GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1851 - 1875** of **2090** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Cytoprotection by HMOX1	3'-5' exoribonuclease HELZ2 Albumin Biliverdin reductase A CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX18, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Fatty acid-binding protein, liver Flavin reductase (NADPH) Heme oxygenase 1 Heme oxygenase 2 Hemoglobin subunit alpha Hemoglobin subunit beta Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Leucine-rich PPR motif-containing protein, mitochondrial Mediator of RNA polymerase II transcription subunit 1 Multidrug resistance-associated protein 1 NACHT, LRR and PYD domains-containing protein 3 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Paired amphipathic helix protein Sin3a Peroxisome proliferator-activated receptor alpha Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial Protein-tyrosine kinase 6 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Signal transducer and activator of transcription 3 Signal-transducing adaptor protein 2 Surfeit locus protein 1 Thioredoxin-interacting protein Translational activator of cytochrome c oxidase 1 Trimethylguanosine synthase	O00483 O14548 O15379 O43819 O60907 O75376 O75880 P00395 P00403 P00414 P02768 P07148 P09601 P09669 P10176 P10606 P12074 P13073 P14854 P15954 P19793 P20674 P24311 P30043 P30519 P33527 P40763 P42704 P53004 P68871 P69905 P99999 Q07869 Q13882 Q14686 Q15526 Q15596 Q15648 Q15788 Q3L8U1 Q49B96 Q5RI15 Q6STE5 Q86X55 Q8N8Q8 Q92793 Q96I36 Q96P20 Q96RS0 Q96ST3 Q9BSH4 Q9BYK8 Q9BZK7 Q9H3M7 Q9P0S2 Q9UGK3 Q9Y618 Q9Y6N1	ABCC1 AIB3 ALB APRF ARC205 BAF60C BHLHE74 BHLHE75 BKS BLVR BLVRA BLVRB BRK BVR C12orf62 C14orf112 C1orf7 CARM1 CBP CCDC44 CHD9 CIAS1 COI COII COIII COX11 COX14 COX16 COX18 COX19 COX2 COX20 COX4 COX4I1 COX5A COX5B COX6A1 COX6AL COX6B COX6B1 COX6C COX7A2L COX7AR COX7B COX7C COX7RP COX8 COX8A COX8L COXI COXII COXIII CREBBP CRSP1 CRSP200 CTG26 CYC CYCS DRIP205 DRIP230 FABP1 FABPL FAM36A FLR HBA1 HBA2 HBB HCA137 HDAC3 HELZ2 HMOX1 HMOX2 HO HO1 HO2 IRA1 KIAA0181 KIAA0308 KIAA1047 KIAA1769 KISH2 LRP130 LRPPRC MED1 MRP MRP1 MT-CO1 MT-CO2 MT-CO3 MTCO1 MTCO2 MTCO3 NALP3 NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NCOR2 NDUFA4 NLRP3 NR1C1 NR2B1 OXA1L2 PBP PIMT PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 PTK6 PYPAF1 RAP250 RB18A RXRA SCAN SCO1 SCO2 SCOD1 SIN3A SMARCD3 SRC1 SRC2 STAP2 STAT3 SURF-1 SURF1 TACO1 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TRAP220 TRBP TRIP2 TXNIP VDUP1	Homo sapiens (human)
Transcriptional regulation of white adipocyte differentiation	3'-5' exoribonuclease HELZ2 Adipogenesis regulatory factor Adiponectin Angiopoietin-related protein 4 CCAAT/enhancer-binding protein alpha CCAAT/enhancer-binding protein beta CCAAT/enhancer-binding protein delta COUP transcription factor 2 CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Constitutive coactivator of peroxisome proliferator-activated receptor gamma Cyclin-C Cyclin-dependent kinase 19 Cyclin-dependent kinase 4 Cyclin-dependent kinase 8 E3 SUMO-protein ligase EGR2 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Fatty acid-binding protein, adipocyte G1/S-specific cyclin-D3 Histone acetyltransferase p300 Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Krueppel-like factor 4 Krueppel-like factor 5 Leptin Lipoprotein lipase Mediator of RNA polymerase II transcription subunit 10 Mediator of RNA polymerase II transcription subunit 11 Mediator of RNA polymerase II transcription subunit 12 Mediator of RNA polymerase II transcription subunit 13-like Mediator of RNA polymerase II transcription subunit 13 Mediator of RNA polymerase II transcription subunit 14 Mediator of RNA polymerase II transcription subunit 15 Mediator of RNA polymerase II transcription subunit 16 Mediator of RNA polymerase II transcription subunit 17 Mediator of RNA polymerase II transcription subunit 18 Mediator of RNA polymerase II transcription subunit 19 Mediator of RNA polymerase II transcription subunit 1 Mediator of RNA polymerase II transcription subunit 20 Mediator of RNA polymerase II transcription subunit 21 Mediator of RNA polymerase II transcription subunit 22 Mediator of RNA polymerase II transcription subunit 23 Mediator of RNA polymerase II transcription subunit 24 Mediator of RNA polymerase II transcription subunit 25 Mediator of RNA polymerase II transcription subunit 26 Mediator of RNA polymerase II transcription subunit 27 Mediator of RNA polymerase II transcription subunit 28 Mediator of RNA polymerase II transcription subunit 29 Mediator of RNA polymerase II transcription subunit 30 Mediator of RNA polymerase II transcription subunit 31 Mediator of RNA polymerase II transcription subunit 4 Mediator of RNA polymerase II transcription subunit 6 Mediator of RNA polymerase II transcription subunit 7 Mediator of RNA polymerase II transcription subunit 8 Mediator of RNA polymerase II transcription subunit 9 Nuclear factor NF-kappa-B p105 subunit Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 3 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Perilipin-1 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Peroxisome proliferator-activated receptor gamma Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Platelet glycoprotein 4 Protein Wnt-10b Proto-oncogene Wnt-1 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Solute carrier family 2, facilitated glucose transporter member 4 Sterol regulatory element-binding protein 2 Thyroid hormone