GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1601 - 1625** of **2090** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 26S proteasome regulatory subunit 10B 3-phosphoinositide-dependent protein kinase 1 Caveolin-1 Histone acetyltransferase p300 Membrane protein Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nucleoprotein ORF3a protein SUMO-conjugating enzyme UBC9 Transcription factor Sp1	O15530 P08047 P27348 P31946 P31947 P59595 P59596 P59632 P61981 P62258 P62333 P63104 P63279 P84022 Q03135 Q04917 Q09472 Q13485	3a CAV CAV1 DPC4 EP300 HME1 M MADH3 MADH4 N P300 PDK1 PDPK1 PSMC6 SFN SMAD3 SMAD4 SP1 SUG2 TSFP1 UBC9 UBCE9 UBE2I YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
SARS-CoV-1-host interactions	Heterogeneous nuclear ribonucleoprotein A1 Nucleophosmin Nucleoprotein	P06748 P09651 P59595	HNRNPA1 HNRPA1 N NPM NPM1	Homo sapiens (human)
SARS-CoV-1-mediated effects on programmed cell death	Bcl-2-like protein 1 Envelope small membrane protein ORF3a protein ORF7a protein	P59632 P59635 P59637 Q07817	3a 7a BCL2L BCL2L1 BCLX E sM	Homo sapiens (human)
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Aladin Antiviral innate immune response receptor RIG-I Beclin 1-associated autophagy-related key regulator Beclin-1 Beta-2-microglobulin CCHC-type zinc finger nucleic acid binding protein CREB-binding protein E3 SUMO-protein ligase RanBP2 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Envelope small membrane protein HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Importin subunit alpha-1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon alpha/beta receptor 1 Interferon beta Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon-induced helicase C domain-containing protein 1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Interleukin-17 receptor A Interleukin-17 receptor C Interleukin-17A Interleukin-17F La-related protein 1 Mannan-binding lectin serine protease 1 Mannose-binding protein C Membrane protein Mitochondrial antiviral-signaling protein Mitochondrial import receptor subunit TOM70 Mitogen-activated protein kinase kinase kinase 7 NACHT, LRR and PYD domains-containing protein 12 NACHT, LRR and PYD domains-containing protein 3 NF-kappa-B essential modulator Non-receptor tyrosine-protein kinase TYK2 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Nucleoprotein Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 ORF3a protein ORF6 protein ORF7a protein ORF8 protein ORF9b protein Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Protein SEC13 homolog Protein transport protein Sec23A Protein transport protein Sec24A Protein transport protein Sec24B Protein transport protein Sec24C Protein transport protein Sec24D Pulmonary surfactant-associated protein D Putative HLA class I histocompatibility antigen, alpha chain H Ras GTPase-activating protein-binding protein 1 Ras GTPase-activating protein-binding protein 2 Receptor-interacting serine/threonine-protein kinase 2 Replicase polyprotein 1a Replicase polyprotein 1ab Serine/threonine-protein kinase TBK1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Small COPII coat GTPase SAR1B Spike glycoprotein Stimulator of interferon genes protein Suppressor of IKBKE 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 3 TNF receptor-associated factor 6 Toll-like receptor 1 Toll-like receptor 2 Toll-like receptor 7 Toll-like receptor 8 