS4 Q9UNP9	AQR BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CCDC16 CCNH CDK7 CDKN7 CHRAC17 CKN1 CSA CSB CUL4A CUL4B CYP33 DDB1 DINB1 DPE2 ERCC1 ERCC11 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 ERCM2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HAUSP HCNP ISY1 KIAA0039 KIAA0560 KIAA0695 KIAA1160 KIAA1177 KIAA1530 MAT1 MNAT1 MO15 NMP200 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PPIE PRP19 PRPF19 RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF66 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPB7 RPS27A SNEV STK1 SYF1 TCEA1 TFIIS TTDA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP7 UVSSA XAB2 XAP1 XPA XPAC XPB XPBC XPD XPDC XPF XPG XPGC ZNF830	Homo sapiens (human)
Dual Incision in GG-NER	Chromodomain-helicase-DNA-binding protein 1-like Cullin-4A Cullin-4B DNA damage-binding protein 1 DNA damage-binding protein 2 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-5 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair endonuclease XPF DNA repair protein complementing XP-A cells E3 ubiquitin-protein ligase RBX1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P07992 P09874 P0CG47 P0CG48 P12004 P15927 P18074 P19447 P23025 P27694 P28340 P28715 P32780 P35244 P35249 P35250 P35251 P40937 P40938 P49005 P56282 P62877 P62979 P62987 Q07864 Q13619 Q13620 Q13888 Q13889 Q15054 Q16531 Q6ZYL4 Q86WJ1 Q92466 Q92759 Q92889 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UGN5	ADPRT ADPRT2 ADPRTL2 ALC1 BTF2 BTF2P44 C6orf175 CHD1L CHRAC17 CUL4A CUL4B DDB1 DDB2 DINB1 DPE2 ERCC1 ERCC11 ERCC2 ERCC3 ERCC4 ERCC5 ERCM2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KIAA0039 KIAA0695 PARP1 PARP2 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK PPOL RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A TTDA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XAP1 XPA XPAC XPB XPBC XPD XPDC XPF XPG XPGC	Homo sapiens (human)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	P08581 P14210	HGF HPTA MET	Homo sapiens (human)
Drug-mediated inhibition of ERBB2 signaling	Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2	P04626 P07900 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL	Homo sapiens (human)
Drug-mediated inhibition of CDK4/CDK6 activity	Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3	P11802 P24385 P30279 P30281 Q00534	BCL1 CCND1 CCND2 CCND3 CDK4 CDK6 CDKN6 PRAD1	Homo sapiens (human)
Drug resistance in ERBB2 TMD/JMD mutants	Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2	P04626 P07900 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL	Homo sapiens (human)
Downstream signaling of activated FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Leucine-rich repeat transmembrane protein FLRT1 Leucine-rich repeat transmembrane protein FLRT2 Leucine-rich repeat transmembrane protein FLRT3	O15520 O43155 P05230 P08620 P09038 P10767 P11487 P31371 Q9GZV9 Q9HCT0 Q9NP95 Q9NZU0 Q9NZU1	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB FLRT1 FLRT2 FLRT3 HST HST2 HSTF1 HSTF2 HYPF INT2 KIAA0405 KIAA1469 KS3	Homo sapiens (human)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Crk-like protein Cytoplasmic protein NCK2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Proto-oncogene tyrosine-protein kinase Src Rap guanine nucleotide exchange factor 1 Ras GTPase-activating protein 1 SH2/SH3 adapter protein NCK1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Signal transducer and activator of transcription 6 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O00459 O43639 P01111 P01112 P01127 P09619 P12931 P16234 P16333 P19174 P20936 P27986 P40763 P42224 P42226 P42229 P42336 P42338 P46108 P46109 P51692 P56945 Q06124 Q07889 Q13905 Q14451	APRF BCAR1 CAS CASS1 CRK CRKAS CRKL GAP GRB1 GRB4 GRB7 GRF2 HRAS HRAS1 NCK NCK1 NCK2 NRAS PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PTP2C PTPN11 RAPGEF1 RASA RASA1 RHEPDGFRA SHPTP2 SIS SOS1 SRC SRC1 STAT1 STAT3 STAT5 STAT5A STAT5B STAT6	Homo sapiens (human)
Downstream TCR signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 Caspase recruitment domain-containing protein 11 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein kinase C theta type Receptor-interacting serine/threonine-protein kinase 2 S-phase kinase-associated protein 1 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell receptor-associated transmembrane adapter 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TNF receptor-associated factor 6 Transcription factor p65 Tyrosine-protein kinase Lck Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A0A6YYK7 A5LHX3 O00231 O00232 O00233 O00459 O00487 O14818 O14920 O15111 O15530 O43242 O43318 O43353 O75832 O95999 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P0CG47 P0CG48 P13762 P17980 P19838 P20036 P20618 P25786 P25787 P25788 P25789 P25963 P27986 