receptor-associated protein 3 Transcription factor COE1 Transcription factor p65 Transforming growth factor beta-1 proprotein Trimethylguanosine synthase Tumor necrosis factor Zinc finger protein 467 Zinc finger protein 638	A0JLT2 O00744 O15379 O43474 O43513 O60240 O60244 O60907 O75376 O75448 O75586 O95402 P01137 P01375 P04628 P06858 P11161 P11802 P14672 P15090 P16671 P17676 P19793 P19838 P24468 P24863 P30281 P35558 P37231 P41159 P49336 P49715 P49716 Q04206 Q07869 Q09472 Q12772 Q13503 Q13887 Q14686 Q14966 Q15528 Q15596 Q15648 Q15788 Q15847 Q15848 Q3L8U1 Q6P2C8 Q6STE5 Q71F56 Q71SY5 Q7Z7K2 Q86X55 Q92793 Q93074 Q96EK7 Q96G25 Q96HR3 Q96RN5 Q96RS0 Q9BTT4 Q9BUE0 Q9BWU1 Q9BY76 Q9BYK8 Q9BZK7 Q9H204 Q9H944 Q9NPJ6 Q9NVC6 Q9NWA0 Q9NX70 Q9P086 Q9UBK2 Q9UH73 Q9UHV7 Q9ULK4 Q9Y2W1 Q9Y2X0 Q9Y3C7 Q9Y618 Q9Y6Q9	ACDC ACID1 ACRP30 ADIPOQ ADIRF AFRO AIB1 AIB3 ANGPTL4 APM1 APM2 ARC100 ARC105 ARC130 ARC150 ARC205 ARC240 ARC250 ARC33 ARC34 ARC36 ARC70 ARC77 ARC92 ARP1 ARP4 BAF60C BCLAF2 BHLHD2 BHLHE42 BHLHE74 BHLHE75 BTEB2 C10orf116 CAGH45 CARM1 CBP CCNC CCND3 CCPG CD36 CDC2L6 CDK11 CDK19 CDK4 CDK8 CEBP CEBPA CEBPB CEBPD CHD9 CKLF COE1 CREBBP CRSP1 CRSP2 CRSP200 CRSP3 CRSP34 CRSP4 CRSP6 CRSP7 CRSP8 CRSP9 CTG26 CTG7A CXorf4 DRIP100 DRIP130 DRIP150 DRIP205 DRIP230 DRIP36 DRIP77 DRIP80 DRIP92 EBF EBF1 EG1 EGR2 EP300 EXLM1 EZF FABP4 FAM120B GBP28 GKLF GLUT4 GP3B GP4 HCA137 HDAC3 HELZ2 HFARP HOPA IKLF INT1 IRA1 IXL KIAA0130 KIAA0181 KIAA0192 KIAA0308 KIAA0593 KIAA1025 KIAA1028 KIAA1047 KIAA1216 KIAA1769 KIAA1838 KISH2 KLF4 KLF5 KROX20 LCMR1 LEM6 LEP LIPD LPL MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 NCOA1 NCOA2 NCOA3 NCOA6 NCOA6IP NCOR1 NCOR2 NFKB1 NFKB3 NP220 NR1C1 NR1C3 NR2B1 NR2F2 OB OBS P300 PBP PCK1 PCQAP PEPCK1 PERI PGAR PGC1 PGC1A PIMT PLIN PLIN1 PPAR PPARA PPARBP PPARG PPARGBP PPARGC1 PPARGC1A PRIC285 PRIC320 PRMT4 PROSIT240 PTOV2 RAC3 RAP250 RB18A RELA RGR1 RXRA SLC2A4 SMARCD3 SOH1 SRB7 SRC1 SRC2 SREBF2 SREBP2 SUR2 SURB7 SURF5 TBL1 TBL1X TBL1XR1 TBLR1 TCF5 TFCOUP2 TGFB TGFB1 TGS1 THRAP1 THRAP2 THRAP3 THRAP4 THRAP5 THRAP6 TIF2 TIG1 TNF TNFA TNFSF2 TNRC11 TNRC7 TRAM1 TRAP100 TRAP150 TRAP170 TRAP220 TRAP230 TRAP240 TRAP240L TRAP25 TRAP80 TRBP TRFP TRIP2 VDRIP WNT1 WNT10B WNT12 ZFML ZNF467 ZNF638	Homo sapiens (human)
Activation of gene expression by SREBF (SREBP)	3'-5' exoribonuclease HELZ2 7-dehydrocholesterol reductase Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 2 CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Delta(14)-sterol reductase TM7SF2 Diphosphomevalonate decarboxylase F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Farnesyl pyrophosphate synthase Fatty acid synthase Geranylgeranyl pyrophosphate synthase Glycerol-3-phosphate acyltransferase 1, mitochondrial Histone-arginine methyltransferase CARM1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Isopentenyl-diphosphate Delta-isomerase 1 Lanosterol 14-alpha demethylase Lanosterol synthase Lathosterol oxidase Mediator of RNA polymerase II transcription subunit 1 Metal regulatory transcription factor 1 Mevalonate kinase Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Peroxisome proliferator-activated receptor alpha Phosphomevalonate kinase Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Squalene monooxygenase Squalene synthase Stearoyl-CoA desaturase Sterol regulatory element-binding protein 2 Transcription factor Sp1 Trimethylguanosine synthase Very long chain fatty acid elongase 6	O00763 O00767 O60907 O75845 O76062 O95749 P08047 P14324 P19793 P23511 P25208 P37268 P48449 P49327 P53602 Q01581 Q03426 Q07869 Q12772 Q13085 Q13907 Q13952 Q14534 Q14686 Q14872 Q15126 Q15596 Q15648 Q15788 Q16850 Q3L8U1 Q6STE5 Q86X55 Q92793 Q96RS0 Q9BYK8 Q9BZK7 Q9H5J4 Q9HCL2 Q9UBM7	ACAC ACACA ACACB ACC1 ACC2 ACCA ACCB AIB3 ANG1 ARC205 BAF60C BHLHD2 BHLHE74 BHLHE75 CARM1 CBP CHD9 CREBBP CRSP1 CRSP200 CYP51 CYP51A1 D7SR DHCR7 DRIP205 DRIP230 ELOVL6 ERG1 FACE FADS5 FAS FASN FDFT1 FDPS FPS GGPS1 GPAM GPAT1 HAP3 HCA137 HELZ2 HMGCS HMGCS1 IDI1 IRA1 KIAA0181 KIAA0308 KIAA1293 KIAA1560 KIAA1769 KISH2 LCE LSS MED1 MPD MTF1 MVD MVK NCOA1 NCOA2 NCOA6 NCOA6IP NFYA NFYB NFYC NR1C1 NR2B1 OSC PBP PIMT PMKI PMVK PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SC5D SC5DL SCD SCD1 SCDOS SMARCD3 SP1 SQLE SRC1 SRC2 SREBF2 SREBP2 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TM7SF2 TRAP220 TRBP TRIP2 TSFP1	Homo sapiens (human)
PPARA activates gene expression	3'-5' exoribonuclease HELZ2 5-aminolevulinate synthase, non-specific, mitochondrial Acyl-CoA (8-3)-desaturase Angiopoietin-related protein 4 Angiotensinogen Ankyrin repeat domain-containing protein 1 Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-V Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Basic helix-loop-helix ARNT-like protein 1 Bile acid receptor CREB-binding protein Carnitine O-palmitoyltransferase 1, liver isoform Carnitine O-palmitoyltransferase 2, mitochondrial Chromodomain-helicase-DNA-binding protein 9 Circadian locomoter output cycles protein kaput Constitutive coactivator of peroxisome proliferator-activated receptor gamma Cyclin-C Cyclin-dependent kinase 19 Cyclin-dependent kinase 8 Cytochrome P450 1A1 Cytochrome P450 4A11 Cytochrome P450 7A1 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Fatty acid-binding protein, liver Four and a half LIM domains protein 2 G protein pathway suppressor 2 G0/G1 switch protein 2 Glioma pathogenesis-related protein 1 Grainyhead-like protein 1 homolog Histone acetyltransferase p300 Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Hydroxymethylglutaryl-CoA