Triokinase/FMN cyclase Tyrosine-protein kinase JAK1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like protein ISG15 mRNA export factor RAE1	A8CG34 O14920 O15111 O15504 O43187 O43318 O43353 O60603 O75694 O94826 O94855 O95486 O95487 O95786 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P01889 P01893 P04439 P05013 P05014 P05015 P05161 P07900 P08238 P0DTC1 P0DTC2 P0DTC3 P0DTC4 P0DTC5 P0DTC6 P0DTC7 P0DTC8 P0DTC9 P0DTD1 P0DTD2 P10321 P11226 P12270 P13747 P17181 P17693 P23458 P29350 P29597 P30511 P32881 P35247 P35658 P37198 P42224 P48740 P49790 P49792 P51617 P52292 P52630 P53992 P55735 P57740 P59046 P61088 P61769 P62633 P78406 Q06124 Q12769 Q13114 Q13283 Q13404 Q14164 Q14258 Q14457 Q14653 Q15399 Q15436 Q15750 Q16552 Q3LXA3 Q5SRE5 Q6PKG0 Q6ZNE5 Q7Z3B4 Q7Z434 Q86WV6 Q8IUD6 Q8N1F7 Q8N5C8 Q8NAC3 Q8NEB9 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q92793 Q92985 Q96F46 Q96HA1 Q96P20 Q96PD4 Q99567 Q99570 Q9BRV8 Q9BTX1 Q9BW27 Q9BYX4 Q9C037 Q9HC29 Q9NR97 Q9NRG9 Q9NYJ8 Q9NYK1 Q9UHD2 Q9UKX7 Q9UN86 Q9Y239 Q9Y4K3 Q9Y6B6 Q9Y6K9	3a 6 7a 8 9b AAAS ADRACALA ATG14 ATG14L B2M BECN1 BLU C1orf7 C7orf14 CAIN CAN CAP-1 CARD15 CARD4 CARDIAK CBP CG1 CHUK CIAS1 CNBP COLEC1 COLEC7 CRAF1 CRARF CRARF1 CREBBP CROC1 CTLA8 D3S1231E DAK DDX58 E EFP ERIS FIP3 G1P2 G3BP G3BP1 G3BP2 GT197 HCP HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB IFB IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR IFNAR1 IFNB IFNB1 IKBKB IKBKE IKBKG IKKA IKKB IKKE IKKI IL17 IL17A IL17F IL17R IL17RA IL17RC IPS1 IRAK IRAK1 IRAK2 IRF3 IRF7 ISG15 JAK1 JAK1A JAK1B KIAA0012 KIAA0023 KIAA0079 KIAA0095 KIAA0151 KIAA0169 KIAA0197 KIAA0225 KIAA0618 KIAA0660 KIAA0719 KIAA0731 KIAA0733 KIAA0755 KIAA0791 KIAA0831 KIAA0906 KIAA1271 KPNA2 LARP LARP1 M MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MASP1 MAVS MBL MBL2 MDA5 MITA MP44 MRNP41 N NAK NALP12 NALP3 NDC1 NEMO NLRP12 NLRP3 NOD1 NOD2 NPAP60L NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 PCNT1 PIK3C3 PIK3R4 POM121 POM121A POM121C PRSS5 PSPD PTP1C PTP2C PTPN11 PTPN6 PYPAF1 PYPAF7 RAE1 RANBP2 RCH1 RH116 RICK RIGI RIP2 RIPK2 RNF135 RNF147 RNF163 RNF85 RNF87 RNO S SAR1B SARA2 SARB SEC13 SEC13A SEC13L1 SEC13R SEC23A SEC24A SEC24B SEC24C SEC24D SFTP4 SFTPD SHPTP2 SIKE SIKE1 SRP1 STAT1 STAT2 STING STING1 TAB1 TAB2 TAB3 TAK1 TBK1 TCF16 TIL4 TKFC TLR1 TLR2 TLR7 TLR8 TMEM173 TMEM48 TOM70 TOMM70 TOMM70A TPR TRAF3 TRAF6 TRAFAMN TRIM25 TRIM4 TYK2 UBE2N UBE2V UBE2V1 UCRP UEV1 VISA VPS15 VPS34 ZNF147 ZNF9 rep	Homo sapiens (human)
SARS-CoV-2 modulates autophagy	Elongation factor Tu, mitochondrial Membrane protein Microtubule-associated proteins 1A/1B light chain 3B ORF3a protein ORF7a protein UV radiation resistance-associated gene protein Vacuolar protein sorting-associated protein 11 homolog Vacuolar protein sorting-associated protein 16 homolog Vacuolar protein sorting-associated protein 18 homolog Vacuolar protein sorting-associated protein 33A Vacuolar protein sorting-associated protein 33B Vacuolar protein sorting-associated protein 41 homolog Vacuolar protein sorting-associated protein 45 Vam6/Vps39-like protein	P0DTC3 P0DTC5 P0DTC7 P49411 P49754 Q96AX1 Q96JC1 Q9GZQ8 Q9H267 Q9H269 Q9H270 Q9NRW7 Q9P253 Q9P2Y5	3a 7a KIAA0770 KIAA1475 M MAP1ALC3 MAP1LC3B RNF108 TLP TUFM UVRAG VAM6 VPS11 VPS16 VPS18 VPS33A VPS33B VPS39 VPS41 VPS45 VPS45A VPS45B	Homo sapiens (human)