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P42336 P42338 P43686 P48556 P49427 P49720 P49721 P51665 P51668 P55036 P60484 P60896 P60900 P61088 P61289 P62191 P62195 P62333 P62837 P62979 P62987 P63208 P79483 Q04206 Q04759 Q06323 Q13200 Q13404 Q13616 Q14997 Q15008 Q16401 Q30154 Q6PIZ9 Q8TAA3 Q92530 Q92835 Q99436 Q99460 Q9BXL7 Q9NYJ8 Q9UDY8 Q9UKB1 Q9UL46 Q9UNM6 Q9Y297 Q9Y4K3 Q9Y6K9	BCL10 BLU BTRC BTRCP BTRCP2 C7orf76 CARD11 CARDIAK CARMA1 CD3D CD3E CD3G CD4 CDC34 CHUK CIPER CLAP CROC1 CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 GRB1 HC2 HC3 HC8 HC9 HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB HSPC IFI5111 IKBA IKBKB IKBKG IKKA IKKB INPP5D KIAA0072 KIAA0077 KIAA0107 KIAA0696 KIAA0733 LCK LMP10 LMP2 LMP7 LMPX LMPY MAD3 MALT1 MAP3K7 MAP3K7IP2 MB1 MCB1 MECL1 MIP224 MLT MMAC1 MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NU OCP2 PDK1 PDPK1 PFAAP4 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 POH1 PRKCQ PRKCT PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PUBC1 RELA RICK RING10 RING12 RIP2 RIPK2 RNF85 RPS27A SEM1 SFT SHFDG1 SHFM1 SHIP SHIP1 SKP1 SKP1A SUG1 SUG2 T3D T3E T3G TAB2 TAK1 TBP1 TBP7 TCEB1L TCF16 TCRA TCRBV12S3 TCRBV8S1 TCRIM TEP1 TRAC TRAF6 TRAP2 TRAT1 TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBCEP1 UBCEP2 UBCH3 UBCH4 UBCH5 UBCH5A UBCH5B UBE2D1 UBE2D2 UBE2N UBE2R1 UBE2V UBE2V1 UEV1 X Y Y2 Z	Homo sapiens (human)
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 Exportin-1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 7 Myotubularin-related protein 4 Polyubiquitin-B Polyubiquitin-C Protein TMEPAI Protein phosphatase 1 regulatory subunit 15A Serine-threonine kinase receptor-associated protein Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Ubiquitin carboxyl-terminal hydrolase 15 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14980 O15105 O75807 P01137 P0CG47 P0CG48 P36873 P36897 P37173 P62136 P62140 P62979 P62987 P84022 Q13145 Q15796 Q969W9 Q96PU5 Q9HAU4 Q9HCE7 Q9NYA4 Q9UNE7 Q9Y3F4 Q9Y4E8 Q9Y5K5	ALK5 BAMBI CHIP CRM1 GADD34 KIAA0439 KIAA0529 KIAA0647 KIAA1625 MADH2 MADH3 MADH7 MADH8 MADR2 MAWD MTMR4 NEDD4L NEDL3 NMA PMEPA1 PPP1A PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SKR4 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STAG1 STRAP STUB1 TGFB TGFB1 TGFBR1 TGFBR2 TMEPAI UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCH37 UCHL5 UNRIP USP15 XPO1 ZFYVE11	Homo sapiens (human)
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase Arkadia E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 7 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing transcription regulator protein 1	O15105 O75376 P09874 P0CG47 P0CG48 P12755 P12757 P27361 P28482 P35813 P51668 P61077 P62979 P62987 P84022 Q13485 Q13547 Q13573 Q15583 Q15796 Q6ZNA4 Q93008 Q96PU5 Q9GZN2 Q9GZV5 Q9HAU4 Q9UN42 Q9UPN9 Q9Y618	ADPRT ATP1B4 CTG26 DFFRX DPC4 ERK1 ERK2 FAM HDAC1 KIAA0439 KIAA1047 KIAA1113 MADH2 MADH3 MADH4 MADH7 MADH8 MADR2 MAPK1 MAPK3 NCOR1 NCOR2 NEDD4L NEDL3 PARP1 PPM1A PPOL PPPM1A PRKM1 PRKM2 PRKM3 RFG7 RNF111 RPD3L1 RPS27A SFT SKI SKIIP SKIL SKIP SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNO SNW1 TAZ TGIF TGIF1 TGIF2 TIF1G TRIM33 UBA52 UBA80 UBB UBC UBC5A UBC5C UBCEP1 UBCEP2 UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 USP9 USP9X WWTR1	Homo sapiens (human)
Downregulation of ERBB4 signaling	E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase NEDD4 NEDD4-like E3 ubiquitin-protein ligase WWP1 Polyubiquitin-B Polyubiquitin-C Proto-oncogene tyrosine-protein kinase Src Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P12931 P46934 P62979 P62987 Q96J02 Q9H0M0	ITCH KIAA0093 NEDD4 NEDD4-1 RPF1 RPS27A SRC SRC1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WWP1	Homo sapiens (human)
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
Downregulation of ERBB2 signaling	Cullin-5 E3 ubiquitin-protein ligase CHIP Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Megakaryocyte-associated tyrosine-protein kinase Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 18 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 O14944 P00533 P01133 P04626 P07900 P0CG47 P0CG48 P35070 P42679 P56975 P62979 P62987 Q02297 Q05209 Q16543 Q8WWG1 Q93034 Q96RT1 Q99075 Q99952 Q9UNE7	BDP1 BTC CDC37 CDC37A CHIP CTK CUL5 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA HYL KIAA1225 LAP2 MATK MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTPN12 PTPN18 RPS27A SMDF STUB1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VACM1	Homo sapiens (human)
Dopamine receptors	D(1A) dopamine receptor D(1B) dopamine receptor D(2) dopamine receptor D(3) dopamine receptor D(4) dopamine receptor	P14416 P21728 P21917 P21918 P35462	DRD1 DRD1B DRD1L2 DRD2 DRD3 DRD4 DRD5	Homo sapiens (human)

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