synthase, mitochondrial Long-chain fatty acid transport protein 1 Long-chain-fatty-acid--CoA ligase 1 Mediator of RNA polymerase II transcription subunit 10 Mediator of RNA polymerase II transcription subunit 11 Mediator of RNA polymerase II transcription subunit 12 Mediator of RNA polymerase II transcription subunit 13-like Mediator of RNA polymerase II transcription subunit 13 Mediator of RNA polymerase II transcription subunit 14 Mediator of RNA polymerase II transcription subunit 15 Mediator of RNA polymerase II transcription subunit 16 Mediator of RNA polymerase II transcription subunit 17 Mediator of RNA polymerase II transcription subunit 18 Mediator of RNA polymerase II transcription subunit 19 Mediator of RNA polymerase II transcription subunit 1 Mediator of RNA polymerase II transcription subunit 20 Mediator of RNA polymerase II transcription subunit 21 Mediator of RNA polymerase II transcription subunit 22 Mediator of RNA polymerase II transcription subunit 23 Mediator of RNA polymerase II transcription subunit 24 Mediator of RNA polymerase II transcription subunit 25 Mediator of RNA polymerase II transcription subunit 26 Mediator of RNA polymerase II transcription subunit 27 Mediator of RNA polymerase II transcription subunit 28 Mediator of RNA polymerase II transcription subunit 29 Mediator of RNA polymerase II transcription subunit 30 Mediator of RNA polymerase II transcription subunit 31 Mediator of RNA polymerase II transcription subunit 4 Mediator of RNA polymerase II transcription subunit 6 Mediator of RNA polymerase II transcription subunit 7 Mediator of RNA polymerase II transcription subunit 8 Mediator of RNA polymerase II transcription subunit 9 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Metal regulatory transcription factor 1 NADP-dependent malic enzyme Neuronal PAS domain-containing protein 2 Nuclear receptor ROR-alpha Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 3 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Nuclear receptor subfamily 1 group D member 1 Nuclear respiratory factor 1 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Oxysterols receptor LXR-alpha Oxysterols receptor LXR-beta Perilipin-2 Peroxisomal membrane protein 11A Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Peroxisome proliferator-activated receptor gamma coactivator 1-beta Peroxisome proliferator-activated receptor gamma Phosphatidylcholine translocator ABCB4 Phospholipid-transporting ATPase ABCA1 Platelet glycoprotein 4 Ral guanine nucleotide dissociation stimulator-like 1 Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Rho guanine nucleotide exchange factor TIAM2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Squalene synthase Steroid hormone receptor ERR1 Sterol regulatory element-binding protein 2 Sulfotransferase 2A1 Thioredoxin reductase 1, cytoplasmic Thyroid hormone receptor-associated protein 3 Transcription factor Sp1 Tribbles homolog 3 Trimethylguanosine synthase Tumor necrosis factor receptor superfamily member 21 UDP-glucuronosyltransferase 1A9	A0JLT2 A9YTQ3 O00327 O15379 O15516 O43513 O60244 O60427 O60656 O60907 O75192 O75376 O75448 O75509 O75586 O95402 O95477 P01019 P02647 P02652 P04798 P07148 P08047 P11310 P11474 P13196 P16671 P19793 P20393 P21439 P22680 P23511 P23786 P24863 P25208 P27469 P27540 P28702 P33121 P35398 P35869 P37231 P37268 P48060 P48163 P49336 P50416 P54868 P55055 Q01581 Q02928 Q06520 Q07869 Q09472 Q12772 Q13133 Q13227 Q13503 Q13952 Q14192 Q14686 Q14872 Q15327 Q15528 Q15596 Q15648 Q15788 Q16656 Q16881 Q3L8U1 Q6P2C8 Q6PCB7 Q6Q788 Q6STE5 Q71F56 Q71SY5 Q86X55 Q86YN6 Q8IVF5 Q92793 Q93074 Q96EK7 Q96G25 Q96HR3 Q96RI1 Q96RN5 Q96RS0 Q96RU7 Q99541 Q99743 Q9BTT4 Q9BUE0 Q9BWU1 Q9BY76 Q9BYK8 Q9BZK7 Q9H204 Q9H944 Q9HBZ2 Q9NPJ6 Q9NVC6 Q9NWA0 Q9NX70 Q9NZI5 Q9NZL6 Q9P086 Q9UBK2 Q9UHV7 Q9ULK4 Q9Y2W1 Q9Y2X0 Q9Y3C7 Q9Y618 Q9Y6Q9	ABC1 ABCA1 ABCB4 ACADM ACID1 ACSL1 ACSVL5 ADFP AGT AHR AHRR AIB1 AIB3 ALAS1 ALAS3 ALASH ANGPTL4 ANKRD1 APOA1 APOA2 APOA5 ARC100 ARC105 ARC130 ARC150 ARC205 ARC240 ARC250 ARC33 ARC34 ARC36 ARC70 ARC77 ARC92 ARNT ARNT2 ARNTL ARP4 BAF60C BAR BCLAF2 BHLHD2 BHLHE1 BHLHE2 BHLHE42 BHLHE5 BHLHE74 BHLHE75 BHLHE76 BHLHE77 BHLHE8 BHLHE9 BMAL1 C193 C20orf97 CAGH45 CARM1 CARP CBP CCNC CCPG CD36 CDC2L6 CDK11 CDK19 CDK8 CERP CHD9 CLOCK CPT1 CPT1A CPT2 CREBBP CRSP1 CRSP2 CRSP200 CRSP3 CRSP34 CRSP4 CRSP6 CRSP7 CRSP8 CRSP9 CTG26 CTG7A CXorf4 CYP1A1 CYP4A11 CYP4A2 CYP7 CYP7A1 DR6 DRAL DRIP100 DRIP130 DRIP150 DRIP205 DRIP230 DRIP36 DRIP77 DRIP80 DRIP92 EAR1 EG1 EP300 ERR1 ESRL1 ESRRA EXLM1 FABP1 FABPL FACL1 FACL2 FADS1 FADSD5 FAM120B FATP1 FDFT1 FHL2 FXR G0S2 GLIPR GLIPR1 GNT1 GP3B GP4 GPS2 GRHL1 GRIM12 HA1A2 HAP3 HCA137 HDAC3 HELZ2 HFARP HMGCS HMGCS1 HMGCS2 HOPA HREV HRR1 HST IRA1 IXL KDRF KIAA0130 KIAA0181 KIAA0192 KIAA0307 KIAA0308 KIAA0334 KIAA0593 KIAA0959 KIAA1025 KIAA1028 KIAA1047 KIAA1216 KIAA1234 KIAA1769 KIAA1838 KIAA2016 KISH2 LACS LACS1 LACS2 LBP32 LCMR1 LEM6 LXRA LXRB MDR3 ME1 MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 MGR MOP3 MOP4 MTF1 NCOA1 NCOA2 NCOA3 NCOA6 NCOA6IP NCOR1 NCOR2 NER NFYA NFYB NFYC NIPK NPAS2 NR1C1 NR1C3 NR1D1 NR1F1 NR1H2 NR1H3 NR1H4 NR2B1 NR2B2 NR3B1 NRF1 P300 PASD3 PASD4 PBP PCQAP PERC PEX11 PEX11A PGAR PGC1 PGC1A PGC1B PGY3 PIMT PLIN2 PPAR PPARA PPARBP PPARG PPARGBP PPARGC1 PPARGC1A PPARGC1B PRIC285 PRIC320 PRMT4 PROSIT240 PTOV2 RAC3 RAP250 RAP3 RB18A RGL RGL1 RGR1 RIP14 RORA RTVP1 RXRA RXRB RZRA SERPINA8 SKIP3 SLC27A1 SLIM3 SMARCD3 SOH1 SP1 SRB7 SRC1 SRC2 SREBF2 SREBP2 STD STEF SULT2A1 SUR2 SURB7 SURF5 TBL1 TBL1X TBL1XR1 TBLR1 TFCP2L2 TGS1 THRAL THRAP1 THRAP2 THRAP3 THRAP4 THRAP5 THRAP6 TIAM2 TIF2 TIG1 TNFRSF21 TNRC11 TNRC7 TRAM1 TRAP100 TRAP150 TRAP170 TRAP220 TRAP230 TRAP240 TRAP240L TRAP25 TRAP80 TRB3 TRBP TRFP TRIB3 TRIP2 TSFP1 TXNRD1 UGT1 UGT1A9 UNR VDRIP	Homo sapiens (human)