SARS-CoV-2 modulates host translation machinery	Gem-associated protein 2 Gem-associated protein 4 Gem-associated protein 5 Gem-associated protein 6 Gem-associated protein 7 Gem-associated protein 8 Probable ATP-dependent RNA helicase DDX20 Replicase polyprotein 1a Replicase polyprotein 1ab Ribosomal protein eS27-like Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D1 Small nuclear ribonucleoprotein Sm D2 Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated proteins B and B' Small ribosomal subunit protein eS10 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS4, X isoform Small ribosomal subunit protein eS4, Y isoform 1 Small ribosomal subunit protein eS4, Y isoform 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8 Small ribosomal subunit protein uS9 Survival motor neuron protein Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14893 P08708 P08865 P0DTC1 P0DTD1 P14678 P15880 P22090 P23396 P25398 P39019 P42677 P46781 P46782 P46783 P57678 P60866 P61247 P62081 P62241 P62244 P62249 P62263 P62266 P62269 P62273 P62277 P62280 P62304 P62306 P62308 P62314 P62316 P62318 P62701 P62753 P62841 P62847 P62851 P62854 P62857 P62861 P62979 P63220 Q16637 Q71UM5 Q8TD47 Q8TEQ6 Q8WXD5 Q9H840 Q9NWZ8 Q9UHI6	CCG2 COD D6S218E DDX20 DP103 FAM51A1 FAU FTE1 GEMIN2 GEMIN3 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 LAMBR LAMR1 MFTL MPS1 PBSCF PBSCG RIG RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS17L RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4 RPS4X RPS4Y RPS4Y1 RPS4Y2 RPS4Y2P RPS5 RPS6 RPS7 RPS8 RPS9 RPSA SCAR SIP1 SMN SMN1 SMN2 SMNC SMNT SNRPB SNRPB1 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG UBA80 UBCEP1 rep	Homo sapiens (human)
SARS-CoV-2 targets PDZ proteins in cell-cell junction	Envelope small membrane protein Gap junction alpha-1 protein InaD-like protein Protein PALS1 Protein crumbs homolog 3 Tight junction protein ZO-1	P0DTC4 P17302 Q07157 Q8N3R9 Q8NI35 Q9BUF7	CIPP CRB3 E GJA1 GJAL INADL MPP5 PALS1 PATJ TJP1 ZO1	Homo sapiens (human)
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 Caveolin-1 Membrane protein Nucleoprotein ORF3a protein RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	O15530 P0DTC3 P0DTC5 P0DTC9 P27348 P31749 P31751 P31946 P31947 P61981 P62258 P63104 Q03135 Q04917 Q9Y243	3a AKT1 AKT2 AKT3 CAV CAV1 HME1 M N PDK1 PDPK1 PKB PKBG RAC SFN YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
SCF(Skp2)-mediated degradation of p27/p21	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinases regulatory subunit 1 G1/S-specific cyclin-D1 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-10 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein-tyrosine kinase 6 S-phase kinase-associated protein 1 S-phase kinase-associated protein 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00233 O00487 O14818 O43242 O75832 O96020 P0CG47 P0CG48 P11802 P17980 P20248 P20618 P24385 P24864 P24941 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P38936 P40306 P43686 P46527 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61024 P61289 P62191 P62195 P62333 P62979 P62987 P63208 P78396 Q06323 Q13200 Q13309 Q13616 Q13882 Q15008 Q16401 Q92530 Q99436 Q99460 Q9UL46 Q9UNM6	BCL1 BRK C7orf76 CAP20 CCN1 CCNA CCNA1 CCNA2 CCND1 CCNE CCNE1 CCNE2 CDK2 CDK4 CDKN1 CDKN1A CDKN1B CDKN2 CIP1 CKS1 CKS1B CUL1 DSS1 EMC19 FBXL1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0107 KIP1 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MDA6 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 PIC1 POH1 PRAD1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSMF1 PTK6 RING10 RING12 RPS27A SDI1 SEM1 SHFDG1 SHFM1 SKP1 SKP1A SKP2 SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WAF1 X Y Y2 Z p27	Homo sapiens (human)