Transcriptional activation of mitochondrial biogenesis	3'-5' exoribonuclease HELZ2 5-aminolevulinate synthase, non-specific, mitochondrial ATP synthase subunit beta, mitochondrial Acetyl-coenzyme A synthetase, cytoplasmic CREB-binding protein CREB-regulated transcription coactivator 1 CREB-regulated transcription coactivator 2 CREB-regulated transcription coactivator 3 Calcium/calmodulin-dependent protein kinase type IV Calmodulin-1 Chromodomain-helicase-DNA-binding protein 9 Cyclic AMP-dependent transcription factor ATF-2 Cytochrome c DNA polymerase subunit gamma-2 DNA-directed RNA polymerase, mitochondrial Dimethyladenosine transferase 1, mitochondrial Dimethyladenosine transferase 2, mitochondrial F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 GA-binding protein alpha chain Glutamate dehydrogenase 1, mitochondrial Glutamate dehydrogenase 2, mitochondrial Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Host cell factor 1 Isocitrate dehydrogenase [NADP], mitochondrial Mediator of RNA polymerase II transcription subunit 1 Myocyte-specific enhancer factor 2C Myocyte-specific enhancer factor 2D NAD-dependent protein deacetylase sirtuin-3, mitochondrial NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1 Nuclear respiratory factor 1 PGC-1 and ERR-induced regulator in muscle protein 1 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Peroxisome proliferator-activated receptor gamma coactivator 1-beta Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Single-stranded DNA-binding protein, mitochondrial Steroid hormone receptor ERR1 Superoxide dismutase [Mn], mitochondrial Transcription factor A, mitochondrial Transcription termination factor 1, mitochondrial Trimethylguanosine synthase Twinkle mtDNA helicase	O00411 O15379 O60907 O75376 P00367 P04179 P06576 P0DP23 P11474 P13196 P15336 P19793 P20393 P48735 P49448 P51610 P99999 Q00059 Q04837 Q06413 Q06546 Q07869 Q14686 Q14814 Q15596 Q15648 Q15788 Q16566 Q16656 Q3L8U1 Q53ET0 Q5SV97 Q5VV67 Q6STE5 Q6UUV7 Q6UUV9 Q86X55 Q86YN6 Q8WVM0 Q92793 Q96RR1 Q96RS0 Q99551 Q9BYK8 Q9BZK7 Q9H5Q4 Q9NR19 Q9NTG7 Q9NXA8 Q9UBK2 Q9UHN1 Q9Y6E7	ACAS2 ACSS2 AIB3 ALAS1 ALAS3 ALASH ARC205 ATF2 ATP5B ATP5F1B ATPMB ATPSB BAF60C BHLHE74 BHLHE75 C10orf2 C1orf170 CALM CALM1 CAM CAM1 CAMK CAMK-GR CAMK4 CAMKIV CARM1 CBP CHD9 CREB2 CREBBP CREBP1 CRSP1 CRSP200 CRTC1 CRTC2 CRTC3 CYC CYCS DRIP205 DRIP230 E4TF1A EAR1 ERR1 ESRL1 ESRRA GABPA GLUD GLUD1 GLUD2 GLUDP1 HCA137 HCF1 HCFC1 HDAC3 HELZ2 HFC1 HREV IDH2 IRA1 KIAA0181 KIAA0308 KIAA0595 KIAA0616 KIAA1047 KIAA1769 KISH2 LEM6 MECT1 MED1 MEF2C MEF2D MTERF MTERF1 MTPOLB NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NR1C1 NR1D1 NR2B1 NR3B1 NRF1 NS5ATP5 PBP PEO1 PERC PERM1 PGC1 PGC1A PGC1B PIMT POLG2 POLRMT PPAR PPARA PPARBP PPARGBP PPARGC1 PPARGC1A PPARGC1B PPRC1 PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SIR2L3 SIR2L4 SIR2L5 SIRT3 SIRT4 SIRT5 SMARCD3 SOD2 SRC1 SRC2 SSBP SSBP1 TBL1 TBL1X TBL1XR1 TBLR1 TCF6 TCF6L2 TFAM TFB1M TFB2M TGS1 THRAL TIF2 TORC1 TORC2 TORC3 TRAP220 TRBP TRIP2 TWNK WAMTP1	Homo sapiens (human)
Major pathway of rRNA processing in the nucleolus and cytosol	3'-5' exoribonuclease 1 5'-3' exoribonuclease 2 60S ribosome subunit biogenesis protein NIP7 homolog Bystin Casein kinase I isoform delta Casein kinase I isoform epsilon DDB1- and CUL4-associated factor 13 Exosome RNA helicase MTR4 Exosome complex component 10 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 Guanine nucleotide-binding protein-like 3 HEAT repeat-containing protein 1 Interferon-stimulated 20 kDa exonuclease-like 2 KRR1 small subunit processome component homolog Large ribosomal subunit protein P1 Large ribosomal subunit protein P2 Large ribosomal subunit protein eL13 Large ribosomal subunit protein eL14 Large ribosomal subunit protein eL15 Large ribosomal subunit protein eL18 Large ribosomal subunit protein eL19 Large ribosomal subunit protein eL20 Large ribosomal subunit protein eL21 Large ribosomal subunit protein eL22 Large ribosomal subunit protein eL24 Large ribosomal subunit protein eL27 Large ribosomal subunit protein eL28 Large ribosomal subunit protein eL29 Large ribosomal subunit protein eL30 Large ribosomal subunit protein eL31 Large ribosomal subunit protein eL32 Large ribosomal subunit protein eL33 Large ribosomal subunit protein eL34 Large ribosomal subunit protein eL36 Large ribosomal subunit protein eL37 Large ribosomal subunit protein eL38 Large ribosomal subunit protein eL39 Large ribosomal subunit protein eL42 Large ribosomal subunit protein eL43 Large ribosomal subunit protein eL6 Large ribosomal subunit protein eL8 Large ribosomal subunit protein uL10 Large ribosomal subunit protein uL11 Large ribosomal subunit protein uL13 Large ribosomal subunit protein uL14 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL16 Large ribosomal subunit protein uL18 Large ribosomal subunit protein uL1 Large ribosomal subunit protein uL22 Large ribosomal subunit protein uL23 Large ribosomal subunit protein uL24 Large ribosomal subunit protein uL29 Large ribosomal subunit protein uL2 Large ribosomal subunit protein uL30 Large ribosomal subunit protein uL3 Large ribosomal subunit protein uL4 Large ribosomal subunit protein uL5 Large ribosomal subunit protein uL6 M-phase phosphoprotein 6 NHP2-like protein 1 Nuclear nucleic acid-binding protein C1D Nucleolar RNA helicase 2 Nucleolar complex protein 4 homolog Nucleolar protein 11 Nucleolar protein 12 Nucleolar protein 14 Nucleolar protein 56 Nucleolar protein 58 Nucleolar protein 6 Nucleolin Periodic tryptophan protein 2 homolog Pescadillo homolog Polynucleotide 5'-hydroxyl-kinase NOL9 Pre-rRNA-processing protein TSR1 homolog Probable 18S rRNA (guanine-N(7))-methyltransferase Probable ATP-dependent RNA helicase DDX47 Probable ATP-dependent RNA helicase DDX49 Probable ATP-dependent RNA helicase DDX52 Probable ATP-dependent RNA helicase DHX37 Probable U3 small nucleolar RNA-associated protein 11 Probable rRNA-processing protein EBP2 Proline-, glutamic acid- and leucine-rich protein 1 Protein LTV1 homolog Protein RRP5 homolog RNA 3'-terminal phosphate cyclase-like protein RNA-binding protein 28 RNA-binding protein NOB1 RNA-binding protein PNO1 Ribonuclease P protein subunit p14 Ribonuclease P protein subunit p21 Ribonuclease P protein subunit p25 Ribonuclease P protein subunit p30 Ribonuclease P protein subunit p38 Ribonuclease P protein subunit p40 Ribosomal RNA processing protein 1 homolog A Ribosomal RNA processing protein 36 homolog Ribosomal RNA small subunit methyltransferase NEP1 Ribosomal RNA-processing protein 7 homolog A Ribosomal biogenesis protein LAS1L Ribosomal protein eL22-like Ribosomal protein eL39-like 2 Ribosomal protein eL42-like Ribosomal protein eS27-like Ribosomal protein uL16-like Ribosomal protein uL24-like Ribosomal protein uL3-like Ribosome biogenesis protein BMS1 homolog Ribosome biogenesis protein BOP1 Ribosome biogenesis protein WDR12 Sentrin-specific protease 3 Serine/threonine-protein kinase RIO1 Serine/threonine-protein kinase RIO2 Serine/threonine-protein kinase RIO3 Small ribosomal subunit protein eS10 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS32 Small ribosomal subunit protein eS4, X isoform Small ribosomal subunit protein eS4, Y isoform 1 Small ribosomal subunit protein eS4, Y isoform 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8 Small ribosomal subunit protein uS9 Small subunit processome component 20 homolog Something about silencing protein 10 Testis-expressed protein 10 Transducin beta-like protein 3 U3 small nucleolar RNA-associated protein 14 homolog A U3 small nucleolar RNA-associated protein 14 homolog C U3 small nucleolar RNA-associated protein 15 homolog U3 small nucleolar RNA-associated protein 18 homolog U3 small nucleolar RNA-associated protein 25 homolog U3 small nucleolar RNA-associated protein 4 homolog U3 small nucleolar RNA-associated protein 6 homolog U3 small nucleolar RNA-interacting protein 2 U3 small nucleolar ribonucleoprotein protein IMP3 U3 small nucleolar ribonucleoprotein protein IMP4 U3 small nucleolar ribonucleoprotein protein MPP10 Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WD repeat-containing protein 18 WD repeat-containing protein 36 WD repeat-containing protein 3 WD repeat-containing protein 43 WD repeat-containing protein 46 WD repeat-containing protein 75 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 rRNA 2'-O-methyltransferase fibrillarin rRNA-processing protein FCF1 homolog	O00541 O00566 O00567 O14730 O15213 O43709 O43818 O75691 O75818 O95059 P05386 P05387 P05388 P08708 P08865 P15880 P18077 P18124 P18621 P19338 P22087 P22090 P23396 P25398 P26373 P27635 P30050 P32969 P35268 P36578 P39019 P39023 P40429 P42285 P42677 P42766 P46776 P46777 P46778 P46779 P46781 P46782 P46783 P47914 P48730 P49207 P49674 P50914 P55769 P56182 P60866 P61247 P61254 P61313 P61353 P61513 P61927 P62081 P62241 P62244 P62249 P62263 P62266 P62269 P62273 P62277 P62280 P62424 P62701 P62750 P62753 P62829 P62841 P62847 P62851 P62854 P62857 P62861 P62888 P62891 P62899 P62906 P62910 P62913 P62917 P62945 P62979 P62987 P63173 P63220 P78316 P78345 P78346 P83731 P83881 P84098 Q01780 Q02543 Q02878 Q06265 Q07020 Q12788 Q13601 Q13868 Q13895 Q13901 Q14137 Q14690 Q14692 Q15024 Q15061 Q15269 Q2NL82 Q5RKV6 Q5SY16 Q5TAP6 Q68CQ4 Q6P5R6 Q71UM5 Q8IV48 Q8IWA0 Q8IY37 Q8IY81 Q8IZL8 Q8NI36 Q8TD47 Q8TED0 Q92901 Q92979 Q969Q0 Q969X6 Q96B26 Q96EH5 Q96EU6 Q96G21 Q96GA3 Q96L21 Q99547 Q99848 Q9BRS2 Q9BUL9 Q9BV38 Q9BVI4 Q9BVJ6 Q9BVP2 Q9BVS4 Q9GZL7 Q9H0D6 Q9H0S4 Q9H4L4 Q9H583 Q9H633 Q9H6R4 Q9H8H0 Q9H9L3 Q9NPD3 Q9NQT4 Q9NQT5 Q9NQZ2 Q9NR30 Q9NRX1 Q9NV06 Q9NV31 Q9NW13 Q9NXF1 Q9NYH9 Q9UGY1 Q9ULX3 Q9UNX3 Q9UNX4 Q9Y221 Q9Y2L1 Q9Y2P8 Q9Y2R4 Q9Y2X3 Q9Y324 Q9Y3A2 Q9Y3A4 Q9Y3B2 Q9Y3U8 Q9Y4W2 Q9Y5J1 Q9Y6V7	3'EXO ART4 BAP28 BBC1 BING4 BMS1 BMS1L BOP1 BUD23 BXDC4 BYSL C14orf111 C15orf12 C17orf40 C1D C1orf107 C2F C4orf9 C6orf11 C6orf135 C6orf153 C6orf93 CAT60 CCG2 CIRH1A CML28 CRLZ1 CSL4 CSNK1D CSNK1E D11S2243E D21S2056E D6S218E DCAF13 DDX21 DDX37 DDX47 DDX49 DDX52 DEF DHX37 DIEXF DIS3 DOB1 DRIM DXS648E E2IG3 EBNA1BP2 EBP2 EC45 EMG1 ENP1 ERI1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAU FBL FCF1 FIB1 FLRN FTE1 FTSJ3 GNL3 HCA66 HCKID HEATR1 HMX3 HRB2 IMP3 IMP4 ISG20L2 KIAA0007 KIAA0052 KIAA0116 KIAA0124 KIAA0185 KIAA0187 KIAA0266 KIAA1008 KIAA1401 KIAA1517 KIAA1988 KRR1 LAMBR LAMR1 LAS1L LTV1 MERM1 MFTL MHAT MNAR MPHOSPH10 MPHOSPH6 MPP10 MPP6 MPS1 MRPS4 MTR3 MTR4 MTREX NCL NEDD6 NHP2L1 NIP7 NNP1 NOB1 NOB1P NOC4L NOL11 NOL12 NOL14 NOL5 NOL5A NOL6 NOL9 NOP14 NOP5 NOP52 NOP56 NOP58 NS OIP2 PDCD11 PELP1 PES1 PMSCL PMSCL1 PMSCL2 PNO1 PSMD8BP1 PWP2 PWP2H QM RBM28 RCL1 RIG RIO1 RIO2 RIOK1 RIOK2 RIOK3 RNAC RNASEP1 RNASEP2 RNU3IP2 ROK1 RPC2 RPCL1 RPL1 RPL10 RPL10A RPL10L RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL26P1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL36AL RPL37 RPL37A RPL38 RPL39 RPL39L RPL39L1 RPL3L RPL4 RPL41 RPL44 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL9P7 RPL9P8 RPL9P9 RPLP0 RPLP1 RPLP2 RPP14 RPP2 RPP21 RPP25 RPP30 RPP38 RPP40 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS17L RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4 RPS4X RPS4Y RPS4Y1 RPS4Y2 RPS4Y2P RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RRP1 RRP1A RRP36 RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 RRP6 RRP7A RRP9 RTC2 SAS10 SAZD SCAR SDCCAG16 SENP3 SKI6 SKIV2L2 SNU13 SSP3 SUDD SURF-3 SURF3 SUSP3 TBL3 TEX10 THEX1 TSR1 TXREB1 U355K UBA52 UBA80 UBCEP1 UBCEP2 UTP10 UTP11 UTP11L UTP14A UTP14C UTP15 UTP17 UTP18 UTP20 UTP25 UTP3 UTP4 UTP5 UTP6 WBSCR22 WDR12 WDR18 WDR3 WDR36 WDR43 WDR46 WDR50 WDR75 WDSOF1 XRN2 cPERP-E	Homo sapiens (human)
DARPP-32 events	3',5'-cyclic-AMP phosphodiesterase 4A 3',5'-cyclic-AMP phosphodiesterase 4C 3',5'-cyclic-AMP phosphodiesterase 4D Calcineurin subunit B type 1 Calmodulin-1 Cyclin-dependent kinase 5 Protein phosphatase 1 regulatory subunit 1B Protein phosphatase 3 catalytic subunit alpha Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Serine/threonine-protein phosphatase PP1-alpha catalytic subunit cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	P0DP23 P10644 P13861 P16298 P17612 P22612 P22694 P27815 P30153 P30154 P31321 P31323 P48454 P62136 P62714 P63098 P67775 Q00535 Q08209 Q08493 Q08499 Q14738 Q9UD71	CALM CALM1 CALNA CALNA2 CALNA3 CALNB CAM CAM1 CDK5 CDKN5 CNA CNA2 CNA3 CNB DARPP32 DPDE1 DPDE2 DPDE3 PDE4A PDE4C PDE4D PKACA PKR1 PKR2 PPP1A PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B PSSALRE TSE1	Homo sapiens (human)
G alpha (s) signalling events	3',5'-cyclic-AMP phosphodiesterase 4A 3',5'-cyclic-AMP phosphodiesterase 4C 3',5'-cyclic-AMP phosphodiesterase 4D 3',5'-cyclic-AMP phosphodiesterase 7B 5-hydroxytryptamine receptor 4 5-hydroxytryptamine receptor 6 5-hydroxytryptamine receptor 7 Adenosine receptor A2a Adenosine receptor A2b Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Adrenocorticotropic hormone receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic receptor Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Calcitonin gene-related peptide 1 Calcitonin gene-related peptide 2 Calcitonin gene-related peptide type 1 receptor Calcitonin receptor Calcitonin Corticoliberin Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor receptor 2 Cysteinyl leukotriene receptor 2 D(1A) dopamine receptor D(1B) dopamine receptor Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B Follicle-stimulating hormone receptor Follitropin subunit beta G protein-coupled receptor kinase 3 G protein-coupled receptor kinase 5 G protein-coupled receptor kinase 6 G-protein coupled bile acid receptor 1 G-protein coupled receptor 15 G-protein coupled receptor 176 G-protein coupled receptor 20 G-protein coupled receptor 39 G-protein coupled receptor 83 G-protein coupled receptor 84 Gastric inhibitory polypeptide receptor Gastric inhibitory polypeptide Glucagon receptor Glucagon-like peptide 1 receptor Glucagon-like peptide 2 receptor Glycoprotein hormone alpha-2 Glycoprotein hormone beta-5 Glycoprotein hormones alpha chain Growth hormone-releasing hormone receptor Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Guanine nucleotide-binding protein G(t) subunit alpha-3 Guanine nucleotide-binding protein G(z) subunit alpha Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 High affinity 3',5'-cyclic-AMP phosphodiesterase 7A High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Histamine H2 receptor Insulin-like 3 Islet amyloid polypeptide Lutropin subunit beta Lutropin-choriogonadotropic hormone receptor Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor Neuropeptide S receptor Neuropeptide S P2Y purinoceptor 11 Parathyroid hormone 2 receptor Parathyroid hormone-related protein Parathyroid hormone/parathyroid hormone-related peptide receptor Parathyroid hormone Pituitary adenylate cyclase-activating polypeptide type I receptor Pituitary adenylate cyclase-activating polypeptide Pro-adrenomedullin Pro-glucagon Pro-opiomelanocortin Probable G-protein coupled receptor 150 Probable G-protein coupled receptor 25 Probable G-protein coupled receptor 27 Probable G-protein coupled receptor 32 Probable G-protein coupled receptor 45 Prorelaxin H2 Prostacyclin receptor Prostaglandin D2 receptor Prostaglandin E2 receptor EP2 subtype Prostaglandin E2 receptor EP4 subtype Protein ADM2 Proto-oncogene tyrosine-protein kinase Src Putative trace amine-associated receptor 3 Receptor activity-modifying protein 1 Receptor activity-modifying protein 2 Receptor activity-modifying protein 3 Relaxin receptor 1 Relaxin receptor 2 Relaxin-3 Secretin receptor Secretin Somatoliberin Thyrotropin receptor Thyrotropin subunit beta Trace amine-associated receptor 1 Trace amine-associated receptor 2 Trace amine-associated receptor 5 Trace amine-associated receptor 6 Trace amine-associated receptor 8 Trace amine-associated receptor 9 Tuberoinfundibular peptide of 39 residues VIP peptides Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2 Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A cGMP-dependent 3',5'-cyclic phosphodiesterase cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	A8MTJ3 O00155 O00408 O14610 O14775 O14804 O43194 O43306 O60262 O60266 O60503 O60658 O60894 O60895 O60896 O75388 O95263 O95622 O95838 P01185 P01189 P01215 P01222 