SCF-beta-TrCP mediated degradation of Emi1	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cell division cycle protein 20 homolog Cullin-1 F-box only protein 5 F-box/WD repeat-containing protein 1A Fizzy-related protein homolog Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 S-phase kinase-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P63208 Q06323 Q12834 Q13200 Q13616 Q14997 Q15008 Q16401 Q8TAA3 Q92530 Q99436 Q99460 Q9UKT4 Q9UL46 Q9UM11 Q9UNM6 Q9Y297	BTRC BTRCP C7orf76 CDC20 CDH1 CUL1 DSS1 EMC19 EMI1 FBW1A FBX5 FBXO5 FBXW1A FYR FZR FZR1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 KIAA1242 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RING10 RING12 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z	Homo sapiens (human)
SDK interactions	Protein sidekick-1 Protein sidekick-2	Q58EX2 Q7Z5N4	KIAA1514 SDK1 SDK2	Homo sapiens (human)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	FERM, ARHGEF and pleckstrin domain-containing protein 2 Neuropilin-1 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Plexin-A1 Plexin-A2 Plexin-A3 Plexin-A4 Ras-related C3 botulinum toxin substrate 1 Ras-related protein R-Ras Rho-related GTP-binding protein Rho6 Semaphorin-3A Talin-1 Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn	O14786 O60331 O75051 O94887 P06241 P07332 P10301 P51805 P63000 Q14563 Q92730 Q9HCM2 Q9UIW2 Q9Y490	FARP2 FES FPS FYN KIAA0463 KIAA0589 KIAA0793 KIAA1027 KIAA1550 NOV NRP NRP1 OCT PIP5K1C PLEKHC3 PLXN1 PLXN2 PLXN4 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNA4A PLXNA4B RAC1 RHO6 RND1 RRAS SEMA3A SEMAD SEX TC25 TLN TLN1 VEGF165R	Homo sapiens (human)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 GTPase HRas GTPase NRas Son of sevenless homolog 1	O15520 P01111 P01112 P05230 P08620 P09038 P10767 P11487 P31371 Q07889 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF INT2 KS3 NRAS SOS1	Homo sapiens (human)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 GTPase HRas GTPase NRas Son of sevenless homolog 1	O15520 O43320 O76093 P01111 P01112 P05230 P08620 P09038 P10767 P11487 P21781 P31371 Q07889 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF16 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF INT2 KGF KS3 NRAS SOS1	Homo sapiens (human)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 GTPase HRas GTPase NRas Son of sevenless homolog 1	O43320 O76093 P01111 P01112 P05230 P08620 P09038 P31371 Q07889 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB HRAS HRAS1 HST HSTF1 HYPF KS3 NRAS SOS1	Homo sapiens (human)
SHC-mediated cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 GTPase HRas GTPase NRas Son of sevenless homolog 1	O43320 O76093 O95750 P01111 P01112 P05230 P08620 P09038 P10767 P22455 P31371 Q07889 Q86Z14 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 NRAS SOS1 TKF	Homo sapiens (human)
SHC-related events triggered by IGF1R	GTPase HRas GTPase NRas Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II Son of sevenless homolog 1	P01111 P01112 P01344 P05019 P08069 Q07889	HRAS HRAS1 IBP1 IGF1 IGF1R IGF2 NRAS SOS1	Homo sapiens (human)