P01225 P01229 P01258 P01270 P01275 P01282 P01286 P04090 P04899 P06850 P06881 P07550 P08588 P08754 P09681 P09683 P0C0P6 P10092 P10997 P12272 P12931 P13945 P16473 P16520 P18509 P19086 P21728 P21918 P22888 P23945 P25021 P25098 P27815 P29274 P29275 P30518 P30988 P32121 P32241 P32245 P33032 P34947 P34969 P34998 P35318 P35408 P35626 P40145 P41586 P41587 P41968 P43116 P43119 P43220 P43250 P47871 P47872 P48546 P49190 P49407 P49685 P50150 P50151 P50406 P51460 P51828 P54750 P59768 P61952 P62873 P62879 P63092 P63096 P63211 P63215 P63218 Q01064 Q01718 Q01726 Q02643 Q03431 Q08462 Q08493 Q08499 Q08828 Q13258 Q13324 Q13370 Q13639 Q13946 Q14432 Q14439 Q16602 Q5JWF2 Q6W5P4 Q7Z4H4 Q86YW7 Q8NFM4 Q8NGU9 Q8TDU6 Q8WXD0 Q8WXF3 Q969N4 Q96A98 Q96G91 Q96RI8 Q96RI9 Q96RJ0 Q96T91 Q99678 Q9HAV0 Q9HBX9 Q9HCR9 Q9NP56 Q9NQS5 Q9NS67 Q9NS75 Q9NYM4 Q9P1P4 Q9P1P5 Q9P2W3 Q9UBI6 Q9UK08 Q9Y233 Q9Y5Y3	ACTHR ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADHR ADM ADM2 ADORA2 ADORA2A ADORA2B ADRB1 ADRB1R ADRB2 ADRB2R ADRB3 ADRB3R ADRBK1 ADRBK2 AM AM2 ARB2 ARR1 ARR2 ARRB1 ARRB2 ARVP AVP AVPR2 B1AR B2AR B3AR BARK BARK1 BARK2 CALC1 CALC2 CALCA CALCB CALCR CALCRL CGA CGRPR CRF2R CRFR CRFR1 CRH CRH2R CRHR CRHR1 CRHR2 CYSLT2 CYSLT2R CYSLTR2 DIR DIR3 DPDE1 DPDE2 DPDE3 DRD1 DRD1B DRD1L2 DRD5 EX33 FSHB FSHR GCG GCGR GHRF GHRH GHRHR GIP GIPR GLP1R GLP2R GNAI1 GNAI2 GNAI2B GNAI3 GNAS GNAS1 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GPA2 GPB5 GPBAR1 GPHA2 GPHB5 GPR102 GPR106 GPR15 GPR150 GPR154 GPR176 GPR20 GPR25 GPR27 GPR32 GPR39 GPR45 GPR57 GPR58 GPR72 GPR83 GPR84 GPRA GPRK5 GPRK6 GREAT GRK2 GRK3 GRK5 GRK6 GSP HRH2 HTR4 HTR6 HTR7 IAPP INSL3 INSL7 JP05 KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA1060 KIAA1540 LCGR LGR1 LGR2 LGR3 LGR7 LGR8 LHB LHCGR LHRHR MC1R MC2R MC3R MC4R MC5R MSHR NPS NPSR1 P2RY11 PDE10A PDE11A PDE1A PDE1B PDE2A PDE3A PDE3B PDE4A PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDES1B PGR14 PNR POMC PRIPR PTGDR PTGER2 PTGER4 PTGIR PTH PTH1R PTH2 PTH2R PTHLH PTHR PTHR1 PTHR2 PTHRP RAMP1 RAMP2 RAMP3 RLF RLN2 RLN3 RLNL RXFP1 RXFP2 RXN3 SCT SCTR SRC SRC1 SREB1 TA1 TA3 TA4 TA5 TAAR1 TAAR2 TAAR3 TAAR3P TAAR5 TAAR6 TAAR8 TAAR9 TAR1 TAR3 TAR4 TAR5 TGR5 TIP39 TIPF39 TRAR1 TRAR3 TRAR4 TRAR5 TSHB TSHR V2R VIP VIP2R VIPR1 VIPR2 VP ZINS4 ZLUT1 ZSIG51	Homo sapiens (human)
Cytosolic sulfonation of small molecules	3'(2'),5'-bisphosphate nucleotidase 1 Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase Podocalyxin-like protein 2 Protein-tyrosine sulfotransferase 1 Protein-tyrosine sulfotransferase 2 Putative protein-lysine deacylase ABHD14B Sulfotransferase 1A1 Sulfotransferase 1A2 Sulfotransferase 1A3 Sulfotransferase 1A4 Sulfotransferase 1B1 Sulfotransferase 1C2 Sulfotransferase 1C4 Sulfotransferase 1E1 Sulfotransferase 2A1 Sulfotransferase 4A1 Sulfotransferase 6B1	O00338 O43704 O60507 O60704 O75897 O95861 P0DMM9 P0DMN0 P49888 P50225 P50226 Q06520 Q6IMI4 Q96IU4 Q9BR01 Q9NX62 Q9NZ53	ABHD14B BPNT1 BPNT2 CIB HST IMPA3 IMPAD1 PODXL2 ST1B2 STD STE STM STP STP1 STP2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1B2 SULT1C1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT4A1 SULT6B1 SULTX3 TPST1 TPST2	Homo sapiens (human)
Mineralocorticoid biosynthesis	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Cytochrome P450 11B2, mitochondrial Glycoprotein hormones alpha chain Lutropin subunit beta Steroid 21-hydroxylase	P01215 P01229 P08686 P14060 P19099 P26439	3BH CGA CYP11B2 CYP21 CYP21A2 CYP21B HSD3B1 HSD3B2 HSDB3A HSDB3B LHB	Homo sapiens (human)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Bile acid receptor Cytochrome P450 7A1 Cytochrome P450 7B1 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O75881 P17516 P19793 P22680 P42330 P51857 P52895 Q02318 Q04828 Q15596 Q15788 Q16647 Q96RI1 Q9H2F3 Q9UNU6	AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 BAR BHLHE74 BHLHE75 CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 FXR HRR1 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTGIS RIP14 RXRA SRC1 SRC2 SRD5B1 TIF2	Homo sapiens (human)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Acyl-coenzyme A thioesterase 8 Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Alpha-methylacyl-CoA racemase Bile acid receptor Bile acid-CoA Bile salt export pump Cytochrome P450 7A1 Cytochrome P450 7B1 Long-chain fatty acid transport protein 2 Long-chain fatty acid transport protein 5 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal multifunctional enzyme type 2 Prostacyclin synthase Retinoic acid receptor RXR-alpha Sterol 26-hydroxylase, mitochondrial	O14734 O14975 O75881 O95342 P17516 P19793 P22680 P42330 P51659 P51857 P52895 Q02318 Q04828 Q14032 Q15596 Q15788 Q16647 Q96RI1 Q99424 Q9H2F3 Q9UHK6 Q9UNU6 Q9Y2P5	ABCB11 ACOT8 ACOX2 ACSB ACSVL1 ACSVL6 ACTEIII AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR BAAT BAR BHLHE74 BHLHE75 BSEP CHDR CYP12 CYP27 CYP27A1 CYP7 CYP7A1 CYP7B1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 EDH17B4 FACVL1 FACVL3 FATP2 FATP5 FXR HRR1 HSD17B4 HSD17B5 HSD3B7 KIAA0119 NCOA1 NCOA2 NR1H4 NR2B1 PGFS PTE1 PTGIS RIP14 RXRA SDR8C1 SLC27A2 SLC27A5 SRC1 SRC2 SRD5B1 TIF2 VLACS	Homo sapiens (human)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	26S proteasome regulatory subunit 4 Cytosolic endo-beta-N-acetylglucosaminidase Derlin-1 E3 ubiquitin-protein ligase AMFR Glucosidase 2 subunit beta Malectin Mannosyl-oligosaccharide glucosidase Neutral alpha-glucosidase AB Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase UBX domain-containing protein 1 UV excision repair protein RAD23 homolog B Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P14314 P54727 P55072 P62191 P62979 P62987 Q04323 Q13724 Q14165 Q14697 Q8NFI3 Q96IV0 Q9BUN8 Q9UKV5	AMFR DER1 DERL1 ENGASE G19P1 G2AN GANAB GCS1 HEL-220 HEL-S-70 KIAA0088 KIAA0152 MLEC MOGS NGLY1 PNG1 PRKCSH PSMC1 RAD23B RNF45 RPS27A SAKS1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBXN1 VCP	Homo sapiens (human)	G03934XO G25577BM G28233ME G51034LA G58161NS G86419OL