SHC1 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha SHC-transforming protein 1 Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P29353 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SHC SHC1 SHCA SOS1 TGFA	Homo sapiens (human)
SHC1 events in ERBB2 signaling	Epidermal growth factor receptor GTPase HRas GTPase NRas Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein kinase C alpha type Protein kinase C delta type Protein kinase C epsilon type Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 12	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P17252 P29353 P35070 P56975 Q02156 Q02297 Q05209 Q05655 Q07889 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PKCA PKCD PKCE PRKACA PRKCA PRKCD PRKCE PTPN12 SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
SHC1 events in ERBB4 signaling	GTPase HRas GTPase NRas Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P01111 P01112 P29353 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EREG GGF HBEGF HEGFL HGL HRAS HRAS1 HRGA NDF NRAS NRG1 NRG2 NRG3 NRG4 NTAK SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
SHOC2 M1731 mutant abolishes MRAS complex function	14-3-3 protein beta/alpha Leucine-rich repeat protein SHOC-2 RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	O14807 P04049 P10398 P15056 P31946 P36873 P62140 Q9UQ13	ARAF ARAF1 BRAF BRAF1 KIAA0862 MRAS PKS PKS2 PPP1CB PPP1CC RAF RAF1 RAFB1 RRAS3 SHOC2 YWHAB	Homo sapiens (human)
SIRT1 negatively regulates rRNA expression	Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase SUV39H1 NAD-dependent protein deacetylase sirtuin-1 Ribosomal RNA-processing protein 8 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein	O43159 O43463 O60814 P04908 P06899 P0C5Y9 P16104 P20226 P20671 P23527 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q15572 Q15573 Q16777 Q16778 Q53T94 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q96EB6 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H5J8	GTF2D1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JOSD3 KIAA0409 KMT1A NML RRP8 SIR2L1 SIRT1 SUV39H SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TSH2B	Homo sapiens (human)
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	Histone RNA hairpin-binding protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated proteins B and B' U7 snRNA-associated Sm-like protein LSm10 U7 snRNA-associated Sm-like protein LSm11 Zinc finger protein 473	P14678 P52298 P62304 P62306 P62308 P62318 P83369 Q09161 Q14493 Q8WTR7 Q969L4	CBP20 CBP80 COD HBP KIAA1141 LSM10 LSM11 NCBP NCBP1 NCBP2 PBSCF PBSCG SLBP SNRPB SNRPB1 SNRPD3 SNRPE SNRPF SNRPG ZFP100 ZNF473	Homo sapiens (human)
SLBP independent Processing of Histone Pre-mRNAs	Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated proteins B and B' U7 snRNA-associated Sm-like protein LSm10 U7 snRNA-associated Sm-like protein LSm11 Zinc finger protein 473	P14678 P52298 P62304 P62306 P62308 P62318 P83369 Q09161 Q8WTR7 Q969L4	CBP20 CBP80 COD KIAA1141 LSM10 LSM11 NCBP NCBP1 NCBP2 PBSCF PBSCG SNRPB SNRPB1 SNRPD3 SNRPE SNRPF SNRPG ZFP100 ZNF473	Homo sapiens (human)
SLIT2:ROBO1 increases RHOA activity	Roundabout homolog 1 Slit homolog 2 protein Transforming protein RhoA Unconventional myosin-IXb	O94813 P61586 Q13459 Q9Y6N7	ARH12 ARHA DUTT1 MYO9B MYR5 RHO12 RHOA ROBO1 SLIL3 SLIT2	Homo sapiens (human)

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