Metalloprotease DUBs	26S proteasome non-ATPase regulatory subunit 14 AMSH-like protease BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 BRISC complex subunit Abraxas 2 Breast cancer type 1 susceptibility protein Deubiquitinase MYSM1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone acetyltransferase KAT2B Histone acetyltransferase p300 Lys-63-specific deubiquitinase BRCC36 NACHT, LRR and PYD domains-containing protein 3 Polyubiquitin-B Polyubiquitin-C STAM-binding protein Signal transducing adapter molecule 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00487 O95630 P04908 P0C0S8 P0CG47 P0CG48 P20671 P38398 P46736 P62979 P62987 Q09472 Q15018 Q16777 Q5VVJ2 Q6FI13 Q6UWZ7 Q7L7L0 Q8IUE6 Q92783 Q92831 Q93077 Q96FJ0 Q96KK5 Q96P20 Q96QV6 Q96RL1 Q99728 Q99878 Q9NWV8 Q9NXR7	ABRA1 ABRAXAS1 ABRAXAS2 ABRO1 AMSH AMSHLP BABAM1 BABAM2 BARD1 BRCA1 BRCC3 BRCC36 BRCC45 BRE C19orf62 C1orf7 C6.1A CCDC98 CIAS1 CXorf53 EP300 FAM175A FAM175B H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST3H2A KAT2B KIAA0157 KIAA1373 KIAA1915 MERIT40 MYSM1 NALP3 NBA1 NLRP3 P300 PCAF POH1 PSMD14 PYPAF1 RAP80 RNF53 RPS27A RXRIP110 STAM STAM1 STAMBP STAMBPL1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UIMC1	Homo sapiens (human)
Impaired BRCA2 translocation to the nucleus	26S proteasome complex subunit SEM1 Breast cancer type 2 susceptibility protein	P51587 P60896	BRCA2 C7orf76 DSS1 FACD FANCD1 SEM1 SHFDG1 SHFM1	Homo sapiens (human)
Impaired BRCA2 binding to SEM1 (DSS1)	26S proteasome complex subunit SEM1 Breast cancer type 2 susceptibility protein	P51587 P60896	BRCA2 C7orf76 DSS1 FACD FANCD1 SEM1 SHFDG1 SHFM1	Homo sapiens (human)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Homologous DNA Pairing and Strand Exchange	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Regulator of telomere elongation helicase 1 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9NZ71 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C20orf41 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 KIAA1088 MRE11 MRE11A NBN NBS NBS1 NHL P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 RTEL1 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
HDR through Homologous Recombination (HRR)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase eta DNA polymerase kappa DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15315 O43502 O43542 O43543 O60934 O75771 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P38398 P40937 P40938 P49005 P49959 P51530 P51587 P54132 P56282 P60896 P62979 P62987 Q06609 Q07864 Q13315 Q13472 Q14191 Q15054 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UQ84 Q9Y253	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CHRAC17 CTIP DINB1 DNA2 DNA2L DPE2 DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0039 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PCNA PIR51 POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLH POLK RAD30 RAD30A RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN XPV XRCC2 XRCC3	Homo sapiens (human)
Resolution of D-loop Structures through Holliday Junction Intermediates	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Crossover junction endonuclease EME1 Crossover junction endonuclease MUS81 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA repair-scaffolding protein DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 FIGNL1-interacting regulator of recombination and mitosis Fanconi anemia group J protein Fidgetin-like protein 1 Flap endonuclease GEN homolog 1 Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Probable crossover junction endonuclease EME2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM Structure-specific endonuclease subunit SLX1 Structure-specific endonuclease subunit SLX4	A4GXA9 O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14159 Q14191 Q17RS7 Q6PIW4 Q86YC2 Q8IY92 Q92878 Q92993 Q96AY2 Q96B01 Q96E14 Q96NY9 Q99708 Q99728 Q9BQ83 Q9BX63 Q9H9A7 Q9NSG2 Q9UQ84	APOLO1 ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 BTBD12 C16orf75 C1orf112 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EME1 EME2 EXO1 EXOI FACD FANCD1 FANCJ FANCN FIGNL1 FIRRM GEN1 GIYD1 GIYD2 HEX1 HNGS1 HTATIP KAT5 KIAA0083 KIAA0146 KIAA1784 KIAA1987 MMS4 MRE11 MRE11A MUS81 NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 SLX1 SLX1A SLX1B SLX4 SPIDR TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
Impaired BRCA2 binding to RAD51	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR	O60671 O60921 O60934 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD9A RAD9B RBBP8 REC1 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN	Homo sapiens (human)
Presynaptic phase of homologous DNA pairing and strand exchange	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1	O14757 O15315 O43502 O43543 O60671 O60921 O60934 O75771 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CHEK1 CHK1 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RAD9A RAD9B RBBP8 REC1 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN XRCC2	Homo sapiens (human)

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